diff --git a/lib/fetch/index.js b/lib/fetch/index.js
index 298b3ddb27c..cc01f145b48 100644
--- a/lib/fetch/index.js
+++ b/lib/fetch/index.js
@@ -2002,7 +2002,8 @@ async function httpNetworkFetch (
                 location = val
               }
 
-              headers.append(key, val)
+              // Note: Not allow pseudo-header for H2. e.g. `:status`
+              if (key.charCodeAt(0) !== 58) headers.append(key, val)
             }
           } else {
             const keys = Object.keys(headersList)
@@ -2016,7 +2017,8 @@ async function httpNetworkFetch (
                 location = val
               }
 
-              headers.append(key, val)
+              // Note: Not allow pseudo-header for H2. e.g. `:status`
+              if (key.charCodeAt(0) !== 58) headers.append(key, val)
             }
           }