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study-info.xml
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<atom:entry xmlns:atom="http://www.w3.org/2005/Atom">
<atom:id>https://www.wwarn.org/repository/atombeat/content/study-info/CSGYG.atom</atom:id>
<atom:published>2010-09-09T04:40:52.901+01:00</atom:published>
<atom:updated>2010-09-09T14:27:33.176+01:00</atom:updated>
<atom:author>
<atom:email>[email protected]</atom:email>
</atom:author>
<atom:title type="text"/>
<atom:content type="application/vnd.chassis-manta+xml">
<study-info profile="http://www.cggh.org/2010/chassis/manta/1.0">
<start>2010-09-18</start>
<end>2010-09-11</end>
<sites>
<site>
<country>AO</country>
<region>BANES</region>
<district>Bath</district>
<locality>Comber Down</locality>
<lookupAddress> ANGOLA</lookupAddress>
<siteCode>site1</siteCode>
<testingDelay/>
<anticoagulant/>
<transportAndStorageTemperature/>
<latitude>-13.154376055418515</latitude>
<longitude>14.58984375</longitude>
<transmissionIntensity>
<annualParasitologicalIncidence>1.2</annualParasitologicalIncidence>
<annualParasitologicalIncidenceYear>1993</annualParasitologicalIncidenceYear>
<parasitePrevalence>0.95</parasitePrevalence>
<parasitePrevalenceYear>1960</parasitePrevalenceYear>
<transmissionIntensityAgeFrom>0</transmissionIntensityAgeFrom>
<transmissionIntensityAgeFromUnits>year</transmissionIntensityAgeFromUnits>
<transmissionIntensityAgeTo>12</transmissionIntensityAgeTo>
<transmissionIntensityAgeToUnits>years</transmissionIntensityAgeToUnits>
<entomologicalInoculationRate>0.87</entomologicalInoculationRate>
<entomologicalInoculationRateYear>1970</entomologicalInoculationRateYear>
<seasonalTransmission>true</seasonalTransmission>
<transmissionMonths>feb mar jan</transmissionMonths>
</transmissionIntensity>
</site>
<site>
<country>AO</country>
<region>BANES</region>
<district>Bath</district>
<locality>Comber Down</locality>
<lookupAddress> ANGOLA</lookupAddress>
<siteCode>site1</siteCode>
<testingDelay/>
<anticoagulant/>
<transportAndStorageTemperature/>
<latitude>-13.154376055418515</latitude>
<longitude>14.58984375</longitude>
<transmissionIntensity>
<annualParasitologicalIncidence>1.2</annualParasitologicalIncidence>
<annualParasitologicalIncidenceYear>1993</annualParasitologicalIncidenceYear>
<parasitePrevalence>0.95</parasitePrevalence>
<parasitePrevalenceYear>1960</parasitePrevalenceYear>
<transmissionIntensityAgeFrom>0</transmissionIntensityAgeFrom>
<transmissionIntensityAgeFromUnits>year</transmissionIntensityAgeFromUnits>
<transmissionIntensityAgeTo>12</transmissionIntensityAgeTo>
<transmissionIntensityAgeToUnits>years</transmissionIntensityAgeToUnits>
<entomologicalInoculationRate>0.87</entomologicalInoculationRate>
<entomologicalInoculationRateYear>1970</entomologicalInoculationRateYear>
<seasonalTransmission>true</seasonalTransmission>
<transmissionMonths>feb mar jan</transmissionMonths>
</transmissionIntensity>
</site>
</sites>
<modules>clinical</modules>
<pathogens>pfalciparum</pathogens>
<inclusionExclusionCriteria>
<age>
<maxAge>60</maxAge>
<maxAgeUnits>years</maxAgeUnits>
<minAge>0</minAge>
<minAgeUnits>years</minAgeUnits>
</age>
<parasitaemia>
<minParasitaemia>0</minParasitaemia>
<maxParasitaemia>200000</maxParasitaemia>
</parasitaemia>
<includeMixedInfections>true</includeMixedInfections>
<excludeIfPriorAntimalarials>false</excludeIfPriorAntimalarials>
<priorAntimalarialsExclusion>
<priorAntimalarials>TET</priorAntimalarials>
<priorAntimalarialsDetermination>history</priorAntimalarialsDetermination>
<priorAntimalarialsHistoryWeeks>10</priorAntimalarialsHistoryWeeks>
</priorAntimalarialsExclusion>
<pregnancy>exclude</pregnancy>
<treatmentReason>ipt</treatmentReason>
<otherCriteria>height</otherCriteria>
</inclusionExclusionCriteria>
<clinical>
<treatment>
<regimens>
<regimen>
<regimenName>Regime 1</regimenName>
<regimenSupervision>full</regimenSupervision>
<regimenUrl>http://google.com</regimenUrl>
<drugs>
<drug>
<name>CoA</name>
<activeIngredients>
<activeIngredient>
<activeIngredientName>lumefantrine</activeIngredientName>
<activeIngredientMgPerDose>15</activeIngredientMgPerDose>
</activeIngredient>
<activeIngredient>
<activeIngredientName>artemether</activeIngredientName>
<activeIngredientMgPerDose>20</activeIngredientMgPerDose>
</activeIngredient>
</activeIngredients>
<administrationRoute>dispersal</administrationRoute>
<manufacturer>GSK</manufacturer>
<batchNumber>9085HP</batchNumber>
<expiryDate>2008-09-08</expiryDate>
<drugStorage>none</drugStorage>
<drugDosingDeterminant>age</drugDosingDeterminant>
<ageDosing>
<ageDosingSchedule>
<day>0</day>
<hour>morning</hour>
<ageFrom>0</ageFrom>
<ageTo>1</ageTo>
<dose>1</dose>
<doseUnit/>
</ageDosingSchedule>
<ageDosingSchedule>
<day>0</day>
<hour>evening</hour>
<ageFrom>0</ageFrom>
<ageTo>1</ageTo>
<dose>1</dose>
<doseUnit/>
</ageDosingSchedule>
<ageDosingSchedule>
<day>0</day>
<hour>morning</hour>
<ageFrom>1</ageFrom>
<ageTo>5</ageTo>
<dose>2</dose>
<doseUnit/>
</ageDosingSchedule>
<ageDosingSchedule>
<day>0</day>
<hour>morning</hour>
<ageFrom>1</ageFrom>
<ageTo>5</ageTo>
<dose>2</dose>
<doseUnit/>
</ageDosingSchedule>
</ageDosing>
<wGroupDosing>
<wGroupDosingSchedule>
<day>0</day>
<hour>morning</hour>
<wGroupFrom>10</wGroupFrom>
<wGroupTo>20</wGroupTo>
<dose>20</dose>
<doseUnit>tablet</doseUnit>
</wGroupDosingSchedule>
</wGroupDosing>
<weightDosing>
<weightDosingSchedule>
<day>0</day>
<hour>morning</hour>
<dose>20</dose>
</weightDosingSchedule>
</weightDosing>
<feeding>highfat</feeding>
<fatPerMeal>50</fatPerMeal>
<feedingOther>nonstop</feedingOther>
<readministeredOnVomitting>true</readministeredOnVomitting>
<comments>this is a test</comments>
</drug>
</drugs>
</regimen>
<regimen>
<regimenName>Regime 1</regimenName>
<regimenSupervision>full</regimenSupervision>
<regimenUrl>http://paneris.net/</regimenUrl>
<drugs>
<drug>
<name>CoA</name>
<activeIngredients>
<activeIngredient>
<activeIngredientName>lumefantrine</activeIngredientName>
<activeIngredientMgPerDose>15</activeIngredientMgPerDose>
</activeIngredient>
<activeIngredient>
<activeIngredientName>artemether</activeIngredientName>
<activeIngredientMgPerDose>20</activeIngredientMgPerDose>
</activeIngredient>
</activeIngredients>
<administrationRoute>dispersal</administrationRoute>
<manufacturer>GSK</manufacturer>
<batchNumber>9085HP</batchNumber>
<expiryDate>2008-09-08</expiryDate>
<drugStorage>none</drugStorage>
<drugDosingDeterminant>age</drugDosingDeterminant>
<ageDosing>
<ageDosingSchedule>
<day>0</day>
<hour>morning</hour>
<ageFrom>0</ageFrom>
<ageTo>1</ageTo>
<dose>1</dose>
<doseUnit>tablet</doseUnit>
</ageDosingSchedule>
<ageDosingSchedule>
<day>0</day>
<hour>evening</hour>
<ageFrom>0</ageFrom>
<ageTo>1</ageTo>
<dose>1</dose>
<doseUnit>tablet</doseUnit>
</ageDosingSchedule>
<ageDosingSchedule>
<day>0</day>
<hour>morning</hour>
<ageFrom>1</ageFrom>
<ageTo>5</ageTo>
<dose>2</dose>
<doseUnit>tablet</doseUnit>
</ageDosingSchedule>
<ageDosingSchedule>
<day>0</day>
<hour>morning</hour>
<ageFrom>1</ageFrom>
<ageTo>5</ageTo>
<dose>2</dose>
<doseUnit>tablet</doseUnit>
</ageDosingSchedule>
</ageDosing>
<wGroupDosing>
<wGroupDosingSchedule>
<day>0</day>
<hour>morning</hour>
<wGroupFrom>10</wGroupFrom>
<wGroupTo>20</wGroupTo>
<dose>20</dose>
<doseUnit>tablet</doseUnit>
</wGroupDosingSchedule>
</wGroupDosing>
<weightDosing>
<weightDosingSchedule>
<day>0</day>
<hour>morning</hour>
<dose>20</dose>
</weightDosingSchedule>
</weightDosing>
<feeding>highfat</feeding>
<fatPerMeal>50</fatPerMeal>
<feedingOther>nonstop</feedingOther>
<readministeredOnVomitting>true</readministeredOnVomitting>
<comments>this is a test</comments>
</drug>
</drugs>
</regimen>
</regimens>
<regimenAllocation>
<regimenAllocationMethod>randomised</regimenAllocationMethod>
<blinding>double</blinding>
<randomisationProportion>80</randomisationProportion>
</regimenAllocation>
</treatment>
<followup>
<duration>63</duration>
<feverMeasurement>axial</feverMeasurement>
<haemoglobinRecording>
<haemoglobinRecordingType>hb</haemoglobinRecordingType>
</haemoglobinRecording>
</followup>
<microscopy>
<microscopyStain>fieldsstain</microscopyStain>
<microscopyStainOther>other</microscopyStainOther>
<asexualParasitemia>
<asexualParasitemiaNegativeCount>500</asexualParasitemiaNegativeCount>
<asexualParasitemiaPositiveThickUnit>200wbc</asexualParasitemiaPositiveThickUnit>
<asexualParasitemiaPositiveThickUnitOther>other</asexualParasitemiaPositiveThickUnitOther>
<asexualParasitemiaPositiveThinUnit>1000rbc</asexualParasitemiaPositiveThinUnit>
<asexualParasitemiaPositiveThinUnitOther>other</asexualParasitemiaPositiveThinUnitOther>
</asexualParasitemia>
<sexualParasitemia>
<sexualParasitemiaNegativeCount>500</sexualParasitemiaNegativeCount>
<sexualParasitemiaPositiveThickUnit>200wbc</sexualParasitemiaPositiveThickUnit>
<sexualParasitemiaPositiveThickUnitOther>other</sexualParasitemiaPositiveThickUnitOther>
<sexualParasitemiaPositiveThinUnit>1000rbc</sexualParasitemiaPositiveThinUnit>
<sexualParasitemiaPositiveThinUnitOther>other</sexualParasitemiaPositiveThinUnitOther>
</sexualParasitemia>
<thickFilmCalculationOfParasitemia>
<thickFilmFormula>xxx</thickFilmFormula>
<thickFilmFormulaOther>other</thickFilmFormulaOther>
</thickFilmCalculationOfParasitemia>
<thinFilmCalculationOfParasitemia>
<thinFilmFormula>yy</thinFilmFormula>
<thinFilmFormulaOther>other</thinFilmFormulaOther>
</thinFilmCalculationOfParasitemia>
<qualityControl>
<internal>
<percentageRereadBySecondMicroscopist>20</percentageRereadBySecondMicroscopist>
<rereadSlideSelectionMechanism>random</rereadSlideSelectionMechanism>
<rereadSlideSelectionMechanismOther>other</rereadSlideSelectionMechanismOther>
</internal>
<external>
<percentageRereadBySecondMicroscopist>0</percentageRereadBySecondMicroscopist>
<rereadSlideSelectionMechanism>random</rereadSlideSelectionMechanism>
<rereadSlideSelectionMechanismOther>other</rereadSlideSelectionMechanismOther>
</external>
</qualityControl>
</microscopy>
<geneotypingToDistinguishBetweenRecrudescenceAndReinfection>
<applicability>true</applicability>
<applicable>
<markers>
<recrudescenceMarker>
<markerName>msp1</markerName>
<markerOther>other</markerOther>
<numberOfMicroSatellites/>
</recrudescenceMarker>
<recrudescenceMarker>
<markerName/>
<markerOther>other</markerOther>
<numberOfMicroSatellites/>
</recrudescenceMarker>
<recrudescenceMarker>
<markerName>microsatellites</markerName>
<markerOther/>
<numberOfMicroSatellites>12</numberOfMicroSatellites>
</recrudescenceMarker>
</markers>
<genotypingLaboratory>Paris</genotypingLaboratory>
<markerDiscriminant>cap</markerDiscriminant>
<markerDiscriminantOther>other</markerDiscriminantOther>
<analysisProtocol>
<mixedAllelesOpen>
<mixedAlleles>recrudescense</mixedAlleles>
<mixedAllelesOther>other</mixedAllelesOther>
<recrudescence>old</recrudescence>
<reinfection>new</reinfection>
</mixedAllelesOpen>
</analysisProtocol>
</applicable>
</geneotypingToDistinguishBetweenRecrudescenceAndReinfection>
<recrudescenceAndReinfection/>
</clinical>
<molecular>
<criteria>
<sampleSourceOpen>
<sampleSource>trial</sampleSource>
<sampleSourceOther>other</sampleSourceOther>
</sampleSourceOpen>
<malariaStatus>severe</malariaStatus>
</criteria>
<sample>
<sampleTypeOpen>
<sampleType>whole</sampleType>
<sampleTypeOther>other</sampleTypeOther>
<wholeBloodSource>cord</wholeBloodSource>
<dateCultureIsolated>2010/09/02</dateCultureIsolated>
</sampleTypeOpen>
</sample>
<genotypedMarkers>pyrosequencing</genotypedMarkers>
<mixedResistanceAlleles>
<mixedResistanceAllelesInclusion>true</mixedResistanceAllelesInclusion>
<mixedResistanceAllelesDesignation>both mixed mutant</mixedResistanceAllelesDesignation>
</mixedResistanceAlleles>
<additionalGenotypicInformation>
<sequencedLoci>
<wholeGenomesSequenced>true</wholeGenomesSequenced>
<resistanceLociSequenced>true</resistanceLociSequenced>
<resistanceLoci>
<resistanceLocus>
<locusTypeOpen>
<locusType>honey</locusType>
<locusTypeOther>other</locusTypeOther>
</locusTypeOpen>
<locusName>TTP</locusName>
</resistanceLocus>
</resistanceLoci>
<otherLociGenotyped>true</otherLociGenotyped>
<otherLoci>
<otherLocus>
<locusTypeOpen>
<locusType>milk</locusType>
<locusTypeOther>other</locusTypeOther>
</locusTypeOpen>
<locusName>SPQR</locusName>
</otherLocus>
</otherLoci>
</sequencedLoci>
<infectionComplexityEstimated>true</infectionComplexityEstimated>
<infectionComplexityEstimationlociOpen>
<infectionComplexityEstimationloci>NDD</infectionComplexityEstimationloci>
<infectionComplexityEstimationlociOther>OTHER</infectionComplexityEstimationlociOther>
</infectionComplexityEstimationlociOpen>
</additionalGenotypicInformation>
</molecular>
<invitro>
<inclusionCriteria/>
<analysisSite>New York</analysisSite>
<culture>
<incubatorSystem>candle</incubatorSystem>
<co2>100</co2>
<healthyErythrocytesSource>donor</healthyErythrocytesSource>
<hematocrit>100</hematocrit>
<bloodGroup>O</bloodGroup>
</culture>
<drugSusceptibilityMedium>
<medium>rpmi</medium>
<mediumOther>other</mediumOther>
<preparation>aliquots</preparation>
<serum>albumax</serum>
<serum-finalConcentration>10</serum-finalConcentration>
<NaHCO3-finalConcentration>90</NaHCO3-finalConcentration>
<hypoxantine>
<hypoxantine-added>true</hypoxantine-added>
<hypoxantine-finalConcentration>10</hypoxantine-finalConcentration>
</hypoxantine>
<oroticAcid>
<oroticAcid-added>true</oroticAcid-added>
<oroticAcid-finalConcentration>100</oroticAcid-finalConcentration>
</oroticAcid>
<glucose>
<glucose-added>true</glucose-added>
<glucose-finalConcentration>33</glucose-finalConcentration>
</glucose>
<antibioticTreatments>
<antibioticTreatment>
<antibioticOpen>
<!-- Add more here -->
</antibioticOpen>
</antibioticTreatment>
</antibioticTreatments>
</drugSusceptibilityMedium>
<susceptibility>
<timeOfIncubation/>
<susceptibilityMethod/>
</susceptibility>
<drugs/>
<plateBatches/>
</invitro>
<pharmacology>
<samples>
<sample>
<numberPlanned/>
<anticoagulent/>
<centrifugeTime/>
<storages>
<storage>
<storageTemperature/>
<storageDuration/>
<storageDurationUnit/>
</storage>
</storages>
</sample>
</samples>
<analytes>
<analyte>
<drugMeasured/>
<lowerLoQ/>
<sampleMatrixType/>
</analyte>
</analytes>
<assayReferences>
<assayReference>
<referenceType>url</referenceType>
<url/>
<doi/>
<upload>
<uploadedUrl/>
</upload>
<note/>
<assayValidated/>
</assayReference>
</assayReferences>
</pharmacology>
</study-info>
</atom:content>
<ar:comment xmlns:ar="http://purl.org/atompub/revision/1.0">
<atom:author>
<atom:email>[email protected]</atom:email>
</atom:author>
<atom:updated>2010-09-09T14:27:33.176+01:00</atom:updated>
<atom:summary/>
</ar:comment>
<atom:link rel="self" type="application/atom+xml;type=entry" href="https://www.wwarn.org/repository/atombeat/content/study-info/CSGYG.atom"/>
<atom:link rel="edit" type="application/atom+xml;type=entry" href="https://www.wwarn.org/repository/atombeat/content/study-info/CSGYG.atom"/>
<atom:link rel="http://www.cggh.org/2010/chassis/terms/originStudy" href="https://www.wwarn.org/repository/atombeat/content/studies/CSGYG.atom" type="application/atom+xml;type=entry"/>
<atom:link rel="http://purl.org/atombeat/rel/security-descriptor" href="https://www.wwarn.org/repository/atombeat/security/study-info/CSGYG.atom" type="application/atom+xml;type=entry"/>
<atom:link rel="history" href="https://www.wwarn.org/repository/atombeat/history/study-info/CSGYG.atom" type="application/atom+xml;type=feed"/>
</atom:entry>