diff --git a/instrumentation/opentelemetry-instrumentation-boto3sqs/setup.cfg b/instrumentation/opentelemetry-instrumentation-boto3sqs/setup.cfg
index b6cd820a06..6da1b06796 100644
--- a/instrumentation/opentelemetry-instrumentation-boto3sqs/setup.cfg
+++ b/instrumentation/opentelemetry-instrumentation-boto3sqs/setup.cfg
@@ -33,14 +33,13 @@ classifiers =
     License :: OSI Approved :: Apache Software License
     Programming Language :: Python
     Programming Language :: Python :: 3
-    Programming Language :: Python :: 3.6
     Programming Language :: Python :: 3.7
     Programming Language :: Python :: 3.8
     Programming Language :: Python :: 3.9
     Programming Language :: Python :: 3.10
 
 [options]
-python_requires = >=3.6
+python_requires = >=3.7
 package_dir=
     =src
 packages=find_namespace:
diff --git a/instrumentation/opentelemetry-instrumentation-confluent-kafka/setup.cfg b/instrumentation/opentelemetry-instrumentation-confluent-kafka/setup.cfg
index 43a84acfaf..94ffffcff7 100644
--- a/instrumentation/opentelemetry-instrumentation-confluent-kafka/setup.cfg
+++ b/instrumentation/opentelemetry-instrumentation-confluent-kafka/setup.cfg
@@ -28,14 +28,13 @@ classifiers =
     License :: OSI Approved :: Apache Software License
     Programming Language :: Python
     Programming Language :: Python :: 3
-    Programming Language :: Python :: 3.6
     Programming Language :: Python :: 3.7
     Programming Language :: Python :: 3.8
     Programming Language :: Python :: 3.9
     Programming Language :: Python :: 3.10
 
 [options]
-python_requires = >=3.6
+python_requires = >=3.7
 package_dir=
     =src
 packages=find_namespace:
diff --git a/instrumentation/opentelemetry-instrumentation-system-metrics/setup.cfg b/instrumentation/opentelemetry-instrumentation-system-metrics/setup.cfg
index 7704103a2b..4ea9772e36 100644
--- a/instrumentation/opentelemetry-instrumentation-system-metrics/setup.cfg
+++ b/instrumentation/opentelemetry-instrumentation-system-metrics/setup.cfg
@@ -28,14 +28,13 @@ classifiers =
     License :: OSI Approved :: Apache Software License
     Programming Language :: Python
     Programming Language :: Python :: 3
-    Programming Language :: Python :: 3.6
     Programming Language :: Python :: 3.7
     Programming Language :: Python :: 3.8
     Programming Language :: Python :: 3.9
     Programming Language :: Python :: 3.10
 
 [options]
-python_requires = >=3.6
+python_requires = >=3.7
 package_dir=
     =src
 packages=find_namespace:
diff --git a/opentelemetry-contrib-instrumentations/setup.cfg b/opentelemetry-contrib-instrumentations/setup.cfg
index 61e0a9ceca..520e0c62d8 100644
--- a/opentelemetry-contrib-instrumentations/setup.cfg
+++ b/opentelemetry-contrib-instrumentations/setup.cfg
@@ -14,14 +14,13 @@ classifiers =
 	License :: OSI Approved :: Apache Software License
 	Programming Language :: Python
 	Programming Language :: Python :: 3
-	Programming Language :: Python :: 3.6
 	Programming Language :: Python :: 3.7
 	Programming Language :: Python :: 3.8
 	Programming Language :: Python :: 3.9
 	Programming Language :: Python :: 3.10
 
 [options]
-python_requires = >=3.6
+python_requires = >=3.7
 package_dir = 
 	=src
 packages = find_namespace: