diff --git a/packages/compiler/src/core.ts b/packages/compiler/src/core.ts
index e34aa4c1c096b5..ff4eb7d4b898b7 100644
--- a/packages/compiler/src/core.ts
+++ b/packages/compiler/src/core.ts
@@ -154,7 +154,8 @@ export const createSelf = makeMetadataFactory('Self');
 export const createSkipSelf = makeMetadataFactory('SkipSelf');
 export const createHost = makeMetadataFactory('Host');
 
-export interface Type extends Function { new (...args: any[]): any; }
+export interface Type extends Function { prototype: any; }
+
 export const Type = Function;
 
 export enum SecurityContext {
diff --git a/packages/core/src/application_ref.ts b/packages/core/src/application_ref.ts
index 9ec754f3ab30ac..65e3580881398c 100644
--- a/packages/core/src/application_ref.ts
+++ b/packages/core/src/application_ref.ts
@@ -477,7 +477,7 @@ export class ApplicationRef {
 
     // Create a factory associated with the current module if it's not bound to some other
     const ngModule = componentFactory instanceof ComponentFactoryBoundToModule ?
-        null :
+        undefined :
         this._injector.get(NgModuleRef);
     const selectorOrNode = rootSelectorOrNode || componentFactory.selector;
     const compRef = componentFactory.create(Injector.NULL, [], selectorOrNode, ngModule);
diff --git a/packages/core/src/di/injectable.ts b/packages/core/src/di/injectable.ts
index d1dacf103318ff..1dd52772b1643c 100644
--- a/packages/core/src/di/injectable.ts
+++ b/packages/core/src/di/injectable.ts
@@ -8,7 +8,7 @@
 
 import {R3_COMPILE_INJECTABLE} from '../ivy_switch';
 import {ReflectionCapabilities} from '../reflection/reflection_capabilities';
-import {Type} from '../type';
+import {Constructor, Type} from '../type';
 import {makeDecorator, makeParamDecorator} from '../util/decorators';
 import {getClosureSafeProperty} from '../util/property';
 
@@ -69,7 +69,7 @@ export function convertInjectableProviderToFactory(
     const reflectionCapabilities = new ReflectionCapabilities();
     const deps = reflectionCapabilities.parameters(type);
     // TODO - convert to flags.
-    return () => new type(...injectArgs(deps as any[]));
+    return () => new (type as Constructor<any>)(...injectArgs(deps as any[]));
   }
 
   if (USE_VALUE in provider) {
@@ -88,14 +88,14 @@ export function convertInjectableProviderToFactory(
       const reflectionCapabilities = new ReflectionCapabilities();
       deps = reflectionCapabilities.parameters(type);
     }
-    return () => new classProvider.useClass(...injectArgs(deps));
+    return () => new (classProvider.useClass as Constructor<any>)(...injectArgs(deps));
   } else {
     let deps = (provider as ConstructorSansProvider).deps;
     if (!deps) {
       const reflectionCapabilities = new ReflectionCapabilities();
       deps = reflectionCapabilities.parameters(type);
     }
-    return () => new type(...injectArgs(deps !));
+    return () => new (type as Constructor<any>)(...injectArgs(deps !));
   }
 }
 
diff --git a/packages/core/src/di/r3_injector.ts b/packages/core/src/di/r3_injector.ts
index e8dcdf42efe988..ed8731133f02d7 100644
--- a/packages/core/src/di/r3_injector.ts
+++ b/packages/core/src/di/r3_injector.ts
@@ -7,7 +7,7 @@
  */
 
 import {OnDestroy} from '../metadata/lifecycle_hooks';
-import {Type} from '../type';
+import {Constructor, Type} from '../type';
 import {stringify} from '../util';
 
 import {InjectableDef, InjectableType, InjectorDef, InjectorType, InjectorTypeWithProviders} from './defs';
@@ -338,7 +338,7 @@ function injectableDefRecord(token: Type<any>| InjectionToken<any>): Record<any>
     }
     // TODO(alxhub): there should probably be a strict mode which throws here instead of assuming a
     // no-args constructor.
-    return makeRecord(() => new (token as Type<any>)());
+    return makeRecord(() => new (token as Constructor<any>)());
   }
   return makeRecord(def.factory);
 }
@@ -360,7 +360,7 @@ function providerToRecord(provider: SingleProvider): Record<any> {
     } else {
       const classRef = (provider as StaticClassProvider | ClassProvider).useClass || token;
       if (hasDeps(provider)) {
-        factory = () => new (classRef)(...injectArgs(provider.deps));
+        factory = () => new (classRef as Constructor<any>)(...injectArgs(provider.deps));
       } else {
         return injectableDefRecord(classRef);
       }
diff --git a/packages/core/src/reflection/reflection_capabilities.ts b/packages/core/src/reflection/reflection_capabilities.ts
index 57e58c2f18e2b3..9daedcc1ea0ed8 100644
--- a/packages/core/src/reflection/reflection_capabilities.ts
+++ b/packages/core/src/reflection/reflection_capabilities.ts
@@ -6,7 +6,7 @@
  * found in the LICENSE file at https://angular.io/license
  */
 
-import {Type, isType} from '../type';
+import {Constructor, Type, isType} from '../type';
 import {global, stringify} from '../util';
 import {ANNOTATIONS, PARAMETERS, PROP_METADATA} from '../util/decorators';
 
@@ -29,7 +29,7 @@ export class ReflectionCapabilities implements PlatformReflectionCapabilities {
 
   isReflectionEnabled(): boolean { return true; }
 
-  factory<T>(t: Type<T>): (args: any[]) => T { return (...args: any[]) => new t(...args); }
+  factory<T>(t: Constructor<T>): (args: any[]) => T { return (...args: any[]) => new t(...args); }
 
   /** @internal */
   _zipTypesAndAnnotations(paramTypes: any[], paramAnnotations: any[]): any[][] {
diff --git a/packages/core/src/render3/component_ref.ts b/packages/core/src/render3/component_ref.ts
index 6c1a79c8af0e3e..ebac21d86478a7 100644
--- a/packages/core/src/render3/component_ref.ts
+++ b/packages/core/src/render3/component_ref.ts
@@ -21,7 +21,7 @@ import {LifecycleHooksFeature, createRootContext} from './component';
 import {baseDirectiveCreate, createLNode, createLViewData, createTView, elementCreate, enterView, hostElement, initChangeDetectorIfExisting, locateHostElement, renderEmbeddedTemplate} from './instructions';
 import {ComponentDefInternal, ComponentType, RenderFlags} from './interfaces/definition';
 import {LElementNode, TNode, TNodeType} from './interfaces/node';
-import {RElement, domRendererFactory3} from './interfaces/renderer';
+import {RElement, RendererFactory3, domRendererFactory3} from './interfaces/renderer';
 import {CONTEXT, FLAGS, INJECTOR, LViewData, LViewFlags, RootContext, TVIEW} from './interfaces/view';
 import {RootViewRef, ViewRef} from './view_ref';
 
@@ -84,8 +84,9 @@ export class ComponentFactory<T> extends viewEngine_ComponentFactory<T> {
       ngModule?: viewEngine_NgModuleRef<any>|undefined): viewEngine_ComponentRef<T> {
     const isInternalRootView = rootSelectorOrNode === undefined;
 
+    // Cannot call method of union type: https://github.com/Microsoft/TypeScript/issues/7294
     const rendererFactory =
-        ngModule ? ngModule.injector.get(RendererFactory2) : domRendererFactory3;
+        ngModule ? ngModule.injector.get<RendererFactory3>(RendererFactory2) : domRendererFactory3;
     const hostNode = isInternalRootView ?
         elementCreate(
             this.selector, rendererFactory.createRenderer(null, this.componentDef.rendererType)) :
diff --git a/packages/core/src/render3/definition.ts b/packages/core/src/render3/definition.ts
index 0de1e46439c868..e30ed483532b5c 100644
--- a/packages/core/src/render3/definition.ts
+++ b/packages/core/src/render3/definition.ts
@@ -232,13 +232,13 @@ export function defineComponent<T>(componentDefinition: {
     outputs: invertObject(componentDefinition.outputs),
     rendererType: resolveRendererType2(componentDefinition.rendererType) || null,
     exportAs: componentDefinition.exportAs || null,
-    onInit: type.prototype.ngOnInit || null,
-    doCheck: type.prototype.ngDoCheck || null,
-    afterContentInit: type.prototype.ngAfterContentInit || null,
-    afterContentChecked: type.prototype.ngAfterContentChecked || null,
-    afterViewInit: type.prototype.ngAfterViewInit || null,
-    afterViewChecked: type.prototype.ngAfterViewChecked || null,
-    onDestroy: type.prototype.ngOnDestroy || null,
+    onInit: (type.prototype as any).ngOnInit || null,
+    doCheck: (type.prototype as any).ngDoCheck || null,
+    afterContentInit: (type.prototype as any).ngAfterContentInit || null,
+    afterContentChecked: (type.prototype as any).ngAfterContentChecked || null,
+    afterViewInit: (type.prototype as any).ngAfterViewInit || null,
+    afterViewChecked: (type.prototype as any).ngAfterViewChecked || null,
+    onDestroy: (type.prototype as any).ngOnDestroy || null,
     onPush: componentDefinition.changeDetection === ChangeDetectionStrategy.OnPush,
     directiveDefs: directiveTypes ?
         () => (typeof directiveTypes === 'function' ? directiveTypes() : directiveTypes)
@@ -505,6 +505,6 @@ export function definePipe<T>(pipeDef: {
     name: pipeDef.name,
     factory: pipeDef.factory,
     pure: pipeDef.pure !== false,
-    onDestroy: pipeDef.type.prototype.ngOnDestroy || null
+    onDestroy: (pipeDef.type.prototype as any).ngOnDestroy || null
   }) as never;
 }
diff --git a/packages/core/src/type.ts b/packages/core/src/type.ts
index 42f072385bdff5..bc1f71e82d82a6 100644
--- a/packages/core/src/type.ts
+++ b/packages/core/src/type.ts
@@ -22,4 +22,6 @@ export function isType(v: any): v is Type<any> {
   return typeof v === 'function';
 }
 
-export interface Type<T> extends Function { new (...args: any[]): T; }
+export interface Type<T> extends Function { prototype: T; }
+
+export interface Constructor<T> extends Type<T> { new (...args: any[]): T; }
diff --git a/packages/core/test/render3/compiler_canonical/small_app_spec.ts b/packages/core/test/render3/compiler_canonical/small_app_spec.ts
index afc631d7c9ee6c..a8b3807f73c719 100644
--- a/packages/core/test/render3/compiler_canonical/small_app_spec.ts
+++ b/packages/core/test/render3/compiler_canonical/small_app_spec.ts
@@ -97,7 +97,8 @@ class ToDoAppComponent {
 
 // NON-NORMATIVE
 (ToDoAppComponent.ngComponentDef as r3.ComponentDefInternal<any>).directiveDefs = () =>
-    [ToDoItemComponent.ngComponentDef, (NgForOf as r3.DirectiveType<NgForOf<any>>).ngDirectiveDef];
+    [ToDoItemComponent.ngComponentDef,
+     (NgForOf as any as r3.DirectiveType<NgForOf<any>>).ngDirectiveDef];
 // /NON-NORMATIVE
 
 @Component({