diff --git a/crates/oxc_transformer/src/plugins/replace_global_defines.rs b/crates/oxc_transformer/src/plugins/replace_global_defines.rs
index d647bbdc6645c4..6f3293f8acd4fc 100644
--- a/crates/oxc_transformer/src/plugins/replace_global_defines.rs
+++ b/crates/oxc_transformer/src/plugins/replace_global_defines.rs
@@ -538,7 +538,7 @@ impl<'a> ReplaceGlobalDefines<'a> {
             };
         }
 
-        true
+        current_part_member_expression.is_none()
     }
 }
 
diff --git a/crates/oxc_transformer/tests/integrations/plugins/replace_global_defines.rs b/crates/oxc_transformer/tests/integrations/plugins/replace_global_defines.rs
index f57edd9678247c..f7ddd2c7830887 100644
--- a/crates/oxc_transformer/tests/integrations/plugins/replace_global_defines.rs
+++ b/crates/oxc_transformer/tests/integrations/plugins/replace_global_defines.rs
@@ -71,6 +71,20 @@ fn dot_with_overlap() {
     test("import.meta.env.NODE_ENV", "import.meta.env.NODE_ENV", config.clone());
 }
 
+#[test]
+fn dot_define_is_member_expr_postfix() {
+    let config = ReplaceGlobalDefinesConfig::new(&[
+        ("__OBJ__", r#"{"process":{"env":{"SOMEVAR":"foo"}}}"#),
+        ("process.env.SOMEVAR", "\"SOMEVAR\""),
+    ])
+    .unwrap();
+    test(
+        "console.log(__OBJ__.process.env.SOMEVAR)",
+        "console.log({ 'process': { 'env': { 'SOMEVAR': 'foo' } } }.process.env.SOMEVAR);\n",
+        config.clone(),
+    );
+}
+
 #[test]
 fn dot_nested() {
     let config = ReplaceGlobalDefinesConfig::new(&[("process", "production")]).unwrap();