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72 changes: 33 additions & 39 deletions paper/paper.bib
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@article{Perez-Riverol2022-ow,
title = "The {PRIDE} database resources in 2022: a hub for mass
spectrometry-based proteomics evidences",
author = "Perez-Riverol, Yasset and Bai, Jingwen and Bandla, Chakradhar
and Garc{\'\i}a-Seisdedos, David and Hewapathirana, Suresh and
Kamatchinathan, Selvakumar and Kundu, Deepti J and Prakash,
Ananth and Frericks-Zipper, Anika and Eisenacher, Martin and
Walzer, Mathias and Wang, Shengbo and Brazma, Alvis and
Vizca{\'\i}no, Juan Antonio",
abstract = "The PRoteomics IDEntifications (PRIDE) database
(https://www.ebi.ac.uk/pride/) is the world's largest data
repository of mass spectrometry-based proteomics data. PRIDE is
one of the founding members of the global ProteomeXchange (PX)
consortium and an ELIXIR core data resource. In this manuscript,
we summarize the developments in PRIDE resources and related
tools since the previous update manuscript was published in
Nucleic Acids Research in 2019. The number of submitted datasets
to PRIDE Archive (the archival component of PRIDE) has reached
on average around 500 datasets per month during 2021. In
addition to continuous improvements in PRIDE Archive data
pipelines and infrastructure, the PRIDE Spectra Archive has been
developed to provide direct access to the submitted mass spectra
using Universal Spectrum Identifiers. As a key point, the file
format MAGE-TAB for proteomics has been developed to enable the
improvement of sample metadata annotation. Additionally, the
resource PRIDE Peptidome provides access to aggregated
peptide/protein evidences across PRIDE Archive. Furthermore, we
will describe how PRIDE has increased its efforts to reuse and
disseminate high-quality proteomics data into other added-value
resources such as UniProt, Ensembl and Expression Atlas.",
journal = "Nucleic Acids Res.",
publisher = "Oxford University Press (OUP)",
volume = 50,
number = "D1",
pages = "D543--D552",
month = jan,
year = 2022,
copyright = "https://creativecommons.org/licenses/by/4.0/",
language = "en"
@article{Perez-Riverol2025-mo,
title = "The {PRIDE} database at 20 years: 2025 update",
author = "Perez-Riverol, Yasset and Bandla, Chakradhar and Kundu, Deepti J
and Kamatchinathan, Selvakumar and Bai, Jingwen and
Hewapathirana, Suresh and John, Nithu Sara and Prakash, Ananth
and Walzer, Mathias and Wang, Shengbo and Vizca{\'\i}no, Juan
Antonio",
abstract = "The PRoteomics IDEntifications (PRIDE) database
(https://www.ebi.ac.uk/pride/) is the world's leading mass
spectrometry (MS)-based proteomics data repository and one of the
founding members of the ProteomeXchange consortium. This
manuscript summarizes the developments in PRIDE resources and
related tools for the last three years. The number of submitted
datasets to PRIDE Archive (the archival component of PRIDE) has
reached on average around 534 datasets per month. This has been
possible thanks to continuous improvements in infrastructure such
as a new file transfer protocol for very large datasets (Globus),
a new data resubmission pipeline and an automatic dataset
validation process. Additionally, we will highlight novel
activities such as the availability of the PRIDE chatbot (based
on the use of open-source Large Language Models), and our work to
improve support for MS crosslinking datasets. Furthermore, we
will describe how we have increased our efforts to reuse,
reanalyze and disseminate high-quality proteomics data into
added-value resources such as UniProt, Ensembl and Expression
Atlas.",
journal = "Nucleic Acids Res.",
volume = 53,
number = "D1",
pages = "D543--D553",
month = jan,
year = 2025,
language = "en"
}

@article{Dai2024-yc,
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# Summary

The Proteomics Identification Database (PRIDE) [@Perez-Riverol2022-ow] is the world's largest repository for proteomics data and a founding member of ProteomeXchange [@Deutsch2023-mu]. Here, we introduce [`pridepy`](https://github.com/PRIDE-Archive/pridepy), a Python client designed to access PRIDE Archive data, including project metadata and file downloads. `pridepy` offers a flexible programmatic interface for searching, retrieving, and downloading data via the PRIDE REST API. This tool simplifies the integration of PRIDE datasets into bioinformatics pipelines, making it easier for researchers to handle large datasets programmatically.
The Proteomics Identification Database (PRIDE) [@Perez-Riverol2025-mo] is the world's largest repository for proteomics data and a founding member of ProteomeXchange [@Deutsch2023-mu]. Here, we introduce [`pridepy`](https://github.com/PRIDE-Archive/pridepy), a Python client designed to access PRIDE Archive data, including project metadata and file downloads. `pridepy` offers a flexible programmatic interface for searching, retrieving, and downloading data via the PRIDE REST API. This tool simplifies the integration of PRIDE datasets into bioinformatics pipelines, making it easier for researchers to handle large datasets programmatically.

# Statement of Need

The PRIDE Archive hosts an extensive collection of proteomics data [@Perez-Riverol2022-ow], but manual access to this data can be inefficient and time-consuming. With the increasing demand for cloud-based [@Dai2024-yc] and HPC bioinformatics tools [@Mehta2023-og], command-line utilities that integrate seamlessly with the PRIDE API are becoming essential. pridepy addresses this need by enabling researchers to programmatically access PRIDE using Python, a widely adopted programming language. It facilitates efficient integration of datasets into automated workflows and supports large-scale data transfers via [Aspera](https://www.ibm.com/products/aspera), [Globus](https://www.globus.org/data-transfer), FTP, and HTTPS, making it ideal for scalable and reproducible pipelines. Unlike other tools such as ppx [@Fondrie2021-xk], which primarily support data downloads from ProteomeXchange databases using the HTTP protocol, pridepy provides advanced functionality by leveraging multiple protocols and the latest PRIDE API to access both public and private datasets.
The PRIDE Archive hosts an extensive collection of proteomics data [@Perez-Riverol2025-mo], but manual access to this data can be inefficient and time-consuming. With the increasing demand for cloud-based [@Dai2024-yc] and HPC bioinformatics tools [@Mehta2023-og], command-line utilities that integrate seamlessly with the PRIDE API are becoming essential. pridepy addresses this need by enabling researchers to programmatically access PRIDE using Python, a widely adopted programming language. It facilitates efficient integration of datasets into automated workflows and supports large-scale data transfers via [Aspera](https://www.ibm.com/products/aspera), [Globus](https://www.globus.org/data-transfer), FTP, and HTTPS, making it ideal for scalable and reproducible pipelines. Unlike other tools such as ppx [@Fondrie2021-xk], which primarily support data downloads from ProteomeXchange databases using the HTTP protocol, pridepy provides advanced functionality by leveraging multiple protocols and the latest PRIDE API to access both public and private datasets.

# Methods

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