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Gutorm Høgåsen edited this page May 2, 2022 · 33 revisions

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How do I get access to genetic data from MoBa?

You will find details on the NIPH site.

How to obtain access

If your project does not yet have access please review the information and apply as described at the NIPH MoBa website

The datasets will be, if you get access, available on TSD in shared folders between your project and p229mobagenetics (snpArray/GWAS data)/229methylation. If you have access to the shared folder the data should be available to you.

How to acknowledge the use of the data

The Norwegian Mother, Father and Child Cohort Study is today one of the world's largest genotyped triad cohorts. A lot of resources at the Norwegian Institute of Public Health, and in the research groups that funded genotyping and spent a lot of time preparing the data, has been crucial for now allowing general access to this resource for all researchers. Please acknowledge their efforts by following the guidelines at the NIPH webpage checklist for papers

What is ...

MoBa

See https://www.fhi.no/en/studies/moba/ . For projects that already have - or are applying for data see (in Norwegian) https://www.fhi.no/studier/moba/forskere/moba-prosjekter/ .

TSD

See https://www.uio.no/english/services/it/research/sensitive-data/. It is, for now, the only platform that will let you access the data.

What data are you interested in

Note that not all participants have agreed to share biological material. This comes in addition to participants that have withdrawn completely from the cohort. So there are participant where questionnaire data exist, but no data from biological samples.

Regardless of what data you need, you need approval first, see How to obtain access above.

GWAS data

As of March 2021, only snpArray/GWAS data are published, see Version 1.0 and the unfinished Version 1.5. You might want to check out the entry on sharing of QC below.

In theory, the whole MoBa cohort has been genotyped but there are some pitfalls, mostly the fact that we lack some biological samples (roughly around 30000 out of 25000).

Methylation data

(These are not technically part of MoBa Genetics - the name MoBa Genetics is reserved for GWAS data))

See more on Methylation.

Since there are so few methylation data available, there is currently no extra charge for using methylation data if you already have access to GWAS (snpArray) data.

Telomere, metabolomics and exome data

We have a received small sets of these data, but they are not ready for sharing. We are currently prioritizing GWAS and Methylation. Refer to the official MoBa site - particularly the contact link.

Questionnaires

Refer to the official MoBa site - particularly the contact link. There is a separate sub-page concerning questionnaires

Individuals and Samples

Can individuals have samples in different sets

Yes. There can be overlap in both samples and individuals. There are two kind of overlap

  1. The sample belongs to sets in version 1.0 and 1.5. Version 1.5 is a superset of 1.0, so you will easilly be able to identify these
  2. The individual have had multiple samples (each with uniq sentrix-id) genotyped as part of different data-sets/batches. It is up to you to make sure you take this in account when analyzing your data.

Where can I get more help and info?

Official info from the Norwegian Institute of Public Health (NIPH)

https://www.fhi.no/en/studies/moba/

Slack

Slack is an instant messaging app widely used. The NIPH has created a workspace so that researchers working with MoBa can help each other out/collaborate. See our slack page for more info.

How to access data

Can I use other platforms to analyze data than TSD?

For now, according to your contract, the answer is no.

How to return analyzed data to MobaGenetics

This is only relevant for you if you got biological material from MoBa and, as pr. contract, is to return analyzed data to NIPH. We get a lot of questions about why and how: See answers on Returning data to NIPH

Can I share data/results (such as QC) with other projects

Projects in MoBa that already have access to MoBa-based genetic data may share quality-controlled versions (QC) of these data, however an application must be sent to the MoBa administration (mobaadm atsign fhi.no) prior to any sharing of such data.

Requirements that must be met before MoBa can approve an application:

  • Both FROM (the project sharing data) and TO (the project receiving data) must have access to and approval from the Regional Committees for Medical and Health Reseach Ethics (REK) and from MoBa for the use of the same genetic data
  • Both FROM and TO must have approval from REK stating that sharing of such data between the projects is allowed

MoBa will only approve applications with the following conditions:

  • Only quality-controlled versions of the genetic data can be shared
  • The quality-controlled files are only a product of the genetic data that both projects already have access to. No project-specific data can be shared
  • The sharing of data is made in accordance with established data processing plans and within the framework of Services for sensitive data (TSD).
  • The data never leaves TSD. The project administrator of FROM sends a request to TSD to create a folder that allows read-only sharing with and only with TO. The request to TSD must include the REK-approval for sharing of QC-data
  • Any costs associated with such sharing will be charged to the projects involved, and not MoBa
  • The projects themselves must agree upon how to credit the researchers who performed the quality control work.

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