diff --git a/changes/426.feature.rst b/changes/426.feature.rst
new file mode 100644
index 00000000..5a56986b
--- /dev/null
+++ b/changes/426.feature.rst
@@ -0,0 +1 @@
+Add eight multistripe subarray keywords to support NIRCam DHS modes.
diff --git a/src/stdatamodels/jwst/datamodels/schemas/core.schema.yaml b/src/stdatamodels/jwst/datamodels/schemas/core.schema.yaml
index 5b896df2..3413148b 100644
--- a/src/stdatamodels/jwst/datamodels/schemas/core.schema.yaml
+++ b/src/stdatamodels/jwst/datamodels/schemas/core.schema.yaml
@@ -1075,6 +1075,46 @@ properties:
             type: integer
             fits_keyword: DETYSIZ
             blend_table: True
+          multistripe_reads1:
+            title: Num. substripe rows read starting at SUBSTRT1
+            type: integer
+            fits_keyword: MSTR_RD1
+            blend_table: True
+          multistripe_skips1:
+            title: Num. rows to skip after reading MSTR_RD1 rows
+            type: integer
+            fits_keyword: MSTR_SK1
+            blend_table: True
+          multistripe_reads2:
+            title: Num. rows read in subsequent substripes
+            type: integer
+            fits_keyword: MSTR_RD2
+            blend_table: True
+          multistripe_skips2:
+            title: Num. rows to skip between susequent substripes
+            type: integer
+            fits_keyword: MSTR_SK2
+            blend_table: True
+          repeat_stripe:
+            title: Repeat reading MSTR_RD2 rows at first position
+            type: integer
+            fits_keyword: MSTR_RPT
+            blend_table: True
+          interleave_reads1:
+            title: Interleave MSTR_RD1 rows between substripes
+            type: integer
+            fits_keyword: MSTR_ILV
+            blend_table: True
+          superstripe_step:
+            title: Rows to advance superstripe postn btwn intgrtns
+            type: integer
+            fits_keyword: SSTR_STP
+            blend_table: True
+          num_superstripe:
+            title: Num. superstripe positions in super-integration
+            type: integer
+            fits_keyword: SSTR_NST
+            blend_table: True
       dither:
         title: Dither information
         type: object