diff --git a/README.md b/README.md
index 603a56d..5a03b2a 100644
--- a/README.md
+++ b/README.md
@@ -74,7 +74,7 @@ If the `target` registry does _not_ support nested paths, only the base path of
 mycompany.com/myteam/prometheus-operator:v0.40.0
 ```
 
-**Registries that do not support nested paths:** Docker Hub, Quay.io
+**Registries that do not support nested paths:** Docker Hub, GitHub Container Registry, Quay.io
 
 ## Usage
 
diff --git a/internal/manifest/manifest.go b/internal/manifest/manifest.go
index dd77012..17704b7 100644
--- a/internal/manifest/manifest.go
+++ b/internal/manifest/manifest.go
@@ -366,6 +366,11 @@ func hostSupportsNestedRepositories(host string) bool {
 		return false
 	}
 
+	// GHCR.io
+	if strings.Contains(host, "ghcr.io") {
+		return false
+	}
+
 	// Docker Registry (Docker Hub)
 	// An empty host is assumed to be Docker Hub.
 	if strings.Contains(host, "docker.io") || host == "" {