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Similar question: why were these two typings deemed an antigen match/mismatch? In other words, how does Atlas interpret serology typings so they can be compared to molecular typings? (These questions were raised by super-users during the UAT of Atlas, as part of its integration into the WMDA search and match service). |
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Testing has shown that Atlas sometimes returns serology-typed donors that do not appear to match the molecular-typed patient, at least when comparing the serology to the first field of the molecular typing, as the first field denotes the serological antigen the typing is most related to (refer to hla.alleles.org documentation for how alleles are named). Similarly, it is sometimes unclear why a pair of allele-mismatched patient-donor typings were deemed to still be antigen-matched. Atlas uses a "dictionary", named the HLA Metadata Dictionary (HMD), to interpret molecular and serology typings so it can handle subjects that have been typed by a variety of methods and to varying resolutions. When Atlas sees a typing, it categorises it based on its name (i.e., is it a serology, allele, MAC, XX code, G group, etc?), and then looks up the name in the dictionary to find out more information about it. Metadata the HMD holds includes the P/G/"small g" groups and serologies that the typing maps to. The HMD, and the data used to build it, is what ultimately determines which donors will be matched to a given patient, and the antigen-match status. |
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Testing has shown that Atlas sometimes returns serology-typed donors that do not appear to match the molecular-typed patient, at least when comparing the serology to the first field of the molecular typing, as the first field denotes the serological antigen the typing is most related to (refer to hla.alleles.org documentation for how alleles are named). Similarly, it is sometimes unclear why a pair of allele-mismatched patient-donor typings were deemed to still be antigen-matched.
Atlas uses a "dictionary", named the HLA Metadata Dictionary (HMD), to interpret molecular and serology typings so it can handle subjects that have been typed by a variety of methods and to varying resolutions.
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