diff --git a/docs/changes/newsfragments/4623.improved_driver b/docs/changes/newsfragments/4623.improved_driver
new file mode 100644
index 00000000000..1f4fc44a0e0
--- /dev/null
+++ b/docs/changes/newsfragments/4623.improved_driver
@@ -0,0 +1 @@
+The Minicircuits USB SPDT driver now supports running with the more modern version of the driver DLL `mcl_RF_Switch_Controller_NET45.dll`
diff --git a/docs/examples/driver_examples/Qcodes example with Minicircuits Switch boxes (USB-XSPDT).ipynb b/docs/examples/driver_examples/Qcodes example with Minicircuits Switch boxes (USB-XSPDT).ipynb
index f94bdc8311b..84297557707 100644
--- a/docs/examples/driver_examples/Qcodes example with Minicircuits Switch boxes (USB-XSPDT).ipynb	
+++ b/docs/examples/driver_examples/Qcodes example with Minicircuits Switch boxes (USB-XSPDT).ipynb	
@@ -17,6 +17,7 @@
    ]
   },
   {
+   "attachments": {},
    "cell_type": "markdown",
    "metadata": {},
    "source": [
@@ -24,14 +25,17 @@
     "\n",
     "The driver_path should specify the url of the dll for controlling the instrument. You can find it here:\n",
     "\n",
-    "https://ww2.minicircuits.com/softwaredownload/rfswitchcontroller.html\n",
+    "https://www.minicircuits.com/softwaredownload/rfswitchcontroller.html\n",
     "\n",
-    "Download .NET dll and save somewhere. Unblock it (right click properties) and specify the path."
+    "Download .NET dll and save somewhere. Unblock it (right click properties) and specify the path.\n",
+    "\n",
+    "The downloaded ZIP file contains two DLLs. We recommend using mcl_RF_Switch_Controller_NET45.dll\n",
+    "which supports the most recent .net versions. "
    ]
   },
   {
    "cell_type": "code",
-   "execution_count": 3,
+   "execution_count": null,
    "metadata": {},
    "outputs": [
     {
@@ -45,7 +49,7 @@
    "source": [
     "dev = USB_SPDT('test',\n",
     "               serial_number='11703020018',\n",
-    "               driver_path= r'C:\\Users\\a-dovoge\\Qcodes\\qcodes\\instrument_drivers\\Minicircuits\\mcl_RF_Switch_Controller64')"
+    "               driver_path= r'C:\\Users\\a-dovoge\\Qcodes\\qcodes\\instrument_drivers\\Minicircuits\\mcl_RF_Switch_Controller_NET45')"
    ]
   },
   {
@@ -117,7 +121,7 @@
  ],
  "metadata": {
   "kernelspec": {
-   "display_name": "Python 3",
+   "display_name": "qcodespip310",
    "language": "python",
    "name": "python3"
   },
@@ -131,10 +135,15 @@
    "name": "python",
    "nbconvert_exporter": "python",
    "pygments_lexer": "ipython3",
-   "version": "3.6.6"
+   "version": "3.10.8 | packaged by conda-forge | (main, Nov 24 2022, 14:07:00) [MSC v.1916 64 bit (AMD64)]"
   },
   "nbsphinx": {
    "execute": "never"
+  },
+  "vscode": {
+   "interpreter": {
+    "hash": "2643ef1ecb4e72f15331668d402315679b29a004e65b7ec963f6cfe589581b49"
+   }
   }
  },
  "nbformat": 4,
diff --git a/pyproject.toml b/pyproject.toml
index 4aa770cccf6..a0600f79934 100644
--- a/pyproject.toml
+++ b/pyproject.toml
@@ -211,6 +211,7 @@ module = [
     "lomentum.tools",
     "matplotlib.*",
     "mcl_RF_Switch_Controller64",
+    "mcl_RF_Switch_Controller_NET45",
     "opencensus.ext.azure.*",
     "pythoncom",
     "pyqtgraph.*",
diff --git a/qcodes/instrument_drivers/Minicircuits/USB_SPDT.py b/qcodes/instrument_drivers/Minicircuits/USB_SPDT.py
index d6a441f7394..8c4c7b1442b 100644
--- a/qcodes/instrument_drivers/Minicircuits/USB_SPDT.py
+++ b/qcodes/instrument_drivers/Minicircuits/USB_SPDT.py
@@ -37,7 +37,8 @@ class USB_SPDT(SPDT_Base):
     """
 
     CHANNEL_CLASS = SwitchChannelUSB
-    PATH_TO_DRIVER = r'mcl_RF_Switch_Controller64'
+    PATH_TO_DRIVER = r"mcl_RF_Switch_Controller64"
+    PATH_TO_DRIVER_45 = r"mcl_RF_Switch_Controller_NET45"
 
     def __init__(self, name: str, driver_path: Optional[str] = None,
                  serial_number: Optional[str] = None, **kwargs: Any):
@@ -57,19 +58,26 @@ def __init__(self, name: str, driver_path: Optional[str] = None,
             raise ImportError("""This driver only works in Windows.""")
         try:
             if driver_path is None:
-                clr.AddReference(self.PATH_TO_DRIVER)
+                try:
+                    clr.AddReference(self.PATH_TO_DRIVER)
+                except FileNotFoundError:
+                    clr.AddReference(self.PATH_TO_DRIVER_45)
             else:
                 clr.AddReference(driver_path)
 
         except (ImportError, FileNotFoundException):
             raise ImportError(
-                """Load of mcl_RF_Switch_Controller64.dll not possible. Make sure
-                the dll file is not blocked by Windows. To unblock right-click
-                the dll to open properties and check the 'unblock' checkmark
+                """Load of mcl_RF_Switch_Controller64.dll or mcl_RF_Switch_Controller_NET45.dll
+                not possible. Make sure the dll file is not blocked by Windows.
+                To unblock right-click the dll to open properties and check the 'unblock' checkmark
                 in the bottom. Check that your python installation is 64bit."""
             )
-        import mcl_RF_Switch_Controller64  # pyright: ignore[reportMissingImports]
-        self.switch = mcl_RF_Switch_Controller64.USB_RF_SwitchBox()
+        try:
+            import mcl_RF_Switch_Controller64 as mw_driver  # pyright: ignore[reportMissingImports]
+        except ImportError:
+            import mcl_RF_Switch_Controller_NET45 as mw_driver  # pyright: ignore[reportMissingImports]
+
+        self.switch = mw_driver.USB_RF_SwitchBox()
 
         if not self.switch.Connect(serial_number):
             raise RuntimeError('Could not connect to device')