Skip to content

Commit

Permalink
Add Exercise: Protein Translation (#245)
Browse files Browse the repository at this point in the history
* Add assert_equal for arrays of strings

This is needed for e.g. the Protein-Translation exercise feautred in 48in24.

* Add exercise: protein-translation

* Remove tests with invalid codons

---------

Co-authored-by: Joel <[email protected]>
  • Loading branch information
D3usXMachina and D3usXMachina authored Feb 15, 2024
1 parent 55e68b1 commit 9491982
Show file tree
Hide file tree
Showing 8 changed files with 407 additions and 0 deletions.
12 changes: 12 additions & 0 deletions config.json
Original file line number Diff line number Diff line change
Expand Up @@ -477,6 +477,18 @@
"practices": [],
"prerequisites": [],
"difficulty": 8
},
{
"slug": "protein-translation",
"name": "Protein Translation",
"uuid": "3d2ba0a1-2a2a-4e1f-89e8-c5add9ddceef",
"practices": [],
"prerequisites": [],
"difficulty": 5,
"topics": [
"lists",
"strings"
]
}
]
}
Expand Down
45 changes: 45 additions & 0 deletions exercises/practice/protein-translation/.docs/instructions.md
Original file line number Diff line number Diff line change
@@ -0,0 +1,45 @@
# Instructions

Translate RNA sequences into proteins.

RNA can be broken into three nucleotide sequences called codons, and then translated to a polypeptide like so:

RNA: `"AUGUUUUCU"` => translates to

Codons: `"AUG", "UUU", "UCU"`
=> which become a polypeptide with the following sequence =>

Protein: `"Methionine", "Phenylalanine", "Serine"`

There are 64 codons which in turn correspond to 20 amino acids; however, all of the codon sequences and resulting amino acids are not important in this exercise.
If it works for one codon, the program should work for all of them.
However, feel free to expand the list in the test suite to include them all.

There are also three terminating codons (also known as 'STOP' codons); if any of these codons are encountered (by the ribosome), all translation ends and the protein is terminated.

All subsequent codons after are ignored, like this:

RNA: `"AUGUUUUCUUAAAUG"` =>

Codons: `"AUG", "UUU", "UCU", "UAA", "AUG"` =>

Protein: `"Methionine", "Phenylalanine", "Serine"`

Note the stop codon `"UAA"` terminates the translation and the final methionine is not translated into the protein sequence.

Below are the codons and resulting Amino Acids needed for the exercise.

| Codon | Protein |
| :----------------- | :------------ |
| AUG | Methionine |
| UUU, UUC | Phenylalanine |
| UUA, UUG | Leucine |
| UCU, UCC, UCA, UCG | Serine |
| UAU, UAC | Tyrosine |
| UGU, UGC | Cysteine |
| UGG | Tryptophan |
| UAA, UAG, UGA | STOP |

Learn more about [protein translation on Wikipedia][protein-translation].

[protein-translation]: https://en.wikipedia.org/wiki/Translation_(biology)
16 changes: 16 additions & 0 deletions exercises/practice/protein-translation/.meta/config.json
Original file line number Diff line number Diff line change
@@ -0,0 +1,16 @@
{
"authors": ["D3usXMachina"],
"files": {
"solution": [
"protein_translation.f90"
],
"test": [
"protein_translation_test.f90"
],
"example": [
".meta/example.f90"
]
},
"blurb": "Translate RNA sequences into proteins.",
"source": "Tyler Long"
}
63 changes: 63 additions & 0 deletions exercises/practice/protein-translation/.meta/example.f90
Original file line number Diff line number Diff line change
@@ -0,0 +1,63 @@
module protein_translation
implicit none

character(len=13), parameter, private :: protein_names(7) = [&
"Methionine ", &
"Phenylalanine", &
"Leucine ", &
"Serine ", &
"Tyrosine ", &
"Cysteine ", &
"Tryptophan " &
]

contains

function proteins(rna) result(names)
character(len=*), intent(in) :: rna
integer, allocatable :: protein_ids(:)
character(len=13), allocatable :: names(:)
integer :: i, n_protein, max_n_proteins

max_n_proteins = len(rna)/3
allocate(protein_ids(0:max_n_proteins-1))

n_protein = 0
do i = 1, len(rna), 3
if (i + 2 > len(rna)) then
n_protein = 0
exit ! Invalid codon
end if
select case (rna(i:i+2))
case ("AUG")
protein_ids(n_protein+1) = 1
case ("UUU", "UUC")
protein_ids(n_protein+1) = 2
case ("UUA", "UUG")
protein_ids(n_protein+1) = 3
case ("UCU", "UCC", "UCA", "UCG")
protein_ids(n_protein+1) = 4
case ("UAU", "UAC")
protein_ids(n_protein+1) = 5
case ("UGU", "UGC")
protein_ids(n_protein+1) = 6
case ("UGG")
protein_ids(n_protein+1) = 7
case ("UAA", "UAG", "UGA")
exit ! stop codon
case default
n_protein = 0
exit ! invalid codon
end select
n_protein = n_protein + 1
end do

allocate(names(n_protein))
do i = 1, n_protein
names(i) = protein_names(protein_ids(i))
end do

end function proteins

end module protein_translation

88 changes: 88 additions & 0 deletions exercises/practice/protein-translation/.meta/tests.toml
Original file line number Diff line number Diff line change
@@ -0,0 +1,88 @@
# This is an auto-generated file.
#
# Regenerating this file via `configlet sync` will:
# - Recreate every `description` key/value pair
# - Recreate every `reimplements` key/value pair, where they exist in problem-specifications
# - Remove any `include = true` key/value pair (an omitted `include` key implies inclusion)
# - Preserve any other key/value pair
#
# As user-added comments (using the # character) will be removed when this file
# is regenerated, comments can be added via a `comment` key.

[2c44f7bf-ba20-43f7-a3bf-f2219c0c3f98]
description = "Empty RNA sequence results in no proteins"

[96d3d44f-34a2-4db4-84cd-fff523e069be]
description = "Methionine RNA sequence"

[1b4c56d8-d69f-44eb-be0e-7b17546143d9]
description = "Phenylalanine RNA sequence 1"

[81b53646-bd57-4732-b2cb-6b1880e36d11]
description = "Phenylalanine RNA sequence 2"

[42f69d4f-19d2-4d2c-a8b0-f0ae9ee1b6b4]
description = "Leucine RNA sequence 1"

[ac5edadd-08ed-40a3-b2b9-d82bb50424c4]
description = "Leucine RNA sequence 2"

[8bc36e22-f984-44c3-9f6b-ee5d4e73f120]
description = "Serine RNA sequence 1"

[5c3fa5da-4268-44e5-9f4b-f016ccf90131]
description = "Serine RNA sequence 2"

[00579891-b594-42b4-96dc-7ff8bf519606]
description = "Serine RNA sequence 3"

[08c61c3b-fa34-4950-8c4a-133945570ef6]
description = "Serine RNA sequence 4"

[54e1e7d8-63c0-456d-91d2-062c72f8eef5]
description = "Tyrosine RNA sequence 1"

[47bcfba2-9d72-46ad-bbce-22f7666b7eb1]
description = "Tyrosine RNA sequence 2"

[3a691829-fe72-43a7-8c8e-1bd083163f72]
description = "Cysteine RNA sequence 1"

[1b6f8a26-ca2f-43b8-8262-3ee446021767]
description = "Cysteine RNA sequence 2"

[1e91c1eb-02c0-48a0-9e35-168ad0cb5f39]
description = "Tryptophan RNA sequence"

[e547af0b-aeab-49c7-9f13-801773a73557]
description = "STOP codon RNA sequence 1"

[67640947-ff02-4f23-a2ef-816f8a2ba72e]
description = "STOP codon RNA sequence 2"

[9c2ad527-ebc9-4ace-808b-2b6447cb54cb]
description = "STOP codon RNA sequence 3"

[f4d9d8ee-00a8-47bf-a1e3-1641d4428e54]
description = "Sequence of two protein codons translates into proteins"

[dd22eef3-b4f1-4ad6-bb0b-27093c090a9d]
description = "Sequence of two different protein codons translates into proteins"

[d0f295df-fb70-425c-946c-ec2ec185388e]
description = "Translate RNA strand into correct protein list"

[e30e8505-97ec-4e5f-a73e-5726a1faa1f4]
description = "Translation stops if STOP codon at beginning of sequence"

[5358a20b-6f4c-4893-bce4-f929001710f3]
description = "Translation stops if STOP codon at end of two-codon sequence"

[ba16703a-1a55-482f-bb07-b21eef5093a3]
description = "Translation stops if STOP codon at end of three-codon sequence"

[4089bb5a-d5b4-4e71-b79e-b8d1f14a2911]
description = "Translation stops if STOP codon in middle of three-codon sequence"

[2c2a2a60-401f-4a80-b977-e0715b23b93d]
description = "Translation stops if STOP codon in middle of six-codon sequence"
71 changes: 71 additions & 0 deletions exercises/practice/protein-translation/CMakeLists.txt
Original file line number Diff line number Diff line change
@@ -0,0 +1,71 @@
# Get the exercise name from the current directory
get_filename_component(exercise ${CMAKE_CURRENT_SOURCE_DIR} NAME)

# Basic CMake project
cmake_minimum_required(VERSION 3.0.0)

# Name the project after the exercise
project(${exercise} Fortran)

# set debug build default
set(CMAKE_BUILD_TYPE Debug)

# Get a source filename from the exercise name by replacing -'s with _'s
string(REPLACE "-" "_" file ${exercise})

# Activate Fortran compiler warnings
if(CMAKE_Fortran_COMPILER_ID MATCHES "Intel") # Intel fortran
if(WIN32)
add_compile_options(/warn:all)
else()
add_compile_options(-warn all)
endif()
endif()
if(CMAKE_Fortran_COMPILER_ID MATCHES "GNU") # GFortran
add_compile_options(-std=f2008 -W -Wall -Wextra -pedantic -fbacktrace)
endif()

# Configure to run all the tests?
if(${EXERCISM_RUN_ALL_TESTS})
add_definitions(-DEXERCISM_RUN_ALL_TESTS)
set(exercise_f90 ${file}_build_all.f90)
else()
# if building in exercise folder add testlib
set(testlib_path ${CMAKE_CURRENT_SOURCE_DIR}/testlib)
if (NOT EXISTS ${testlib_path})
if (EXISTS ${CMAKE_CURRENT_SOURCE_DIR}/../../../testlib) # in git repo locally?
file(COPY ${CMAKE_CURRENT_SOURCE_DIR}/../../../testlib DESTINATION ${CMAKE_CURRENT_SOURCE_DIR} PATTERN *)
else() # get from git with http
message("Downloading testlib from https://raw.githubusercontent.com/exercism/fortran/master")
file(MAKE_DIRECTORY ${testlib_path} )
file(DOWNLOAD https://raw.githubusercontent.com/exercism/fortran/master/testlib/TesterMain.f90 ${testlib_path}/TesterMain.f90 SHOW_PROGRESS)
file(DOWNLOAD https://raw.githubusercontent.com/exercism/fortran/master/testlib/CMakeLists.txt ${testlib_path}/CMakeLists.txt SHOW_PROGRESS)
endif()
endif()
# add lib to build
add_subdirectory(testlib)
include_directories(testlib ${CMAKE_CURRENT_BINARY_DIR}/testlib)
if(EXISTS ${CMAKE_CURRENT_SOURCE_DIR}/${file}.f90)
set(exercise_f90 ${file}.f90)
endif()
endif()

# Get test_files if exercise needs it
file(GLOB test_files test_files/*.*)
foreach(test_file ${test_files})
message("Copying ${test_file} to binary directory for example ${file}")
configure_file(${test_file} . COPYONLY)
endforeach()

# Build executable from sources and headers
add_executable(${exercise} ${exercise_f90} ${file}_test.f90 )

target_link_libraries(${exercise} TesterMain)

include(CTest)

add_test (${exercise}_test ${exercise} )

# Run the tests on every build
#add_custom_target(test_${exercise} ALL DEPENDS ${exercise} COMMAND ${exercise})

14 changes: 14 additions & 0 deletions exercises/practice/protein-translation/protein_translation.f90
Original file line number Diff line number Diff line change
@@ -0,0 +1,14 @@
module protein_translation
implicit none

contains

function proteins(rna) result(names)
character(len=*), intent(in) :: rna
character(len=13), allocatable :: names(:)

names = [character(len=13) :: rna] ! Replace this line in your implementation
end function proteins

end module protein_translation

Loading

0 comments on commit 9491982

Please sign in to comment.