diff --git a/compiler/rustc_codegen_gcc/src/asm.rs b/compiler/rustc_codegen_gcc/src/asm.rs
index 9b679019e96ce..06b14a1f118a3 100644
--- a/compiler/rustc_codegen_gcc/src/asm.rs
+++ b/compiler/rustc_codegen_gcc/src/asm.rs
@@ -541,7 +541,7 @@ impl<'a, 'gcc, 'tcx> AsmBuilderMethods<'tcx> for Builder<'a, 'gcc, 'tcx> {
             let builtin_unreachable: RValue<'gcc> = unsafe {
                 std::mem::transmute(builtin_unreachable)
             };
-            self.call(self.type_void(), None, None, builtin_unreachable, &[], None);
+            self.call(self.type_void(), None, None, builtin_unreachable, &[], None, None);
         }
 
         // Write results to outputs.
diff --git a/compiler/rustc_codegen_gcc/src/builder.rs b/compiler/rustc_codegen_gcc/src/builder.rs
index f5cda81f6ab86..43cc46cfe682f 100644
--- a/compiler/rustc_codegen_gcc/src/builder.rs
+++ b/compiler/rustc_codegen_gcc/src/builder.rs
@@ -25,7 +25,7 @@ use rustc_middle::ty::layout::{
     FnAbiError, FnAbiOfHelpers, FnAbiRequest, HasParamEnv, HasTyCtxt, LayoutError, LayoutOfHelpers,
     TyAndLayout,
 };
-use rustc_middle::ty::{ParamEnv, Ty, TyCtxt};
+use rustc_middle::ty::{ParamEnv, Ty, TyCtxt, Instance};
 use rustc_span::def_id::DefId;
 use rustc_span::Span;
 use rustc_target::abi::{
@@ -592,12 +592,13 @@ impl<'a, 'gcc, 'tcx> BuilderMethods<'a, 'tcx> for Builder<'a, 'gcc, 'tcx> {
         then: Block<'gcc>,
         catch: Block<'gcc>,
         _funclet: Option<&Funclet>,
+        instance: Option<Instance<'tcx>>,
     ) -> RValue<'gcc> {
         let try_block = self.current_func().new_block("try");
 
         let current_block = self.block.clone();
         self.block = try_block;
-        let call = self.call(typ, fn_attrs, None, func, args, None); // TODO(antoyo): use funclet here?
+        let call = self.call(typ, fn_attrs, None, func, args, None, instance); // TODO(antoyo): use funclet here?
         self.block = current_block;
 
         let return_value =
@@ -1667,6 +1668,7 @@ impl<'a, 'gcc, 'tcx> BuilderMethods<'a, 'tcx> for Builder<'a, 'gcc, 'tcx> {
         func: RValue<'gcc>,
         args: &[RValue<'gcc>],
         funclet: Option<&Funclet>,
+        _instance: Option<Instance<'tcx>>,
     ) -> RValue<'gcc> {
         // FIXME(antoyo): remove when having a proper API.
         let gcc_func = unsafe { std::mem::transmute(func) };
diff --git a/compiler/rustc_codegen_gcc/src/intrinsic/mod.rs b/compiler/rustc_codegen_gcc/src/intrinsic/mod.rs
index a6c8b72e851b2..cebd45c09aa39 100644
--- a/compiler/rustc_codegen_gcc/src/intrinsic/mod.rs
+++ b/compiler/rustc_codegen_gcc/src/intrinsic/mod.rs
@@ -133,6 +133,7 @@ impl<'a, 'gcc, 'tcx> IntrinsicCallMethods<'tcx> for Builder<'a, 'gcc, 'tcx> {
                     func,
                     &args.iter().map(|arg| arg.immediate()).collect::<Vec<_>>(),
                     None,
+                    None,
                 )
             }
             sym::likely => self.expect(args[0].immediate(), true),
@@ -401,7 +402,7 @@ impl<'a, 'gcc, 'tcx> IntrinsicCallMethods<'tcx> for Builder<'a, 'gcc, 'tcx> {
     fn abort(&mut self) {
         let func = self.context.get_builtin_function("abort");
         let func: RValue<'gcc> = unsafe { std::mem::transmute(func) };
-        self.call(self.type_void(), None, None, func, &[], None);
+        self.call(self.type_void(), None, None, func, &[], None, None);
     }
 
     fn assume(&mut self, value: Self::Value) {
@@ -1103,7 +1104,7 @@ fn try_intrinsic<'a, 'b, 'gcc, 'tcx>(
     dest: RValue<'gcc>,
 ) {
     if bx.sess().panic_strategy() == PanicStrategy::Abort {
-        bx.call(bx.type_void(), None, None, try_func, &[data], None);
+        bx.call(bx.type_void(), None, None, try_func, &[data], None, None);
         // Return 0 unconditionally from the intrinsic call;
         // we can never unwind.
         let ret_align = bx.tcx.data_layout.i32_align.abi;
@@ -1177,21 +1178,21 @@ fn codegen_gnu_try<'gcc>(
         let zero = bx.cx.context.new_rvalue_zero(bx.int_type);
         let ptr = bx.cx.context.new_call(None, eh_pointer_builtin, &[zero]);
         let catch_ty = bx.type_func(&[bx.type_i8p(), bx.type_i8p()], bx.type_void());
-        bx.call(catch_ty, None, None, catch_func, &[data, ptr], None);
+        bx.call(catch_ty, None, None, catch_func, &[data, ptr], None, None);
         bx.ret(bx.const_i32(1));
 
         // NOTE: the blocks must be filled before adding the try/catch, otherwise gcc will not
         // generate a try/catch.
         // FIXME(antoyo): add a check in the libgccjit API to prevent this.
         bx.switch_to_block(current_block);
-        bx.invoke(try_func_ty, None, None, try_func, &[data], then, catch, None);
+        bx.invoke(try_func_ty, None, None, try_func, &[data], then, catch, None, None);
     });
 
     let func = unsafe { std::mem::transmute(func) };
 
     // Note that no invoke is used here because by definition this function
     // can't panic (that's what it's catching).
-    let ret = bx.call(llty, None, None, func, &[try_func, data, catch_func], None);
+    let ret = bx.call(llty, None, None, func, &[try_func, data, catch_func], None, None);
     let i32_align = bx.tcx().data_layout.i32_align.abi;
     bx.store(ret, dest, i32_align);
 }
diff --git a/compiler/rustc_codegen_llvm/src/asm.rs b/compiler/rustc_codegen_llvm/src/asm.rs
index 74539d4d49570..500904ce18805 100644
--- a/compiler/rustc_codegen_llvm/src/asm.rs
+++ b/compiler/rustc_codegen_llvm/src/asm.rs
@@ -466,11 +466,11 @@ pub(crate) fn inline_asm_call<'ll>(
 
             let call = if !labels.is_empty() {
                 assert!(catch_funclet.is_none());
-                bx.callbr(fty, None, None, v, inputs, dest.unwrap(), labels, None)
+                bx.callbr(fty, None, None, v, inputs, dest.unwrap(), labels, None, None)
             } else if let Some((catch, funclet)) = catch_funclet {
-                bx.invoke(fty, None, None, v, inputs, dest.unwrap(), catch, funclet)
+                bx.invoke(fty, None, None, v, inputs, dest.unwrap(), catch, funclet, None)
             } else {
-                bx.call(fty, None, None, v, inputs, None)
+                bx.call(fty, None, None, v, inputs, None, None)
             };
 
             // Store mark in a metadata node so we can map LLVM errors
diff --git a/compiler/rustc_codegen_llvm/src/builder.rs b/compiler/rustc_codegen_llvm/src/builder.rs
index 63e59ea13fc35..a5a5ae73d77a1 100644
--- a/compiler/rustc_codegen_llvm/src/builder.rs
+++ b/compiler/rustc_codegen_llvm/src/builder.rs
@@ -19,9 +19,12 @@ use rustc_middle::middle::codegen_fn_attrs::CodegenFnAttrs;
 use rustc_middle::ty::layout::{
     FnAbiError, FnAbiOfHelpers, FnAbiRequest, LayoutError, LayoutOfHelpers, TyAndLayout,
 };
-use rustc_middle::ty::{self, Ty, TyCtxt};
+use rustc_middle::ty::{self, Instance, Ty, TyCtxt};
 use rustc_span::Span;
-use rustc_symbol_mangling::typeid::{kcfi_typeid_for_fnabi, typeid_for_fnabi, TypeIdOptions};
+use rustc_symbol_mangling::typeid::{
+    kcfi_typeid_for_fnabi, kcfi_typeid_for_instance, typeid_for_fnabi, typeid_for_instance,
+    TypeIdOptions,
+};
 use rustc_target::abi::{self, call::FnAbi, Align, Size, WrappingRange};
 use rustc_target::spec::{HasTargetSpec, SanitizerSet, Target};
 use smallvec::SmallVec;
@@ -221,6 +224,7 @@ impl<'a, 'll, 'tcx> BuilderMethods<'a, 'tcx> for Builder<'a, 'll, 'tcx> {
         then: &'ll BasicBlock,
         catch: &'ll BasicBlock,
         funclet: Option<&Funclet<'ll>>,
+        instance: Option<Instance<'tcx>>,
     ) -> &'ll Value {
         debug!("invoke {:?} with args ({:?})", llfn, args);
 
@@ -233,10 +237,10 @@ impl<'a, 'll, 'tcx> BuilderMethods<'a, 'tcx> for Builder<'a, 'll, 'tcx> {
         }
 
         // Emit CFI pointer type membership test
-        self.cfi_type_test(fn_attrs, fn_abi, llfn);
+        self.cfi_type_test(fn_attrs, fn_abi, instance, llfn);
 
         // Emit KCFI operand bundle
-        let kcfi_bundle = self.kcfi_operand_bundle(fn_attrs, fn_abi, llfn);
+        let kcfi_bundle = self.kcfi_operand_bundle(fn_attrs, fn_abi, instance, llfn);
         let kcfi_bundle = kcfi_bundle.as_ref().map(|b| &*b.raw);
         if let Some(kcfi_bundle) = kcfi_bundle {
             bundles.push(kcfi_bundle);
@@ -1231,6 +1235,7 @@ impl<'a, 'll, 'tcx> BuilderMethods<'a, 'tcx> for Builder<'a, 'll, 'tcx> {
         llfn: &'ll Value,
         args: &[&'ll Value],
         funclet: Option<&Funclet<'ll>>,
+        instance: Option<Instance<'tcx>>,
     ) -> &'ll Value {
         debug!("call {:?} with args ({:?})", llfn, args);
 
@@ -1243,10 +1248,10 @@ impl<'a, 'll, 'tcx> BuilderMethods<'a, 'tcx> for Builder<'a, 'll, 'tcx> {
         }
 
         // Emit CFI pointer type membership test
-        self.cfi_type_test(fn_attrs, fn_abi, llfn);
+        self.cfi_type_test(fn_attrs, fn_abi, instance, llfn);
 
         // Emit KCFI operand bundle
-        let kcfi_bundle = self.kcfi_operand_bundle(fn_attrs, fn_abi, llfn);
+        let kcfi_bundle = self.kcfi_operand_bundle(fn_attrs, fn_abi, instance, llfn);
         let kcfi_bundle = kcfi_bundle.as_ref().map(|b| &*b.raw);
         if let Some(kcfi_bundle) = kcfi_bundle {
             bundles.push(kcfi_bundle);
@@ -1468,7 +1473,7 @@ impl<'a, 'll, 'tcx> Builder<'a, 'll, 'tcx> {
 
     pub(crate) fn call_intrinsic(&mut self, intrinsic: &str, args: &[&'ll Value]) -> &'ll Value {
         let (ty, f) = self.cx.get_intrinsic(intrinsic);
-        self.call(ty, None, None, f, args, None)
+        self.call(ty, None, None, f, args, None, None)
     }
 
     fn call_lifetime_intrinsic(&mut self, intrinsic: &str, ptr: &'ll Value, size: Size) {
@@ -1526,7 +1531,7 @@ impl<'a, 'll, 'tcx> Builder<'a, 'll, 'tcx> {
             format!("llvm.{instr}.sat.i{int_width}.f{float_width}")
         };
         let f = self.declare_cfn(&name, llvm::UnnamedAddr::No, self.type_func(&[src_ty], dest_ty));
-        self.call(self.type_func(&[src_ty], dest_ty), None, None, f, &[val], None)
+        self.call(self.type_func(&[src_ty], dest_ty), None, None, f, &[val], None, None)
     }
 
     pub(crate) fn landing_pad(
@@ -1554,6 +1559,7 @@ impl<'a, 'll, 'tcx> Builder<'a, 'll, 'tcx> {
         default_dest: &'ll BasicBlock,
         indirect_dest: &[&'ll BasicBlock],
         funclet: Option<&Funclet<'ll>>,
+        instance: Option<Instance<'tcx>>,
     ) -> &'ll Value {
         debug!("invoke {:?} with args ({:?})", llfn, args);
 
@@ -1566,10 +1572,10 @@ impl<'a, 'll, 'tcx> Builder<'a, 'll, 'tcx> {
         }
 
         // Emit CFI pointer type membership test
-        self.cfi_type_test(fn_attrs, fn_abi, llfn);
+        self.cfi_type_test(fn_attrs, fn_abi, instance, llfn);
 
         // Emit KCFI operand bundle
-        let kcfi_bundle = self.kcfi_operand_bundle(fn_attrs, fn_abi, llfn);
+        let kcfi_bundle = self.kcfi_operand_bundle(fn_attrs, fn_abi, instance, llfn);
         let kcfi_bundle = kcfi_bundle.as_ref().map(|b| &*b.raw);
         if let Some(kcfi_bundle) = kcfi_bundle {
             bundles.push(kcfi_bundle);
@@ -1601,6 +1607,7 @@ impl<'a, 'll, 'tcx> Builder<'a, 'll, 'tcx> {
         &mut self,
         fn_attrs: Option<&CodegenFnAttrs>,
         fn_abi: Option<&FnAbi<'tcx, Ty<'tcx>>>,
+        instance: Option<Instance<'tcx>>,
         llfn: &'ll Value,
     ) {
         let is_indirect_call = unsafe { llvm::LLVMRustIsNonGVFunctionPointerTy(llfn) };
@@ -1622,7 +1629,11 @@ impl<'a, 'll, 'tcx> Builder<'a, 'll, 'tcx> {
                 options.insert(TypeIdOptions::NORMALIZE_INTEGERS);
             }
 
-            let typeid = typeid_for_fnabi(self.tcx, fn_abi, options);
+            let typeid = if let Some(instance) = instance {
+                typeid_for_instance(self.tcx, &instance, options)
+            } else {
+                typeid_for_fnabi(self.tcx, fn_abi, options)
+            };
             let typeid_metadata = self.cx.typeid_metadata(typeid).unwrap();
 
             // Test whether the function pointer is associated with the type identifier.
@@ -1644,6 +1655,7 @@ impl<'a, 'll, 'tcx> Builder<'a, 'll, 'tcx> {
         &mut self,
         fn_attrs: Option<&CodegenFnAttrs>,
         fn_abi: Option<&FnAbi<'tcx, Ty<'tcx>>>,
+        instance: Option<Instance<'tcx>>,
         llfn: &'ll Value,
     ) -> Option<llvm::OperandBundleDef<'ll>> {
         let is_indirect_call = unsafe { llvm::LLVMRustIsNonGVFunctionPointerTy(llfn) };
@@ -1665,7 +1677,12 @@ impl<'a, 'll, 'tcx> Builder<'a, 'll, 'tcx> {
                 options.insert(TypeIdOptions::NORMALIZE_INTEGERS);
             }
 
-            let kcfi_typeid = kcfi_typeid_for_fnabi(self.tcx, fn_abi, options);
+            let kcfi_typeid = if let Some(instance) = instance {
+                kcfi_typeid_for_instance(self.tcx, &instance, options)
+            } else {
+                kcfi_typeid_for_fnabi(self.tcx, fn_abi, options)
+            };
+
             Some(llvm::OperandBundleDef::new("kcfi", &[self.const_u32(kcfi_typeid)]))
         } else {
             None
diff --git a/compiler/rustc_codegen_llvm/src/intrinsic.rs b/compiler/rustc_codegen_llvm/src/intrinsic.rs
index 71b69a94e99e7..78ed31f9d9aca 100644
--- a/compiler/rustc_codegen_llvm/src/intrinsic.rs
+++ b/compiler/rustc_codegen_llvm/src/intrinsic.rs
@@ -181,6 +181,7 @@ impl<'ll, 'tcx> IntrinsicCallMethods<'tcx> for Builder<'_, 'll, 'tcx> {
                     simple_fn,
                     &args.iter().map(|arg| arg.immediate()).collect::<Vec<_>>(),
                     None,
+                    Some(instance),
                 )
             }
             sym::likely => {
@@ -539,7 +540,7 @@ fn catch_unwind_intrinsic<'ll>(
 ) {
     if bx.sess().panic_strategy() == PanicStrategy::Abort {
         let try_func_ty = bx.type_func(&[bx.type_ptr()], bx.type_void());
-        bx.call(try_func_ty, None, None, try_func, &[data], None);
+        bx.call(try_func_ty, None, None, try_func, &[data], None, None);
         // Return 0 unconditionally from the intrinsic call;
         // we can never unwind.
         let ret_align = bx.tcx().data_layout.i32_align.abi;
@@ -640,7 +641,7 @@ fn codegen_msvc_try<'ll>(
         let ptr_align = bx.tcx().data_layout.pointer_align.abi;
         let slot = bx.alloca(bx.type_ptr(), ptr_align);
         let try_func_ty = bx.type_func(&[bx.type_ptr()], bx.type_void());
-        bx.invoke(try_func_ty, None, None, try_func, &[data], normal, catchswitch, None);
+        bx.invoke(try_func_ty, None, None, try_func, &[data], normal, catchswitch, None, None);
 
         bx.switch_to_block(normal);
         bx.ret(bx.const_i32(0));
@@ -684,7 +685,7 @@ fn codegen_msvc_try<'ll>(
         let funclet = bx.catch_pad(cs, &[tydesc, flags, slot]);
         let ptr = bx.load(bx.type_ptr(), slot, ptr_align);
         let catch_ty = bx.type_func(&[bx.type_ptr(), bx.type_ptr()], bx.type_void());
-        bx.call(catch_ty, None, None, catch_func, &[data, ptr], Some(&funclet));
+        bx.call(catch_ty, None, None, catch_func, &[data, ptr], Some(&funclet), None);
         bx.catch_ret(&funclet, caught);
 
         // The flag value of 64 indicates a "catch-all".
@@ -692,7 +693,7 @@ fn codegen_msvc_try<'ll>(
         let flags = bx.const_i32(64);
         let null = bx.const_null(bx.type_ptr());
         let funclet = bx.catch_pad(cs, &[null, flags, null]);
-        bx.call(catch_ty, None, None, catch_func, &[data, null], Some(&funclet));
+        bx.call(catch_ty, None, None, catch_func, &[data, null], Some(&funclet), None);
         bx.catch_ret(&funclet, caught);
 
         bx.switch_to_block(caught);
@@ -701,7 +702,7 @@ fn codegen_msvc_try<'ll>(
 
     // Note that no invoke is used here because by definition this function
     // can't panic (that's what it's catching).
-    let ret = bx.call(llty, None, None, llfn, &[try_func, data, catch_func], None);
+    let ret = bx.call(llty, None, None, llfn, &[try_func, data, catch_func], None, None);
     let i32_align = bx.tcx().data_layout.i32_align.abi;
     bx.store(ret, dest, i32_align);
 }
@@ -750,7 +751,7 @@ fn codegen_wasm_try<'ll>(
         //   }
         //
         let try_func_ty = bx.type_func(&[bx.type_ptr()], bx.type_void());
-        bx.invoke(try_func_ty, None, None, try_func, &[data], normal, catchswitch, None);
+        bx.invoke(try_func_ty, None, None, try_func, &[data], normal, catchswitch, None, None);
 
         bx.switch_to_block(normal);
         bx.ret(bx.const_i32(0));
@@ -766,7 +767,7 @@ fn codegen_wasm_try<'ll>(
         let _sel = bx.call_intrinsic("llvm.wasm.get.ehselector", &[funclet.cleanuppad()]);
 
         let catch_ty = bx.type_func(&[bx.type_ptr(), bx.type_ptr()], bx.type_void());
-        bx.call(catch_ty, None, None, catch_func, &[data, ptr], Some(&funclet));
+        bx.call(catch_ty, None, None, catch_func, &[data, ptr], Some(&funclet), None);
         bx.catch_ret(&funclet, caught);
 
         bx.switch_to_block(caught);
@@ -775,7 +776,7 @@ fn codegen_wasm_try<'ll>(
 
     // Note that no invoke is used here because by definition this function
     // can't panic (that's what it's catching).
-    let ret = bx.call(llty, None, None, llfn, &[try_func, data, catch_func], None);
+    let ret = bx.call(llty, None, None, llfn, &[try_func, data, catch_func], None, None);
     let i32_align = bx.tcx().data_layout.i32_align.abi;
     bx.store(ret, dest, i32_align);
 }
@@ -818,7 +819,7 @@ fn codegen_gnu_try<'ll>(
         let data = llvm::get_param(bx.llfn(), 1);
         let catch_func = llvm::get_param(bx.llfn(), 2);
         let try_func_ty = bx.type_func(&[bx.type_ptr()], bx.type_void());
-        bx.invoke(try_func_ty, None, None, try_func, &[data], then, catch, None);
+        bx.invoke(try_func_ty, None, None, try_func, &[data], then, catch, None, None);
 
         bx.switch_to_block(then);
         bx.ret(bx.const_i32(0));
@@ -836,13 +837,13 @@ fn codegen_gnu_try<'ll>(
         bx.add_clause(vals, tydesc);
         let ptr = bx.extract_value(vals, 0);
         let catch_ty = bx.type_func(&[bx.type_ptr(), bx.type_ptr()], bx.type_void());
-        bx.call(catch_ty, None, None, catch_func, &[data, ptr], None);
+        bx.call(catch_ty, None, None, catch_func, &[data, ptr], None, None);
         bx.ret(bx.const_i32(1));
     });
 
     // Note that no invoke is used here because by definition this function
     // can't panic (that's what it's catching).
-    let ret = bx.call(llty, None, None, llfn, &[try_func, data, catch_func], None);
+    let ret = bx.call(llty, None, None, llfn, &[try_func, data, catch_func], None, None);
     let i32_align = bx.tcx().data_layout.i32_align.abi;
     bx.store(ret, dest, i32_align);
 }
@@ -882,7 +883,7 @@ fn codegen_emcc_try<'ll>(
         let data = llvm::get_param(bx.llfn(), 1);
         let catch_func = llvm::get_param(bx.llfn(), 2);
         let try_func_ty = bx.type_func(&[bx.type_ptr()], bx.type_void());
-        bx.invoke(try_func_ty, None, None, try_func, &[data], then, catch, None);
+        bx.invoke(try_func_ty, None, None, try_func, &[data], then, catch, None, None);
 
         bx.switch_to_block(then);
         bx.ret(bx.const_i32(0));
@@ -920,13 +921,13 @@ fn codegen_emcc_try<'ll>(
         bx.store(is_rust_panic, catch_data_1, i8_align);
 
         let catch_ty = bx.type_func(&[bx.type_ptr(), bx.type_ptr()], bx.type_void());
-        bx.call(catch_ty, None, None, catch_func, &[data, catch_data], None);
+        bx.call(catch_ty, None, None, catch_func, &[data, catch_data], None, None);
         bx.ret(bx.const_i32(1));
     });
 
     // Note that no invoke is used here because by definition this function
     // can't panic (that's what it's catching).
-    let ret = bx.call(llty, None, None, llfn, &[try_func, data, catch_func], None);
+    let ret = bx.call(llty, None, None, llfn, &[try_func, data, catch_func], None, None);
     let i32_align = bx.tcx().data_layout.i32_align.abi;
     bx.store(ret, dest, i32_align);
 }
@@ -1439,6 +1440,7 @@ fn generic_simd_intrinsic<'ll, 'tcx>(
             f,
             &args.iter().map(|arg| arg.immediate()).collect::<Vec<_>>(),
             None,
+            None,
         );
         Ok(c)
     }
@@ -1607,6 +1609,7 @@ fn generic_simd_intrinsic<'ll, 'tcx>(
             f,
             &[args[1].immediate(), alignment, mask, args[0].immediate()],
             None,
+            None,
         );
         return Ok(v);
     }
@@ -1706,6 +1709,7 @@ fn generic_simd_intrinsic<'ll, 'tcx>(
             f,
             &[args[1].immediate(), alignment, mask, args[2].immediate()],
             None,
+            None,
         );
         return Ok(v);
     }
@@ -1799,6 +1803,7 @@ fn generic_simd_intrinsic<'ll, 'tcx>(
             f,
             &[args[2].immediate(), args[1].immediate(), alignment, mask],
             None,
+            None,
         );
         return Ok(v);
     }
@@ -1904,6 +1909,7 @@ fn generic_simd_intrinsic<'ll, 'tcx>(
             f,
             &[args[0].immediate(), args[1].immediate(), alignment, mask],
             None,
+            None,
         );
         return Ok(v);
     }
@@ -2352,11 +2358,12 @@ fn generic_simd_intrinsic<'ll, 'tcx>(
                 f,
                 &[args[0].immediate(), bx.const_int(bx.type_i1(), 0)],
                 None,
+                None,
             ))
         } else {
             let fn_ty = bx.type_func(&[vec_ty], vec_ty);
             let f = bx.declare_cfn(llvm_intrinsic, llvm::UnnamedAddr::No, fn_ty);
-            Ok(bx.call(fn_ty, None, None, f, &[args[0].immediate()], None))
+            Ok(bx.call(fn_ty, None, None, f, &[args[0].immediate()], None, None))
         };
     }
 
@@ -2409,7 +2416,7 @@ fn generic_simd_intrinsic<'ll, 'tcx>(
 
         let fn_ty = bx.type_func(&[vec_ty, vec_ty], vec_ty);
         let f = bx.declare_cfn(llvm_intrinsic, llvm::UnnamedAddr::No, fn_ty);
-        let v = bx.call(fn_ty, None, None, f, &[lhs, rhs], None);
+        let v = bx.call(fn_ty, None, None, f, &[lhs, rhs], None, None);
         return Ok(v);
     }
 
diff --git a/compiler/rustc_codegen_ssa/src/base.rs b/compiler/rustc_codegen_ssa/src/base.rs
index c316d19e04119..51006839a9b69 100644
--- a/compiler/rustc_codegen_ssa/src/base.rs
+++ b/compiler/rustc_codegen_ssa/src/base.rs
@@ -462,27 +462,34 @@ pub fn maybe_create_entry_wrapper<'a, 'tcx, Bx: BuilderMethods<'a, 'tcx>>(
         let ptr_ty = cx.type_ptr();
         let (arg_argc, arg_argv) = get_argc_argv(cx, &mut bx);
 
-        let (start_fn, start_ty, args) = if let EntryFnType::Main { sigpipe } = entry_type {
+        let (start_fn, start_ty, args, instance) = if let EntryFnType::Main { sigpipe } = entry_type
+        {
             let start_def_id = cx.tcx().require_lang_item(LangItem::Start, None);
-            let start_fn = cx.get_fn_addr(ty::Instance::expect_resolve(
+            let start_instance = ty::Instance::expect_resolve(
                 cx.tcx(),
                 ty::ParamEnv::reveal_all(),
                 start_def_id,
                 cx.tcx().mk_args(&[main_ret_ty.into()]),
-            ));
+            );
+            let start_fn = cx.get_fn_addr(start_instance);
 
             let i8_ty = cx.type_i8();
             let arg_sigpipe = bx.const_u8(sigpipe);
 
             let start_ty = cx.type_func(&[cx.val_ty(rust_main), isize_ty, ptr_ty, i8_ty], isize_ty);
-            (start_fn, start_ty, vec![rust_main, arg_argc, arg_argv, arg_sigpipe])
+            (
+                start_fn,
+                start_ty,
+                vec![rust_main, arg_argc, arg_argv, arg_sigpipe],
+                Some(start_instance),
+            )
         } else {
             debug!("using user-defined start fn");
             let start_ty = cx.type_func(&[isize_ty, ptr_ty], isize_ty);
-            (rust_main, start_ty, vec![arg_argc, arg_argv])
+            (rust_main, start_ty, vec![arg_argc, arg_argv], None)
         };
 
-        let result = bx.call(start_ty, None, None, start_fn, &args, None);
+        let result = bx.call(start_ty, None, None, start_fn, &args, None, instance);
         if cx.sess().target.os.contains("uefi") {
             bx.ret(result);
         } else {
diff --git a/compiler/rustc_codegen_ssa/src/mir/block.rs b/compiler/rustc_codegen_ssa/src/mir/block.rs
index 02e7bb05b7709..a4716b7b34f99 100644
--- a/compiler/rustc_codegen_ssa/src/mir/block.rs
+++ b/compiler/rustc_codegen_ssa/src/mir/block.rs
@@ -147,6 +147,10 @@ impl<'a, 'tcx> TerminatorCodegenHelper<'tcx> {
 
     /// Call `fn_ptr` of `fn_abi` with the arguments `llargs`, the optional
     /// return destination `destination` and the unwind action `unwind`.
+    ///
+    /// You must provide `instance` if it might affect the alias set of the target.
+    /// This will never be the case for direct calls. It is currently only required
+    /// for `Virtual` calls, but providing it when available will avoid complications.
     fn do_call<Bx: BuilderMethods<'a, 'tcx>>(
         &self,
         fx: &mut FunctionCx<'a, 'tcx, Bx>,
@@ -158,6 +162,7 @@ impl<'a, 'tcx> TerminatorCodegenHelper<'tcx> {
         mut unwind: mir::UnwindAction,
         copied_constant_arguments: &[PlaceRef<'tcx, <Bx as BackendTypes>::Value>],
         mergeable_succ: bool,
+        instance: Option<Instance<'tcx>>,
     ) -> MergingSucc {
         // If there is a cleanup block and the function we're calling can unwind, then
         // do an invoke, otherwise do a call.
@@ -210,6 +215,7 @@ impl<'a, 'tcx> TerminatorCodegenHelper<'tcx> {
                 ret_llbb,
                 unwind_block,
                 self.funclet(fx),
+                instance,
             );
             if fx.mir[self.bb].is_cleanup {
                 bx.apply_attrs_to_cleanup_callsite(invokeret);
@@ -225,7 +231,8 @@ impl<'a, 'tcx> TerminatorCodegenHelper<'tcx> {
             }
             MergingSucc::False
         } else {
-            let llret = bx.call(fn_ty, fn_attrs, Some(fn_abi), fn_ptr, llargs, self.funclet(fx));
+            let llret =
+                bx.call(fn_ty, fn_attrs, Some(fn_abi), fn_ptr, llargs, self.funclet(fx), instance);
             if fx.mir[self.bb].is_cleanup {
                 bx.apply_attrs_to_cleanup_callsite(llret);
             }
@@ -495,7 +502,7 @@ impl<'a, 'tcx, Bx: BuilderMethods<'a, 'tcx>> FunctionCx<'a, 'tcx, Bx> {
             args1 = [place.llval];
             &args1[..]
         };
-        let (drop_fn, fn_abi) =
+        let (drop_fn, fn_abi, drop_instance) =
             match ty.kind() {
                 // FIXME(eddyb) perhaps move some of this logic into
                 // `Instance::resolve_drop_in_place`?
@@ -527,6 +534,7 @@ impl<'a, 'tcx, Bx: BuilderMethods<'a, 'tcx>> FunctionCx<'a, 'tcx, Bx> {
                         meth::VirtualIndex::from_index(ty::COMMON_VTABLE_ENTRIES_DROPINPLACE)
                             .get_fn(bx, vtable, ty, fn_abi),
                         fn_abi,
+                        virtual_drop,
                     )
                 }
                 ty::Dynamic(_, _, ty::DynStar) => {
@@ -569,9 +577,14 @@ impl<'a, 'tcx, Bx: BuilderMethods<'a, 'tcx>> FunctionCx<'a, 'tcx, Bx> {
                         meth::VirtualIndex::from_index(ty::COMMON_VTABLE_ENTRIES_DROPINPLACE)
                             .get_fn(bx, meta.immediate(), ty, fn_abi),
                         fn_abi,
+                        virtual_drop,
                     )
                 }
-                _ => (bx.get_fn_addr(drop_fn), bx.fn_abi_of_instance(drop_fn, ty::List::empty())),
+                _ => (
+                    bx.get_fn_addr(drop_fn),
+                    bx.fn_abi_of_instance(drop_fn, ty::List::empty()),
+                    drop_fn,
+                ),
             };
         helper.do_call(
             self,
@@ -583,6 +596,7 @@ impl<'a, 'tcx, Bx: BuilderMethods<'a, 'tcx>> FunctionCx<'a, 'tcx, Bx> {
             unwind,
             &[],
             mergeable_succ,
+            Some(drop_instance),
         )
     }
 
@@ -661,7 +675,8 @@ impl<'a, 'tcx, Bx: BuilderMethods<'a, 'tcx>> FunctionCx<'a, 'tcx, Bx> {
         let (fn_abi, llfn) = common::build_langcall(bx, Some(span), lang_item);
 
         // Codegen the actual panic invoke/call.
-        let merging_succ = helper.do_call(self, bx, fn_abi, llfn, &args, None, unwind, &[], false);
+        let merging_succ =
+            helper.do_call(self, bx, fn_abi, llfn, &args, None, unwind, &[], false, None);
         assert_eq!(merging_succ, MergingSucc::False);
         MergingSucc::False
     }
@@ -690,6 +705,7 @@ impl<'a, 'tcx, Bx: BuilderMethods<'a, 'tcx>> FunctionCx<'a, 'tcx, Bx> {
             mir::UnwindAction::Unreachable,
             &[],
             false,
+            None,
         );
         assert_eq!(merging_succ, MergingSucc::False);
     }
@@ -752,6 +768,7 @@ impl<'a, 'tcx, Bx: BuilderMethods<'a, 'tcx>> FunctionCx<'a, 'tcx, Bx> {
                     unwind,
                     &[],
                     mergeable_succ,
+                    None,
                 )
             } else {
                 // a NOP
@@ -1107,6 +1124,7 @@ impl<'a, 'tcx, Bx: BuilderMethods<'a, 'tcx>> FunctionCx<'a, 'tcx, Bx> {
             unwind,
             &copied_constant_arguments,
             mergeable_succ,
+            instance,
         )
     }
 
@@ -1667,7 +1685,7 @@ impl<'a, 'tcx, Bx: BuilderMethods<'a, 'tcx>> FunctionCx<'a, 'tcx, Bx> {
         let (fn_abi, fn_ptr) = common::build_langcall(&bx, None, reason.lang_item());
         let fn_ty = bx.fn_decl_backend_type(fn_abi);
 
-        let llret = bx.call(fn_ty, None, Some(fn_abi), fn_ptr, &[], funclet.as_ref());
+        let llret = bx.call(fn_ty, None, Some(fn_abi), fn_ptr, &[], funclet.as_ref(), None);
         bx.apply_attrs_to_cleanup_callsite(llret);
 
         bx.unreachable();
diff --git a/compiler/rustc_codegen_ssa/src/mir/rvalue.rs b/compiler/rustc_codegen_ssa/src/mir/rvalue.rs
index 8159f76b421b3..96732b711d0ea 100644
--- a/compiler/rustc_codegen_ssa/src/mir/rvalue.rs
+++ b/compiler/rustc_codegen_ssa/src/mir/rvalue.rs
@@ -715,7 +715,7 @@ impl<'a, 'tcx, Bx: BuilderMethods<'a, 'tcx>> FunctionCx<'a, 'tcx, Bx> {
                     } else {
                         None
                     };
-                    bx.call(fn_ty, fn_attrs, Some(fn_abi), fn_ptr, &[], None)
+                    bx.call(fn_ty, fn_attrs, Some(fn_abi), fn_ptr, &[], None, Some(instance))
                 } else {
                     bx.get_static(def_id)
                 };
diff --git a/compiler/rustc_codegen_ssa/src/size_of_val.rs b/compiler/rustc_codegen_ssa/src/size_of_val.rs
index 087836ca37de0..3cddfb673b98e 100644
--- a/compiler/rustc_codegen_ssa/src/size_of_val.rs
+++ b/compiler/rustc_codegen_ssa/src/size_of_val.rs
@@ -69,7 +69,15 @@ pub fn size_and_align_of_dst<'a, 'tcx, Bx: BuilderMethods<'a, 'tcx>>(
             // (But we are in good company, this code is duplicated plenty of times.)
             let fn_ty = bx.fn_decl_backend_type(fn_abi);
 
-            bx.call(fn_ty, /* fn_attrs */ None, Some(fn_abi), llfn, &[msg.0, msg.1], None);
+            bx.call(
+                fn_ty,
+                /* fn_attrs */ None,
+                Some(fn_abi),
+                llfn,
+                &[msg.0, msg.1],
+                None,
+                None,
+            );
 
             // This function does not return so we can now return whatever we want.
             let size = bx.const_usize(layout.size.bytes());
diff --git a/compiler/rustc_codegen_ssa/src/traits/builder.rs b/compiler/rustc_codegen_ssa/src/traits/builder.rs
index 36f37e3791bc5..70eecf4f189f6 100644
--- a/compiler/rustc_codegen_ssa/src/traits/builder.rs
+++ b/compiler/rustc_codegen_ssa/src/traits/builder.rs
@@ -16,7 +16,7 @@ use crate::MemFlags;
 
 use rustc_middle::middle::codegen_fn_attrs::CodegenFnAttrs;
 use rustc_middle::ty::layout::{HasParamEnv, TyAndLayout};
-use rustc_middle::ty::Ty;
+use rustc_middle::ty::{Instance, Ty};
 use rustc_span::Span;
 use rustc_target::abi::call::FnAbi;
 use rustc_target::abi::{Abi, Align, Scalar, Size, WrappingRange};
@@ -80,6 +80,7 @@ pub trait BuilderMethods<'a, 'tcx>:
         then: Self::BasicBlock,
         catch: Self::BasicBlock,
         funclet: Option<&Self::Funclet>,
+        instance: Option<Instance<'tcx>>,
     ) -> Self::Value;
     fn unreachable(&mut self);
 
@@ -339,6 +340,7 @@ pub trait BuilderMethods<'a, 'tcx>:
         llfn: Self::Value,
         args: &[Self::Value],
         funclet: Option<&Self::Funclet>,
+        instance: Option<Instance<'tcx>>,
     ) -> Self::Value;
     fn zext(&mut self, val: Self::Value, dest_ty: Self::Type) -> Self::Value;