Minimal Hodgkin–Huxley Type Models for Different classes of Cortical and Thalamic Neurons

Contributors:

1. Abhinav Menon (2020114001)
2. Harshit Gupta (2020114017)

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Objective:

We intend to use computer simulations to implement Hodgkin-Huxley models of various cells. These cells are drawn from various regions of the brain (like the visual and somatosensory cortices) and from various animals (ferrets, rats, etc.).
We also plot the voltages and the various constituent ion currents, along with their gating variables. We analyse the periodicity of these currents under a repetitive spiking behaviour.

Paper Citation: Pospischil, Martin et al. “Minimal Hodgkin-Huxley type models for different classes of cortical and thalamic neurons.” Biological cybernetics vol. 99,4-5 (2008): 427-41. doi:10.1007/s00422-008-0263-8

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File Structure:

1. FSHH_model.ipynb notebook containing code and visualizations for Ferret Visual Cortex and Rat Somatosensory Cortex Pyramidal. (FS: Fast Spiking)
2. IBHH_model.ipynb notebook containing code and visualizations for Guinea Pig Somatosensory Cortex and Cat Visual Cortex. (IB: Intrinsic Bursting)
3. LTSHH_model.ipynb notebook containing code and visualizations for Cat Association Cortex and Rat Somatosensory Cortex. (LTS: Low Threshold Spiking)
4. RSHH_model.ipynb notebook containing code and visualizations for Ferret Visual Cortex and Rat Somatosensory Cortex Pyramidal. (RS: Regular Spiking)
5. plots contains various plots for all models of each of the above cell types.
6. report.pdf Explanation of our approach, the parameters chose by us and analysis of the plots generated.

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Video Demo

The video demo of the project has been uploaded to YouTube and can be viewed here.

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