diff --git a/packages/stream/lib/index.test.ts b/packages/stream/lib/index.test.ts
index 01201b53f..c221208a5 100644
--- a/packages/stream/lib/index.test.ts
+++ b/packages/stream/lib/index.test.ts
@@ -791,6 +791,26 @@ describe('SerialPort', () => {
         })
       })
     })
+
+    describe('#destroy', () => {
+      it('calls close', done => {
+        const port = new SerialPortStream(openOpts)
+        port.on('close', () => done())
+        port.destroy()
+      })
+
+      it("doesn't open after destroy", done => {
+        const port = new SerialPortStream(openOpts)
+        port.on('open', () => {
+          port.destroy()
+          assert.isTrue(port.destroyed)
+          port.open(err => {
+            assert.instanceOf(err, Error)
+            done()
+          })
+        })
+      })
+    })
   })
 
   describe('reading data', () => {
diff --git a/packages/stream/lib/index.ts b/packages/stream/lib/index.ts
index 6272499c2..9262beff0 100644
--- a/packages/stream/lib/index.ts
+++ b/packages/stream/lib/index.ts
@@ -148,6 +148,10 @@ export class SerialPortStream<T extends BindingInterface = BindingInterface> ext
    * @emits open
    */
   open(openCallback?: ErrorCallback): void {
+    if (this.destroyed) {
+      return this._asyncError(new Error('Port is already destroyed - it cannot be reopened'), openCallback)
+    }
+
     if (this.isOpen) {
       return this._asyncError(new Error('Port is already open'), openCallback)
     }
@@ -473,6 +477,30 @@ export class SerialPortStream<T extends BindingInterface = BindingInterface> ext
       },
     )
   }
+
+  /**
+   * Implementation for Duplex._destroy. Disposes of underlying resources and forbids this port from being reopened
+   * @param err
+   * @param callback
+   */
+  _destroy(err: Error | null, callback: ErrorCallback) {
+    debug('_destroy')
+    if (this.port) {
+      debug('_destroy', 'releasing port')
+      this.port.close().then(
+        () => {
+          callback(err)
+        },
+        e => {
+          callback(e)
+        },
+      )
+      this.port = undefined
+    } else {
+      debug('_destroy', 'nothing to do; port has not been opened')
+      callback(err)
+    }
+  }
 }
 
 /**