diff --git a/change/react-native-windows-77e0d25a-8269-4693-8568-96ba49675a87.json b/change/react-native-windows-77e0d25a-8269-4693-8568-96ba49675a87.json
new file mode 100644
index 00000000000..27812246d03
--- /dev/null
+++ b/change/react-native-windows-77e0d25a-8269-4693-8568-96ba49675a87.json
@@ -0,0 +1,7 @@
+{
+  "type": "prerelease",
+  "comment": "Switch to MUX:CommandBarFlyout in XAML Islands proofing menu",
+  "packageName": "react-native-windows",
+  "email": "jthysell@microsoft.com",
+  "dependentChangeType": "patch"
+}
diff --git a/vnext/Microsoft.ReactNative/Utils/XamlIslandUtils.cpp b/vnext/Microsoft.ReactNative/Utils/XamlIslandUtils.cpp
index d5f93ed12c1..091cabc88f7 100644
--- a/vnext/Microsoft.ReactNative/Utils/XamlIslandUtils.cpp
+++ b/vnext/Microsoft.ReactNative/Utils/XamlIslandUtils.cpp
@@ -30,14 +30,23 @@ struct CustomAppBarButton : xaml::Controls::AppBarButtonT<CustomAppBarButton> {
   }
 };
 
-void FixProofingMenuCrashForXamlIsland(xaml::Controls::TextCommandBarFlyout const &flyout) {
+void FixProofingMenuCrashForXamlIsland(xaml::Controls::Primitives::FlyoutBase const &flyout) {
   flyout.Opening([](winrt::IInspectable const &sender, auto &&) {
-    const auto &flyout = sender.as<xaml::Controls::TextCommandBarFlyout>();
+    const auto &flyout = sender.as<winrt::Microsoft::UI::Xaml::Controls::TextCommandBarFlyout>();
     if (const auto &textBox = flyout.Target().try_as<xaml::Controls::TextBox>()) {
       const auto &commands = flyout.SecondaryCommands();
       for (uint32_t i = 0; i < commands.Size(); ++i) {
         if (const auto &appBarButton = commands.GetAt(i).try_as<xaml::Controls::AppBarButton>()) {
-          if (appBarButton.Flyout() == textBox.ProofingMenuFlyout()) {
+          if (!appBarButton.Flyout()) {
+            // This works around a loss of focus from the target element when clicking on
+            // on the menu items.
+            // https://github.com/microsoft/microsoft-ui-xaml/issues/5818
+            appBarButton.Click([weakCommandBarFlyout = winrt::make_weak(flyout)](auto &&...) {
+              if (auto flyout = weakCommandBarFlyout.get()) {
+                xaml::Input::FocusManager::TryFocusAsync(flyout.Target(), xaml::FocusState::Programmatic);
+              }
+            });
+          } else if (appBarButton.Flyout() == textBox.ProofingMenuFlyout()) {
             if (!appBarButton.try_as<CustomAppBarButton>()) {
               // Replace the AppBarButton for the proofing menu with one that doesn't crash
               const auto customAppBarButton = winrt::make<CustomAppBarButton>();
diff --git a/vnext/Microsoft.ReactNative/Utils/XamlIslandUtils.h b/vnext/Microsoft.ReactNative/Utils/XamlIslandUtils.h
index d00d4f1ed95..87c8c728df8 100644
--- a/vnext/Microsoft.ReactNative/Utils/XamlIslandUtils.h
+++ b/vnext/Microsoft.ReactNative/Utils/XamlIslandUtils.h
@@ -8,9 +8,11 @@
 #include <UI.Xaml.Controls.Primitives.h>
 #include <UI.Xaml.Controls.h>
 
+#include <winrt/Microsoft.UI.Xaml.Controls.h>
+
 namespace Microsoft::ReactNative {
 
-void FixProofingMenuCrashForXamlIsland(xaml::Controls::TextCommandBarFlyout const &flyout);
+void FixProofingMenuCrashForXamlIsland(xaml::Controls::Primitives::FlyoutBase const &flyout);
 
 template <typename T>
 inline void EnsureUniqueTextFlyoutForXamlIsland(T const &textView) {
@@ -19,7 +21,7 @@ inline void EnsureUniqueTextFlyoutForXamlIsland(T const &textView) {
   // to show the flyout on other windows cause the first window to get focus.
   // https://github.com/microsoft/microsoft-ui-xaml/issues/5341
   if (IsXamlIsland()) {
-    xaml::Controls::TextCommandBarFlyout flyout;
+    winrt::Microsoft::UI::Xaml::Controls::TextCommandBarFlyout flyout;
     flyout.Placement(xaml::Controls::Primitives::FlyoutPlacementMode::BottomEdgeAlignedLeft);
 
     // This works around a XAML Islands bug where the Proofing sub-menu for