diff --git a/.github/workflows/build_wheels.yml b/.github/workflows/build_wheels.yml
index 51cb90dd76..09154914d9 100644
--- a/.github/workflows/build_wheels.yml
+++ b/.github/workflows/build_wheels.yml
@@ -35,7 +35,7 @@ jobs:
         run: |
           python -m cibuildwheel --output-dir wheelhouse
         env:
-          CIBW_ENVIRONMENT: "PYBAMM_USE_VCPKG=ON VCPKG_ROOT_DIR=$cd/vcpkg VCPKG_DEFAULT_TRIPLET=x64-windows-static VCPKG_FEATURE_FLAGS=manifests,registries CMAKE_GENERATOR=\"Visual Studio 17 2022\" CMAKE_GENERATOR_PLATFORM=x64"
+          CIBW_ENVIRONMENT: "PYBAMM_USE_VCPKG=ON VCPKG_ROOT_DIR=$cd/vcpkg VCPKG_DEFAULT_TRIPLET=x64-windows-static-md VCPKG_FEATURE_FLAGS=manifests,registries CMAKE_GENERATOR=\"Visual Studio 17 2022\" CMAKE_GENERATOR_PLATFORM=x64"
           CIBW_ARCHS: "AMD64"
 
       - uses: actions/upload-artifact@v2
@@ -74,7 +74,11 @@ jobs:
         run: python -m cibuildwheel --output-dir wheelhouse
         env:
           CIBW_BEFORE_ALL_LINUX: "bash build_manylinux_wheels/install_sundials.sh 5.8.1 5.7.0"
-          CIBW_BEFORE_BUILD: "python -m pip install cmake casadi numpy"
+          CIBW_BEFORE_BUILD_LINUX: "python -m pip install cmake casadi numpy"
+          CIBW_BEFORE_BUILD_MACOS: "python -m pip install cmake casadi numpy && python scripts/fix_casadi_rpath_mac.py"
+          # got error "re.error: multiple repeat at position 104" on python 3.7 when --require-archs added, so remove
+          # it for mac
+          CIBW_REPAIR_WHEEL_COMMAND_MACOS: "delocate-listdeps {wheel} && delocate-wheel -v -w {dest_dir} {wheel}"
           CIBW_SKIP: pp*
 
       - uses: actions/upload-artifact@v2
diff --git a/scripts/fix_casadi_rpath_mac.py b/scripts/fix_casadi_rpath_mac.py
new file mode 100644
index 0000000000..73657bfc31
--- /dev/null
+++ b/scripts/fix_casadi_rpath_mac.py
@@ -0,0 +1,36 @@
+"""
+Removes the rpath from libcasadi.dylib in the casadi python install
+and uses a fixed path
+
+Used when building the wheels for macos
+"""
+import casadi
+import os
+import subprocess
+
+casadi_dir = casadi.__path__[0]
+print('Removing rpath references in python casadi install at', casadi_dir)
+
+libcpp_name = "libc++.1.dylib"
+libcppabi_name = "libc++abi.dylib"
+libcasadi_name = "libcasadi.dylib"
+install_name_tool_args = [
+    "-change",
+    os.path.join("@rpath", libcpp_name),
+    os.path.join(casadi_dir, libcpp_name),
+    os.path.join(casadi_dir, libcasadi_name),
+]
+subprocess.run(["otool"] + ["-L", os.path.join(casadi_dir, libcasadi_name)])
+print(' '.join(["install_name_tool"] + install_name_tool_args))
+subprocess.run(["install_name_tool"] + install_name_tool_args)
+subprocess.run(["otool"] + ["-L", os.path.join(casadi_dir, libcasadi_name)])
+install_name_tool_args = [
+    "-change",
+    os.path.join("@rpath", libcppabi_name),
+    os.path.join(casadi_dir, libcppabi_name),
+    os.path.join(casadi_dir, libcpp_name),
+]
+subprocess.run(["otool"] + ["-L", os.path.join(casadi_dir, libcpp_name)])
+print(' '.join(["install_name_tool"] + install_name_tool_args))
+subprocess.run(["install_name_tool"] + install_name_tool_args)
+subprocess.run(["otool"] + ["-L", os.path.join(casadi_dir, libcpp_name)])
diff --git a/scripts/install_KLU_Sundials.py b/scripts/install_KLU_Sundials.py
index d13ca52088..756c42aef8 100755
--- a/scripts/install_KLU_Sundials.py
+++ b/scripts/install_KLU_Sundials.py
@@ -106,6 +106,8 @@ def download_extract_library(url, download_dir):
     "-DKLU_INCLUDE_DIR={}".format(KLU_INCLUDE_DIR),
     "-DKLU_LIBRARY_DIR={}".format(KLU_LIBRARY_DIR),
     "-DCMAKE_INSTALL_PREFIX=" + install_dir,
+    # on mac use fixed paths rather than rpath
+    "-DCMAKE_INSTALL_NAME_DIR=" + KLU_LIBRARY_DIR,
 ]
 
 # SUNDIALS are built within download_dir 'build_sundials' in the PyBaMM root
diff --git a/vcpkg-configuration.json b/vcpkg-configuration.json
index 378b18f6c3..ecdff5f79d 100644
--- a/vcpkg-configuration.json
+++ b/vcpkg-configuration.json
@@ -13,7 +13,7 @@
     {
       "kind": "git",
       "repository": "https://github.com/pybamm-team/casadi-vcpkg-registry.git",
-      "baseline": "c44b0b834404dea4af79b8bc621ac513aefbd53d",
+      "baseline": "70f49f3c22fee4874fb8a36ef1a559f2c185ef1f",
       "packages": [ "casadi" ]
     }
   ]