diff --git a/muted-tests.yml b/muted-tests.yml
index af561d3200e98..6bc7c5008b0c4 100644
--- a/muted-tests.yml
+++ b/muted-tests.yml
@@ -395,6 +395,9 @@ tests:
 - class: org.elasticsearch.test.rest.ClientYamlTestSuiteIT
   method: test {yaml=update/100_synthetic_source/keyword}
   issue: https://github.com/elastic/elasticsearch/issues/121965
+- class: org.elasticsearch.xpack.esql.plugin.DataNodeRequestSenderTests
+  method: testDoNotRetryOnRequestLevelFailure
+  issue: https://github.com/elastic/elasticsearch/issues/121966
 
 # Examples:
 #