From 8ad93489574fe053c4819eb1f7da2b1d70d7cb13 Mon Sep 17 00:00:00 2001 From: Emily de la Rua Date: Thu, 14 Dec 2023 17:08:41 -0500 Subject: [PATCH 01/10] Add fun `expect_snapshot_ggplot` to process graph snapshots as ggplots --- package/tests/testthat/test-graph-snaps.R | 72 ++++++++++++++++------- 1 file changed, 51 insertions(+), 21 deletions(-) diff --git a/package/tests/testthat/test-graph-snaps.R b/package/tests/testthat/test-graph-snaps.R index 1707a4c664..694f474167 100644 --- a/package/tests/testthat/test-graph-snaps.R +++ b/package/tests/testthat/test-graph-snaps.R @@ -20,37 +20,67 @@ if (length(skip_tests)) { ) } +# expect_snapshot_ggplot - set custom plot dimensions +expect_snapshot_ggplot <- function(title, fig, width = NA, height = NA) { + skip_if_not_installed("svglite") + + name <- paste0(title, ".svg") + path <- tempdir() + suppressMessages(ggplot2::ggsave(name, fig, path = path, width = width, height = height)) + path <- file.path(path, name) + + testthat::announce_snapshot_file(name = name) + testthat::expect_snapshot_file(path, name) +} + for (snapshot_variant in intersect(snapshot_variants, rds_variants)) { path <- file.path(test_data_path, paste0(snapshot_variant, ".rds")) if (isFALSE(file.exists(path))) { testthat::skip(paste( - "Data snapshot file", path, - "not found. Skipping tests for the article:", - paste0(snapshot_variant, ".qmd"), + "Data snapshot file", path, "not found. Skipping tests for the article:", paste0(snapshot_variant, ".qmd"), sep = " " )) } data_snap <- readRDS(path) - for (i in names(data_snap)) { - # Some plot objects have multiple plots in them and stored as unnamed list of plots - if (inherits(data_snap[[i]], "list")) { - for (plot_index in seq_len(length(data_snap[[i]]))) { - # Random seed to get consistent graphs - set.seed(123) - vdiffr::expect_doppelganger( - title = paste(snapshot_variant, i, plot_index, sep = "-"), - fig = data_snap[[i]][[plot_index]] - ) - } + plot_nms <- grep("width|height", names(data_snap), value = TRUE, invert = TRUE) + for (i in plot_nms) { + if (grepl("table", i)) { + testthat::expect_snapshot( + print(data_snap[[i]]), + variant = snapshot_variant + ) } else { - testthat::test_that(i, { - # Random seed to get consistent graphs - set.seed(123) - vdiffr::expect_doppelganger( - title = paste(snapshot_variant, i, sep = "-"), - fig = data_snap[[i]] - ) + plot_dims <- sapply(c("width", "height"), function(x) if (paste0(i, ".", x) %in% names(data_snap)) { + data_snap[[paste0(i, ".", x)]] + } else if (x %in% names(data_snap)) { + data_snap[[x]] + } else { + if (x == "width") 7 else 5 }) + # Some plot objects have multiple plots in them and stored as unnamed list of plots + if (inherits(data_snap[[i]], "list")) { + for (plot_index in seq_len(length(data_snap[[i]]))) { + # Random seed to get consistent graphs + set.seed(123) + expect_snapshot_ggplot( + title = paste(snapshot_variant, i, plot_index, sep = "-"), + fig = data_snap[[i]][[plot_index]], + width = plot_dims[["width"]], + height = plot_dims[["height"]] + ) + } + } else { + testthat::test_that(i, { + # Random seed to get consistent graphs + set.seed(123) + expect_snapshot_ggplot( + title = paste(snapshot_variant, i, sep = "-"), + fig = data_snap[[i]], + width = plot_dims[["width"]], + height = plot_dims[["height"]] + ) + }) + } } } } From cc7e184d29405ceeabd94bb967edb47bcad74544 Mon Sep 17 00:00:00 2001 From: Emily de la Rua Date: Thu, 14 Dec 2023 17:09:27 -0500 Subject: [PATCH 02/10] Update fstg01 and fstg02 to generate snapshots with custom widths --- book/graphs/efficacy/fstg01.qmd | 49 ++++++++++++++++----------------- book/graphs/efficacy/fstg02.qmd | 42 ++++++++++++++-------------- 2 files changed, 44 insertions(+), 47 deletions(-) diff --git a/book/graphs/efficacy/fstg01.qmd b/book/graphs/efficacy/fstg01.qmd index c125566994..43c829427e 100644 --- a/book/graphs/efficacy/fstg01.qmd +++ b/book/graphs/efficacy/fstg01.qmd @@ -5,6 +5,8 @@ subtitle: Subgroup Analysis of Best Overall Response ------------------------------------------------------------------------ +{{< include ../../test-utils/envir_hook.qmd >}} + ::: panel-tabset ## Data Setup @@ -42,7 +44,7 @@ var_labels(anl_rsp_arms_ab) <- c(anl_labels, is_rsp = "Is Responder") ## Standard Plot -```{r, warning=FALSE, fig.width = 15} +```{r plot1, test = list(plot_v1 = "plot"), fig.width = 20, fig.height = 5} df <- extract_rsp_subgroups( variables = list( rsp = "is_rsp", @@ -57,15 +59,13 @@ df <- extract_rsp_subgroups( result <- basic_table() %>% tabulate_rsp_subgroups(df, vars = c("n_tot", "n", "n_rsp", "prop", "or", "ci")) -p <- g_forest( - tbl = result -) -grid::grid.draw(p) +plot <- g_forest(tbl = result) +plot ``` ## Plot Specifying Class Variables and
Options for the Treatment Variable -```{r, warning=FALSE, fig.width = 15} +```{r plot2, test = list(plot_v2 = "plot"), fig.width = 20, fig.height = 5} anl_rsp_comb_arms_ac <- anl %>% mutate(is_rsp = AVALC %in% c("CR", "PR")) %>% filter(ARMCD %in% c("ARM B", "ARM A", "ARM C")) %>% @@ -98,16 +98,13 @@ df <- extract_rsp_subgroups( result <- basic_table() %>% tabulate_rsp_subgroups(df, vars = c("n_tot", "n", "n_rsp", "prop", "or", "ci")) -p <- g_forest( - tbl = result -) - -grid::grid.draw(p) +plot <- g_forest(tbl = result) +plot ``` ## Plot Selecting Columns and
Changing the Alpha Level -```{r, warning=FALSE, fig.width = 15} +```{r plot3, test = list(plot_v3 = "plot"), fig.width = 10, fig.height = 4} df <- extract_rsp_subgroups( variables = list( rsp = "is_rsp", @@ -122,16 +119,13 @@ df <- extract_rsp_subgroups( result <- basic_table() %>% tabulate_rsp_subgroups(df, vars = c("n_tot", "or", "ci")) -p <- g_forest( - tbl = result -) - -grid::grid.draw(p) +plot <- g_forest(tbl = result) +plot ``` ## Plot with Fixed
Symbol Size -```{r, warning=FALSE, fig.width = 15} +```{r plot4, test = list(plot_v4 = "plot"), fig.width = 20, fig.height = 5} df <- extract_rsp_subgroups( variables = list( rsp = "is_rsp", @@ -146,17 +140,16 @@ df <- extract_rsp_subgroups( result <- basic_table() %>% tabulate_rsp_subgroups(df, vars = c("n_tot", "n", "n_rsp", "prop", "or", "ci")) -p <- g_forest( +plot <- g_forest( tbl = result, col_symbol_size = NULL ) - -grid::grid.draw(p) +plot ``` ## Plot of CR Only, Setting
Values Indicating Response -```{r, warning=FALSE, fig.width = 15} +```{r plot5, test = list(plot_v5 = "plot"), fig.width = 20, fig.height = 5} anl_cr_arms_ab <- anl %>% mutate(is_rsp = AVALC == "CR") %>% filter(ARMCD %in% c("ARM B", "ARM A")) %>% @@ -183,13 +176,17 @@ df <- extract_rsp_subgroups( result <- basic_table() %>% tabulate_rsp_subgroups(df, vars = c("n_tot", "n", "n_rsp", "prop", "or", "ci")) -p <- g_forest( - tbl = result -) +plot <- g_forest(tbl = result) +plot +``` -grid::grid.draw(p) +```{r test parameters, test = list(width = "width", height = "height"), echo=FALSE} +width <- 20 +height <- 5 ``` +{{< include ../../test-utils/save_results.qmd >}} + ## `teal` App ```{r teal, message=FALSE, opts.label='skip_if_testing'} diff --git a/book/graphs/efficacy/fstg02.qmd b/book/graphs/efficacy/fstg02.qmd index d466421d85..183ec91f85 100644 --- a/book/graphs/efficacy/fstg02.qmd +++ b/book/graphs/efficacy/fstg02.qmd @@ -5,6 +5,8 @@ subtitle: Subgroup Analysis of Survival Duration ------------------------------------------------------------------------ +{{< include ../../test-utils/envir_hook.qmd >}} + ::: panel-tabset ## Data Setup @@ -54,7 +56,7 @@ anl <- synthetic_cdisc_dataset("latest", "adtte") %>% ## Standard Plot -```{r variant1, warning=FALSE, fig.width = 15} +```{r plot1, test = list(plot_v1 = "plot"), fig.width = 15, fig.height = 4} anl1 <- anl df <- extract_survival_subgroups( @@ -71,16 +73,13 @@ result <- basic_table() %>% result # Add plot. -p <- g_forest( - tbl = result -) - -grid::grid.draw(p) +plot <- g_forest(tbl = result) +plot ``` ## Plot Specifying Class Variables and
Options for the Treatment Variable -```{r variant2, warning=FALSE, fig.width = 15} +```{r plot2, test = list(plot_v2 = "plot"), fig.width = 15, fig.height = 4} anl2 <- anl %>% mutate( # Recode levels of arm. @@ -108,16 +107,13 @@ result <- basic_table() %>% ) result -p <- g_forest( - tbl = result -) - -grid::grid.draw(p) +plot <- g_forest(tbl = result) +plot ``` ## Plot Selecting Columns and
Changing the Alpha Level) -```{r variant3, warning=FALSE, fig.width = 15} +```{r plot3, test = list(plot_v3 = "plot"), fig.width = 8, fig.height = 4} anl3 <- anl df <- extract_survival_subgroups( @@ -134,16 +130,13 @@ result <- basic_table() %>% result # Add plot. -p <- g_forest( - tbl = result -) - -grid::grid.draw(p) +plot <- g_forest(tbl = result) +plot ``` ## Plot with Fixed
Symbol Size -```{r variant4, warning=FALSE, fig.width = 15} +```{r plot4, test = list(plot_v4 = "plot"), fig.width = 15, fig.height = 4} anl4 <- anl df <- extract_survival_subgroups( @@ -160,14 +153,21 @@ result <- basic_table() %>% result # Add plot. -p <- g_forest( +plot <- g_forest( tbl = result, col_symbol_size = NULL ) +plot +``` -grid::grid.draw(p) +```{r test parameters, test = list(width = "width", height = "height", plot_v3.width = "plot_v3.width"), echo=FALSE} +width <- 15 +height <- 4 +plot_v3.width <- 8 ``` +{{< include ../../test-utils/save_results.qmd >}} + ## `teal` App ```{r teal, message=FALSE, opts.label='skip_if_testing'} From 3e7a09e386be95c21955b521bf270648b1576313 Mon Sep 17 00:00:00 2001 From: Emily de la Rua Date: Thu, 14 Dec 2023 17:10:14 -0500 Subject: [PATCH 03/10] Add custom dimensions for mmrmg02 plots --- book/graphs/efficacy/mmrmg02.qmd | 10 +++++++--- 1 file changed, 7 insertions(+), 3 deletions(-) diff --git a/book/graphs/efficacy/mmrmg02.qmd b/book/graphs/efficacy/mmrmg02.qmd index aad8a75cf6..254ec3efd9 100644 --- a/book/graphs/efficacy/mmrmg02.qmd +++ b/book/graphs/efficacy/mmrmg02.qmd @@ -80,7 +80,7 @@ From these results a table is obtained using the `tern.mmrm::tabulate_mmrm_subgr Here we compare `ARM A` with the reference arm, `ARM B`. -```{r plot1, warning=FALSE, fig.width = 15, test = list(plot_v1 = "plot")} +```{r plot1, test = list(plot_v1 = "plot"), fig.width = 15, fig.height = 4} df_a <- extract_mmrm_subgroups( fit = mmrm_results, visit = "SCREENING", @@ -106,7 +106,7 @@ plot Then we compare `ARM C` with `ARM B`. -```{r plot2, warning=FALSE, fig.width = 15, test = list(plot_v2 = "plot")} +```{r plot2, test = list(plot_v2 = "plot"), fig.width = 15, fig.height = 4} df_c <- extract_mmrm_subgroups( fit = mmrm_results, visit = "SCREENING", @@ -130,8 +130,12 @@ plot <- g_forest( plot ``` +```{r test parameters, test = list(width = "width", width = "width"), echo=FALSE} +width <- 15 +height <- 4 +``` + {{< include ../../test-utils/save_results.qmd >}} {{< include ../../repro.qmd >}} - ::: From ddc830d1cfa755ac62fe3af0fe31ef0a102eba98 Mon Sep 17 00:00:00 2001 From: Emily de la Rua Date: Thu, 14 Dec 2023 17:13:06 -0500 Subject: [PATCH 04/10] Update dependency versions --- package/DESCRIPTION | 8 ++++---- 1 file changed, 4 insertions(+), 4 deletions(-) diff --git a/package/DESCRIPTION b/package/DESCRIPTION index e777b92b44..58b9c6ff89 100644 --- a/package/DESCRIPTION +++ b/package/DESCRIPTION @@ -17,7 +17,7 @@ Suggests: DescTools, dplyr, forcats, - formatters (>= 0.5.4), + formatters (>= 0.5.5), ggplot2 (>= 3.4.0), ggpubr, ggrepel, @@ -25,8 +25,8 @@ Suggests: lubridate, nestcolor, renv, - rlistings (>= 0.2.6), - rtables (>= 0.6.5), + rlistings (>= 0.2.7), + rtables (>= 0.6.6), scales, scda, scda.2022 (>= 0.1.5), @@ -35,7 +35,7 @@ Suggests: teal (>= 0.14.0.9027), teal.modules.clinical (>= 0.8.16.9019), teal.modules.general (>= 0.2.16.9014), - tern (>= 0.9.2), + tern (>= 0.9.3), tern.mmrm (>= 0.2.2), 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package/tests/testthat/_snaps/graph-snaps/pkpg06-plot_v2.svg create mode 100644 package/tests/testthat/_snaps/graph-snaps/pkpg06-plot_v3.svg create mode 100644 package/tests/testthat/_snaps/graph-snaps/pkpg06-plot_v4.svg diff --git a/package/tests/testthat/_snaps/cig01/graph-snaps.md b/package/tests/testthat/_snaps/cig01/graph-snaps.md new file mode 100644 index 0000000000..e48b5fe58e --- /dev/null +++ b/package/tests/testthat/_snaps/cig01/graph-snaps.md @@ -0,0 +1,10 @@ +# plot_v9 + + Code + print(data_snap[[i]]) + Output + ARM A ARM B ARM C + ———————————————————————————————————————————————— + Mean (SD) 17.7 (9.9) 18.7 (9.8) 19.5 (9.1) + Median 17.5 18.2 19.0 + diff --git a/package/tests/testthat/_snaps/graph-snaps/brg01-plot-v1.svg b/package/tests/testthat/_snaps/graph-snaps/brg01-plot-v1.svg deleted file mode 100644 index 0ccbb811e3..0000000000 --- a/package/tests/testthat/_snaps/graph-snaps/brg01-plot-v1.svg +++ /dev/null @@ -1,70 +0,0 @@ - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - -104 -101 -99 - - -0 -25 -50 -75 -100 - - - - - - - - -A: Drug X -B: Placebo -C: Combination -Description of Actual Arm (N = 400) -Frequency -Frequency of Subjects With Serious AEs: Safety-Evaluable Subjects - - diff --git a/package/tests/testthat/_snaps/graph-snaps/brg01-plot-v2.svg b/package/tests/testthat/_snaps/graph-snaps/brg01-plot-v2.svg deleted file mode 100644 index 2749386536..0000000000 --- a/package/tests/testthat/_snaps/graph-snaps/brg01-plot-v2.svg +++ /dev/null @@ -1,71 +0,0 @@ - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - -19.5 -18.75 -22.25 - - -0 -5 -10 -15 -20 - - - - - - - - -A: Drug X -B: Placebo -C: Combination -Description of Actual Arm (N = 400) -Percent -Percent of Subjects With cl A Disorders: Safety-Evaluable Subjects - - diff --git a/package/tests/testthat/_snaps/graph-snaps/brg01-plot-v3.svg b/package/tests/testthat/_snaps/graph-snaps/brg01-plot-v3.svg deleted file mode 100644 index 507d0becdd..0000000000 --- a/package/tests/testthat/_snaps/graph-snaps/brg01-plot-v3.svg +++ /dev/null @@ -1,70 +0,0 @@ - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - -0 -25 -50 -75 - - - - - - - -A: Drug X - -N = 78 -B: Placebo - -N = 75 -C: Combination - -N = 89 -Description of Actual Arm (N = 400) -Frequency -Frequency of Subjects With Serious AEs: Safety-Evaluable Subjects - - diff --git a/package/tests/testthat/_snaps/graph-snaps/brg01-plot-v4.svg b/package/tests/testthat/_snaps/graph-snaps/brg01-plot-v4.svg deleted file mode 100644 index fb2f621d39..0000000000 --- a/package/tests/testthat/_snaps/graph-snaps/brg01-plot-v4.svg +++ /dev/null @@ -1,67 +0,0 @@ - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - -A: Drug X -B: Placebo -C: Combination - - - - - - - - -0 -25 -50 -75 -100 -Frequency -Description of Actual Arm (N = 400) -Frequency of Subjects With Serious AEs: Safety-Evaluable Subjects - - diff --git 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-Description of Actual Arm (N = 400) -Percent - -Sex - - - - -F -M -Percent of Subjects With Serious AEs: Safety-Evaluable Subjects - - diff --git a/package/tests/testthat/_snaps/graph-snaps/brg01-plot-v7.svg b/package/tests/testthat/_snaps/graph-snaps/brg01-plot-v7.svg deleted file mode 100644 index 784ef00071..0000000000 --- a/package/tests/testthat/_snaps/graph-snaps/brg01-plot-v7.svg +++ /dev/null @@ -1,74 +0,0 @@ - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - -0 -5 -10 -15 - - - - - - -F -M -Sex (N = 400) -Percent - -Description of Actual Arm - - - - - - -A: Drug X -B: Placebo -C: Combination -Percent of Subjects With Serious AEs: Safety-Evaluable Subjects - - diff --git a/package/tests/testthat/_snaps/graph-snaps/brg01-plot-v8.svg b/package/tests/testthat/_snaps/graph-snaps/brg01-plot-v8.svg deleted file mode 100644 index c86dd948a5..0000000000 --- a/package/tests/testthat/_snaps/graph-snaps/brg01-plot-v8.svg +++ /dev/null @@ -1,104 +0,0 @@ - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - -5 -5.5 -4.25 - - -0 -2 -4 -6 - - - - - - - -A: Drug X -B: Placebo -C: Combination -Description of Actual Arm (N = 400) -Percent -Percent of Subjects with Abnormaly High CRP at Baseline - Safety-Evaluable Subjects - - - - - - - - - - - - - - - - - - -10.45 -10.34 -10.46 -10.23 -10.25 -10.33 - - -Median -Mean - - diff --git a/package/tests/testthat/_snaps/graph-snaps/brg01-plot-v9.svg b/package/tests/testthat/_snaps/graph-snaps/brg01-plot-v9.svg deleted file mode 100644 index 298504689e..0000000000 --- a/package/tests/testthat/_snaps/graph-snaps/brg01-plot-v9.svg +++ /dev/null @@ -1,93 +0,0 @@ - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - -0 -10 -20 -30 - - - - - - - -A: Drug X -B: Placebo -C: Combination -Description of Actual Arm (N = 400) -Percent - -Analysis Toxicity Grade (C) - - - - - - - - - - -1 -2 -3 -4 -5 -Percent of Subjects With AE by Highest - NCI CTCAE Grade: Safety-Evaluable Subjects - - diff --git a/package/tests/testthat/_snaps/graph-snaps/brg01-plot_v1.svg b/package/tests/testthat/_snaps/graph-snaps/brg01-plot_v1.svg new file mode 100644 index 0000000000..80f13721e0 --- /dev/null +++ b/package/tests/testthat/_snaps/graph-snaps/brg01-plot_v1.svg @@ -0,0 +1,73 @@ + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + +104 +101 +99 + + +0 +25 +50 +75 +100 + + + + + + + + +A: Drug X +B: Placebo +C: Combination +Description of Actual Arm (N = 400) +Frequency +Frequency of Subjects With Serious AEs: Safety-Evaluable Subjects + + diff --git a/package/tests/testthat/_snaps/graph-snaps/brg01-plot_v2.svg b/package/tests/testthat/_snaps/graph-snaps/brg01-plot_v2.svg new file mode 100644 index 0000000000..673d0ffcc1 --- /dev/null +++ b/package/tests/testthat/_snaps/graph-snaps/brg01-plot_v2.svg @@ -0,0 +1,74 @@ + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + +19.5 +18.75 +22.25 + + +0 +5 +10 +15 +20 + + + + + + + + +A: Drug X +B: Placebo +C: Combination +Description of Actual Arm (N = 400) +Percent +Percent of Subjects With cl A Disorders: Safety-Evaluable Subjects + + diff --git a/package/tests/testthat/_snaps/graph-snaps/brg01-plot_v3.svg b/package/tests/testthat/_snaps/graph-snaps/brg01-plot_v3.svg new file mode 100644 index 0000000000..b68a04e5c1 --- /dev/null +++ b/package/tests/testthat/_snaps/graph-snaps/brg01-plot_v3.svg @@ -0,0 +1,73 @@ + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + +0 +25 +50 +75 + + + + + + + +A: Drug X + +N = 78 +B: Placebo + +N = 75 +C: Combination + +N = 89 +Description of Actual Arm (N = 400) +Frequency +Frequency of Subjects With Serious AEs: Safety-Evaluable Subjects + + diff --git a/package/tests/testthat/_snaps/graph-snaps/brg01-plot_v4.svg b/package/tests/testthat/_snaps/graph-snaps/brg01-plot_v4.svg new file mode 100644 index 0000000000..c1022bd5bf --- /dev/null +++ b/package/tests/testthat/_snaps/graph-snaps/brg01-plot_v4.svg @@ -0,0 +1,70 @@ + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + +A: Drug X +B: Placebo +C: Combination + + + + + + + + +0 +25 +50 +75 +100 +Frequency +Description of Actual Arm (N = 400) +Frequency of Subjects With Serious AEs: Safety-Evaluable Subjects + + diff --git a/package/tests/testthat/_snaps/graph-snaps/brg01-plot_v5.svg b/package/tests/testthat/_snaps/graph-snaps/brg01-plot_v5.svg new file mode 100644 index 0000000000..5e1f7d11e4 --- /dev/null +++ b/package/tests/testthat/_snaps/graph-snaps/brg01-plot_v5.svg @@ -0,0 +1,72 @@ + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + +0 +1 +2 + + + + + + +A: Drug X +B: Placebo +C: Combination +Description of Actual Arm (N = 400) +Percentage +Percent of Subjects with Abnormaly High ALT: Safety-Evaluable Subjects + + diff --git a/package/tests/testthat/_snaps/graph-snaps/brg01-plot_v6.svg 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+Percent of Subjects With Serious AEs: Safety-Evaluable Subjects + + diff --git a/package/tests/testthat/_snaps/graph-snaps/brg01-plot_v8.svg b/package/tests/testthat/_snaps/graph-snaps/brg01-plot_v8.svg new file mode 100644 index 0000000000..1c600683ca --- /dev/null +++ b/package/tests/testthat/_snaps/graph-snaps/brg01-plot_v8.svg @@ -0,0 +1,107 @@ + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + +5 +5.5 +4.25 + + +0 +2 +4 +6 + + + + + + + +A: Drug X +B: Placebo +C: Combination +Description of Actual Arm (N = 400) +Percent +Percent of Subjects with Abnormaly High CRP at Baseline + Safety-Evaluable Subjects + + + + + + + + + + + + + + + + + + +10.45 +10.34 +10.46 +10.23 +10.25 +10.33 + + +Median +Mean + + diff --git a/package/tests/testthat/_snaps/graph-snaps/brg01-plot_v9.svg b/package/tests/testthat/_snaps/graph-snaps/brg01-plot_v9.svg new file mode 100644 index 0000000000..399dbccdef --- /dev/null +++ b/package/tests/testthat/_snaps/graph-snaps/brg01-plot_v9.svg @@ -0,0 +1,96 @@ + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + +0 +10 +20 +30 + + + + + + + +A: Drug X +B: Placebo +C: Combination +Description of Actual Arm (N = 400) +Percent + +Analysis Toxicity Grade (C) + + + + + + + + + + +1 +2 +3 +4 +5 +Percent of Subjects With AE by Highest + NCI CTCAE Grade: Safety-Evaluable Subjects + + diff --git a/package/tests/testthat/_snaps/graph-snaps/bwg01-plot-v1.svg b/package/tests/testthat/_snaps/graph-snaps/bwg01-plot-v1.svg deleted file mode 100644 index b4096d7b86..0000000000 --- a/package/tests/testthat/_snaps/graph-snaps/bwg01-plot-v1.svg +++ /dev/null @@ -1,97 +0,0 @@ - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - -0 -10 -20 -30 -40 - - - - - - - - -ARM A -ARM B -ARM C -Treatment Group -ALT (U/L) -Visit: WEEK 2 DAY 15 -Box Plot of Laboratory Test 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Values outside the whiskers have not been plotted. + + diff --git a/package/tests/testthat/_snaps/graph-snaps/bwg01-plot_v3.svg b/package/tests/testthat/_snaps/graph-snaps/bwg01-plot_v3.svg new file mode 100644 index 0000000000..640dfbfc15 --- /dev/null +++ b/package/tests/testthat/_snaps/graph-snaps/bwg01-plot_v3.svg @@ -0,0 +1,142 @@ + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + +0 +10 +20 +30 +40 + + + + + + + + +ARM A +ARM B +ARM C +Treatment Group +ALT (U/L) +Visit: WEEK 2 DAY 15 +Box Plot of Laboratory Test Results +The whiskers extend to the 5th and 95th percentile. + + diff --git a/package/tests/testthat/_snaps/graph-snaps/bwg01-plot_v4.svg b/package/tests/testthat/_snaps/graph-snaps/bwg01-plot_v4.svg new file mode 100644 index 0000000000..43006b26af --- /dev/null +++ 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+Visit: WEEK 2 DAY 15 +Box Plot of Laboratory Test Results +The whiskers extend to the minimum and maximum values. + + diff --git a/package/tests/testthat/_snaps/graph-snaps/bwg01-plot_v6.svg b/package/tests/testthat/_snaps/graph-snaps/bwg01-plot_v6.svg new file mode 100644 index 0000000000..22f9fe188b --- /dev/null +++ b/package/tests/testthat/_snaps/graph-snaps/bwg01-plot_v6.svg @@ -0,0 +1,216 @@ + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + +0 +20 +40 + + + + + + + +WEEK 1 DAY 8 +WEEK 2 DAY 15 +WEEK 3 DAY 22 +WEEK 4 DAY 29 +Visit +ALT (U/L) + +ARMCD + + + + + + + + + + + + + + + +ARM A +ARM B +ARM C +Box Plot of Laboratory Test Results +The whiskers extend to the minimum and maximum values. + + diff 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-BASELINE -WEEK 1 DAY 8 -WEEK 2 DAY 15 -WEEK 3 DAY 22 -WEEK 4 DAY 29 -WEEK 5 DAY 36 -SCREENING -BASELINE -WEEK 1 DAY 8 -WEEK 2 DAY 15 -WEEK 3 DAY 22 -WEEK 4 DAY 29 -WEEK 5 DAY 36 -SCREENING -BASELINE -WEEK 1 DAY 8 -WEEK 2 DAY 15 -WEEK 3 DAY 22 -WEEK 4 DAY 29 -WEEK 5 DAY 36 -SCREENING -BASELINE -WEEK 1 DAY 8 -WEEK 2 DAY 15 -WEEK 3 DAY 22 -WEEK 4 DAY 29 -WEEK 5 DAY 36 -SCREENING -BASELINE -WEEK 1 DAY 8 -WEEK 2 DAY 15 -WEEK 3 DAY 22 -WEEK 4 DAY 29 -WEEK 5 DAY 36 -SCREENING -BASELINE -WEEK 1 DAY 8 -WEEK 2 DAY 15 -WEEK 3 DAY 22 -WEEK 4 DAY 29 -WEEK 5 DAY 36 -SCREENING -BASELINE -WEEK 1 DAY 8 -WEEK 2 DAY 15 -WEEK 3 DAY 22 -WEEK 4 DAY 29 -WEEK 5 DAY 36 -SCREENING -BASELINE -WEEK 1 DAY 8 -WEEK 2 DAY 15 -WEEK 3 DAY 22 -WEEK 4 DAY 29 -WEEK 5 DAY 36 -SCREENING -BASELINE -WEEK 1 DAY 8 -WEEK 2 DAY 15 -WEEK 3 DAY 22 -WEEK 4 DAY 29 -WEEK 5 DAY 36 -SCREENING -BASELINE -WEEK 1 DAY 8 -WEEK 2 DAY 15 -WEEK 3 DAY 22 -WEEK 4 DAY 29 -WEEK 5 DAY 36 -SCREENING -BASELINE -WEEK 1 DAY 8 -WEEK 2 DAY 15 -WEEK 3 DAY 22 -WEEK 4 DAY 29 -WEEK 5 DAY 36 -SCREENING -BASELINE -WEEK 1 DAY 8 -WEEK 2 DAY 15 -WEEK 3 DAY 22 -WEEK 4 DAY 29 -WEEK 5 DAY 36 -SCREENING -BASELINE -WEEK 1 DAY 8 -WEEK 2 DAY 15 -WEEK 3 DAY 22 -WEEK 4 DAY 29 -WEEK 5 DAY 36 -SCREENING -BASELINE -WEEK 1 DAY 8 -WEEK 2 DAY 15 -WEEK 3 DAY 22 -WEEK 4 DAY 29 -WEEK 5 DAY 36 -SCREENING -BASELINE -WEEK 1 DAY 8 -WEEK 2 DAY 15 -WEEK 3 DAY 22 -WEEK 4 DAY 29 -WEEK 5 DAY 36 -SCREENING -BASELINE -WEEK 1 DAY 8 -WEEK 2 DAY 15 -WEEK 3 DAY 22 -WEEK 4 DAY 29 -WEEK 5 DAY 36 -SCREENING -BASELINE -WEEK 1 DAY 8 -WEEK 2 DAY 15 -WEEK 3 DAY 22 -WEEK 4 DAY 29 -WEEK 5 DAY 36 -SCREENING -BASELINE -WEEK 1 DAY 8 -WEEK 2 DAY 15 -WEEK 3 DAY 22 -WEEK 4 DAY 29 -WEEK 5 DAY 36 -SCREENING -BASELINE -WEEK 1 DAY 8 -WEEK 2 DAY 15 -WEEK 3 DAY 22 -WEEK 4 DAY 29 -WEEK 5 DAY 36 -SCREENING -BASELINE -WEEK 1 DAY 8 -WEEK 2 DAY 15 -WEEK 3 DAY 22 -WEEK 4 DAY 29 -WEEK 5 DAY 36 -SCREENING -BASELINE -WEEK 1 DAY 8 -WEEK 2 DAY 15 -WEEK 3 DAY 22 -WEEK 4 DAY 29 -WEEK 5 DAY 36 -SCREENING -BASELINE -WEEK 1 DAY 8 -WEEK 2 DAY 15 -WEEK 3 DAY 22 -WEEK 4 DAY 29 -WEEK 5 DAY 36 -SCREENING -BASELINE -WEEK 1 DAY 8 -WEEK 2 DAY 15 -WEEK 3 DAY 22 -WEEK 4 DAY 29 -WEEK 5 DAY 36 -SCREENING -BASELINE -WEEK 1 DAY 8 -WEEK 2 DAY 15 -WEEK 3 DAY 22 -WEEK 4 DAY 29 -WEEK 5 DAY 36 -SCREENING -BASELINE -WEEK 1 DAY 8 -WEEK 2 DAY 15 -WEEK 3 DAY 22 -WEEK 4 DAY 29 -WEEK 5 DAY 36 -SCREENING -BASELINE -WEEK 1 DAY 8 -WEEK 2 DAY 15 -WEEK 3 DAY 22 -WEEK 4 DAY 29 -WEEK 5 DAY 36 -SCREENING -BASELINE -WEEK 1 DAY 8 -WEEK 2 DAY 15 -WEEK 3 DAY 22 -WEEK 4 DAY 29 -WEEK 5 DAY 36 -SCREENING -BASELINE -WEEK 1 DAY 8 -WEEK 2 DAY 15 -WEEK 3 DAY 22 -WEEK 4 DAY 29 -WEEK 5 DAY 36 -SCREENING -BASELINE -WEEK 1 DAY 8 -WEEK 2 DAY 15 -WEEK 3 DAY 22 -WEEK 4 DAY 29 -WEEK 5 DAY 36 -SCREENING -BASELINE -WEEK 1 DAY 8 -WEEK 2 DAY 15 -WEEK 3 DAY 22 -WEEK 4 DAY 29 -WEEK 5 DAY 36 -SCREENING -BASELINE -WEEK 1 DAY 8 -WEEK 2 DAY 15 -WEEK 3 DAY 22 -WEEK 4 DAY 29 -WEEK 5 DAY 36 -SCREENING -BASELINE -WEEK 1 DAY 8 -WEEK 2 DAY 15 -WEEK 3 DAY 22 -WEEK 4 DAY 29 -WEEK 5 DAY 36 -SCREENING -BASELINE -WEEK 1 DAY 8 -WEEK 2 DAY 15 -WEEK 3 DAY 22 -WEEK 4 DAY 29 -WEEK 5 DAY 36 -SCREENING -BASELINE -WEEK 1 DAY 8 -WEEK 2 DAY 15 -WEEK 3 DAY 22 -WEEK 4 DAY 29 -WEEK 5 DAY 36 -SCREENING -BASELINE -WEEK 1 DAY 8 -WEEK 2 DAY 15 -WEEK 3 DAY 22 -WEEK 4 DAY 29 -WEEK 5 DAY 36 -SCREENING -BASELINE -WEEK 1 DAY 8 -WEEK 2 DAY 15 -WEEK 3 DAY 22 -WEEK 4 DAY 29 -WEEK 5 DAY 36 -SCREENING -BASELINE -WEEK 1 DAY 8 -WEEK 2 DAY 15 -WEEK 3 DAY 22 -WEEK 4 DAY 29 -WEEK 5 DAY 36 -SCREENING -BASELINE -WEEK 1 DAY 8 -WEEK 2 DAY 15 -WEEK 3 DAY 22 -WEEK 4 DAY 29 -WEEK 5 DAY 36 -SCREENING -BASELINE -WEEK 1 DAY 8 -WEEK 2 DAY 15 -WEEK 3 DAY 22 -WEEK 4 DAY 29 -WEEK 5 DAY 36 -SCREENING -BASELINE -WEEK 1 DAY 8 -WEEK 2 DAY 15 -WEEK 3 DAY 22 -WEEK 4 DAY 29 -WEEK 5 DAY 36 -SCREENING -BASELINE -WEEK 1 DAY 8 -WEEK 2 DAY 15 -WEEK 3 DAY 22 -WEEK 4 DAY 29 -WEEK 5 DAY 36 -SCREENING -BASELINE -WEEK 1 DAY 8 -WEEK 2 DAY 15 -WEEK 3 DAY 22 -WEEK 4 DAY 29 -WEEK 5 DAY 36 -SCREENING -BASELINE -WEEK 1 DAY 8 -WEEK 2 DAY 15 -WEEK 3 DAY 22 -WEEK 4 DAY 29 -WEEK 5 DAY 36 -SCREENING -BASELINE -WEEK 1 DAY 8 -WEEK 2 DAY 15 -WEEK 3 DAY 22 -WEEK 4 DAY 29 -WEEK 5 DAY 36 -SCREENING -BASELINE -WEEK 1 DAY 8 -WEEK 2 DAY 15 -WEEK 3 DAY 22 -WEEK 4 DAY 29 -WEEK 5 DAY 36 -SCREENING -BASELINE -WEEK 1 DAY 8 -WEEK 2 DAY 15 -WEEK 3 DAY 22 -WEEK 4 DAY 29 -WEEK 5 DAY 36 -SCREENING -BASELINE -WEEK 1 DAY 8 -WEEK 2 DAY 15 -WEEK 3 DAY 22 -WEEK 4 DAY 29 -WEEK 5 DAY 36 -SCREENING -BASELINE -WEEK 1 DAY 8 -WEEK 2 DAY 15 -WEEK 3 DAY 22 -WEEK 4 DAY 29 -WEEK 5 DAY 36 -SCREENING -BASELINE -WEEK 1 DAY 8 -WEEK 2 DAY 15 -WEEK 3 DAY 22 -WEEK 4 DAY 29 -WEEK 5 DAY 36 -SCREENING -BASELINE -WEEK 1 DAY 8 -WEEK 2 DAY 15 -WEEK 3 DAY 22 -WEEK 4 DAY 29 -WEEK 5 DAY 36 -SCREENING -BASELINE -WEEK 1 DAY 8 -WEEK 2 DAY 15 -WEEK 3 DAY 22 -WEEK 4 DAY 29 -WEEK 5 DAY 36 -SCREENING -BASELINE -WEEK 1 DAY 8 -WEEK 2 DAY 15 -WEEK 3 DAY 22 -WEEK 4 DAY 29 -WEEK 5 DAY 36 -SCREENING -BASELINE -WEEK 1 DAY 8 -WEEK 2 DAY 15 -WEEK 3 DAY 22 -WEEK 4 DAY 29 -WEEK 5 DAY 36 -SCREENING -BASELINE -WEEK 1 DAY 8 -WEEK 2 DAY 15 -WEEK 3 DAY 22 -WEEK 4 DAY 29 -WEEK 5 DAY 36 -SCREENING -BASELINE -WEEK 1 DAY 8 -WEEK 2 DAY 15 -WEEK 3 DAY 22 -WEEK 4 DAY 29 -WEEK 5 DAY 36 -SCREENING -BASELINE -WEEK 1 DAY 8 -WEEK 2 DAY 15 -WEEK 3 DAY 22 -WEEK 4 DAY 29 -WEEK 5 DAY 36 -SCREENING -BASELINE -WEEK 1 DAY 8 -WEEK 2 DAY 15 -WEEK 3 DAY 22 -WEEK 4 DAY 29 -WEEK 5 DAY 36 -SCREENING -BASELINE -WEEK 1 DAY 8 -WEEK 2 DAY 15 -WEEK 3 DAY 22 -WEEK 4 DAY 29 -WEEK 5 DAY 36 -SCREENING -BASELINE -WEEK 1 DAY 8 -WEEK 2 DAY 15 -WEEK 3 DAY 22 -WEEK 4 DAY 29 -WEEK 5 DAY 36 -SCREENING -BASELINE -WEEK 1 DAY 8 -WEEK 2 DAY 15 -WEEK 3 DAY 22 -WEEK 4 DAY 29 -WEEK 5 DAY 36 -SCREENING -BASELINE -WEEK 1 DAY 8 -WEEK 2 DAY 15 -WEEK 3 DAY 22 -WEEK 4 DAY 29 -WEEK 5 DAY 36 -SCREENING -BASELINE -WEEK 1 DAY 8 -WEEK 2 DAY 15 -WEEK 3 DAY 22 -WEEK 4 DAY 29 -WEEK 5 DAY 36 -SCREENING -BASELINE -WEEK 1 DAY 8 -WEEK 2 DAY 15 -WEEK 3 DAY 22 -WEEK 4 DAY 29 -WEEK 5 DAY 36 -SCREENING -BASELINE -WEEK 1 DAY 8 -WEEK 2 DAY 15 -WEEK 3 DAY 22 -WEEK 4 DAY 29 -WEEK 5 DAY 36 -SCREENING -BASELINE -WEEK 1 DAY 8 -WEEK 2 DAY 15 -WEEK 3 DAY 22 -WEEK 4 DAY 29 -WEEK 5 DAY 36 -SCREENING -BASELINE -WEEK 1 DAY 8 -WEEK 2 DAY 15 -WEEK 3 DAY 22 -WEEK 4 DAY 29 -WEEK 5 DAY 36 -SCREENING -BASELINE -WEEK 1 DAY 8 -WEEK 2 DAY 15 -WEEK 3 DAY 22 -WEEK 4 DAY 29 -WEEK 5 DAY 36 -SCREENING -BASELINE -WEEK 1 DAY 8 -WEEK 2 DAY 15 -WEEK 3 DAY 22 -WEEK 4 DAY 29 -WEEK 5 DAY 36 -SCREENING -BASELINE -WEEK 1 DAY 8 -WEEK 2 DAY 15 -WEEK 3 DAY 22 -WEEK 4 DAY 29 -WEEK 5 DAY 36 -SCREENING -BASELINE -WEEK 1 DAY 8 -WEEK 2 DAY 15 -WEEK 3 DAY 22 -WEEK 4 DAY 29 -WEEK 5 DAY 36 -SCREENING -BASELINE -WEEK 1 DAY 8 -WEEK 2 DAY 15 -WEEK 3 DAY 22 -WEEK 4 DAY 29 -WEEK 5 DAY 36 -SCREENING -BASELINE -WEEK 1 DAY 8 -WEEK 2 DAY 15 -WEEK 3 DAY 22 -WEEK 4 DAY 29 -WEEK 5 DAY 36 -SCREENING -BASELINE -WEEK 1 DAY 8 -WEEK 2 DAY 15 -WEEK 3 DAY 22 -WEEK 4 DAY 29 -WEEK 5 DAY 36 -SCREENING -BASELINE -WEEK 1 DAY 8 -WEEK 2 DAY 15 -WEEK 3 DAY 22 -WEEK 4 DAY 29 -WEEK 5 DAY 36 -SCREENING -BASELINE -WEEK 1 DAY 8 -WEEK 2 DAY 15 -WEEK 3 DAY 22 -WEEK 4 DAY 29 -WEEK 5 DAY 36 -SCREENING -BASELINE -WEEK 1 DAY 8 -WEEK 2 DAY 15 -WEEK 3 DAY 22 -WEEK 4 DAY 29 -WEEK 5 DAY 36 -SCREENING -BASELINE -WEEK 1 DAY 8 -WEEK 2 DAY 15 -WEEK 3 DAY 22 -WEEK 4 DAY 29 -WEEK 5 DAY 36 -SCREENING -BASELINE -WEEK 1 DAY 8 -WEEK 2 DAY 15 -WEEK 3 DAY 22 -WEEK 4 DAY 29 -WEEK 5 DAY 36 -SCREENING -BASELINE -WEEK 1 DAY 8 -WEEK 2 DAY 15 -WEEK 3 DAY 22 -WEEK 4 DAY 29 -WEEK 5 DAY 36 -SCREENING -BASELINE -WEEK 1 DAY 8 -WEEK 2 DAY 15 -WEEK 3 DAY 22 -WEEK 4 DAY 29 -WEEK 5 DAY 36 -SCREENING -BASELINE -WEEK 1 DAY 8 -WEEK 2 DAY 15 -WEEK 3 DAY 22 -WEEK 4 DAY 29 -WEEK 5 DAY 36 -SCREENING -BASELINE -WEEK 1 DAY 8 -WEEK 2 DAY 15 -WEEK 3 DAY 22 -WEEK 4 DAY 29 -WEEK 5 DAY 36 -SCREENING -BASELINE -WEEK 1 DAY 8 -WEEK 2 DAY 15 -WEEK 3 DAY 22 -WEEK 4 DAY 29 -WEEK 5 DAY 36 -SCREENING -BASELINE -WEEK 1 DAY 8 -WEEK 2 DAY 15 -WEEK 3 DAY 22 -WEEK 4 DAY 29 -WEEK 5 DAY 36 -SCREENING 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22 -WEEK 4 DAY 29 -WEEK 5 DAY 36 -SCREENING -BASELINE -WEEK 1 DAY 8 -WEEK 2 DAY 15 -WEEK 3 DAY 22 -WEEK 4 DAY 29 -WEEK 5 DAY 36 -SCREENING -BASELINE -WEEK 1 DAY 8 -WEEK 2 DAY 15 -WEEK 3 DAY 22 -WEEK 4 DAY 29 -WEEK 5 DAY 36 -SCREENING -BASELINE -WEEK 1 DAY 8 -WEEK 2 DAY 15 -WEEK 3 DAY 22 -WEEK 4 DAY 29 -WEEK 5 DAY 36 -SCREENING -BASELINE -WEEK 1 DAY 8 -WEEK 2 DAY 15 -WEEK 3 DAY 22 -WEEK 4 DAY 29 -WEEK 5 DAY 36 -SCREENING -BASELINE -WEEK 1 DAY 8 -WEEK 2 DAY 15 -WEEK 3 DAY 22 -WEEK 4 DAY 29 -WEEK 5 DAY 36 -SCREENING -BASELINE -WEEK 1 DAY 8 -WEEK 2 DAY 15 -WEEK 3 DAY 22 -WEEK 4 DAY 29 -WEEK 5 DAY 36 -SCREENING -BASELINE -WEEK 1 DAY 8 -WEEK 2 DAY 15 -WEEK 3 DAY 22 -WEEK 4 DAY 29 -WEEK 5 DAY 36 -SCREENING -BASELINE -WEEK 1 DAY 8 -WEEK 2 DAY 15 -WEEK 3 DAY 22 -WEEK 4 DAY 29 -WEEK 5 DAY 36 -SCREENING -BASELINE -WEEK 1 DAY 8 -WEEK 2 DAY 15 -WEEK 3 DAY 22 -WEEK 4 DAY 29 -WEEK 5 DAY 36 -SCREENING -BASELINE -WEEK 1 DAY 8 -WEEK 2 DAY 15 -WEEK 3 DAY 22 -WEEK 4 DAY 29 -WEEK 5 DAY 36 -SCREENING -BASELINE -WEEK 1 DAY 8 -WEEK 2 DAY 15 -WEEK 3 DAY 22 -WEEK 4 DAY 29 -WEEK 5 DAY 36 -SCREENING -BASELINE -WEEK 1 DAY 8 -WEEK 2 DAY 15 -WEEK 3 DAY 22 -WEEK 4 DAY 29 -WEEK 5 DAY 36 -SCREENING -BASELINE -WEEK 1 DAY 8 -WEEK 2 DAY 15 -WEEK 3 DAY 22 -WEEK 4 DAY 29 -WEEK 5 DAY 36 -SCREENING -BASELINE -WEEK 1 DAY 8 -WEEK 2 DAY 15 -WEEK 3 DAY 22 -WEEK 4 DAY 29 -WEEK 5 DAY 36 -SCREENING -BASELINE -WEEK 1 DAY 8 -WEEK 2 DAY 15 -WEEK 3 DAY 22 -WEEK 4 DAY 29 -WEEK 5 DAY 36 -SCREENING -BASELINE -WEEK 1 DAY 8 -WEEK 2 DAY 15 -WEEK 3 DAY 22 -WEEK 4 DAY 29 -WEEK 5 DAY 36 -SCREENING -BASELINE -WEEK 1 DAY 8 -WEEK 2 DAY 15 -WEEK 3 DAY 22 -WEEK 4 DAY 29 -WEEK 5 DAY 36 - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - -SCREENING -BASELINE -WEEK 1 DAY 8 -WEEK 2 DAY 15 -WEEK 3 DAY 22 -WEEK 4 DAY 29 -WEEK 5 DAY 36 -SCREENING -BASELINE -WEEK 1 DAY 8 -WEEK 2 DAY 15 -WEEK 3 DAY 22 -WEEK 4 DAY 29 -WEEK 5 DAY 36 -SCREENING -BASELINE -WEEK 1 DAY 8 -WEEK 2 DAY 15 -WEEK 3 DAY 22 -WEEK 4 DAY 29 -WEEK 5 DAY 36 -SCREENING -BASELINE -WEEK 1 DAY 8 -WEEK 2 DAY 15 -WEEK 3 DAY 22 -WEEK 4 DAY 29 -WEEK 5 DAY 36 -SCREENING -BASELINE -WEEK 1 DAY 8 -WEEK 2 DAY 15 -WEEK 3 DAY 22 -WEEK 4 DAY 29 -WEEK 5 DAY 36 -SCREENING -BASELINE -WEEK 1 DAY 8 -WEEK 2 DAY 15 -WEEK 3 DAY 22 -WEEK 4 DAY 29 -WEEK 5 DAY 36 -SCREENING -BASELINE -WEEK 1 DAY 8 -WEEK 2 DAY 15 -WEEK 3 DAY 22 -WEEK 4 DAY 29 -WEEK 5 DAY 36 -SCREENING -BASELINE -WEEK 1 DAY 8 -WEEK 2 DAY 15 -WEEK 3 DAY 22 -WEEK 4 DAY 29 -WEEK 5 DAY 36 -SCREENING -BASELINE -WEEK 1 DAY 8 -WEEK 2 DAY 15 -WEEK 3 DAY 22 -WEEK 4 DAY 29 -WEEK 5 DAY 36 -SCREENING -BASELINE -WEEK 1 DAY 8 -WEEK 2 DAY 15 -WEEK 3 DAY 22 -WEEK 4 DAY 29 -WEEK 5 DAY 36 -SCREENING -BASELINE -WEEK 1 DAY 8 -WEEK 2 DAY 15 -WEEK 3 DAY 22 -WEEK 4 DAY 29 -WEEK 5 DAY 36 -SCREENING -BASELINE -WEEK 1 DAY 8 -WEEK 2 DAY 15 -WEEK 3 DAY 22 -WEEK 4 DAY 29 -WEEK 5 DAY 36 -SCREENING -BASELINE -WEEK 1 DAY 8 -WEEK 2 DAY 15 -WEEK 3 DAY 22 -WEEK 4 DAY 29 -WEEK 5 DAY 36 -SCREENING -BASELINE -WEEK 1 DAY 8 -WEEK 2 DAY 15 -WEEK 3 DAY 22 -WEEK 4 DAY 29 -WEEK 5 DAY 36 -SCREENING -BASELINE -WEEK 1 DAY 8 -WEEK 2 DAY 15 -WEEK 3 DAY 22 -WEEK 4 DAY 29 -WEEK 5 DAY 36 -SCREENING -BASELINE -WEEK 1 DAY 8 -WEEK 2 DAY 15 -WEEK 3 DAY 22 -WEEK 4 DAY 29 -WEEK 5 DAY 36 -SCREENING -BASELINE -WEEK 1 DAY 8 -WEEK 2 DAY 15 -WEEK 3 DAY 22 -WEEK 4 DAY 29 -WEEK 5 DAY 36 -SCREENING -BASELINE -WEEK 1 DAY 8 -WEEK 2 DAY 15 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-SCREENING -BASELINE -WEEK 1 DAY 8 -WEEK 2 DAY 15 -WEEK 3 DAY 22 -WEEK 4 DAY 29 -WEEK 5 DAY 36 -SCREENING -BASELINE -WEEK 1 DAY 8 -WEEK 2 DAY 15 -WEEK 3 DAY 22 -WEEK 4 DAY 29 -WEEK 5 DAY 36 -SCREENING -BASELINE -WEEK 1 DAY 8 -WEEK 2 DAY 15 -WEEK 3 DAY 22 -WEEK 4 DAY 29 -WEEK 5 DAY 36 -SCREENING -BASELINE -WEEK 1 DAY 8 -WEEK 2 DAY 15 -WEEK 3 DAY 22 -WEEK 4 DAY 29 -WEEK 5 DAY 36 -SCREENING -BASELINE -WEEK 1 DAY 8 -WEEK 2 DAY 15 -WEEK 3 DAY 22 -WEEK 4 DAY 29 -WEEK 5 DAY 36 -SCREENING -BASELINE -WEEK 1 DAY 8 -WEEK 2 DAY 15 -WEEK 3 DAY 22 -WEEK 4 DAY 29 -WEEK 5 DAY 36 -SCREENING -BASELINE -WEEK 1 DAY 8 -WEEK 2 DAY 15 -WEEK 3 DAY 22 -WEEK 4 DAY 29 -WEEK 5 DAY 36 -SCREENING -BASELINE -WEEK 1 DAY 8 -WEEK 2 DAY 15 -WEEK 3 DAY 22 -WEEK 4 DAY 29 -WEEK 5 DAY 36 -SCREENING -BASELINE -WEEK 1 DAY 8 -WEEK 2 DAY 15 -WEEK 3 DAY 22 -WEEK 4 DAY 29 -WEEK 5 DAY 36 -SCREENING -BASELINE -WEEK 1 DAY 8 -WEEK 2 DAY 15 -WEEK 3 DAY 22 -WEEK 4 DAY 29 -WEEK 5 DAY 36 -SCREENING -BASELINE -WEEK 1 DAY 8 -WEEK 2 DAY 15 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-SCREENING -BASELINE -WEEK 1 DAY 8 -WEEK 2 DAY 15 -WEEK 3 DAY 22 -WEEK 4 DAY 29 -WEEK 5 DAY 36 -SCREENING -BASELINE -WEEK 1 DAY 8 -WEEK 2 DAY 15 -WEEK 3 DAY 22 -WEEK 4 DAY 29 -WEEK 5 DAY 36 -SCREENING -BASELINE -WEEK 1 DAY 8 -WEEK 2 DAY 15 -WEEK 3 DAY 22 -WEEK 4 DAY 29 -WEEK 5 DAY 36 -SCREENING -BASELINE -WEEK 1 DAY 8 -WEEK 2 DAY 15 -WEEK 3 DAY 22 -WEEK 4 DAY 29 -WEEK 5 DAY 36 -SCREENING -BASELINE -WEEK 1 DAY 8 -WEEK 2 DAY 15 -WEEK 3 DAY 22 -WEEK 4 DAY 29 -WEEK 5 DAY 36 -SCREENING -BASELINE -WEEK 1 DAY 8 -WEEK 2 DAY 15 -WEEK 3 DAY 22 -WEEK 4 DAY 29 -WEEK 5 DAY 36 -SCREENING -BASELINE -WEEK 1 DAY 8 -WEEK 2 DAY 15 -WEEK 3 DAY 22 -WEEK 4 DAY 29 -WEEK 5 DAY 36 -SCREENING -BASELINE -WEEK 1 DAY 8 -WEEK 2 DAY 15 -WEEK 3 DAY 22 -WEEK 4 DAY 29 -WEEK 5 DAY 36 -SCREENING -BASELINE -WEEK 1 DAY 8 -WEEK 2 DAY 15 -WEEK 3 DAY 22 -WEEK 4 DAY 29 -WEEK 5 DAY 36 -SCREENING -BASELINE -WEEK 1 DAY 8 -WEEK 2 DAY 15 -WEEK 3 DAY 22 -WEEK 4 DAY 29 -WEEK 5 DAY 36 -SCREENING -BASELINE -WEEK 1 DAY 8 -WEEK 2 DAY 15 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-BASELINE -WEEK 1 DAY 8 -WEEK 2 DAY 15 -WEEK 3 DAY 22 -WEEK 4 DAY 29 -WEEK 5 DAY 36 -SCREENING -BASELINE -WEEK 1 DAY 8 -WEEK 2 DAY 15 -WEEK 3 DAY 22 -WEEK 4 DAY 29 -WEEK 5 DAY 36 -SCREENING -BASELINE -WEEK 1 DAY 8 -WEEK 2 DAY 15 -WEEK 3 DAY 22 -WEEK 4 DAY 29 -WEEK 5 DAY 36 -SCREENING -BASELINE -WEEK 1 DAY 8 -WEEK 2 DAY 15 -WEEK 3 DAY 22 -WEEK 4 DAY 29 -WEEK 5 DAY 36 -SCREENING -BASELINE -WEEK 1 DAY 8 -WEEK 2 DAY 15 -WEEK 3 DAY 22 -WEEK 4 DAY 29 -WEEK 5 DAY 36 -SCREENING -BASELINE -WEEK 1 DAY 8 -WEEK 2 DAY 15 -WEEK 3 DAY 22 -WEEK 4 DAY 29 -WEEK 5 DAY 36 -SCREENING -BASELINE -WEEK 1 DAY 8 -WEEK 2 DAY 15 -WEEK 3 DAY 22 -WEEK 4 DAY 29 -WEEK 5 DAY 36 -SCREENING -BASELINE -WEEK 1 DAY 8 -WEEK 2 DAY 15 -WEEK 3 DAY 22 -WEEK 4 DAY 29 -WEEK 5 DAY 36 -SCREENING -BASELINE -WEEK 1 DAY 8 -WEEK 2 DAY 15 -WEEK 3 DAY 22 -WEEK 4 DAY 29 -WEEK 5 DAY 36 -SCREENING -BASELINE -WEEK 1 DAY 8 -WEEK 2 DAY 15 -WEEK 3 DAY 22 -WEEK 4 DAY 29 -WEEK 5 DAY 36 -SCREENING -BASELINE -WEEK 1 DAY 8 -WEEK 2 DAY 15 -WEEK 3 DAY 22 -WEEK 4 DAY 29 -WEEK 5 DAY 36 -SCREENING -BASELINE -WEEK 1 DAY 8 -WEEK 2 DAY 15 -WEEK 3 DAY 22 -WEEK 4 DAY 29 -WEEK 5 DAY 36 -SCREENING -BASELINE -WEEK 1 DAY 8 -WEEK 2 DAY 15 -WEEK 3 DAY 22 -WEEK 4 DAY 29 -WEEK 5 DAY 36 -SCREENING -BASELINE -WEEK 1 DAY 8 -WEEK 2 DAY 15 -WEEK 3 DAY 22 -WEEK 4 DAY 29 -WEEK 5 DAY 36 -SCREENING -BASELINE -WEEK 1 DAY 8 -WEEK 2 DAY 15 -WEEK 3 DAY 22 -WEEK 4 DAY 29 -WEEK 5 DAY 36 -SCREENING -BASELINE -WEEK 1 DAY 8 -WEEK 2 DAY 15 -WEEK 3 DAY 22 -WEEK 4 DAY 29 -WEEK 5 DAY 36 -SCREENING -BASELINE -WEEK 1 DAY 8 -WEEK 2 DAY 15 -WEEK 3 DAY 22 -WEEK 4 DAY 29 -WEEK 5 DAY 36 -SCREENING -BASELINE -WEEK 1 DAY 8 -WEEK 2 DAY 15 -WEEK 3 DAY 22 -WEEK 4 DAY 29 -WEEK 5 DAY 36 -SCREENING -BASELINE -WEEK 1 DAY 8 -WEEK 2 DAY 15 -WEEK 3 DAY 22 -WEEK 4 DAY 29 -WEEK 5 DAY 36 -SCREENING -BASELINE -WEEK 1 DAY 8 -WEEK 2 DAY 15 -WEEK 3 DAY 22 -WEEK 4 DAY 29 -WEEK 5 DAY 36 -SCREENING -BASELINE -WEEK 1 DAY 8 -WEEK 2 DAY 15 -WEEK 3 DAY 22 -WEEK 4 DAY 29 -WEEK 5 DAY 36 -SCREENING -BASELINE -WEEK 1 DAY 8 -WEEK 2 DAY 15 -WEEK 3 DAY 22 -WEEK 4 DAY 29 -WEEK 5 DAY 36 -SCREENING -BASELINE -WEEK 1 DAY 8 -WEEK 2 DAY 15 -WEEK 3 DAY 22 -WEEK 4 DAY 29 -WEEK 5 DAY 36 -SCREENING -BASELINE -WEEK 1 DAY 8 -WEEK 2 DAY 15 -WEEK 3 DAY 22 -WEEK 4 DAY 29 -WEEK 5 DAY 36 -SCREENING -BASELINE -WEEK 1 DAY 8 -WEEK 2 DAY 15 -WEEK 3 DAY 22 -WEEK 4 DAY 29 -WEEK 5 DAY 36 -SCREENING -BASELINE -WEEK 1 DAY 8 -WEEK 2 DAY 15 -WEEK 3 DAY 22 -WEEK 4 DAY 29 -WEEK 5 DAY 36 -SCREENING -BASELINE -WEEK 1 DAY 8 -WEEK 2 DAY 15 -WEEK 3 DAY 22 -WEEK 4 DAY 29 -WEEK 5 DAY 36 -SCREENING -BASELINE -WEEK 1 DAY 8 -WEEK 2 DAY 15 -WEEK 3 DAY 22 -WEEK 4 DAY 29 -WEEK 5 DAY 36 -SCREENING -BASELINE -WEEK 1 DAY 8 -WEEK 2 DAY 15 -WEEK 3 DAY 22 -WEEK 4 DAY 29 -WEEK 5 DAY 36 -SCREENING -BASELINE -WEEK 1 DAY 8 -WEEK 2 DAY 15 -WEEK 3 DAY 22 -WEEK 4 DAY 29 -WEEK 5 DAY 36 -SCREENING -BASELINE -WEEK 1 DAY 8 -WEEK 2 DAY 15 -WEEK 3 DAY 22 -WEEK 4 DAY 29 -WEEK 5 DAY 36 -SCREENING -BASELINE -WEEK 1 DAY 8 -WEEK 2 DAY 15 -WEEK 3 DAY 22 -WEEK 4 DAY 29 -WEEK 5 DAY 36 -SCREENING -BASELINE -WEEK 1 DAY 8 -WEEK 2 DAY 15 -WEEK 3 DAY 22 -WEEK 4 DAY 29 -WEEK 5 DAY 36 -SCREENING -BASELINE -WEEK 1 DAY 8 -WEEK 2 DAY 15 -WEEK 3 DAY 22 -WEEK 4 DAY 29 -WEEK 5 DAY 36 -SCREENING -BASELINE -WEEK 1 DAY 8 -WEEK 2 DAY 15 -WEEK 3 DAY 22 -WEEK 4 DAY 29 -WEEK 5 DAY 36 -SCREENING -BASELINE -WEEK 1 DAY 8 -WEEK 2 DAY 15 -WEEK 3 DAY 22 -WEEK 4 DAY 29 -WEEK 5 DAY 36 -SCREENING -BASELINE -WEEK 1 DAY 8 -WEEK 2 DAY 15 -WEEK 3 DAY 22 -WEEK 4 DAY 29 -WEEK 5 DAY 36 -SCREENING -BASELINE -WEEK 1 DAY 8 -WEEK 2 DAY 15 -WEEK 3 DAY 22 -WEEK 4 DAY 29 -WEEK 5 DAY 36 -SCREENING -BASELINE -WEEK 1 DAY 8 -WEEK 2 DAY 15 -WEEK 3 DAY 22 -WEEK 4 DAY 29 -WEEK 5 DAY 36 -SCREENING -BASELINE -WEEK 1 DAY 8 -WEEK 2 DAY 15 -WEEK 3 DAY 22 -WEEK 4 DAY 29 -WEEK 5 DAY 36 -SCREENING -BASELINE -WEEK 1 DAY 8 -WEEK 2 DAY 15 -WEEK 3 DAY 22 -WEEK 4 DAY 29 -WEEK 5 DAY 36 -SCREENING -BASELINE -WEEK 1 DAY 8 -WEEK 2 DAY 15 -WEEK 3 DAY 22 -WEEK 4 DAY 29 -WEEK 5 DAY 36 -SCREENING -BASELINE -WEEK 1 DAY 8 -WEEK 2 DAY 15 -WEEK 3 DAY 22 -WEEK 4 DAY 29 -WEEK 5 DAY 36 -SCREENING -BASELINE -WEEK 1 DAY 8 -WEEK 2 DAY 15 -WEEK 3 DAY 22 -WEEK 4 DAY 29 -WEEK 5 DAY 36 -SCREENING -BASELINE -WEEK 1 DAY 8 -WEEK 2 DAY 15 -WEEK 3 DAY 22 -WEEK 4 DAY 29 -WEEK 5 DAY 36 -SCREENING -BASELINE -WEEK 1 DAY 8 -WEEK 2 DAY 15 -WEEK 3 DAY 22 -WEEK 4 DAY 29 -WEEK 5 DAY 36 -SCREENING -BASELINE -WEEK 1 DAY 8 -WEEK 2 DAY 15 -WEEK 3 DAY 22 -WEEK 4 DAY 29 -WEEK 5 DAY 36 -SCREENING -BASELINE -WEEK 1 DAY 8 -WEEK 2 DAY 15 -WEEK 3 DAY 22 -WEEK 4 DAY 29 -WEEK 5 DAY 36 -SCREENING -BASELINE -WEEK 1 DAY 8 -WEEK 2 DAY 15 -WEEK 3 DAY 22 -WEEK 4 DAY 29 -WEEK 5 DAY 36 -SCREENING -BASELINE -WEEK 1 DAY 8 -WEEK 2 DAY 15 -WEEK 3 DAY 22 -WEEK 4 DAY 29 -WEEK 5 DAY 36 -SCREENING -BASELINE -WEEK 1 DAY 8 -WEEK 2 DAY 15 -WEEK 3 DAY 22 -WEEK 4 DAY 29 -WEEK 5 DAY 36 -SCREENING -BASELINE -WEEK 1 DAY 8 -WEEK 2 DAY 15 -WEEK 3 DAY 22 -WEEK 4 DAY 29 -WEEK 5 DAY 36 -SCREENING -BASELINE -WEEK 1 DAY 8 -WEEK 2 DAY 15 -WEEK 3 DAY 22 -WEEK 4 DAY 29 -WEEK 5 DAY 36 -SCREENING -BASELINE -WEEK 1 DAY 8 -WEEK 2 DAY 15 -WEEK 3 DAY 22 -WEEK 4 DAY 29 -WEEK 5 DAY 36 -SCREENING -BASELINE -WEEK 1 DAY 8 -WEEK 2 DAY 15 -WEEK 3 DAY 22 -WEEK 4 DAY 29 -WEEK 5 DAY 36 -SCREENING -BASELINE -WEEK 1 DAY 8 -WEEK 2 DAY 15 -WEEK 3 DAY 22 -WEEK 4 DAY 29 -WEEK 5 DAY 36 -SCREENING -BASELINE -WEEK 1 DAY 8 -WEEK 2 DAY 15 -WEEK 3 DAY 22 -WEEK 4 DAY 29 -WEEK 5 DAY 36 -SCREENING -BASELINE -WEEK 1 DAY 8 -WEEK 2 DAY 15 -WEEK 3 DAY 22 -WEEK 4 DAY 29 -WEEK 5 DAY 36 -SCREENING -BASELINE -WEEK 1 DAY 8 -WEEK 2 DAY 15 -WEEK 3 DAY 22 -WEEK 4 DAY 29 -WEEK 5 DAY 36 -SCREENING -BASELINE -WEEK 1 DAY 8 -WEEK 2 DAY 15 -WEEK 3 DAY 22 -WEEK 4 DAY 29 -WEEK 5 DAY 36 -SCREENING -BASELINE -WEEK 1 DAY 8 -WEEK 2 DAY 15 -WEEK 3 DAY 22 -WEEK 4 DAY 29 -WEEK 5 DAY 36 -SCREENING -BASELINE -WEEK 1 DAY 8 -WEEK 2 DAY 15 -WEEK 3 DAY 22 -WEEK 4 DAY 29 -WEEK 5 DAY 36 -SCREENING -BASELINE -WEEK 1 DAY 8 -WEEK 2 DAY 15 -WEEK 3 DAY 22 -WEEK 4 DAY 29 -WEEK 5 DAY 36 -SCREENING -BASELINE -WEEK 1 DAY 8 -WEEK 2 DAY 15 -WEEK 3 DAY 22 -WEEK 4 DAY 29 -WEEK 5 DAY 36 -SCREENING -BASELINE -WEEK 1 DAY 8 -WEEK 2 DAY 15 -WEEK 3 DAY 22 -WEEK 4 DAY 29 -WEEK 5 DAY 36 -SCREENING -BASELINE -WEEK 1 DAY 8 -WEEK 2 DAY 15 -WEEK 3 DAY 22 -WEEK 4 DAY 29 -WEEK 5 DAY 36 -SCREENING -BASELINE -WEEK 1 DAY 8 -WEEK 2 DAY 15 -WEEK 3 DAY 22 -WEEK 4 DAY 29 -WEEK 5 DAY 36 -SCREENING -BASELINE -WEEK 1 DAY 8 -WEEK 2 DAY 15 -WEEK 3 DAY 22 -WEEK 4 DAY 29 -WEEK 5 DAY 36 -SCREENING -BASELINE -WEEK 1 DAY 8 -WEEK 2 DAY 15 -WEEK 3 DAY 22 -WEEK 4 DAY 29 -WEEK 5 DAY 36 -SCREENING -BASELINE -WEEK 1 DAY 8 -WEEK 2 DAY 15 -WEEK 3 DAY 22 -WEEK 4 DAY 29 -WEEK 5 DAY 36 -SCREENING -BASELINE -WEEK 1 DAY 8 -WEEK 2 DAY 15 -WEEK 3 DAY 22 -WEEK 4 DAY 29 -WEEK 5 DAY 36 -SCREENING -BASELINE -WEEK 1 DAY 8 -WEEK 2 DAY 15 -WEEK 3 DAY 22 -WEEK 4 DAY 29 -WEEK 5 DAY 36 -SCREENING -BASELINE -WEEK 1 DAY 8 -WEEK 2 DAY 15 -WEEK 3 DAY 22 -WEEK 4 DAY 29 -WEEK 5 DAY 36 -SCREENING -BASELINE -WEEK 1 DAY 8 -WEEK 2 DAY 15 -WEEK 3 DAY 22 -WEEK 4 DAY 29 -WEEK 5 DAY 36 -SCREENING -BASELINE -WEEK 1 DAY 8 -WEEK 2 DAY 15 -WEEK 3 DAY 22 -WEEK 4 DAY 29 -WEEK 5 DAY 36 -SCREENING -BASELINE -WEEK 1 DAY 8 -WEEK 2 DAY 15 -WEEK 3 DAY 22 -WEEK 4 DAY 29 -WEEK 5 DAY 36 -SCREENING -BASELINE -WEEK 1 DAY 8 -WEEK 2 DAY 15 -WEEK 3 DAY 22 -WEEK 4 DAY 29 -WEEK 5 DAY 36 -SCREENING -BASELINE -WEEK 1 DAY 8 -WEEK 2 DAY 15 -WEEK 3 DAY 22 -WEEK 4 DAY 29 -WEEK 5 DAY 36 -SCREENING -BASELINE -WEEK 1 DAY 8 -WEEK 2 DAY 15 -WEEK 3 DAY 22 -WEEK 4 DAY 29 -WEEK 5 DAY 36 -SCREENING -BASELINE -WEEK 1 DAY 8 -WEEK 2 DAY 15 -WEEK 3 DAY 22 -WEEK 4 DAY 29 -WEEK 5 DAY 36 -SCREENING -BASELINE -WEEK 1 DAY 8 -WEEK 2 DAY 15 -WEEK 3 DAY 22 -WEEK 4 DAY 29 -WEEK 5 DAY 36 -SCREENING -BASELINE -WEEK 1 DAY 8 -WEEK 2 DAY 15 -WEEK 3 DAY 22 -WEEK 4 DAY 29 -WEEK 5 DAY 36 -SCREENING -BASELINE -WEEK 1 DAY 8 -WEEK 2 DAY 15 -WEEK 3 DAY 22 -WEEK 4 DAY 29 -WEEK 5 DAY 36 -SCREENING -BASELINE -WEEK 1 DAY 8 -WEEK 2 DAY 15 -WEEK 3 DAY 22 -WEEK 4 DAY 29 -WEEK 5 DAY 36 -SCREENING -BASELINE -WEEK 1 DAY 8 -WEEK 2 DAY 15 -WEEK 3 DAY 22 -WEEK 4 DAY 29 -WEEK 5 DAY 36 -SCREENING -BASELINE -WEEK 1 DAY 8 -WEEK 2 DAY 15 -WEEK 3 DAY 22 -WEEK 4 DAY 29 -WEEK 5 DAY 36 -SCREENING -BASELINE -WEEK 1 DAY 8 -WEEK 2 DAY 15 -WEEK 3 DAY 22 -WEEK 4 DAY 29 -WEEK 5 DAY 36 -SCREENING -BASELINE -WEEK 1 DAY 8 -WEEK 2 DAY 15 -WEEK 3 DAY 22 -WEEK 4 DAY 29 -WEEK 5 DAY 36 -SCREENING -BASELINE -WEEK 1 DAY 8 -WEEK 2 DAY 15 -WEEK 3 DAY 22 -WEEK 4 DAY 29 -WEEK 5 DAY 36 -SCREENING -BASELINE -WEEK 1 DAY 8 -WEEK 2 DAY 15 -WEEK 3 DAY 22 -WEEK 4 DAY 29 -WEEK 5 DAY 36 -SCREENING -BASELINE -WEEK 1 DAY 8 -WEEK 2 DAY 15 -WEEK 3 DAY 22 -WEEK 4 DAY 29 -WEEK 5 DAY 36 -SCREENING -BASELINE -WEEK 1 DAY 8 -WEEK 2 DAY 15 -WEEK 3 DAY 22 -WEEK 4 DAY 29 -WEEK 5 DAY 36 -SCREENING -BASELINE -WEEK 1 DAY 8 -WEEK 2 DAY 15 -WEEK 3 DAY 22 -WEEK 4 DAY 29 -WEEK 5 DAY 36 -SCREENING -BASELINE -WEEK 1 DAY 8 -WEEK 2 DAY 15 -WEEK 3 DAY 22 -WEEK 4 DAY 29 -WEEK 5 DAY 36 -SCREENING -BASELINE -WEEK 1 DAY 8 -WEEK 2 DAY 15 -WEEK 3 DAY 22 -WEEK 4 DAY 29 -WEEK 5 DAY 36 -SCREENING -BASELINE -WEEK 1 DAY 8 -WEEK 2 DAY 15 -WEEK 3 DAY 22 -WEEK 4 DAY 29 -WEEK 5 DAY 36 -SCREENING -BASELINE -WEEK 1 DAY 8 -WEEK 2 DAY 15 -WEEK 3 DAY 22 -WEEK 4 DAY 29 -WEEK 5 DAY 36 -SCREENING -BASELINE -WEEK 1 DAY 8 -WEEK 2 DAY 15 -WEEK 3 DAY 22 -WEEK 4 DAY 29 -WEEK 5 DAY 36 -SCREENING -BASELINE -WEEK 1 DAY 8 -WEEK 2 DAY 15 -WEEK 3 DAY 22 -WEEK 4 DAY 29 -WEEK 5 DAY 36 -SCREENING -BASELINE -WEEK 1 DAY 8 -WEEK 2 DAY 15 -WEEK 3 DAY 22 -WEEK 4 DAY 29 -WEEK 5 DAY 36 -SCREENING -BASELINE -WEEK 1 DAY 8 -WEEK 2 DAY 15 -WEEK 3 DAY 22 -WEEK 4 DAY 29 -WEEK 5 DAY 36 -SCREENING -BASELINE -WEEK 1 DAY 8 -WEEK 2 DAY 15 -WEEK 3 DAY 22 -WEEK 4 DAY 29 -WEEK 5 DAY 36 -SCREENING -BASELINE -WEEK 1 DAY 8 -WEEK 2 DAY 15 -WEEK 3 DAY 22 -WEEK 4 DAY 29 -WEEK 5 DAY 36 -SCREENING -BASELINE -WEEK 1 DAY 8 -WEEK 2 DAY 15 -WEEK 3 DAY 22 -WEEK 4 DAY 29 -WEEK 5 DAY 36 -SCREENING -BASELINE -WEEK 1 DAY 8 -WEEK 2 DAY 15 -WEEK 3 DAY 22 -WEEK 4 DAY 29 -WEEK 5 DAY 36 -SCREENING -BASELINE -WEEK 1 DAY 8 -WEEK 2 DAY 15 -WEEK 3 DAY 22 -WEEK 4 DAY 29 -WEEK 5 DAY 36 -SCREENING -BASELINE -WEEK 1 DAY 8 -WEEK 2 DAY 15 -WEEK 3 DAY 22 -WEEK 4 DAY 29 -WEEK 5 DAY 36 -SCREENING -BASELINE -WEEK 1 DAY 8 -WEEK 2 DAY 15 -WEEK 3 DAY 22 -WEEK 4 DAY 29 -WEEK 5 DAY 36 -SCREENING -BASELINE -WEEK 1 DAY 8 -WEEK 2 DAY 15 -WEEK 3 DAY 22 -WEEK 4 DAY 29 -WEEK 5 DAY 36 -SCREENING -BASELINE -WEEK 1 DAY 8 -WEEK 2 DAY 15 -WEEK 3 DAY 22 -WEEK 4 DAY 29 -WEEK 5 DAY 36 -SCREENING -BASELINE -WEEK 1 DAY 8 -WEEK 2 DAY 15 -WEEK 3 DAY 22 -WEEK 4 DAY 29 -WEEK 5 DAY 36 -SCREENING -BASELINE -WEEK 1 DAY 8 -WEEK 2 DAY 15 -WEEK 3 DAY 22 -WEEK 4 DAY 29 -WEEK 5 DAY 36 -SCREENING -BASELINE -WEEK 1 DAY 8 -WEEK 2 DAY 15 -WEEK 3 DAY 22 -WEEK 4 DAY 29 -WEEK 5 DAY 36 -SCREENING -BASELINE -WEEK 1 DAY 8 -WEEK 2 DAY 15 -WEEK 3 DAY 22 -WEEK 4 DAY 29 -WEEK 5 DAY 36 -SCREENING -BASELINE -WEEK 1 DAY 8 -WEEK 2 DAY 15 -WEEK 3 DAY 22 -WEEK 4 DAY 29 -WEEK 5 DAY 36 - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - -SCREENING -BASELINE -WEEK 1 DAY 8 -WEEK 2 DAY 15 -WEEK 3 DAY 22 -WEEK 4 DAY 29 -WEEK 5 DAY 36 -SCREENING -BASELINE -WEEK 1 DAY 8 -WEEK 2 DAY 15 -WEEK 3 DAY 22 -WEEK 4 DAY 29 -WEEK 5 DAY 36 -SCREENING -BASELINE -WEEK 1 DAY 8 -WEEK 2 DAY 15 -WEEK 3 DAY 22 -WEEK 4 DAY 29 -WEEK 5 DAY 36 -SCREENING -BASELINE -WEEK 1 DAY 8 -WEEK 2 DAY 15 -WEEK 3 DAY 22 -WEEK 4 DAY 29 -WEEK 5 DAY 36 -SCREENING -BASELINE -WEEK 1 DAY 8 -WEEK 2 DAY 15 -WEEK 3 DAY 22 -WEEK 4 DAY 29 -WEEK 5 DAY 36 -SCREENING -BASELINE -WEEK 1 DAY 8 -WEEK 2 DAY 15 -WEEK 3 DAY 22 -WEEK 4 DAY 29 -WEEK 5 DAY 36 -SCREENING -BASELINE -WEEK 1 DAY 8 -WEEK 2 DAY 15 -WEEK 3 DAY 22 -WEEK 4 DAY 29 -WEEK 5 DAY 36 -SCREENING -BASELINE -WEEK 1 DAY 8 -WEEK 2 DAY 15 -WEEK 3 DAY 22 -WEEK 4 DAY 29 -WEEK 5 DAY 36 -SCREENING -BASELINE -WEEK 1 DAY 8 -WEEK 2 DAY 15 -WEEK 3 DAY 22 -WEEK 4 DAY 29 -WEEK 5 DAY 36 -SCREENING -BASELINE -WEEK 1 DAY 8 -WEEK 2 DAY 15 -WEEK 3 DAY 22 -WEEK 4 DAY 29 -WEEK 5 DAY 36 -SCREENING -BASELINE -WEEK 1 DAY 8 -WEEK 2 DAY 15 -WEEK 3 DAY 22 -WEEK 4 DAY 29 -WEEK 5 DAY 36 -SCREENING -BASELINE -WEEK 1 DAY 8 -WEEK 2 DAY 15 -WEEK 3 DAY 22 -WEEK 4 DAY 29 -WEEK 5 DAY 36 -SCREENING -BASELINE -WEEK 1 DAY 8 -WEEK 2 DAY 15 -WEEK 3 DAY 22 -WEEK 4 DAY 29 -WEEK 5 DAY 36 -SCREENING -BASELINE -WEEK 1 DAY 8 -WEEK 2 DAY 15 -WEEK 3 DAY 22 -WEEK 4 DAY 29 -WEEK 5 DAY 36 -SCREENING -BASELINE -WEEK 1 DAY 8 -WEEK 2 DAY 15 -WEEK 3 DAY 22 -WEEK 4 DAY 29 -WEEK 5 DAY 36 -SCREENING -BASELINE -WEEK 1 DAY 8 -WEEK 2 DAY 15 -WEEK 3 DAY 22 -WEEK 4 DAY 29 -WEEK 5 DAY 36 -SCREENING -BASELINE -WEEK 1 DAY 8 -WEEK 2 DAY 15 -WEEK 3 DAY 22 -WEEK 4 DAY 29 -WEEK 5 DAY 36 -SCREENING -BASELINE -WEEK 1 DAY 8 -WEEK 2 DAY 15 -WEEK 3 DAY 22 -WEEK 4 DAY 29 -WEEK 5 DAY 36 -SCREENING -BASELINE -WEEK 1 DAY 8 -WEEK 2 DAY 15 -WEEK 3 DAY 22 -WEEK 4 DAY 29 -WEEK 5 DAY 36 -SCREENING -BASELINE -WEEK 1 DAY 8 -WEEK 2 DAY 15 -WEEK 3 DAY 22 -WEEK 4 DAY 29 -WEEK 5 DAY 36 -SCREENING -BASELINE -WEEK 1 DAY 8 -WEEK 2 DAY 15 -WEEK 3 DAY 22 -WEEK 4 DAY 29 -WEEK 5 DAY 36 -SCREENING -BASELINE -WEEK 1 DAY 8 -WEEK 2 DAY 15 -WEEK 3 DAY 22 -WEEK 4 DAY 29 -WEEK 5 DAY 36 -SCREENING -BASELINE -WEEK 1 DAY 8 -WEEK 2 DAY 15 -WEEK 3 DAY 22 -WEEK 4 DAY 29 -WEEK 5 DAY 36 -SCREENING -BASELINE -WEEK 1 DAY 8 -WEEK 2 DAY 15 -WEEK 3 DAY 22 -WEEK 4 DAY 29 -WEEK 5 DAY 36 -SCREENING -BASELINE -WEEK 1 DAY 8 -WEEK 2 DAY 15 -WEEK 3 DAY 22 -WEEK 4 DAY 29 -WEEK 5 DAY 36 -SCREENING -BASELINE -WEEK 1 DAY 8 -WEEK 2 DAY 15 -WEEK 3 DAY 22 -WEEK 4 DAY 29 -WEEK 5 DAY 36 -SCREENING -BASELINE -WEEK 1 DAY 8 -WEEK 2 DAY 15 -WEEK 3 DAY 22 -WEEK 4 DAY 29 -WEEK 5 DAY 36 -SCREENING -BASELINE -WEEK 1 DAY 8 -WEEK 2 DAY 15 -WEEK 3 DAY 22 -WEEK 4 DAY 29 -WEEK 5 DAY 36 -SCREENING -BASELINE -WEEK 1 DAY 8 -WEEK 2 DAY 15 -WEEK 3 DAY 22 -WEEK 4 DAY 29 -WEEK 5 DAY 36 -SCREENING -BASELINE -WEEK 1 DAY 8 -WEEK 2 DAY 15 -WEEK 3 DAY 22 -WEEK 4 DAY 29 -WEEK 5 DAY 36 -SCREENING -BASELINE -WEEK 1 DAY 8 -WEEK 2 DAY 15 -WEEK 3 DAY 22 -WEEK 4 DAY 29 -WEEK 5 DAY 36 -SCREENING -BASELINE -WEEK 1 DAY 8 -WEEK 2 DAY 15 -WEEK 3 DAY 22 -WEEK 4 DAY 29 -WEEK 5 DAY 36 -SCREENING -BASELINE -WEEK 1 DAY 8 -WEEK 2 DAY 15 -WEEK 3 DAY 22 -WEEK 4 DAY 29 -WEEK 5 DAY 36 -SCREENING -BASELINE -WEEK 1 DAY 8 -WEEK 2 DAY 15 -WEEK 3 DAY 22 -WEEK 4 DAY 29 -WEEK 5 DAY 36 -SCREENING -BASELINE -WEEK 1 DAY 8 -WEEK 2 DAY 15 -WEEK 3 DAY 22 -WEEK 4 DAY 29 -WEEK 5 DAY 36 -SCREENING -BASELINE -WEEK 1 DAY 8 -WEEK 2 DAY 15 -WEEK 3 DAY 22 -WEEK 4 DAY 29 -WEEK 5 DAY 36 -SCREENING -BASELINE -WEEK 1 DAY 8 -WEEK 2 DAY 15 -WEEK 3 DAY 22 -WEEK 4 DAY 29 -WEEK 5 DAY 36 -SCREENING -BASELINE -WEEK 1 DAY 8 -WEEK 2 DAY 15 -WEEK 3 DAY 22 -WEEK 4 DAY 29 -WEEK 5 DAY 36 -SCREENING -BASELINE -WEEK 1 DAY 8 -WEEK 2 DAY 15 -WEEK 3 DAY 22 -WEEK 4 DAY 29 -WEEK 5 DAY 36 -SCREENING -BASELINE -WEEK 1 DAY 8 -WEEK 2 DAY 15 -WEEK 3 DAY 22 -WEEK 4 DAY 29 -WEEK 5 DAY 36 -SCREENING -BASELINE -WEEK 1 DAY 8 -WEEK 2 DAY 15 -WEEK 3 DAY 22 -WEEK 4 DAY 29 -WEEK 5 DAY 36 -SCREENING -BASELINE -WEEK 1 DAY 8 -WEEK 2 DAY 15 -WEEK 3 DAY 22 -WEEK 4 DAY 29 -WEEK 5 DAY 36 -SCREENING -BASELINE -WEEK 1 DAY 8 -WEEK 2 DAY 15 -WEEK 3 DAY 22 -WEEK 4 DAY 29 -WEEK 5 DAY 36 -SCREENING -BASELINE -WEEK 1 DAY 8 -WEEK 2 DAY 15 -WEEK 3 DAY 22 -WEEK 4 DAY 29 -WEEK 5 DAY 36 -SCREENING -BASELINE -WEEK 1 DAY 8 -WEEK 2 DAY 15 -WEEK 3 DAY 22 -WEEK 4 DAY 29 -WEEK 5 DAY 36 -SCREENING -BASELINE -WEEK 1 DAY 8 -WEEK 2 DAY 15 -WEEK 3 DAY 22 -WEEK 4 DAY 29 -WEEK 5 DAY 36 -SCREENING -BASELINE -WEEK 1 DAY 8 -WEEK 2 DAY 15 -WEEK 3 DAY 22 -WEEK 4 DAY 29 -WEEK 5 DAY 36 -SCREENING -BASELINE -WEEK 1 DAY 8 -WEEK 2 DAY 15 -WEEK 3 DAY 22 -WEEK 4 DAY 29 -WEEK 5 DAY 36 -SCREENING -BASELINE -WEEK 1 DAY 8 -WEEK 2 DAY 15 -WEEK 3 DAY 22 -WEEK 4 DAY 29 -WEEK 5 DAY 36 -SCREENING -BASELINE -WEEK 1 DAY 8 -WEEK 2 DAY 15 -WEEK 3 DAY 22 -WEEK 4 DAY 29 -WEEK 5 DAY 36 -SCREENING -BASELINE -WEEK 1 DAY 8 -WEEK 2 DAY 15 -WEEK 3 DAY 22 -WEEK 4 DAY 29 -WEEK 5 DAY 36 -SCREENING -BASELINE -WEEK 1 DAY 8 -WEEK 2 DAY 15 -WEEK 3 DAY 22 -WEEK 4 DAY 29 -WEEK 5 DAY 36 -SCREENING -BASELINE -WEEK 1 DAY 8 -WEEK 2 DAY 15 -WEEK 3 DAY 22 -WEEK 4 DAY 29 -WEEK 5 DAY 36 -SCREENING -BASELINE -WEEK 1 DAY 8 -WEEK 2 DAY 15 -WEEK 3 DAY 22 -WEEK 4 DAY 29 -WEEK 5 DAY 36 -SCREENING -BASELINE -WEEK 1 DAY 8 -WEEK 2 DAY 15 -WEEK 3 DAY 22 -WEEK 4 DAY 29 -WEEK 5 DAY 36 -SCREENING -BASELINE -WEEK 1 DAY 8 -WEEK 2 DAY 15 -WEEK 3 DAY 22 -WEEK 4 DAY 29 -WEEK 5 DAY 36 -SCREENING -BASELINE -WEEK 1 DAY 8 -WEEK 2 DAY 15 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-SCREENING -BASELINE -WEEK 1 DAY 8 -WEEK 2 DAY 15 -WEEK 3 DAY 22 -WEEK 4 DAY 29 -WEEK 5 DAY 36 -SCREENING -BASELINE -WEEK 1 DAY 8 -WEEK 2 DAY 15 -WEEK 3 DAY 22 -WEEK 4 DAY 29 -WEEK 5 DAY 36 -SCREENING -BASELINE -WEEK 1 DAY 8 -WEEK 2 DAY 15 -WEEK 3 DAY 22 -WEEK 4 DAY 29 -WEEK 5 DAY 36 -SCREENING -BASELINE -WEEK 1 DAY 8 -WEEK 2 DAY 15 -WEEK 3 DAY 22 -WEEK 4 DAY 29 -WEEK 5 DAY 36 -SCREENING -BASELINE -WEEK 1 DAY 8 -WEEK 2 DAY 15 -WEEK 3 DAY 22 -WEEK 4 DAY 29 -WEEK 5 DAY 36 -SCREENING -BASELINE -WEEK 1 DAY 8 -WEEK 2 DAY 15 -WEEK 3 DAY 22 -WEEK 4 DAY 29 -WEEK 5 DAY 36 -SCREENING -BASELINE -WEEK 1 DAY 8 -WEEK 2 DAY 15 -WEEK 3 DAY 22 -WEEK 4 DAY 29 -WEEK 5 DAY 36 -SCREENING -BASELINE -WEEK 1 DAY 8 -WEEK 2 DAY 15 -WEEK 3 DAY 22 -WEEK 4 DAY 29 -WEEK 5 DAY 36 -SCREENING -BASELINE -WEEK 1 DAY 8 -WEEK 2 DAY 15 -WEEK 3 DAY 22 -WEEK 4 DAY 29 -WEEK 5 DAY 36 -SCREENING -BASELINE -WEEK 1 DAY 8 -WEEK 2 DAY 15 -WEEK 3 DAY 22 -WEEK 4 DAY 29 -WEEK 5 DAY 36 -SCREENING -BASELINE -WEEK 1 DAY 8 -WEEK 2 DAY 15 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-SCREENING -BASELINE -WEEK 1 DAY 8 -WEEK 2 DAY 15 -WEEK 3 DAY 22 -WEEK 4 DAY 29 -WEEK 5 DAY 36 -SCREENING -BASELINE -WEEK 1 DAY 8 -WEEK 2 DAY 15 -WEEK 3 DAY 22 -WEEK 4 DAY 29 -WEEK 5 DAY 36 -SCREENING -BASELINE -WEEK 1 DAY 8 -WEEK 2 DAY 15 -WEEK 3 DAY 22 -WEEK 4 DAY 29 -WEEK 5 DAY 36 -SCREENING -BASELINE -WEEK 1 DAY 8 -WEEK 2 DAY 15 -WEEK 3 DAY 22 -WEEK 4 DAY 29 -WEEK 5 DAY 36 -SCREENING -BASELINE -WEEK 1 DAY 8 -WEEK 2 DAY 15 -WEEK 3 DAY 22 -WEEK 4 DAY 29 -WEEK 5 DAY 36 -SCREENING -BASELINE -WEEK 1 DAY 8 -WEEK 2 DAY 15 -WEEK 3 DAY 22 -WEEK 4 DAY 29 -WEEK 5 DAY 36 -SCREENING -BASELINE -WEEK 1 DAY 8 -WEEK 2 DAY 15 -WEEK 3 DAY 22 -WEEK 4 DAY 29 -WEEK 5 DAY 36 -SCREENING -BASELINE -WEEK 1 DAY 8 -WEEK 2 DAY 15 -WEEK 3 DAY 22 -WEEK 4 DAY 29 -WEEK 5 DAY 36 -SCREENING -BASELINE -WEEK 1 DAY 8 -WEEK 2 DAY 15 -WEEK 3 DAY 22 -WEEK 4 DAY 29 -WEEK 5 DAY 36 -SCREENING -BASELINE -WEEK 1 DAY 8 -WEEK 2 DAY 15 -WEEK 3 DAY 22 -WEEK 4 DAY 29 -WEEK 5 DAY 36 -SCREENING -BASELINE -WEEK 1 DAY 8 -WEEK 2 DAY 15 -WEEK 3 DAY 22 -WEEK 4 DAY 29 -WEEK 5 DAY 36 -SCREENING -BASELINE -WEEK 1 DAY 8 -WEEK 2 DAY 15 -WEEK 3 DAY 22 -WEEK 4 DAY 29 -WEEK 5 DAY 36 -SCREENING -BASELINE -WEEK 1 DAY 8 -WEEK 2 DAY 15 -WEEK 3 DAY 22 -WEEK 4 DAY 29 -WEEK 5 DAY 36 -SCREENING -BASELINE -WEEK 1 DAY 8 -WEEK 2 DAY 15 -WEEK 3 DAY 22 -WEEK 4 DAY 29 -WEEK 5 DAY 36 -SCREENING -BASELINE -WEEK 1 DAY 8 -WEEK 2 DAY 15 -WEEK 3 DAY 22 -WEEK 4 DAY 29 -WEEK 5 DAY 36 -SCREENING -BASELINE -WEEK 1 DAY 8 -WEEK 2 DAY 15 -WEEK 3 DAY 22 -WEEK 4 DAY 29 -WEEK 5 DAY 36 -SCREENING -BASELINE -WEEK 1 DAY 8 -WEEK 2 DAY 15 -WEEK 3 DAY 22 -WEEK 4 DAY 29 -WEEK 5 DAY 36 -SCREENING -BASELINE -WEEK 1 DAY 8 -WEEK 2 DAY 15 -WEEK 3 DAY 22 -WEEK 4 DAY 29 -WEEK 5 DAY 36 -SCREENING -BASELINE -WEEK 1 DAY 8 -WEEK 2 DAY 15 -WEEK 3 DAY 22 -WEEK 4 DAY 29 -WEEK 5 DAY 36 -SCREENING -BASELINE -WEEK 1 DAY 8 -WEEK 2 DAY 15 -WEEK 3 DAY 22 -WEEK 4 DAY 29 -WEEK 5 DAY 36 -SCREENING -BASELINE -WEEK 1 DAY 8 -WEEK 2 DAY 15 -WEEK 3 DAY 22 -WEEK 4 DAY 29 -WEEK 5 DAY 36 -SCREENING -BASELINE -WEEK 1 DAY 8 -WEEK 2 DAY 15 -WEEK 3 DAY 22 -WEEK 4 DAY 29 -WEEK 5 DAY 36 -SCREENING -BASELINE -WEEK 1 DAY 8 -WEEK 2 DAY 15 -WEEK 3 DAY 22 -WEEK 4 DAY 29 -WEEK 5 DAY 36 -SCREENING -BASELINE -WEEK 1 DAY 8 -WEEK 2 DAY 15 -WEEK 3 DAY 22 -WEEK 4 DAY 29 -WEEK 5 DAY 36 -SCREENING -BASELINE -WEEK 1 DAY 8 -WEEK 2 DAY 15 -WEEK 3 DAY 22 -WEEK 4 DAY 29 -WEEK 5 DAY 36 -SCREENING -BASELINE -WEEK 1 DAY 8 -WEEK 2 DAY 15 -WEEK 3 DAY 22 -WEEK 4 DAY 29 -WEEK 5 DAY 36 -SCREENING -BASELINE -WEEK 1 DAY 8 -WEEK 2 DAY 15 -WEEK 3 DAY 22 -WEEK 4 DAY 29 -WEEK 5 DAY 36 -SCREENING -BASELINE -WEEK 1 DAY 8 -WEEK 2 DAY 15 -WEEK 3 DAY 22 -WEEK 4 DAY 29 -WEEK 5 DAY 36 -SCREENING -BASELINE -WEEK 1 DAY 8 -WEEK 2 DAY 15 -WEEK 3 DAY 22 -WEEK 4 DAY 29 -WEEK 5 DAY 36 -SCREENING -BASELINE -WEEK 1 DAY 8 -WEEK 2 DAY 15 -WEEK 3 DAY 22 -WEEK 4 DAY 29 -WEEK 5 DAY 36 -SCREENING -BASELINE -WEEK 1 DAY 8 -WEEK 2 DAY 15 -WEEK 3 DAY 22 -WEEK 4 DAY 29 -WEEK 5 DAY 36 -SCREENING -BASELINE -WEEK 1 DAY 8 -WEEK 2 DAY 15 -WEEK 3 DAY 22 -WEEK 4 DAY 29 -WEEK 5 DAY 36 - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - 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-WEEK 4 DAY 29 -WEEK 5 DAY 36 -SCREENING -BASELINE -WEEK 1 DAY 8 -WEEK 2 DAY 15 -WEEK 3 DAY 22 -WEEK 4 DAY 29 -WEEK 5 DAY 36 -SCREENING -BASELINE -WEEK 1 DAY 8 -WEEK 2 DAY 15 -WEEK 3 DAY 22 -WEEK 4 DAY 29 -WEEK 5 DAY 36 -SCREENING -BASELINE -WEEK 1 DAY 8 -WEEK 2 DAY 15 -WEEK 3 DAY 22 -WEEK 4 DAY 29 -WEEK 5 DAY 36 -SCREENING -BASELINE -WEEK 1 DAY 8 -WEEK 2 DAY 15 -WEEK 3 DAY 22 -WEEK 4 DAY 29 -WEEK 5 DAY 36 -SCREENING -BASELINE -WEEK 1 DAY 8 -WEEK 2 DAY 15 -WEEK 3 DAY 22 -WEEK 4 DAY 29 -WEEK 5 DAY 36 -SCREENING -BASELINE -WEEK 1 DAY 8 -WEEK 2 DAY 15 -WEEK 3 DAY 22 -WEEK 4 DAY 29 -WEEK 5 DAY 36 -SCREENING -BASELINE -WEEK 1 DAY 8 -WEEK 2 DAY 15 -WEEK 3 DAY 22 -WEEK 4 DAY 29 -WEEK 5 DAY 36 -SCREENING -BASELINE -WEEK 1 DAY 8 -WEEK 2 DAY 15 -WEEK 3 DAY 22 -WEEK 4 DAY 29 -WEEK 5 DAY 36 -SCREENING -BASELINE -WEEK 1 DAY 8 -WEEK 2 DAY 15 -WEEK 3 DAY 22 -WEEK 4 DAY 29 -WEEK 5 DAY 36 -SCREENING -BASELINE -WEEK 1 DAY 8 -WEEK 2 DAY 15 -WEEK 3 DAY 22 -WEEK 4 DAY 29 -WEEK 5 DAY 36 -SCREENING -BASELINE -WEEK 1 DAY 8 -WEEK 2 DAY 15 -WEEK 3 DAY 22 -WEEK 4 DAY 29 -WEEK 5 DAY 36 -SCREENING -BASELINE -WEEK 1 DAY 8 -WEEK 2 DAY 15 -WEEK 3 DAY 22 -WEEK 4 DAY 29 -WEEK 5 DAY 36 -SCREENING -BASELINE -WEEK 1 DAY 8 -WEEK 2 DAY 15 -WEEK 3 DAY 22 -WEEK 4 DAY 29 -WEEK 5 DAY 36 -SCREENING -BASELINE -WEEK 1 DAY 8 -WEEK 2 DAY 15 -WEEK 3 DAY 22 -WEEK 4 DAY 29 -WEEK 5 DAY 36 -SCREENING -BASELINE -WEEK 1 DAY 8 -WEEK 2 DAY 15 -WEEK 3 DAY 22 -WEEK 4 DAY 29 -WEEK 5 DAY 36 -SCREENING -BASELINE -WEEK 1 DAY 8 -WEEK 2 DAY 15 -WEEK 3 DAY 22 -WEEK 4 DAY 29 -WEEK 5 DAY 36 -SCREENING -BASELINE -WEEK 1 DAY 8 -WEEK 2 DAY 15 -WEEK 3 DAY 22 -WEEK 4 DAY 29 -WEEK 5 DAY 36 -SCREENING -BASELINE -WEEK 1 DAY 8 -WEEK 2 DAY 15 -WEEK 3 DAY 22 -WEEK 4 DAY 29 -WEEK 5 DAY 36 -SCREENING -BASELINE -WEEK 1 DAY 8 -WEEK 2 DAY 15 -WEEK 3 DAY 22 -WEEK 4 DAY 29 -WEEK 5 DAY 36 -SCREENING -BASELINE -WEEK 1 DAY 8 -WEEK 2 DAY 15 -WEEK 3 DAY 22 -WEEK 4 DAY 29 -WEEK 5 DAY 36 -SCREENING -BASELINE -WEEK 1 DAY 8 -WEEK 2 DAY 15 -WEEK 3 DAY 22 -WEEK 4 DAY 29 -WEEK 5 DAY 36 -SCREENING -BASELINE -WEEK 1 DAY 8 -WEEK 2 DAY 15 -WEEK 3 DAY 22 -WEEK 4 DAY 29 -WEEK 5 DAY 36 -SCREENING -BASELINE -WEEK 1 DAY 8 -WEEK 2 DAY 15 -WEEK 3 DAY 22 -WEEK 4 DAY 29 -WEEK 5 DAY 36 -SCREENING -BASELINE -WEEK 1 DAY 8 -WEEK 2 DAY 15 -WEEK 3 DAY 22 -WEEK 4 DAY 29 -WEEK 5 DAY 36 -SCREENING -BASELINE -WEEK 1 DAY 8 -WEEK 2 DAY 15 -WEEK 3 DAY 22 -WEEK 4 DAY 29 -WEEK 5 DAY 36 -SCREENING -BASELINE -WEEK 1 DAY 8 -WEEK 2 DAY 15 -WEEK 3 DAY 22 -WEEK 4 DAY 29 -WEEK 5 DAY 36 -SCREENING -BASELINE -WEEK 1 DAY 8 -WEEK 2 DAY 15 -WEEK 3 DAY 22 -WEEK 4 DAY 29 -WEEK 5 DAY 36 -SCREENING -BASELINE -WEEK 1 DAY 8 -WEEK 2 DAY 15 -WEEK 3 DAY 22 -WEEK 4 DAY 29 -WEEK 5 DAY 36 -SCREENING -BASELINE -WEEK 1 DAY 8 -WEEK 2 DAY 15 -WEEK 3 DAY 22 -WEEK 4 DAY 29 -WEEK 5 DAY 36 -SCREENING -BASELINE -WEEK 1 DAY 8 -WEEK 2 DAY 15 -WEEK 3 DAY 22 -WEEK 4 DAY 29 -WEEK 5 DAY 36 -SCREENING -BASELINE -WEEK 1 DAY 8 -WEEK 2 DAY 15 -WEEK 3 DAY 22 -WEEK 4 DAY 29 -WEEK 5 DAY 36 -SCREENING -BASELINE -WEEK 1 DAY 8 -WEEK 2 DAY 15 -WEEK 3 DAY 22 -WEEK 4 DAY 29 -WEEK 5 DAY 36 -SCREENING -BASELINE -WEEK 1 DAY 8 -WEEK 2 DAY 15 -WEEK 3 DAY 22 -WEEK 4 DAY 29 -WEEK 5 DAY 36 -SCREENING -BASELINE -WEEK 1 DAY 8 -WEEK 2 DAY 15 -WEEK 3 DAY 22 -WEEK 4 DAY 29 -WEEK 5 DAY 36 -SCREENING -BASELINE -WEEK 1 DAY 8 -WEEK 2 DAY 15 -WEEK 3 DAY 22 -WEEK 4 DAY 29 -WEEK 5 DAY 36 -SCREENING -BASELINE -WEEK 1 DAY 8 -WEEK 2 DAY 15 -WEEK 3 DAY 22 -WEEK 4 DAY 29 -WEEK 5 DAY 36 -SCREENING -BASELINE -WEEK 1 DAY 8 -WEEK 2 DAY 15 -WEEK 3 DAY 22 -WEEK 4 DAY 29 -WEEK 5 DAY 36 -SCREENING -BASELINE -WEEK 1 DAY 8 -WEEK 2 DAY 15 -WEEK 3 DAY 22 -WEEK 4 DAY 29 -WEEK 5 DAY 36 -SCREENING -BASELINE -WEEK 1 DAY 8 -WEEK 2 DAY 15 -WEEK 3 DAY 22 -WEEK 4 DAY 29 -WEEK 5 DAY 36 -SCREENING -BASELINE -WEEK 1 DAY 8 -WEEK 2 DAY 15 -WEEK 3 DAY 22 -WEEK 4 DAY 29 -WEEK 5 DAY 36 -SCREENING -BASELINE -WEEK 1 DAY 8 -WEEK 2 DAY 15 -WEEK 3 DAY 22 -WEEK 4 DAY 29 -WEEK 5 DAY 36 -SCREENING -BASELINE -WEEK 1 DAY 8 -WEEK 2 DAY 15 -WEEK 3 DAY 22 -WEEK 4 DAY 29 -WEEK 5 DAY 36 -SCREENING -BASELINE -WEEK 1 DAY 8 -WEEK 2 DAY 15 -WEEK 3 DAY 22 -WEEK 4 DAY 29 -WEEK 5 DAY 36 -SCREENING -BASELINE -WEEK 1 DAY 8 -WEEK 2 DAY 15 -WEEK 3 DAY 22 -WEEK 4 DAY 29 -WEEK 5 DAY 36 -SCREENING -BASELINE -WEEK 1 DAY 8 -WEEK 2 DAY 15 -WEEK 3 DAY 22 -WEEK 4 DAY 29 -WEEK 5 DAY 36 -SCREENING -BASELINE -WEEK 1 DAY 8 -WEEK 2 DAY 15 -WEEK 3 DAY 22 -WEEK 4 DAY 29 -WEEK 5 DAY 36 -SCREENING -BASELINE -WEEK 1 DAY 8 -WEEK 2 DAY 15 -WEEK 3 DAY 22 -WEEK 4 DAY 29 -WEEK 5 DAY 36 -SCREENING -BASELINE -WEEK 1 DAY 8 -WEEK 2 DAY 15 -WEEK 3 DAY 22 -WEEK 4 DAY 29 -WEEK 5 DAY 36 -SCREENING -BASELINE -WEEK 1 DAY 8 -WEEK 2 DAY 15 -WEEK 3 DAY 22 -WEEK 4 DAY 29 -WEEK 5 DAY 36 -SCREENING -BASELINE -WEEK 1 DAY 8 -WEEK 2 DAY 15 -WEEK 3 DAY 22 -WEEK 4 DAY 29 -WEEK 5 DAY 36 -SCREENING -BASELINE -WEEK 1 DAY 8 -WEEK 2 DAY 15 -WEEK 3 DAY 22 -WEEK 4 DAY 29 -WEEK 5 DAY 36 -SCREENING -BASELINE -WEEK 1 DAY 8 -WEEK 2 DAY 15 -WEEK 3 DAY 22 -WEEK 4 DAY 29 -WEEK 5 DAY 36 -SCREENING -BASELINE -WEEK 1 DAY 8 -WEEK 2 DAY 15 -WEEK 3 DAY 22 -WEEK 4 DAY 29 -WEEK 5 DAY 36 -SCREENING -BASELINE -WEEK 1 DAY 8 -WEEK 2 DAY 15 -WEEK 3 DAY 22 -WEEK 4 DAY 29 -WEEK 5 DAY 36 -SCREENING -BASELINE -WEEK 1 DAY 8 -WEEK 2 DAY 15 -WEEK 3 DAY 22 -WEEK 4 DAY 29 -WEEK 5 DAY 36 -SCREENING -BASELINE -WEEK 1 DAY 8 -WEEK 2 DAY 15 -WEEK 3 DAY 22 -WEEK 4 DAY 29 -WEEK 5 DAY 36 -SCREENING -BASELINE -WEEK 1 DAY 8 -WEEK 2 DAY 15 -WEEK 3 DAY 22 -WEEK 4 DAY 29 -WEEK 5 DAY 36 -SCREENING -BASELINE -WEEK 1 DAY 8 -WEEK 2 DAY 15 -WEEK 3 DAY 22 -WEEK 4 DAY 29 -WEEK 5 DAY 36 -SCREENING -BASELINE -WEEK 1 DAY 8 -WEEK 2 DAY 15 -WEEK 3 DAY 22 -WEEK 4 DAY 29 -WEEK 5 DAY 36 -SCREENING -BASELINE -WEEK 1 DAY 8 -WEEK 2 DAY 15 -WEEK 3 DAY 22 -WEEK 4 DAY 29 -WEEK 5 DAY 36 -SCREENING -BASELINE -WEEK 1 DAY 8 -WEEK 2 DAY 15 -WEEK 3 DAY 22 -WEEK 4 DAY 29 -WEEK 5 DAY 36 -SCREENING -BASELINE -WEEK 1 DAY 8 -WEEK 2 DAY 15 -WEEK 3 DAY 22 -WEEK 4 DAY 29 -WEEK 5 DAY 36 -SCREENING -BASELINE -WEEK 1 DAY 8 -WEEK 2 DAY 15 -WEEK 3 DAY 22 -WEEK 4 DAY 29 -WEEK 5 DAY 36 -SCREENING -BASELINE -WEEK 1 DAY 8 -WEEK 2 DAY 15 -WEEK 3 DAY 22 -WEEK 4 DAY 29 -WEEK 5 DAY 36 -SCREENING -BASELINE -WEEK 1 DAY 8 -WEEK 2 DAY 15 -WEEK 3 DAY 22 -WEEK 4 DAY 29 -WEEK 5 DAY 36 -SCREENING -BASELINE -WEEK 1 DAY 8 -WEEK 2 DAY 15 -WEEK 3 DAY 22 -WEEK 4 DAY 29 -WEEK 5 DAY 36 -SCREENING -BASELINE -WEEK 1 DAY 8 -WEEK 2 DAY 15 -WEEK 3 DAY 22 -WEEK 4 DAY 29 -WEEK 5 DAY 36 -SCREENING -BASELINE -WEEK 1 DAY 8 -WEEK 2 DAY 15 -WEEK 3 DAY 22 -WEEK 4 DAY 29 -WEEK 5 DAY 36 -SCREENING -BASELINE -WEEK 1 DAY 8 -WEEK 2 DAY 15 -WEEK 3 DAY 22 -WEEK 4 DAY 29 -WEEK 5 DAY 36 -SCREENING -BASELINE -WEEK 1 DAY 8 -WEEK 2 DAY 15 -WEEK 3 DAY 22 -WEEK 4 DAY 29 -WEEK 5 DAY 36 -SCREENING -BASELINE -WEEK 1 DAY 8 -WEEK 2 DAY 15 -WEEK 3 DAY 22 -WEEK 4 DAY 29 -WEEK 5 DAY 36 -SCREENING -BASELINE -WEEK 1 DAY 8 -WEEK 2 DAY 15 -WEEK 3 DAY 22 -WEEK 4 DAY 29 -WEEK 5 DAY 36 -SCREENING -BASELINE -WEEK 1 DAY 8 -WEEK 2 DAY 15 -WEEK 3 DAY 22 -WEEK 4 DAY 29 -WEEK 5 DAY 36 -SCREENING -BASELINE -WEEK 1 DAY 8 -WEEK 2 DAY 15 -WEEK 3 DAY 22 -WEEK 4 DAY 29 -WEEK 5 DAY 36 -SCREENING -BASELINE -WEEK 1 DAY 8 -WEEK 2 DAY 15 -WEEK 3 DAY 22 -WEEK 4 DAY 29 -WEEK 5 DAY 36 -SCREENING -BASELINE -WEEK 1 DAY 8 -WEEK 2 DAY 15 -WEEK 3 DAY 22 -WEEK 4 DAY 29 -WEEK 5 DAY 36 -SCREENING -BASELINE -WEEK 1 DAY 8 -WEEK 2 DAY 15 -WEEK 3 DAY 22 -WEEK 4 DAY 29 -WEEK 5 DAY 36 -SCREENING -BASELINE -WEEK 1 DAY 8 -WEEK 2 DAY 15 -WEEK 3 DAY 22 -WEEK 4 DAY 29 -WEEK 5 DAY 36 -SCREENING -BASELINE -WEEK 1 DAY 8 -WEEK 2 DAY 15 -WEEK 3 DAY 22 -WEEK 4 DAY 29 -WEEK 5 DAY 36 -SCREENING -BASELINE -WEEK 1 DAY 8 -WEEK 2 DAY 15 -WEEK 3 DAY 22 -WEEK 4 DAY 29 -WEEK 5 DAY 36 -SCREENING -BASELINE -WEEK 1 DAY 8 -WEEK 2 DAY 15 -WEEK 3 DAY 22 -WEEK 4 DAY 29 -WEEK 5 DAY 36 -SCREENING -BASELINE -WEEK 1 DAY 8 -WEEK 2 DAY 15 -WEEK 3 DAY 22 -WEEK 4 DAY 29 -WEEK 5 DAY 36 -SCREENING -BASELINE -WEEK 1 DAY 8 -WEEK 2 DAY 15 -WEEK 3 DAY 22 -WEEK 4 DAY 29 -WEEK 5 DAY 36 -SCREENING -BASELINE -WEEK 1 DAY 8 -WEEK 2 DAY 15 -WEEK 3 DAY 22 -WEEK 4 DAY 29 -WEEK 5 DAY 36 -SCREENING -BASELINE -WEEK 1 DAY 8 -WEEK 2 DAY 15 -WEEK 3 DAY 22 -WEEK 4 DAY 29 -WEEK 5 DAY 36 -SCREENING -BASELINE -WEEK 1 DAY 8 -WEEK 2 DAY 15 -WEEK 3 DAY 22 -WEEK 4 DAY 29 -WEEK 5 DAY 36 -SCREENING -BASELINE -WEEK 1 DAY 8 -WEEK 2 DAY 15 -WEEK 3 DAY 22 -WEEK 4 DAY 29 -WEEK 5 DAY 36 -SCREENING -BASELINE -WEEK 1 DAY 8 -WEEK 2 DAY 15 -WEEK 3 DAY 22 -WEEK 4 DAY 29 -WEEK 5 DAY 36 -SCREENING -BASELINE -WEEK 1 DAY 8 -WEEK 2 DAY 15 -WEEK 3 DAY 22 -WEEK 4 DAY 29 -WEEK 5 DAY 36 -SCREENING -BASELINE -WEEK 1 DAY 8 -WEEK 2 DAY 15 -WEEK 3 DAY 22 -WEEK 4 DAY 29 -WEEK 5 DAY 36 -SCREENING -BASELINE -WEEK 1 DAY 8 -WEEK 2 DAY 15 -WEEK 3 DAY 22 -WEEK 4 DAY 29 -WEEK 5 DAY 36 -SCREENING -BASELINE -WEEK 1 DAY 8 -WEEK 2 DAY 15 -WEEK 3 DAY 22 -WEEK 4 DAY 29 -WEEK 5 DAY 36 -SCREENING -BASELINE -WEEK 1 DAY 8 -WEEK 2 DAY 15 -WEEK 3 DAY 22 -WEEK 4 DAY 29 -WEEK 5 DAY 36 -SCREENING -BASELINE -WEEK 1 DAY 8 -WEEK 2 DAY 15 -WEEK 3 DAY 22 -WEEK 4 DAY 29 -WEEK 5 DAY 36 -SCREENING -BASELINE -WEEK 1 DAY 8 -WEEK 2 DAY 15 -WEEK 3 DAY 22 -WEEK 4 DAY 29 -WEEK 5 DAY 36 -SCREENING -BASELINE -WEEK 1 DAY 8 -WEEK 2 DAY 15 -WEEK 3 DAY 22 -WEEK 4 DAY 29 -WEEK 5 DAY 36 -SCREENING -BASELINE -WEEK 1 DAY 8 -WEEK 2 DAY 15 -WEEK 3 DAY 22 -WEEK 4 DAY 29 -WEEK 5 DAY 36 -SCREENING -BASELINE -WEEK 1 DAY 8 -WEEK 2 DAY 15 -WEEK 3 DAY 22 -WEEK 4 DAY 29 -WEEK 5 DAY 36 -SCREENING -BASELINE -WEEK 1 DAY 8 -WEEK 2 DAY 15 -WEEK 3 DAY 22 -WEEK 4 DAY 29 -WEEK 5 DAY 36 -SCREENING -BASELINE -WEEK 1 DAY 8 -WEEK 2 DAY 15 -WEEK 3 DAY 22 -WEEK 4 DAY 29 -WEEK 5 DAY 36 -SCREENING -BASELINE -WEEK 1 DAY 8 -WEEK 2 DAY 15 -WEEK 3 DAY 22 -WEEK 4 DAY 29 -WEEK 5 DAY 36 -SCREENING -BASELINE -WEEK 1 DAY 8 -WEEK 2 DAY 15 -WEEK 3 DAY 22 -WEEK 4 DAY 29 -WEEK 5 DAY 36 -SCREENING -BASELINE -WEEK 1 DAY 8 -WEEK 2 DAY 15 -WEEK 3 DAY 22 -WEEK 4 DAY 29 -WEEK 5 DAY 36 -SCREENING -BASELINE -WEEK 1 DAY 8 -WEEK 2 DAY 15 -WEEK 3 DAY 22 -WEEK 4 DAY 29 -WEEK 5 DAY 36 -SCREENING -BASELINE -WEEK 1 DAY 8 -WEEK 2 DAY 15 -WEEK 3 DAY 22 -WEEK 4 DAY 29 -WEEK 5 DAY 36 -SCREENING -BASELINE -WEEK 1 DAY 8 -WEEK 2 DAY 15 -WEEK 3 DAY 22 -WEEK 4 DAY 29 -WEEK 5 DAY 36 -SCREENING -BASELINE -WEEK 1 DAY 8 -WEEK 2 DAY 15 -WEEK 3 DAY 22 -WEEK 4 DAY 29 -WEEK 5 DAY 36 -SCREENING -BASELINE -WEEK 1 DAY 8 -WEEK 2 DAY 15 -WEEK 3 DAY 22 -WEEK 4 DAY 29 -WEEK 5 DAY 36 -SCREENING -BASELINE -WEEK 1 DAY 8 -WEEK 2 DAY 15 -WEEK 3 DAY 22 -WEEK 4 DAY 29 -WEEK 5 DAY 36 -SCREENING -BASELINE -WEEK 1 DAY 8 -WEEK 2 DAY 15 -WEEK 3 DAY 22 -WEEK 4 DAY 29 -WEEK 5 DAY 36 -SCREENING -BASELINE -WEEK 1 DAY 8 -WEEK 2 DAY 15 -WEEK 3 DAY 22 -WEEK 4 DAY 29 -WEEK 5 DAY 36 - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - 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- - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - -SCREENING -BASELINE -WEEK 1 DAY 8 -WEEK 2 DAY 15 -WEEK 3 DAY 22 -WEEK 4 DAY 29 -WEEK 5 DAY 36 -SCREENING -BASELINE -WEEK 1 DAY 8 -WEEK 2 DAY 15 -WEEK 3 DAY 22 -WEEK 4 DAY 29 -WEEK 5 DAY 36 -SCREENING -BASELINE -WEEK 1 DAY 8 -WEEK 2 DAY 15 -WEEK 3 DAY 22 -WEEK 4 DAY 29 -WEEK 5 DAY 36 -SCREENING -BASELINE -WEEK 1 DAY 8 -WEEK 2 DAY 15 -WEEK 3 DAY 22 -WEEK 4 DAY 29 -WEEK 5 DAY 36 -SCREENING -BASELINE -WEEK 1 DAY 8 -WEEK 2 DAY 15 -WEEK 3 DAY 22 -WEEK 4 DAY 29 -WEEK 5 DAY 36 -SCREENING -BASELINE -WEEK 1 DAY 8 -WEEK 2 DAY 15 -WEEK 3 DAY 22 -WEEK 4 DAY 29 -WEEK 5 DAY 36 -SCREENING -BASELINE -WEEK 1 DAY 8 -WEEK 2 DAY 15 -WEEK 3 DAY 22 -WEEK 4 DAY 29 -WEEK 5 DAY 36 -SCREENING -BASELINE -WEEK 1 DAY 8 -WEEK 2 DAY 15 -WEEK 3 DAY 22 -WEEK 4 DAY 29 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5 DAY 36 -SCREENING -BASELINE -WEEK 1 DAY 8 -WEEK 2 DAY 15 -WEEK 3 DAY 22 -WEEK 4 DAY 29 -WEEK 5 DAY 36 -SCREENING -BASELINE -WEEK 1 DAY 8 -WEEK 2 DAY 15 -WEEK 3 DAY 22 -WEEK 4 DAY 29 -WEEK 5 DAY 36 -SCREENING -BASELINE -WEEK 1 DAY 8 -WEEK 2 DAY 15 -WEEK 3 DAY 22 -WEEK 4 DAY 29 -WEEK 5 DAY 36 -SCREENING -BASELINE -WEEK 1 DAY 8 -WEEK 2 DAY 15 -WEEK 3 DAY 22 -WEEK 4 DAY 29 -WEEK 5 DAY 36 -SCREENING -BASELINE -WEEK 1 DAY 8 -WEEK 2 DAY 15 -WEEK 3 DAY 22 -WEEK 4 DAY 29 -WEEK 5 DAY 36 -SCREENING -BASELINE -WEEK 1 DAY 8 -WEEK 2 DAY 15 -WEEK 3 DAY 22 -WEEK 4 DAY 29 -WEEK 5 DAY 36 -SCREENING -BASELINE -WEEK 1 DAY 8 -WEEK 2 DAY 15 -WEEK 3 DAY 22 -WEEK 4 DAY 29 -WEEK 5 DAY 36 -SCREENING -BASELINE -WEEK 1 DAY 8 -WEEK 2 DAY 15 -WEEK 3 DAY 22 -WEEK 4 DAY 29 -WEEK 5 DAY 36 -SCREENING -BASELINE -WEEK 1 DAY 8 -WEEK 2 DAY 15 -WEEK 3 DAY 22 -WEEK 4 DAY 29 -WEEK 5 DAY 36 -SCREENING -BASELINE -WEEK 1 DAY 8 -WEEK 2 DAY 15 -WEEK 3 DAY 22 -WEEK 4 DAY 29 -WEEK 5 DAY 36 -SCREENING -BASELINE -WEEK 1 DAY 8 -WEEK 2 DAY 15 -WEEK 3 DAY 22 -WEEK 4 DAY 29 -WEEK 5 DAY 36 -SCREENING -BASELINE -WEEK 1 DAY 8 -WEEK 2 DAY 15 -WEEK 3 DAY 22 -WEEK 4 DAY 29 -WEEK 5 DAY 36 -SCREENING -BASELINE -WEEK 1 DAY 8 -WEEK 2 DAY 15 -WEEK 3 DAY 22 -WEEK 4 DAY 29 -WEEK 5 DAY 36 -SCREENING -BASELINE -WEEK 1 DAY 8 -WEEK 2 DAY 15 -WEEK 3 DAY 22 -WEEK 4 DAY 29 -WEEK 5 DAY 36 -SCREENING -BASELINE -WEEK 1 DAY 8 -WEEK 2 DAY 15 -WEEK 3 DAY 22 -WEEK 4 DAY 29 -WEEK 5 DAY 36 -SCREENING -BASELINE -WEEK 1 DAY 8 -WEEK 2 DAY 15 -WEEK 3 DAY 22 -WEEK 4 DAY 29 -WEEK 5 DAY 36 -SCREENING -BASELINE -WEEK 1 DAY 8 -WEEK 2 DAY 15 -WEEK 3 DAY 22 -WEEK 4 DAY 29 -WEEK 5 DAY 36 -SCREENING -BASELINE -WEEK 1 DAY 8 -WEEK 2 DAY 15 -WEEK 3 DAY 22 -WEEK 4 DAY 29 -WEEK 5 DAY 36 -SCREENING -BASELINE -WEEK 1 DAY 8 -WEEK 2 DAY 15 -WEEK 3 DAY 22 -WEEK 4 DAY 29 -WEEK 5 DAY 36 -SCREENING -BASELINE -WEEK 1 DAY 8 -WEEK 2 DAY 15 -WEEK 3 DAY 22 -WEEK 4 DAY 29 -WEEK 5 DAY 36 -SCREENING -BASELINE -WEEK 1 DAY 8 -WEEK 2 DAY 15 -WEEK 3 DAY 22 -WEEK 4 DAY 29 -WEEK 5 DAY 36 -SCREENING -BASELINE -WEEK 1 DAY 8 -WEEK 2 DAY 15 -WEEK 3 DAY 22 -WEEK 4 DAY 29 -WEEK 5 DAY 36 -SCREENING -BASELINE -WEEK 1 DAY 8 -WEEK 2 DAY 15 -WEEK 3 DAY 22 -WEEK 4 DAY 29 -WEEK 5 DAY 36 -SCREENING -BASELINE -WEEK 1 DAY 8 -WEEK 2 DAY 15 -WEEK 3 DAY 22 -WEEK 4 DAY 29 -WEEK 5 DAY 36 -SCREENING -BASELINE -WEEK 1 DAY 8 -WEEK 2 DAY 15 -WEEK 3 DAY 22 -WEEK 4 DAY 29 -WEEK 5 DAY 36 -SCREENING -BASELINE -WEEK 1 DAY 8 -WEEK 2 DAY 15 -WEEK 3 DAY 22 -WEEK 4 DAY 29 -WEEK 5 DAY 36 -SCREENING -BASELINE -WEEK 1 DAY 8 -WEEK 2 DAY 15 -WEEK 3 DAY 22 -WEEK 4 DAY 29 -WEEK 5 DAY 36 -SCREENING -BASELINE -WEEK 1 DAY 8 -WEEK 2 DAY 15 -WEEK 3 DAY 22 -WEEK 4 DAY 29 -WEEK 5 DAY 36 -SCREENING -BASELINE -WEEK 1 DAY 8 -WEEK 2 DAY 15 -WEEK 3 DAY 22 -WEEK 4 DAY 29 -WEEK 5 DAY 36 -SCREENING -BASELINE -WEEK 1 DAY 8 -WEEK 2 DAY 15 -WEEK 3 DAY 22 -WEEK 4 DAY 29 -WEEK 5 DAY 36 -SCREENING -BASELINE -WEEK 1 DAY 8 -WEEK 2 DAY 15 -WEEK 3 DAY 22 -WEEK 4 DAY 29 -WEEK 5 DAY 36 -SCREENING -BASELINE -WEEK 1 DAY 8 -WEEK 2 DAY 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-SCREENING -BASELINE -WEEK 1 DAY 8 -WEEK 2 DAY 15 -WEEK 3 DAY 22 -WEEK 4 DAY 29 -WEEK 5 DAY 36 -SCREENING -BASELINE -WEEK 1 DAY 8 -WEEK 2 DAY 15 -WEEK 3 DAY 22 -WEEK 4 DAY 29 -WEEK 5 DAY 36 -SCREENING -BASELINE -WEEK 1 DAY 8 -WEEK 2 DAY 15 -WEEK 3 DAY 22 -WEEK 4 DAY 29 -WEEK 5 DAY 36 -SCREENING -BASELINE -WEEK 1 DAY 8 -WEEK 2 DAY 15 -WEEK 3 DAY 22 -WEEK 4 DAY 29 -WEEK 5 DAY 36 -SCREENING -BASELINE -WEEK 1 DAY 8 -WEEK 2 DAY 15 -WEEK 3 DAY 22 -WEEK 4 DAY 29 -WEEK 5 DAY 36 -SCREENING -BASELINE -WEEK 1 DAY 8 -WEEK 2 DAY 15 -WEEK 3 DAY 22 -WEEK 4 DAY 29 -WEEK 5 DAY 36 -SCREENING -BASELINE -WEEK 1 DAY 8 -WEEK 2 DAY 15 -WEEK 3 DAY 22 -WEEK 4 DAY 29 -WEEK 5 DAY 36 -SCREENING -BASELINE -WEEK 1 DAY 8 -WEEK 2 DAY 15 -WEEK 3 DAY 22 -WEEK 4 DAY 29 -WEEK 5 DAY 36 -SCREENING -BASELINE -WEEK 1 DAY 8 -WEEK 2 DAY 15 -WEEK 3 DAY 22 -WEEK 4 DAY 29 -WEEK 5 DAY 36 -SCREENING -BASELINE -WEEK 1 DAY 8 -WEEK 2 DAY 15 -WEEK 3 DAY 22 -WEEK 4 DAY 29 -WEEK 5 DAY 36 -SCREENING -BASELINE -WEEK 1 DAY 8 -WEEK 2 DAY 15 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- - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - -SCREENING -BASELINE -WEEK 1 DAY 8 -WEEK 2 DAY 15 -WEEK 3 DAY 22 -WEEK 4 DAY 29 -WEEK 5 DAY 36 -SCREENING -BASELINE -WEEK 1 DAY 8 -WEEK 2 DAY 15 -WEEK 3 DAY 22 -WEEK 4 DAY 29 -WEEK 5 DAY 36 -SCREENING -BASELINE -WEEK 1 DAY 8 -WEEK 2 DAY 15 -WEEK 3 DAY 22 -WEEK 4 DAY 29 -WEEK 5 DAY 36 -SCREENING -BASELINE -WEEK 1 DAY 8 -WEEK 2 DAY 15 -WEEK 3 DAY 22 -WEEK 4 DAY 29 -WEEK 5 DAY 36 -SCREENING -BASELINE -WEEK 1 DAY 8 -WEEK 2 DAY 15 -WEEK 3 DAY 22 -WEEK 4 DAY 29 -WEEK 5 DAY 36 -SCREENING -BASELINE -WEEK 1 DAY 8 -WEEK 2 DAY 15 -WEEK 3 DAY 22 -WEEK 4 DAY 29 -WEEK 5 DAY 36 -SCREENING -BASELINE -WEEK 1 DAY 8 -WEEK 2 DAY 15 -WEEK 3 DAY 22 -WEEK 4 DAY 29 -WEEK 5 DAY 36 -SCREENING -BASELINE -WEEK 1 DAY 8 -WEEK 2 DAY 15 -WEEK 3 DAY 22 -WEEK 4 DAY 29 -WEEK 5 DAY 36 -SCREENING -BASELINE -WEEK 1 DAY 8 -WEEK 2 DAY 15 -WEEK 3 DAY 22 -WEEK 4 DAY 29 -WEEK 5 DAY 36 -SCREENING -BASELINE -WEEK 1 DAY 8 -WEEK 2 DAY 15 -WEEK 3 DAY 22 -WEEK 4 DAY 29 -WEEK 5 DAY 36 -SCREENING -BASELINE -WEEK 1 DAY 8 -WEEK 2 DAY 15 -WEEK 3 DAY 22 -WEEK 4 DAY 29 -WEEK 5 DAY 36 -SCREENING -BASELINE -WEEK 1 DAY 8 -WEEK 2 DAY 15 -WEEK 3 DAY 22 -WEEK 4 DAY 29 -WEEK 5 DAY 36 -SCREENING -BASELINE -WEEK 1 DAY 8 -WEEK 2 DAY 15 -WEEK 3 DAY 22 -WEEK 4 DAY 29 -WEEK 5 DAY 36 -SCREENING -BASELINE -WEEK 1 DAY 8 -WEEK 2 DAY 15 -WEEK 3 DAY 22 -WEEK 4 DAY 29 -WEEK 5 DAY 36 -SCREENING -BASELINE -WEEK 1 DAY 8 -WEEK 2 DAY 15 -WEEK 3 DAY 22 -WEEK 4 DAY 29 -WEEK 5 DAY 36 -SCREENING -BASELINE -WEEK 1 DAY 8 -WEEK 2 DAY 15 -WEEK 3 DAY 22 -WEEK 4 DAY 29 -WEEK 5 DAY 36 -SCREENING -BASELINE -WEEK 1 DAY 8 -WEEK 2 DAY 15 -WEEK 3 DAY 22 -WEEK 4 DAY 29 -WEEK 5 DAY 36 -SCREENING -BASELINE -WEEK 1 DAY 8 -WEEK 2 DAY 15 -WEEK 3 DAY 22 -WEEK 4 DAY 29 -WEEK 5 DAY 36 -SCREENING -BASELINE -WEEK 1 DAY 8 -WEEK 2 DAY 15 -WEEK 3 DAY 22 -WEEK 4 DAY 29 -WEEK 5 DAY 36 -SCREENING -BASELINE -WEEK 1 DAY 8 -WEEK 2 DAY 15 -WEEK 3 DAY 22 -WEEK 4 DAY 29 -WEEK 5 DAY 36 -SCREENING -BASELINE -WEEK 1 DAY 8 -WEEK 2 DAY 15 -WEEK 3 DAY 22 -WEEK 4 DAY 29 -WEEK 5 DAY 36 -SCREENING -BASELINE -WEEK 1 DAY 8 -WEEK 2 DAY 15 -WEEK 3 DAY 22 -WEEK 4 DAY 29 -WEEK 5 DAY 36 -SCREENING -BASELINE -WEEK 1 DAY 8 -WEEK 2 DAY 15 -WEEK 3 DAY 22 -WEEK 4 DAY 29 -WEEK 5 DAY 36 -SCREENING -BASELINE -WEEK 1 DAY 8 -WEEK 2 DAY 15 -WEEK 3 DAY 22 -WEEK 4 DAY 29 -WEEK 5 DAY 36 -SCREENING -BASELINE -WEEK 1 DAY 8 -WEEK 2 DAY 15 -WEEK 3 DAY 22 -WEEK 4 DAY 29 -WEEK 5 DAY 36 -SCREENING -BASELINE -WEEK 1 DAY 8 -WEEK 2 DAY 15 -WEEK 3 DAY 22 -WEEK 4 DAY 29 -WEEK 5 DAY 36 -SCREENING -BASELINE -WEEK 1 DAY 8 -WEEK 2 DAY 15 -WEEK 3 DAY 22 -WEEK 4 DAY 29 -WEEK 5 DAY 36 -SCREENING -BASELINE -WEEK 1 DAY 8 -WEEK 2 DAY 15 -WEEK 3 DAY 22 -WEEK 4 DAY 29 -WEEK 5 DAY 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DAY 29 -WEEK 5 DAY 36 -SCREENING -BASELINE -WEEK 1 DAY 8 -WEEK 2 DAY 15 -WEEK 3 DAY 22 -WEEK 4 DAY 29 -WEEK 5 DAY 36 -SCREENING -BASELINE -WEEK 1 DAY 8 -WEEK 2 DAY 15 -WEEK 3 DAY 22 -WEEK 4 DAY 29 -WEEK 5 DAY 36 -SCREENING -BASELINE -WEEK 1 DAY 8 -WEEK 2 DAY 15 -WEEK 3 DAY 22 -WEEK 4 DAY 29 -WEEK 5 DAY 36 -SCREENING -BASELINE -WEEK 1 DAY 8 -WEEK 2 DAY 15 -WEEK 3 DAY 22 -WEEK 4 DAY 29 -WEEK 5 DAY 36 -SCREENING -BASELINE -WEEK 1 DAY 8 -WEEK 2 DAY 15 -WEEK 3 DAY 22 -WEEK 4 DAY 29 -WEEK 5 DAY 36 -SCREENING -BASELINE -WEEK 1 DAY 8 -WEEK 2 DAY 15 -WEEK 3 DAY 22 -WEEK 4 DAY 29 -WEEK 5 DAY 36 -SCREENING -BASELINE -WEEK 1 DAY 8 -WEEK 2 DAY 15 -WEEK 3 DAY 22 -WEEK 4 DAY 29 -WEEK 5 DAY 36 -SCREENING -BASELINE -WEEK 1 DAY 8 -WEEK 2 DAY 15 -WEEK 3 DAY 22 -WEEK 4 DAY 29 -WEEK 5 DAY 36 -SCREENING -BASELINE -WEEK 1 DAY 8 -WEEK 2 DAY 15 -WEEK 3 DAY 22 -WEEK 4 DAY 29 -WEEK 5 DAY 36 -SCREENING -BASELINE -WEEK 1 DAY 8 -WEEK 2 DAY 15 -WEEK 3 DAY 22 -WEEK 4 DAY 29 -WEEK 5 DAY 36 -SCREENING -BASELINE -WEEK 1 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5 DAY 36 -SCREENING -BASELINE -WEEK 1 DAY 8 -WEEK 2 DAY 15 -WEEK 3 DAY 22 -WEEK 4 DAY 29 -WEEK 5 DAY 36 -SCREENING -BASELINE -WEEK 1 DAY 8 -WEEK 2 DAY 15 -WEEK 3 DAY 22 -WEEK 4 DAY 29 -WEEK 5 DAY 36 -SCREENING -BASELINE -WEEK 1 DAY 8 -WEEK 2 DAY 15 -WEEK 3 DAY 22 -WEEK 4 DAY 29 -WEEK 5 DAY 36 -SCREENING -BASELINE -WEEK 1 DAY 8 -WEEK 2 DAY 15 -WEEK 3 DAY 22 -WEEK 4 DAY 29 -WEEK 5 DAY 36 -SCREENING -BASELINE -WEEK 1 DAY 8 -WEEK 2 DAY 15 -WEEK 3 DAY 22 -WEEK 4 DAY 29 -WEEK 5 DAY 36 -SCREENING -BASELINE -WEEK 1 DAY 8 -WEEK 2 DAY 15 -WEEK 3 DAY 22 -WEEK 4 DAY 29 -WEEK 5 DAY 36 -SCREENING -BASELINE -WEEK 1 DAY 8 -WEEK 2 DAY 15 -WEEK 3 DAY 22 -WEEK 4 DAY 29 -WEEK 5 DAY 36 -SCREENING -BASELINE -WEEK 1 DAY 8 -WEEK 2 DAY 15 -WEEK 3 DAY 22 -WEEK 4 DAY 29 -WEEK 5 DAY 36 -SCREENING -BASELINE -WEEK 1 DAY 8 -WEEK 2 DAY 15 -WEEK 3 DAY 22 -WEEK 4 DAY 29 -WEEK 5 DAY 36 -SCREENING -BASELINE -WEEK 1 DAY 8 -WEEK 2 DAY 15 -WEEK 3 DAY 22 -WEEK 4 DAY 29 -WEEK 5 DAY 36 -SCREENING -BASELINE -WEEK 1 DAY 8 -WEEK 2 DAY 15 -WEEK 3 DAY 22 -WEEK 4 DAY 29 -WEEK 5 DAY 36 -SCREENING -BASELINE -WEEK 1 DAY 8 -WEEK 2 DAY 15 -WEEK 3 DAY 22 -WEEK 4 DAY 29 -WEEK 5 DAY 36 -SCREENING -BASELINE -WEEK 1 DAY 8 -WEEK 2 DAY 15 -WEEK 3 DAY 22 -WEEK 4 DAY 29 -WEEK 5 DAY 36 -SCREENING -BASELINE -WEEK 1 DAY 8 -WEEK 2 DAY 15 -WEEK 3 DAY 22 -WEEK 4 DAY 29 -WEEK 5 DAY 36 -SCREENING -BASELINE -WEEK 1 DAY 8 -WEEK 2 DAY 15 -WEEK 3 DAY 22 -WEEK 4 DAY 29 -WEEK 5 DAY 36 -SCREENING -BASELINE -WEEK 1 DAY 8 -WEEK 2 DAY 15 -WEEK 3 DAY 22 -WEEK 4 DAY 29 -WEEK 5 DAY 36 -SCREENING -BASELINE -WEEK 1 DAY 8 -WEEK 2 DAY 15 -WEEK 3 DAY 22 -WEEK 4 DAY 29 -WEEK 5 DAY 36 -SCREENING -BASELINE -WEEK 1 DAY 8 -WEEK 2 DAY 15 -WEEK 3 DAY 22 -WEEK 4 DAY 29 -WEEK 5 DAY 36 -SCREENING -BASELINE -WEEK 1 DAY 8 -WEEK 2 DAY 15 -WEEK 3 DAY 22 -WEEK 4 DAY 29 -WEEK 5 DAY 36 -SCREENING -BASELINE -WEEK 1 DAY 8 -WEEK 2 DAY 15 -WEEK 3 DAY 22 -WEEK 4 DAY 29 -WEEK 5 DAY 36 -SCREENING -BASELINE -WEEK 1 DAY 8 -WEEK 2 DAY 15 -WEEK 3 DAY 22 -WEEK 4 DAY 29 -WEEK 5 DAY 36 -SCREENING -BASELINE -WEEK 1 DAY 8 -WEEK 2 DAY 15 -WEEK 3 DAY 22 -WEEK 4 DAY 29 -WEEK 5 DAY 36 -SCREENING -BASELINE -WEEK 1 DAY 8 -WEEK 2 DAY 15 -WEEK 3 DAY 22 -WEEK 4 DAY 29 -WEEK 5 DAY 36 -SCREENING -BASELINE -WEEK 1 DAY 8 -WEEK 2 DAY 15 -WEEK 3 DAY 22 -WEEK 4 DAY 29 -WEEK 5 DAY 36 -SCREENING -BASELINE -WEEK 1 DAY 8 -WEEK 2 DAY 15 -WEEK 3 DAY 22 -WEEK 4 DAY 29 -WEEK 5 DAY 36 -SCREENING -BASELINE -WEEK 1 DAY 8 -WEEK 2 DAY 15 -WEEK 3 DAY 22 -WEEK 4 DAY 29 -WEEK 5 DAY 36 -SCREENING -BASELINE -WEEK 1 DAY 8 -WEEK 2 DAY 15 -WEEK 3 DAY 22 -WEEK 4 DAY 29 -WEEK 5 DAY 36 -SCREENING -BASELINE -WEEK 1 DAY 8 -WEEK 2 DAY 15 -WEEK 3 DAY 22 -WEEK 4 DAY 29 -WEEK 5 DAY 36 -SCREENING -BASELINE -WEEK 1 DAY 8 -WEEK 2 DAY 15 -WEEK 3 DAY 22 -WEEK 4 DAY 29 -WEEK 5 DAY 36 -SCREENING -BASELINE -WEEK 1 DAY 8 -WEEK 2 DAY 15 -WEEK 3 DAY 22 -WEEK 4 DAY 29 -WEEK 5 DAY 36 -SCREENING -BASELINE -WEEK 1 DAY 8 -WEEK 2 DAY 15 -WEEK 3 DAY 22 -WEEK 4 DAY 29 -WEEK 5 DAY 36 -SCREENING -BASELINE -WEEK 1 DAY 8 -WEEK 2 DAY 15 -WEEK 3 DAY 22 -WEEK 4 DAY 29 -WEEK 5 DAY 36 -SCREENING -BASELINE -WEEK 1 DAY 8 -WEEK 2 DAY 15 -WEEK 3 DAY 22 -WEEK 4 DAY 29 -WEEK 5 DAY 36 -SCREENING -BASELINE -WEEK 1 DAY 8 -WEEK 2 DAY 15 -WEEK 3 DAY 22 -WEEK 4 DAY 29 -WEEK 5 DAY 36 -SCREENING -BASELINE -WEEK 1 DAY 8 -WEEK 2 DAY 15 -WEEK 3 DAY 22 -WEEK 4 DAY 29 -WEEK 5 DAY 36 -SCREENING -BASELINE -WEEK 1 DAY 8 -WEEK 2 DAY 15 -WEEK 3 DAY 22 -WEEK 4 DAY 29 -WEEK 5 DAY 36 -SCREENING -BASELINE -WEEK 1 DAY 8 -WEEK 2 DAY 15 -WEEK 3 DAY 22 -WEEK 4 DAY 29 -WEEK 5 DAY 36 -SCREENING -BASELINE -WEEK 1 DAY 8 -WEEK 2 DAY 15 -WEEK 3 DAY 22 -WEEK 4 DAY 29 -WEEK 5 DAY 36 -SCREENING -BASELINE -WEEK 1 DAY 8 -WEEK 2 DAY 15 -WEEK 3 DAY 22 -WEEK 4 DAY 29 -WEEK 5 DAY 36 -SCREENING -BASELINE -WEEK 1 DAY 8 -WEEK 2 DAY 15 -WEEK 3 DAY 22 -WEEK 4 DAY 29 -WEEK 5 DAY 36 -SCREENING -BASELINE -WEEK 1 DAY 8 -WEEK 2 DAY 15 -WEEK 3 DAY 22 -WEEK 4 DAY 29 -WEEK 5 DAY 36 -SCREENING -BASELINE -WEEK 1 DAY 8 -WEEK 2 DAY 15 -WEEK 3 DAY 22 -WEEK 4 DAY 29 -WEEK 5 DAY 36 -SCREENING -BASELINE -WEEK 1 DAY 8 -WEEK 2 DAY 15 -WEEK 3 DAY 22 -WEEK 4 DAY 29 -WEEK 5 DAY 36 -SCREENING -BASELINE -WEEK 1 DAY 8 -WEEK 2 DAY 15 -WEEK 3 DAY 22 -WEEK 4 DAY 29 -WEEK 5 DAY 36 -SCREENING -BASELINE -WEEK 1 DAY 8 -WEEK 2 DAY 15 -WEEK 3 DAY 22 -WEEK 4 DAY 29 -WEEK 5 DAY 36 -SCREENING -BASELINE -WEEK 1 DAY 8 -WEEK 2 DAY 15 -WEEK 3 DAY 22 -WEEK 4 DAY 29 -WEEK 5 DAY 36 -SCREENING -BASELINE -WEEK 1 DAY 8 -WEEK 2 DAY 15 -WEEK 3 DAY 22 -WEEK 4 DAY 29 -WEEK 5 DAY 36 -SCREENING -BASELINE -WEEK 1 DAY 8 -WEEK 2 DAY 15 -WEEK 3 DAY 22 -WEEK 4 DAY 29 -WEEK 5 DAY 36 -SCREENING -BASELINE -WEEK 1 DAY 8 -WEEK 2 DAY 15 -WEEK 3 DAY 22 -WEEK 4 DAY 29 -WEEK 5 DAY 36 -SCREENING -BASELINE -WEEK 1 DAY 8 -WEEK 2 DAY 15 -WEEK 3 DAY 22 -WEEK 4 DAY 29 -WEEK 5 DAY 36 -SCREENING -BASELINE -WEEK 1 DAY 8 -WEEK 2 DAY 15 -WEEK 3 DAY 22 -WEEK 4 DAY 29 -WEEK 5 DAY 36 -SCREENING -BASELINE -WEEK 1 DAY 8 -WEEK 2 DAY 15 -WEEK 3 DAY 22 -WEEK 4 DAY 29 -WEEK 5 DAY 36 -SCREENING -BASELINE -WEEK 1 DAY 8 -WEEK 2 DAY 15 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- - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - -SCREENING -BASELINE -WEEK 1 DAY 8 -WEEK 2 DAY 15 -WEEK 3 DAY 22 -WEEK 4 DAY 29 -WEEK 5 DAY 36 -SCREENING -BASELINE -WEEK 1 DAY 8 -WEEK 2 DAY 15 -WEEK 3 DAY 22 -WEEK 4 DAY 29 -WEEK 5 DAY 36 -SCREENING -BASELINE -WEEK 1 DAY 8 -WEEK 2 DAY 15 -WEEK 3 DAY 22 -WEEK 4 DAY 29 -WEEK 5 DAY 36 -SCREENING -BASELINE -WEEK 1 DAY 8 -WEEK 2 DAY 15 -WEEK 3 DAY 22 -WEEK 4 DAY 29 -WEEK 5 DAY 36 -SCREENING -BASELINE -WEEK 1 DAY 8 -WEEK 2 DAY 15 -WEEK 3 DAY 22 -WEEK 4 DAY 29 -WEEK 5 DAY 36 -SCREENING -BASELINE -WEEK 1 DAY 8 -WEEK 2 DAY 15 -WEEK 3 DAY 22 -WEEK 4 DAY 29 -WEEK 5 DAY 36 -SCREENING -BASELINE -WEEK 1 DAY 8 -WEEK 2 DAY 15 -WEEK 3 DAY 22 -WEEK 4 DAY 29 -WEEK 5 DAY 36 -SCREENING -BASELINE -WEEK 1 DAY 8 -WEEK 2 DAY 15 -WEEK 3 DAY 22 -WEEK 4 DAY 29 -WEEK 5 DAY 36 -SCREENING -BASELINE -WEEK 1 DAY 8 -WEEK 2 DAY 15 -WEEK 3 DAY 22 -WEEK 4 DAY 29 -WEEK 5 DAY 36 -SCREENING -BASELINE -WEEK 1 DAY 8 -WEEK 2 DAY 15 -WEEK 3 DAY 22 -WEEK 4 DAY 29 -WEEK 5 DAY 36 -SCREENING -BASELINE -WEEK 1 DAY 8 -WEEK 2 DAY 15 -WEEK 3 DAY 22 -WEEK 4 DAY 29 -WEEK 5 DAY 36 -SCREENING -BASELINE -WEEK 1 DAY 8 -WEEK 2 DAY 15 -WEEK 3 DAY 22 -WEEK 4 DAY 29 -WEEK 5 DAY 36 -SCREENING -BASELINE -WEEK 1 DAY 8 -WEEK 2 DAY 15 -WEEK 3 DAY 22 -WEEK 4 DAY 29 -WEEK 5 DAY 36 -SCREENING -BASELINE -WEEK 1 DAY 8 -WEEK 2 DAY 15 -WEEK 3 DAY 22 -WEEK 4 DAY 29 -WEEK 5 DAY 36 -SCREENING -BASELINE -WEEK 1 DAY 8 -WEEK 2 DAY 15 -WEEK 3 DAY 22 -WEEK 4 DAY 29 -WEEK 5 DAY 36 -SCREENING -BASELINE -WEEK 1 DAY 8 -WEEK 2 DAY 15 -WEEK 3 DAY 22 -WEEK 4 DAY 29 -WEEK 5 DAY 36 -SCREENING -BASELINE -WEEK 1 DAY 8 -WEEK 2 DAY 15 -WEEK 3 DAY 22 -WEEK 4 DAY 29 -WEEK 5 DAY 36 -SCREENING -BASELINE -WEEK 1 DAY 8 -WEEK 2 DAY 15 -WEEK 3 DAY 22 -WEEK 4 DAY 29 -WEEK 5 DAY 36 -SCREENING -BASELINE -WEEK 1 DAY 8 -WEEK 2 DAY 15 -WEEK 3 DAY 22 -WEEK 4 DAY 29 -WEEK 5 DAY 36 -SCREENING -BASELINE -WEEK 1 DAY 8 -WEEK 2 DAY 15 -WEEK 3 DAY 22 -WEEK 4 DAY 29 -WEEK 5 DAY 36 -SCREENING -BASELINE -WEEK 1 DAY 8 -WEEK 2 DAY 15 -WEEK 3 DAY 22 -WEEK 4 DAY 29 -WEEK 5 DAY 36 -SCREENING -BASELINE -WEEK 1 DAY 8 -WEEK 2 DAY 15 -WEEK 3 DAY 22 -WEEK 4 DAY 29 -WEEK 5 DAY 36 -SCREENING -BASELINE -WEEK 1 DAY 8 -WEEK 2 DAY 15 -WEEK 3 DAY 22 -WEEK 4 DAY 29 -WEEK 5 DAY 36 -SCREENING -BASELINE -WEEK 1 DAY 8 -WEEK 2 DAY 15 -WEEK 3 DAY 22 -WEEK 4 DAY 29 -WEEK 5 DAY 36 -SCREENING -BASELINE -WEEK 1 DAY 8 -WEEK 2 DAY 15 -WEEK 3 DAY 22 -WEEK 4 DAY 29 -WEEK 5 DAY 36 -SCREENING -BASELINE -WEEK 1 DAY 8 -WEEK 2 DAY 15 -WEEK 3 DAY 22 -WEEK 4 DAY 29 -WEEK 5 DAY 36 -SCREENING -BASELINE -WEEK 1 DAY 8 -WEEK 2 DAY 15 -WEEK 3 DAY 22 -WEEK 4 DAY 29 -WEEK 5 DAY 36 -SCREENING -BASELINE -WEEK 1 DAY 8 -WEEK 2 DAY 15 -WEEK 3 DAY 22 -WEEK 4 DAY 29 -WEEK 5 DAY 36 -SCREENING -BASELINE -WEEK 1 DAY 8 -WEEK 2 DAY 15 -WEEK 3 DAY 22 -WEEK 4 DAY 29 -WEEK 5 DAY 36 -SCREENING -BASELINE -WEEK 1 DAY 8 -WEEK 2 DAY 15 -WEEK 3 DAY 22 -WEEK 4 DAY 29 -WEEK 5 DAY 36 -SCREENING -BASELINE -WEEK 1 DAY 8 -WEEK 2 DAY 15 -WEEK 3 DAY 22 -WEEK 4 DAY 29 -WEEK 5 DAY 36 -SCREENING -BASELINE -WEEK 1 DAY 8 -WEEK 2 DAY 15 -WEEK 3 DAY 22 -WEEK 4 DAY 29 -WEEK 5 DAY 36 -SCREENING -BASELINE -WEEK 1 DAY 8 -WEEK 2 DAY 15 -WEEK 3 DAY 22 -WEEK 4 DAY 29 -WEEK 5 DAY 36 -SCREENING -BASELINE -WEEK 1 DAY 8 -WEEK 2 DAY 15 -WEEK 3 DAY 22 -WEEK 4 DAY 29 -WEEK 5 DAY 36 -SCREENING -BASELINE -WEEK 1 DAY 8 -WEEK 2 DAY 15 -WEEK 3 DAY 22 -WEEK 4 DAY 29 -WEEK 5 DAY 36 -SCREENING -BASELINE -WEEK 1 DAY 8 -WEEK 2 DAY 15 -WEEK 3 DAY 22 -WEEK 4 DAY 29 -WEEK 5 DAY 36 -SCREENING -BASELINE -WEEK 1 DAY 8 -WEEK 2 DAY 15 -WEEK 3 DAY 22 -WEEK 4 DAY 29 -WEEK 5 DAY 36 -SCREENING -BASELINE -WEEK 1 DAY 8 -WEEK 2 DAY 15 -WEEK 3 DAY 22 -WEEK 4 DAY 29 -WEEK 5 DAY 36 -SCREENING -BASELINE -WEEK 1 DAY 8 -WEEK 2 DAY 15 -WEEK 3 DAY 22 -WEEK 4 DAY 29 -WEEK 5 DAY 36 -SCREENING -BASELINE -WEEK 1 DAY 8 -WEEK 2 DAY 15 -WEEK 3 DAY 22 -WEEK 4 DAY 29 -WEEK 5 DAY 36 -SCREENING -BASELINE -WEEK 1 DAY 8 -WEEK 2 DAY 15 -WEEK 3 DAY 22 -WEEK 4 DAY 29 -WEEK 5 DAY 36 -SCREENING -BASELINE -WEEK 1 DAY 8 -WEEK 2 DAY 15 -WEEK 3 DAY 22 -WEEK 4 DAY 29 -WEEK 5 DAY 36 -SCREENING -BASELINE -WEEK 1 DAY 8 -WEEK 2 DAY 15 -WEEK 3 DAY 22 -WEEK 4 DAY 29 -WEEK 5 DAY 36 -SCREENING -BASELINE -WEEK 1 DAY 8 -WEEK 2 DAY 15 -WEEK 3 DAY 22 -WEEK 4 DAY 29 -WEEK 5 DAY 36 -SCREENING -BASELINE -WEEK 1 DAY 8 -WEEK 2 DAY 15 -WEEK 3 DAY 22 -WEEK 4 DAY 29 -WEEK 5 DAY 36 -SCREENING -BASELINE -WEEK 1 DAY 8 -WEEK 2 DAY 15 -WEEK 3 DAY 22 -WEEK 4 DAY 29 -WEEK 5 DAY 36 -SCREENING -BASELINE -WEEK 1 DAY 8 -WEEK 2 DAY 15 -WEEK 3 DAY 22 -WEEK 4 DAY 29 -WEEK 5 DAY 36 -SCREENING -BASELINE -WEEK 1 DAY 8 -WEEK 2 DAY 15 -WEEK 3 DAY 22 -WEEK 4 DAY 29 -WEEK 5 DAY 36 -SCREENING -BASELINE -WEEK 1 DAY 8 -WEEK 2 DAY 15 -WEEK 3 DAY 22 -WEEK 4 DAY 29 -WEEK 5 DAY 36 -SCREENING -BASELINE -WEEK 1 DAY 8 -WEEK 2 DAY 15 -WEEK 3 DAY 22 -WEEK 4 DAY 29 -WEEK 5 DAY 36 -SCREENING -BASELINE -WEEK 1 DAY 8 -WEEK 2 DAY 15 -WEEK 3 DAY 22 -WEEK 4 DAY 29 -WEEK 5 DAY 36 -SCREENING -BASELINE -WEEK 1 DAY 8 -WEEK 2 DAY 15 -WEEK 3 DAY 22 -WEEK 4 DAY 29 -WEEK 5 DAY 36 -SCREENING -BASELINE -WEEK 1 DAY 8 -WEEK 2 DAY 15 -WEEK 3 DAY 22 -WEEK 4 DAY 29 -WEEK 5 DAY 36 -SCREENING -BASELINE -WEEK 1 DAY 8 -WEEK 2 DAY 15 -WEEK 3 DAY 22 -WEEK 4 DAY 29 -WEEK 5 DAY 36 -SCREENING -BASELINE -WEEK 1 DAY 8 -WEEK 2 DAY 15 -WEEK 3 DAY 22 -WEEK 4 DAY 29 -WEEK 5 DAY 36 -SCREENING -BASELINE -WEEK 1 DAY 8 -WEEK 2 DAY 15 -WEEK 3 DAY 22 -WEEK 4 DAY 29 -WEEK 5 DAY 36 -SCREENING -BASELINE -WEEK 1 DAY 8 -WEEK 2 DAY 15 -WEEK 3 DAY 22 -WEEK 4 DAY 29 -WEEK 5 DAY 36 -SCREENING -BASELINE -WEEK 1 DAY 8 -WEEK 2 DAY 15 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-SCREENING -BASELINE -WEEK 1 DAY 8 -WEEK 2 DAY 15 -WEEK 3 DAY 22 -WEEK 4 DAY 29 -WEEK 5 DAY 36 -SCREENING -BASELINE -WEEK 1 DAY 8 -WEEK 2 DAY 15 -WEEK 3 DAY 22 -WEEK 4 DAY 29 -WEEK 5 DAY 36 -SCREENING -BASELINE -WEEK 1 DAY 8 -WEEK 2 DAY 15 -WEEK 3 DAY 22 -WEEK 4 DAY 29 -WEEK 5 DAY 36 -SCREENING -BASELINE -WEEK 1 DAY 8 -WEEK 2 DAY 15 -WEEK 3 DAY 22 -WEEK 4 DAY 29 -WEEK 5 DAY 36 -SCREENING -BASELINE -WEEK 1 DAY 8 -WEEK 2 DAY 15 -WEEK 3 DAY 22 -WEEK 4 DAY 29 -WEEK 5 DAY 36 -SCREENING -BASELINE -WEEK 1 DAY 8 -WEEK 2 DAY 15 -WEEK 3 DAY 22 -WEEK 4 DAY 29 -WEEK 5 DAY 36 -SCREENING -BASELINE -WEEK 1 DAY 8 -WEEK 2 DAY 15 -WEEK 3 DAY 22 -WEEK 4 DAY 29 -WEEK 5 DAY 36 -SCREENING -BASELINE -WEEK 1 DAY 8 -WEEK 2 DAY 15 -WEEK 3 DAY 22 -WEEK 4 DAY 29 -WEEK 5 DAY 36 -SCREENING -BASELINE -WEEK 1 DAY 8 -WEEK 2 DAY 15 -WEEK 3 DAY 22 -WEEK 4 DAY 29 -WEEK 5 DAY 36 -SCREENING -BASELINE -WEEK 1 DAY 8 -WEEK 2 DAY 15 -WEEK 3 DAY 22 -WEEK 4 DAY 29 -WEEK 5 DAY 36 -SCREENING -BASELINE -WEEK 1 DAY 8 -WEEK 2 DAY 15 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-SCREENING -BASELINE -WEEK 1 DAY 8 -WEEK 2 DAY 15 -WEEK 3 DAY 22 -WEEK 4 DAY 29 -WEEK 5 DAY 36 -SCREENING -BASELINE -WEEK 1 DAY 8 -WEEK 2 DAY 15 -WEEK 3 DAY 22 -WEEK 4 DAY 29 -WEEK 5 DAY 36 -SCREENING -BASELINE -WEEK 1 DAY 8 -WEEK 2 DAY 15 -WEEK 3 DAY 22 -WEEK 4 DAY 29 -WEEK 5 DAY 36 -SCREENING -BASELINE -WEEK 1 DAY 8 -WEEK 2 DAY 15 -WEEK 3 DAY 22 -WEEK 4 DAY 29 -WEEK 5 DAY 36 -SCREENING -BASELINE -WEEK 1 DAY 8 -WEEK 2 DAY 15 -WEEK 3 DAY 22 -WEEK 4 DAY 29 -WEEK 5 DAY 36 -SCREENING -BASELINE -WEEK 1 DAY 8 -WEEK 2 DAY 15 -WEEK 3 DAY 22 -WEEK 4 DAY 29 -WEEK 5 DAY 36 -SCREENING -BASELINE -WEEK 1 DAY 8 -WEEK 2 DAY 15 -WEEK 3 DAY 22 -WEEK 4 DAY 29 -WEEK 5 DAY 36 -SCREENING -BASELINE -WEEK 1 DAY 8 -WEEK 2 DAY 15 -WEEK 3 DAY 22 -WEEK 4 DAY 29 -WEEK 5 DAY 36 -SCREENING -BASELINE -WEEK 1 DAY 8 -WEEK 2 DAY 15 -WEEK 3 DAY 22 -WEEK 4 DAY 29 -WEEK 5 DAY 36 -SCREENING -BASELINE -WEEK 1 DAY 8 -WEEK 2 DAY 15 -WEEK 3 DAY 22 -WEEK 4 DAY 29 -WEEK 5 DAY 36 -SCREENING -BASELINE -WEEK 1 DAY 8 -WEEK 2 DAY 15 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-SCREENING -BASELINE -WEEK 1 DAY 8 -WEEK 2 DAY 15 -WEEK 3 DAY 22 -WEEK 4 DAY 29 -WEEK 5 DAY 36 -SCREENING -BASELINE -WEEK 1 DAY 8 -WEEK 2 DAY 15 -WEEK 3 DAY 22 -WEEK 4 DAY 29 -WEEK 5 DAY 36 -SCREENING -BASELINE -WEEK 1 DAY 8 -WEEK 2 DAY 15 -WEEK 3 DAY 22 -WEEK 4 DAY 29 -WEEK 5 DAY 36 -SCREENING -BASELINE -WEEK 1 DAY 8 -WEEK 2 DAY 15 -WEEK 3 DAY 22 -WEEK 4 DAY 29 -WEEK 5 DAY 36 -SCREENING -BASELINE -WEEK 1 DAY 8 -WEEK 2 DAY 15 -WEEK 3 DAY 22 -WEEK 4 DAY 29 -WEEK 5 DAY 36 -SCREENING -BASELINE -WEEK 1 DAY 8 -WEEK 2 DAY 15 -WEEK 3 DAY 22 -WEEK 4 DAY 29 -WEEK 5 DAY 36 -SCREENING -BASELINE -WEEK 1 DAY 8 -WEEK 2 DAY 15 -WEEK 3 DAY 22 -WEEK 4 DAY 29 -WEEK 5 DAY 36 -SCREENING -BASELINE -WEEK 1 DAY 8 -WEEK 2 DAY 15 -WEEK 3 DAY 22 -WEEK 4 DAY 29 -WEEK 5 DAY 36 -SCREENING -BASELINE -WEEK 1 DAY 8 -WEEK 2 DAY 15 -WEEK 3 DAY 22 -WEEK 4 DAY 29 -WEEK 5 DAY 36 -SCREENING -BASELINE -WEEK 1 DAY 8 -WEEK 2 DAY 15 -WEEK 3 DAY 22 -WEEK 4 DAY 29 -WEEK 5 DAY 36 - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - -SCREENING -BASELINE -WEEK 1 DAY 8 -WEEK 2 DAY 15 -WEEK 3 DAY 22 -WEEK 4 DAY 29 -WEEK 5 DAY 36 -SCREENING -BASELINE -WEEK 1 DAY 8 -WEEK 2 DAY 15 -WEEK 3 DAY 22 -WEEK 4 DAY 29 -WEEK 5 DAY 36 -SCREENING -BASELINE -WEEK 1 DAY 8 -WEEK 2 DAY 15 -WEEK 3 DAY 22 -WEEK 4 DAY 29 -WEEK 5 DAY 36 -SCREENING -BASELINE -WEEK 1 DAY 8 -WEEK 2 DAY 15 -WEEK 3 DAY 22 -WEEK 4 DAY 29 -WEEK 5 DAY 36 -SCREENING -BASELINE -WEEK 1 DAY 8 -WEEK 2 DAY 15 -WEEK 3 DAY 22 -WEEK 4 DAY 29 -WEEK 5 DAY 36 -SCREENING -BASELINE -WEEK 1 DAY 8 -WEEK 2 DAY 15 -WEEK 3 DAY 22 -WEEK 4 DAY 29 -WEEK 5 DAY 36 -SCREENING -BASELINE -WEEK 1 DAY 8 -WEEK 2 DAY 15 -WEEK 3 DAY 22 -WEEK 4 DAY 29 -WEEK 5 DAY 36 -SCREENING -BASELINE -WEEK 1 DAY 8 -WEEK 2 DAY 15 -WEEK 3 DAY 22 -WEEK 4 DAY 29 -WEEK 5 DAY 36 -SCREENING -BASELINE -WEEK 1 DAY 8 -WEEK 2 DAY 15 -WEEK 3 DAY 22 -WEEK 4 DAY 29 -WEEK 5 DAY 36 -SCREENING -BASELINE -WEEK 1 DAY 8 -WEEK 2 DAY 15 -WEEK 3 DAY 22 -WEEK 4 DAY 29 -WEEK 5 DAY 36 -SCREENING -BASELINE -WEEK 1 DAY 8 -WEEK 2 DAY 15 -WEEK 3 DAY 22 -WEEK 4 DAY 29 -WEEK 5 DAY 36 -SCREENING -BASELINE -WEEK 1 DAY 8 -WEEK 2 DAY 15 -WEEK 3 DAY 22 -WEEK 4 DAY 29 -WEEK 5 DAY 36 -SCREENING -BASELINE -WEEK 1 DAY 8 -WEEK 2 DAY 15 -WEEK 3 DAY 22 -WEEK 4 DAY 29 -WEEK 5 DAY 36 -SCREENING -BASELINE -WEEK 1 DAY 8 -WEEK 2 DAY 15 -WEEK 3 DAY 22 -WEEK 4 DAY 29 -WEEK 5 DAY 36 -SCREENING -BASELINE -WEEK 1 DAY 8 -WEEK 2 DAY 15 -WEEK 3 DAY 22 -WEEK 4 DAY 29 -WEEK 5 DAY 36 -SCREENING -BASELINE -WEEK 1 DAY 8 -WEEK 2 DAY 15 -WEEK 3 DAY 22 -WEEK 4 DAY 29 -WEEK 5 DAY 36 -SCREENING -BASELINE -WEEK 1 DAY 8 -WEEK 2 DAY 15 -WEEK 3 DAY 22 -WEEK 4 DAY 29 -WEEK 5 DAY 36 -SCREENING -BASELINE -WEEK 1 DAY 8 -WEEK 2 DAY 15 -WEEK 3 DAY 22 -WEEK 4 DAY 29 -WEEK 5 DAY 36 -SCREENING -BASELINE -WEEK 1 DAY 8 -WEEK 2 DAY 15 -WEEK 3 DAY 22 -WEEK 4 DAY 29 -WEEK 5 DAY 36 -SCREENING -BASELINE -WEEK 1 DAY 8 -WEEK 2 DAY 15 -WEEK 3 DAY 22 -WEEK 4 DAY 29 -WEEK 5 DAY 36 -SCREENING -BASELINE -WEEK 1 DAY 8 -WEEK 2 DAY 15 -WEEK 3 DAY 22 -WEEK 4 DAY 29 -WEEK 5 DAY 36 -SCREENING -BASELINE -WEEK 1 DAY 8 -WEEK 2 DAY 15 -WEEK 3 DAY 22 -WEEK 4 DAY 29 -WEEK 5 DAY 36 -SCREENING -BASELINE -WEEK 1 DAY 8 -WEEK 2 DAY 15 -WEEK 3 DAY 22 -WEEK 4 DAY 29 -WEEK 5 DAY 36 -SCREENING -BASELINE -WEEK 1 DAY 8 -WEEK 2 DAY 15 -WEEK 3 DAY 22 -WEEK 4 DAY 29 -WEEK 5 DAY 36 -SCREENING -BASELINE -WEEK 1 DAY 8 -WEEK 2 DAY 15 -WEEK 3 DAY 22 -WEEK 4 DAY 29 -WEEK 5 DAY 36 -SCREENING -BASELINE -WEEK 1 DAY 8 -WEEK 2 DAY 15 -WEEK 3 DAY 22 -WEEK 4 DAY 29 -WEEK 5 DAY 36 -SCREENING -BASELINE -WEEK 1 DAY 8 -WEEK 2 DAY 15 -WEEK 3 DAY 22 -WEEK 4 DAY 29 -WEEK 5 DAY 36 -SCREENING -BASELINE -WEEK 1 DAY 8 -WEEK 2 DAY 15 -WEEK 3 DAY 22 -WEEK 4 DAY 29 -WEEK 5 DAY 36 -SCREENING -BASELINE -WEEK 1 DAY 8 -WEEK 2 DAY 15 -WEEK 3 DAY 22 -WEEK 4 DAY 29 -WEEK 5 DAY 36 -SCREENING -BASELINE -WEEK 1 DAY 8 -WEEK 2 DAY 15 -WEEK 3 DAY 22 -WEEK 4 DAY 29 -WEEK 5 DAY 36 -SCREENING -BASELINE -WEEK 1 DAY 8 -WEEK 2 DAY 15 -WEEK 3 DAY 22 -WEEK 4 DAY 29 -WEEK 5 DAY 36 -SCREENING -BASELINE -WEEK 1 DAY 8 -WEEK 2 DAY 15 -WEEK 3 DAY 22 -WEEK 4 DAY 29 -WEEK 5 DAY 36 -SCREENING -BASELINE -WEEK 1 DAY 8 -WEEK 2 DAY 15 -WEEK 3 DAY 22 -WEEK 4 DAY 29 -WEEK 5 DAY 36 -SCREENING -BASELINE -WEEK 1 DAY 8 -WEEK 2 DAY 15 -WEEK 3 DAY 22 -WEEK 4 DAY 29 -WEEK 5 DAY 36 -SCREENING -BASELINE -WEEK 1 DAY 8 -WEEK 2 DAY 15 -WEEK 3 DAY 22 -WEEK 4 DAY 29 -WEEK 5 DAY 36 -SCREENING -BASELINE -WEEK 1 DAY 8 -WEEK 2 DAY 15 -WEEK 3 DAY 22 -WEEK 4 DAY 29 -WEEK 5 DAY 36 -SCREENING -BASELINE -WEEK 1 DAY 8 -WEEK 2 DAY 15 -WEEK 3 DAY 22 -WEEK 4 DAY 29 -WEEK 5 DAY 36 -SCREENING -BASELINE -WEEK 1 DAY 8 -WEEK 2 DAY 15 -WEEK 3 DAY 22 -WEEK 4 DAY 29 -WEEK 5 DAY 36 -SCREENING -BASELINE -WEEK 1 DAY 8 -WEEK 2 DAY 15 -WEEK 3 DAY 22 -WEEK 4 DAY 29 -WEEK 5 DAY 36 -SCREENING -BASELINE -WEEK 1 DAY 8 -WEEK 2 DAY 15 -WEEK 3 DAY 22 -WEEK 4 DAY 29 -WEEK 5 DAY 36 -SCREENING -BASELINE -WEEK 1 DAY 8 -WEEK 2 DAY 15 -WEEK 3 DAY 22 -WEEK 4 DAY 29 -WEEK 5 DAY 36 -SCREENING -BASELINE -WEEK 1 DAY 8 -WEEK 2 DAY 15 -WEEK 3 DAY 22 -WEEK 4 DAY 29 -WEEK 5 DAY 36 -SCREENING -BASELINE -WEEK 1 DAY 8 -WEEK 2 DAY 15 -WEEK 3 DAY 22 -WEEK 4 DAY 29 -WEEK 5 DAY 36 -SCREENING -BASELINE -WEEK 1 DAY 8 -WEEK 2 DAY 15 -WEEK 3 DAY 22 -WEEK 4 DAY 29 -WEEK 5 DAY 36 -SCREENING -BASELINE -WEEK 1 DAY 8 -WEEK 2 DAY 15 -WEEK 3 DAY 22 -WEEK 4 DAY 29 -WEEK 5 DAY 36 -SCREENING -BASELINE -WEEK 1 DAY 8 -WEEK 2 DAY 15 -WEEK 3 DAY 22 -WEEK 4 DAY 29 -WEEK 5 DAY 36 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+WEEK 3 DAY 22 +WEEK 4 DAY 29 +WEEK 5 DAY 36 +SCREENING +BASELINE +WEEK 1 DAY 8 +WEEK 2 DAY 15 +WEEK 3 DAY 22 +WEEK 4 DAY 29 +WEEK 5 DAY 36 +SCREENING +BASELINE +WEEK 1 DAY 8 +WEEK 2 DAY 15 +WEEK 3 DAY 22 +WEEK 4 DAY 29 +WEEK 5 DAY 36 +SCREENING +BASELINE +WEEK 1 DAY 8 +WEEK 2 DAY 15 +WEEK 3 DAY 22 +WEEK 4 DAY 29 +WEEK 5 DAY 36 +SCREENING +BASELINE +WEEK 1 DAY 8 +WEEK 2 DAY 15 +WEEK 3 DAY 22 +WEEK 4 DAY 29 +WEEK 5 DAY 36 +SCREENING +BASELINE +WEEK 1 DAY 8 +WEEK 2 DAY 15 +WEEK 3 DAY 22 +WEEK 4 DAY 29 +WEEK 5 DAY 36 +SCREENING +BASELINE +WEEK 1 DAY 8 +WEEK 2 DAY 15 +WEEK 3 DAY 22 +WEEK 4 DAY 29 +WEEK 5 DAY 36 +0 +10 +20 +30 +40 + + + + + +8 +10 +12 + + + +2.8 +3.0 +3.2 + + + + + + + +Median +/- 80% CI + + diff --git a/package/tests/testthat/_snaps/graph-snaps/mmrmg01-plot-v1.svg b/package/tests/testthat/_snaps/graph-snaps/mmrmg01-plot-v1.svg deleted file mode 100644 index 522e56bd23..0000000000 --- a/package/tests/testthat/_snaps/graph-snaps/mmrmg01-plot-v1.svg +++ /dev/null @@ -1,152 +0,0 @@ - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - -Adjusted mean of Analysis Value by treatment at visits - - - - - - - - -SCREENING -WEEK 1 DAY 8 -WEEK 2 DAY 15 -WEEK 3 DAY 22 -WEEK 4 DAY 29 -WEEK 5 DAY 36 -50 -60 -70 - - - -Visit -Estimates with 95% CIs - -ARM - - - - - - - - - -B: Placebo -A: Drug X -C: Combination -mmrmg01-plot_v1 - - diff --git a/package/tests/testthat/_snaps/graph-snaps/mmrmg01-plot-v2.svg b/package/tests/testthat/_snaps/graph-snaps/mmrmg01-plot-v2.svg deleted file mode 100644 index 198f12b33b..0000000000 --- a/package/tests/testthat/_snaps/graph-snaps/mmrmg01-plot-v2.svg +++ /dev/null @@ -1,158 +0,0 @@ - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - -Adjusted mean of Analysis Value by treatment at visits - - - - - - - - -SCREENING -WEEK 1 DAY 8 -WEEK 2 DAY 15 -WEEK 3 DAY 22 -WEEK 4 DAY 29 -WEEK 5 DAY 36 -50 -60 -70 - - - -Visit -Estimates with 95% CIs - -ARM - - - - - - - - - - - - -B: Placebo -A: Drug X -C: Combination -mmrmg01-plot_v2 - - diff --git a/package/tests/testthat/_snaps/graph-snaps/mmrmg01-plot-v3.svg b/package/tests/testthat/_snaps/graph-snaps/mmrmg01-plot-v3.svg deleted file mode 100644 index 868c85d613..0000000000 --- a/package/tests/testthat/_snaps/graph-snaps/mmrmg01-plot-v3.svg +++ /dev/null @@ -1,329 +0,0 @@ - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - -Adjusted mean of Analysis Value by treatment at visits - - - - - - - - -SCREENING -WEEK 1 DAY 8 -WEEK 2 DAY 15 -WEEK 3 DAY 22 -WEEK 4 DAY 29 -WEEK 5 DAY 36 -50 -60 -70 - - - -Visit -Estimates with 95% CIs - -ARM - - - - - - - - - -B: Placebo -A: Drug X -C: Combination - - - - - - - - - - - - - - - - - - -134 -45.2 -0.7 -(43.78, 46.68) -134 -54.3 -0.7 -(52.99, 55.71) -134 -60.0 -0.8 -(58.49, 61.50) -134 -64.4 -0.9 -(62.71, 66.11) -134 -69.0 -1.0 -(67.01, 70.92) -134 -74.4 -1.1 -(72.29, 76.44) - - - - - - - - - - -134 -44.6 -0.7 -(43.12, 46.02) -134 -55.0 -0.7 -(53.66, 56.38) -134 -59.8 -0.8 -(58.29, 61.30) -134 -66.8 -0.9 -(65.09, 68.49) -134 -70.3 -1.0 -(68.30, 72.21) -134 -75.7 -1.1 -(73.63, 77.78) - - - - - - - - - - -132 -44.7 -0.7 -(43.24, 46.16) -132 -53.9 -0.7 -(52.57, 55.31) -132 -59.3 -0.8 -(57.77, 60.80) -132 -66.6 -0.9 -(64.85, 68.28) -132 -70.3 -1.0 -(68.32, 72.26) -132 -74.5 -1.1 -(72.39, 76.58) - - - - - - - - - - -C: Combination - - - - - - - - - - -A: Drug X - - - - - - - - - - -B: Placebo - - -95% CI -Std. Error -LS mean -n -95% CI -Std. Error -LS mean -n -95% CI -Std. Error -LS mean -n - - diff --git a/package/tests/testthat/_snaps/graph-snaps/mmrmg01-plot-v4.svg b/package/tests/testthat/_snaps/graph-snaps/mmrmg01-plot-v4.svg deleted file mode 100644 index 28fce869c2..0000000000 --- a/package/tests/testthat/_snaps/graph-snaps/mmrmg01-plot-v4.svg +++ /dev/null @@ -1,125 +0,0 @@ - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - -0.5235 -0.6112 -0.4924 -0.6772 -0.8504 -0.5140 -0.0528 -0.0800 -0.3593 -0.3480 -0.3704 -0.9378 - - -Contrasts of FKSI-FWB means - - - - - - -SCREENING -WEEK 1 DAY 8 -WEEK 2 DAY 15 -WEEK 3 DAY 22 -WEEK 4 DAY 29 -WEEK 5 DAY 36 --2.5 -0.0 -2.5 -5.0 - - - - -Visit -Estimates with 95% CIs - -ARM - - - - - - - - - -B: Placebo -A: Drug X -C: Combination -mmrmg01-plot_v4 - - diff --git a/package/tests/testthat/_snaps/graph-snaps/mmrmg01-plot-v5.svg b/package/tests/testthat/_snaps/graph-snaps/mmrmg01-plot-v5.svg deleted file mode 100644 index 3bc32f9620..0000000000 --- a/package/tests/testthat/_snaps/graph-snaps/mmrmg01-plot-v5.svg +++ /dev/null @@ -1,2642 +0,0 @@ - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - 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+ + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + +16 +18 +20 + + + + + + + + +WEEK 1 DAY 8 +WEEK 2 DAY 15 +WEEK 3 DAY 22 +WEEK 4 DAY 29 +WEEK 5 DAY 36 + + + + + + + + + + + + + +A: Drug X (N = 134) +B: Placebo (N = 134) +C: Combination (N = 132) +Laboratory Test: ALT (U/L) +Plot of Mean and 95% Confidence Limits by Visit + + diff --git a/package/tests/testthat/_snaps/graph-snaps/mng01-plot_v2.svg b/package/tests/testthat/_snaps/graph-snaps/mng01-plot_v2.svg new file mode 100644 index 0000000000..ccc319b168 --- /dev/null +++ b/package/tests/testthat/_snaps/graph-snaps/mng01-plot_v2.svg @@ -0,0 +1,137 @@ + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + +-10 +-5 +0 +5 +10 + + + + + + + + + + +WEEK 1 DAY 8 +WEEK 2 DAY 15 +WEEK 3 DAY 22 +WEEK 4 DAY 29 +WEEK 5 DAY 36 + + + + + + + + + + + + + +A: Drug X (N = 134) +B: Placebo (N = 134) +C: Combination (N = 132) +Assessment: DIABP (Pa) +Plot of Mean and 95% Confidence Intervals of Change from Baseline by Visit + + diff --git a/package/tests/testthat/_snaps/graph-snaps/mng01-plot_v3.svg b/package/tests/testthat/_snaps/graph-snaps/mng01-plot_v3.svg new file mode 100644 index 0000000000..514497132e --- /dev/null +++ b/package/tests/testthat/_snaps/graph-snaps/mng01-plot_v3.svg @@ -0,0 +1,137 @@ + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + +10 +15 +20 +25 +30 + + + + + + + + + + +WEEK 1 DAY 8 +WEEK 2 DAY 15 +WEEK 3 DAY 22 +WEEK 4 DAY 29 +WEEK 5 DAY 36 + + + + + + + + + + + + + +A: Drug X (N = 134) +B: Placebo (N = 134) +C: Combination (N = 132) +Laboratory Test: ALT (U/L) +Plot of Mean (+/-SD) + + diff --git a/package/tests/testthat/_snaps/graph-snaps/mng01-plot_v4.svg b/package/tests/testthat/_snaps/graph-snaps/mng01-plot_v4.svg new file mode 100644 index 0000000000..4f8fa132f2 --- /dev/null +++ b/package/tests/testthat/_snaps/graph-snaps/mng01-plot_v4.svg @@ -0,0 +1,137 @@ + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + +16 +17 +18 +19 +20 + + + + + + + + + + +WEEK 1 DAY 8 +WEEK 2 DAY 15 +WEEK 3 DAY 22 +WEEK 4 DAY 29 +WEEK 5 DAY 36 + + + + + + + + + + + + + +A: Drug X (N = 134) +B: Placebo (N = 134) +C: Combination (N = 132) +Laboratory Test: ALT (U/L) +Plot of Mean and 80% Confidence Limits by Visit + + diff --git a/package/tests/testthat/_snaps/graph-snaps/mng01-plot_v5.svg b/package/tests/testthat/_snaps/graph-snaps/mng01-plot_v5.svg new file mode 100644 index 0000000000..a9fd89abf9 --- /dev/null +++ b/package/tests/testthat/_snaps/graph-snaps/mng01-plot_v5.svg @@ -0,0 +1,233 @@ + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + +16 +18 +20 + + + + + + + + +WEEK 1 DAY 8 +WEEK 2 DAY 15 +WEEK 3 DAY 22 +WEEK 4 DAY 29 +WEEK 5 DAY 36 + + + + + + + + + + + + + +A: Drug X (N = 134) +B: Placebo (N = 134) +C: Combination (N = 132) +Laboratory Test: ALT (U/L) +Plot of Mean and 95% Confidence Limits by Visit + + + + + + + + + + + + + + + + + + +134 +134 +134 +134 +134 + + + + + + + + + + +134 +134 +134 +134 +134 + + + + + + + + + + +132 +132 +132 +132 +132 + + + + + + + + + + +C: Combination + + + + + + + + + + +B: Placebo + + + + + + + + + + +A: Drug X + + +n +n +n + + diff --git a/package/tests/testthat/_snaps/graph-snaps/mng01-plot_v6.svg b/package/tests/testthat/_snaps/graph-snaps/mng01-plot_v6.svg new file mode 100644 index 0000000000..5d7b90728c --- /dev/null +++ b/package/tests/testthat/_snaps/graph-snaps/mng01-plot_v6.svg @@ -0,0 +1,269 @@ + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + +16 +18 +20 + + + + + + + + +WEEK 1 DAY 8 +WEEK 2 DAY 15 +WEEK 3 DAY 22 +WEEK 4 DAY 29 +WEEK 5 DAY 36 + + + + + + + + + + + + + +A: Drug X (N = 134) +B: Placebo (N = 134) +C: Combination (N = 132) +Laboratory Test: ALT (U/L) +Plot of Mean and 95% Confidence Limits by Visit + + + + + + + + + + + + + + + + + + +134 +16.8 +(15.20, 18.30) +134 +17.8 +(16.18, 19.46) +134 +18.4 +(16.78, 19.96) +134 +19.2 +(17.30, 21.05) +134 +19.2 +(17.60, 20.83) + + + + + + + + + + +134 +18.9 +(17.36, 20.50) +134 +18.8 +(17.15, 20.48) +134 +17.6 +(16.01, 19.28) +134 +17.2 +(15.40, 19.04) +134 +18.0 +(16.32, 19.71) + + + + + + + + + + +132 +19.6 +(18.01, 21.20) +132 +16.5 +(15.14, 17.95) +132 +16.8 +(15.11, 18.40) +132 +17.9 +(16.32, 19.52) +132 +18.5 +(16.89, 20.14) + + + + + + + + + + +C: Combination + + + + + + + + + + +B: Placebo + + + + + + + + + + +A: Drug X + + +Mean 95% CI +Mean +n +Mean 95% CI +Mean +n +Mean 95% CI +Mean +n + + diff --git a/package/tests/testthat/_snaps/graph-snaps/mng01-plot_v7.svg b/package/tests/testthat/_snaps/graph-snaps/mng01-plot_v7.svg new file mode 100644 index 0000000000..fa4c56bb9a --- /dev/null +++ b/package/tests/testthat/_snaps/graph-snaps/mng01-plot_v7.svg @@ -0,0 +1,152 @@ + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + +17 +18 +19 +20 +21 + + + + + + + + + + +WEEK 1 DAY 8 +WEEK 2 DAY 15 +WEEK 3 DAY 22 +WEEK 4 DAY 29 +WEEK 5 DAY 36 + + + + + + + + + + + + + +A: Drug X (N = 134) +B: Placebo (N = 134) +C: Combination (N = 132) +Laboratory Test: ALT (U/L) +Plot of Mean and 95% Confidence Limits by Visit + + diff --git a/package/tests/testthat/_snaps/graph-snaps/pkcg01-plot-v1.svg b/package/tests/testthat/_snaps/graph-snaps/pkcg01-plot-v1.svg deleted file mode 100644 index fb9b18f179..0000000000 --- a/package/tests/testthat/_snaps/graph-snaps/pkcg01-plot-v1.svg +++ /dev/null @@ -1,78 +0,0 @@ - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - -0 -5 -10 -15 - - - - - - - - - - -0 -5 -10 -15 -20 -25 -Norminal Time from First Dose (hr) -Concentration (ug/mL) - -Patient_ID - - - -1 -Analyte: Plasma Drug X (ug/mL) -Treatment Group: ARM A -Plot of Plasma Drug X (ug/mL) Concentrations Over Time by -Patient: PK Evaluable Patients -Program: -Output: - - diff --git a/package/tests/testthat/_snaps/graph-snaps/pkcg01-plot-v2.svg b/package/tests/testthat/_snaps/graph-snaps/pkcg01-plot-v2.svg deleted file mode 100644 index fdba8df35c..0000000000 --- a/package/tests/testthat/_snaps/graph-snaps/pkcg01-plot-v2.svg +++ /dev/null @@ -1,80 +0,0 @@ - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - -0.001 -0.01 -0.1 -1 -10 - - - - - - - - - - - -0 -5 -10 -15 -20 -25 -Norminal Time from First Dose (hr) -Concentration (ug/mL) - -Patient_ID - - - -1 -Analyte: Plasma Drug X (ug/mL) -Treatment Group: ARM A -Plot of Plasma Drug X (ug/mL) Concentrations Over Time by -Patient: PK Evaluable Patients -Program: -Output: - - diff --git a/package/tests/testthat/_snaps/graph-snaps/pkcg01-plot_v1.svg b/package/tests/testthat/_snaps/graph-snaps/pkcg01-plot_v1.svg new file mode 100644 index 0000000000..84ad9d8345 --- /dev/null +++ b/package/tests/testthat/_snaps/graph-snaps/pkcg01-plot_v1.svg @@ -0,0 +1,81 @@ + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + +0 +5 +10 +15 + + + + + + + + + + +0 +5 +10 +15 +20 +25 +Norminal Time from First Dose (hr) +Concentration (ug/mL) + +Patient_ID + + + +1 +Analyte: Plasma Drug X (ug/mL) +Treatment Group: ARM A +Plot of Plasma Drug X (ug/mL) Concentrations Over Time by +Patient: PK Evaluable Patients +Program: +Output: + + diff --git a/package/tests/testthat/_snaps/graph-snaps/pkcg01-plot_v2.svg b/package/tests/testthat/_snaps/graph-snaps/pkcg01-plot_v2.svg new file mode 100644 index 0000000000..65291e106e --- /dev/null +++ b/package/tests/testthat/_snaps/graph-snaps/pkcg01-plot_v2.svg @@ -0,0 +1,83 @@ + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + +0.001 +0.01 +0.1 +1 +10 + + + + + + + + + + + +0 +5 +10 +15 +20 +25 +Norminal Time from First Dose (hr) +Concentration (ug/mL) + +Patient_ID + + + +1 +Analyte: Plasma Drug X (ug/mL) +Treatment Group: ARM A +Plot of Plasma Drug X (ug/mL) Concentrations Over Time by +Patient: PK Evaluable Patients +Program: +Output: + + diff --git a/package/tests/testthat/_snaps/graph-snaps/pkcg02-plot-v1.svg b/package/tests/testthat/_snaps/graph-snaps/pkcg02-plot-v1.svg deleted file mode 100644 index 3035c4aaaf..0000000000 --- a/package/tests/testthat/_snaps/graph-snaps/pkcg02-plot-v1.svg +++ /dev/null @@ -1,213 +0,0 @@ - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - -0 -5 -10 -15 - - - - - - - - - - -0 -5 -10 -15 -20 -25 -Norminal Time from First Dose (hr) -Concentration (ug/mL) - -Patient_ID - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - -105 -134 -177 -217 -23 -345 -397 -42 -50 -93 -Analyte: Plasma X (ug/mL) -Treatment Group: ARM A -Plot of X Concentration (ug/mL) Over Time by Treatment: -PK Evaluable Patients -Program: -Output: - - diff --git a/package/tests/testthat/_snaps/graph-snaps/pkcg02-plot-v2.svg b/package/tests/testthat/_snaps/graph-snaps/pkcg02-plot-v2.svg deleted file mode 100644 index 3f51e3156e..0000000000 --- a/package/tests/testthat/_snaps/graph-snaps/pkcg02-plot-v2.svg +++ /dev/null @@ -1,215 +0,0 @@ - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - -0.001 -0.01 -0.1 -1 -10 - - - - - - - - - - - -0 -5 -10 -15 -20 -25 -Norminal Time from First Dose (hr) -Concentration (ug/mL) - -Patient_ID - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - -105 -134 -177 -217 -23 -345 -397 -42 -50 -93 -Analyte: Plasma X (ug/mL) -Treatment Group: ARM A -Log-scale Plot of X Concentration (ug/mL) Over Time by Treatment: -PK Evaluable Patients -Program: -Output: - - diff --git a/package/tests/testthat/_snaps/graph-snaps/pkcg02-plot_v1.svg b/package/tests/testthat/_snaps/graph-snaps/pkcg02-plot_v1.svg new file mode 100644 index 0000000000..766e3be2a0 --- /dev/null +++ b/package/tests/testthat/_snaps/graph-snaps/pkcg02-plot_v1.svg @@ -0,0 +1,216 @@ + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + +0 +5 +10 +15 + + + + + + + + + + +0 +5 +10 +15 +20 +25 +Norminal Time from First Dose (hr) +Concentration (ug/mL) + +Patient_ID + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + +105 +134 +177 +217 +23 +345 +397 +42 +50 +93 +Analyte: Plasma X (ug/mL) +Treatment Group: ARM A +Plot of X Concentration (ug/mL) Over Time by Treatment: +PK Evaluable Patients +Program: +Output: + + diff --git a/package/tests/testthat/_snaps/graph-snaps/pkcg02-plot_v2.svg b/package/tests/testthat/_snaps/graph-snaps/pkcg02-plot_v2.svg new file mode 100644 index 0000000000..39a7c07e54 --- /dev/null +++ b/package/tests/testthat/_snaps/graph-snaps/pkcg02-plot_v2.svg @@ -0,0 +1,218 @@ + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + +0.001 +0.01 +0.1 +1 +10 + + + + + + + + + + + +0 +5 +10 +15 +20 +25 +Norminal Time from First Dose (hr) +Concentration (ug/mL) + +Patient_ID + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + +105 +134 +177 +217 +23 +345 +397 +42 +50 +93 +Analyte: Plasma X (ug/mL) +Treatment Group: ARM A +Log-scale Plot of X Concentration (ug/mL) Over Time by Treatment: +PK Evaluable Patients +Program: +Output: + + diff --git a/package/tests/testthat/_snaps/graph-snaps/pkcg03-plot-v1.svg b/package/tests/testthat/_snaps/graph-snaps/pkcg03-plot-v1.svg deleted file mode 100644 index 61c8dd4aae..0000000000 --- a/package/tests/testthat/_snaps/graph-snaps/pkcg03-plot-v1.svg +++ /dev/null @@ -1,153 +0,0 @@ - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - -0 -5 -10 -15 - - - - - - - - - - -0 -5 -10 -15 -20 -25 -Nom. Rel. Time from Analyte First Dose -Concentration (ug/mL) - - - - - - - - - -A: Drug X (N = 134) -C: Combination (N = 132) -Analyte: Plasma Drug X (ug/mL) -Plot of Mean (+/- SD) Plasma Concentrations Over Time by Treatment, -PK Evaluable Patients -Program: -Output: - - diff --git a/package/tests/testthat/_snaps/graph-snaps/pkcg03-plot-v2.svg b/package/tests/testthat/_snaps/graph-snaps/pkcg03-plot-v2.svg deleted file mode 100644 index 25182c06e0..0000000000 --- a/package/tests/testthat/_snaps/graph-snaps/pkcg03-plot-v2.svg +++ /dev/null @@ -1,155 +0,0 @@ - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - -0.001 -0.01 -0.1 -1 -10 - - - - - - - - - - - -0 -5 -10 -15 -20 -25 -Nom. Rel. Time from Analyte First Dose -Concentration (ug/mL) - - - - - - - - - -A: Drug X (N = 134) -C: Combination (N = 132) -Analyte: Plasma Drug X (ug/mL) -Plot of Mean (+/- SD) Log-Scale Plasma Concentrations Over Time by Treatment, -PK Evaluable Patients -Program: -Output: - - diff --git a/package/tests/testthat/_snaps/graph-snaps/pkcg03-plot_v1.svg b/package/tests/testthat/_snaps/graph-snaps/pkcg03-plot_v1.svg new file mode 100644 index 0000000000..562219deb7 --- /dev/null +++ b/package/tests/testthat/_snaps/graph-snaps/pkcg03-plot_v1.svg @@ -0,0 +1,156 @@ + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + +0 +5 +10 +15 + + + + + + + + + + +0 +5 +10 +15 +20 +25 +Nom. Rel. Time from Analyte First Dose +Concentration (ug/mL) + + + + + + + + + +A: Drug X (N = 134) +C: Combination (N = 132) +Analyte: Plasma Drug X (ug/mL) +Plot of Mean (+/- SD) Plasma Concentrations Over Time by Treatment, +PK Evaluable Patients +Program: +Output: + + diff --git a/package/tests/testthat/_snaps/graph-snaps/pkcg03-plot_v2.svg b/package/tests/testthat/_snaps/graph-snaps/pkcg03-plot_v2.svg new file mode 100644 index 0000000000..9e466b057a --- /dev/null +++ b/package/tests/testthat/_snaps/graph-snaps/pkcg03-plot_v2.svg @@ -0,0 +1,158 @@ + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + +0.001 +0.01 +0.1 +1 +10 + + + + + + + + + + + +0 +5 +10 +15 +20 +25 +Nom. Rel. Time from Analyte First Dose +Concentration (ug/mL) + + + + + + + + + +A: Drug X (N = 134) +C: Combination (N = 132) +Analyte: Plasma Drug X (ug/mL) +Plot of Mean (+/- SD) Log-Scale Plasma Concentrations Over Time by Treatment, +PK Evaluable Patients +Program: +Output: + + diff --git a/package/tests/testthat/_snaps/graph-snaps/pkpg01-plot-v1.svg b/package/tests/testthat/_snaps/graph-snaps/pkpg01-plot-v1.svg deleted file mode 100644 index 067dd3b4ea..0000000000 --- a/package/tests/testthat/_snaps/graph-snaps/pkpg01-plot-v1.svg +++ /dev/null @@ -1,81 +0,0 @@ - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - -14 -16 -18 - - - - - -12 -24 -Time (hours) -Cummulative Percentage (%) - - - - - - - - - -A: Drug X (N = 134) -C: Combination (N = 132) -Analyte: Plasma Drug X -Visit: CYCLE 1 DAY 1 -PK Parameter: Fe (%) -Plot of Mean (+/- SD) Cummulative Percentage (%) of Recovered Drug in Urine -by Analyte, Visit: PK Evaluable Patients -Program: -Output: - - diff --git a/package/tests/testthat/_snaps/graph-snaps/pkpg01-plot-v2.svg b/package/tests/testthat/_snaps/graph-snaps/pkpg01-plot-v2.svg deleted file mode 100644 index 105821cfcf..0000000000 --- a/package/tests/testthat/_snaps/graph-snaps/pkpg01-plot-v2.svg +++ /dev/null @@ -1,159 +0,0 @@ - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - -12 -14 -16 -18 -20 - - - - - - - -12 -24 -Time (hours) -Cummulative Percentage (%) - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - -A: Drug X (N = 134) -C: Combination (N = 132) -D: Drug D (N = 173) -E: Drug E (N = 138) -F: Drug F (N = 104) -G: Drug G (N = 43) -Analyte: Plasma Drug X -Visit: CYCLE 1 DAY 1 -PK Parameter: Fe (%) -Plot of Mean (+/- SD) Cummulative Percentage (%) of Recovered Drug in Urine -by Analyte, Visit: PK Evaluable Patients -Program: -Output: - - diff --git a/package/tests/testthat/_snaps/graph-snaps/pkpg01-plot_v1.svg b/package/tests/testthat/_snaps/graph-snaps/pkpg01-plot_v1.svg new file mode 100644 index 0000000000..3b09c93e6c --- /dev/null +++ b/package/tests/testthat/_snaps/graph-snaps/pkpg01-plot_v1.svg @@ -0,0 +1,84 @@ + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + +14 +16 +18 + + + + + +12 +24 +Time (hours) +Cummulative Percentage (%) + + + + + + + + + +A: Drug X (N = 134) +C: Combination (N = 132) +Analyte: Plasma Drug X +Visit: CYCLE 1 DAY 1 +PK Parameter: Fe (%) +Plot of Mean (+/- SD) Cummulative Percentage (%) of Recovered Drug in Urine +by Analyte, Visit: PK Evaluable Patients +Program: +Output: + + diff --git a/package/tests/testthat/_snaps/graph-snaps/pkpg01-plot_v2.svg b/package/tests/testthat/_snaps/graph-snaps/pkpg01-plot_v2.svg new file mode 100644 index 0000000000..fc723d9833 --- /dev/null +++ b/package/tests/testthat/_snaps/graph-snaps/pkpg01-plot_v2.svg @@ -0,0 +1,162 @@ + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + +12 +14 +16 +18 +20 + + + + + + + +12 +24 +Time (hours) +Cummulative Percentage (%) + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + +A: Drug X (N = 134) +C: Combination (N = 132) +D: Drug D (N = 173) +E: Drug E (N = 138) +F: Drug F (N = 104) +G: Drug G (N = 43) +Analyte: Plasma Drug X +Visit: CYCLE 1 DAY 1 +PK Parameter: Fe (%) +Plot of Mean (+/- SD) Cummulative Percentage (%) of Recovered Drug in Urine +by Analyte, Visit: PK Evaluable Patients +Program: +Output: + + diff --git a/package/tests/testthat/_snaps/graph-snaps/pkpg02-plot-v1.svg b/package/tests/testthat/_snaps/graph-snaps/pkpg02-plot-v1.svg deleted file mode 100644 index cbdf41f0eb..0000000000 --- a/package/tests/testthat/_snaps/graph-snaps/pkpg02-plot-v1.svg +++ /dev/null @@ -1,875 +0,0 @@ - - - - - - - - - - - - - - - - - - - - -y = 5.34 - 0.01 x , R² = -0.00113 - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - -5 - - - - - - -720 -960 -1200 -480 -1440 -Dose (mg/mL) -AUCinf day*ug/mL - -Treatment Arm - - - - -A: Drug X (268) -C: Combination (528) -Summary of serum PK parameters by treatment -Dose-Proportionality Plot of Serum A: Drug X AUCinf in day*ug/mL - - diff --git a/package/tests/testthat/_snaps/graph-snaps/pkpg02-plot-v2.svg b/package/tests/testthat/_snaps/graph-snaps/pkpg02-plot-v2.svg deleted file mode 100644 index 09050ddd41..0000000000 --- a/package/tests/testthat/_snaps/graph-snaps/pkpg02-plot-v2.svg +++ /dev/null @@ -1,860 +0,0 @@ - - - - - - - - - - - - - - - - - - - - -y = 5.34 - 0.01 x , R² = -0.00113 - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - -5 - - - - - - -720 -960 -1200 -480 -1440 -Dose (mg/mL) -AUCinf day*ug/mL - -Treatment Arm - - - - -A: Drug X (268) -C: Combination (528) -Summary of serum PK parameters by treatment -Dose-Proportionality Plot of Serum A: Drug X AUCinf in day*ug/mL - - diff --git a/package/tests/testthat/_snaps/graph-snaps/pkpg02-plot_v1.svg b/package/tests/testthat/_snaps/graph-snaps/pkpg02-plot_v1.svg new file mode 100644 index 0000000000..81af1fdf96 --- /dev/null +++ b/package/tests/testthat/_snaps/graph-snaps/pkpg02-plot_v1.svg @@ -0,0 +1,878 @@ + + + + + + + + + + + + + + + + + + + + +y = 5.34 - 0.01 x , R² = -0.00113 + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + 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- - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - -id-53 -id-360 -id-10 -id-104 -id-78 -id-224 -id-324 -id-104 -id-140 -id-187 -id-195 -id-99 -id-378 -id-215 -id-245 -id-64 -id-363 -id-181 - - - -10 -20 -30 -40 -50 - - - - - - - - -SCREENING -CYCLE 1 DAY 1 -CYCLE 1 DAY 2 -Visit -Max Conc (ug/mL) - -ACTARM - - - - - - - - - -a - - - - - - - - - -a -A: Drug X -C: Combination -Analyte: -PK Parameter: Max Conc (ug/mL) -Boxplot of Max Conc by Visit -Program: -Output: - - diff --git a/package/tests/testthat/_snaps/graph-snaps/pkpg03-plot_v1.svg b/package/tests/testthat/_snaps/graph-snaps/pkpg03-plot_v1.svg new file mode 100644 index 0000000000..be5bb288a5 --- /dev/null +++ b/package/tests/testthat/_snaps/graph-snaps/pkpg03-plot_v1.svg @@ -0,0 +1,186 @@ + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + 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+ + + + + + + + + +AB12345-CHN-15-id-201 +AB12345-PAK-4-id-15 +AB12345-CHN-15-id-297 + + + +0.5 +1.0 +1.5 +2.0 + + + + + + +AUCIFO +CMAX +Parameter +Metabolite to Parent Ratio + +ACTARM + + + + + + + + + +C: Combination +Analyte: Plasma Drug Y, Metabolite Drug Y +PK Parameter: AUCIFO, CMAX +Visit: CYCLE 1 DAY 1 +Boxplot of Metabolite to Parent Ratios by Treatment +Program: +Output: + + diff --git a/package/tests/testthat/_snaps/graph-snaps/pkpg06-plot_v3.svg b/package/tests/testthat/_snaps/graph-snaps/pkpg06-plot_v3.svg new file mode 100644 index 0000000000..1784d791a0 --- /dev/null +++ b/package/tests/testthat/_snaps/graph-snaps/pkpg06-plot_v3.svg @@ -0,0 +1,131 @@ + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + +1 +2 + + + + +AUCIFO +CMAX +Parameter +Metabolite to Parent Ratio + +ACTARM + + + + + + + + + + + + + + + + + + +A: Drug X +C: Combination +Analyte: Plasma Drug X, Metabolite Drug X +PK Parameter: AUCIFO, CMAX +Visit: CYCLE 1 DAY 1 +Boxplot of Metabolite to Parent Ratios by Treatment +Program: +Output: + + diff --git a/package/tests/testthat/_snaps/graph-snaps/pkpg06-plot_v4.svg b/package/tests/testthat/_snaps/graph-snaps/pkpg06-plot_v4.svg new file mode 100644 index 0000000000..17087e68de --- /dev/null +++ b/package/tests/testthat/_snaps/graph-snaps/pkpg06-plot_v4.svg @@ -0,0 +1,230 @@ + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + +AB12345-PAK-11-id-268 +AB12345-CHN-11-id-263 +AB12345-CHN-14-id-1 +AB12345-CHN-5-id-160 +AB12345-CHN-4-id-114 +AB12345-PAK-12-id-328 +AB12345-CHN-15-id-297 +AB12345-CHN-11-id-392 +AB12345-CHN-5-id-83 +AB12345-JPN-1-id-7 +AB12345-CHN-14-id-228 +AB12345-BRA-14-id-23 +AB12345-JPN-1-id-225 +AB12345-PAK-11-id-49 +AB12345-CHN-3-id-303 +AB12345-CHN-11-id-256 +AB12345-CHN-14-id-375 +AB12345-NGA-1-id-46 +AB12345-CHN-1-id-181 +AB12345-BRA-1-id-93 +AB12345-CHN-1-id-389 +AB12345-RUS-11-id-283 +AB12345-NGA-11-id-41 +AB12345-CHN-14-id-143 +AB12345-BRA-14-id-120 +AB12345-JPN-5-id-252 +AB12345-CHN-1-id-25 +AB12345-RUS-6-id-77 +AB12345-CHN-15-id-262 +AB12345-RUS-1-id-52 +AB12345-BRA-11-id-50 +AB12345-CAN-14-id-104 +AB12345-USA-3-id-320 +AB12345-PAK-12-id-328 +AB12345-CHN-15-id-297 +AB12345-BRA-11-id-217 +AB12345-CHN-12-id-57 +AB12345-CHN-15-id-399 +AB12345-PAK-11-id-49 +AB12345-CHN-11-id-192 +AB12345-CHN-11-id-377 +AB12345-CHN-1-id-279 +AB12345-CHN-12-id-255 +AB12345-USA-12-id-140 +AB12345-CHN-11-id-2 +AB12345-RUS-11-id-283 +AB12345-PAK-12-id-85 +AB12345-CHN-1-id-25 +AB12345-PAK-1-id-125 +AB12345-CHN-11-id-349 +AB12345-USA-11-id-224 +AB12345-CHN-17-id-10 +AB12345-CHN-1-id-71 +AB12345-JPN-6-id-260 +AB12345-CHN-11-id-113 +AB12345-CHN-1-id-277 + + + +1 +2 + + + + +AUCIFO +CMAX +Parameter +Metabolite to Parent Ratio + +ACTARM + + + + + + + + + + + + + + + + + + +A: Drug X +C: Combination +Analyte: Plasma Drug X, Metabolite Drug X +PK Parameter: AUCIFO, CMAX +Visit: CYCLE 1 DAY 1 +Boxplot of Metabolite to Parent Ratios by Treatment +Program: +Output: + + From 0918e694d8c380f619b66f633423ee2c56dd01d2 Mon Sep 17 00:00:00 2001 From: github-actions <41898282+github-actions[bot]@users.noreply.github.com> Date: Thu, 14 Dec 2023 22:48:51 +0000 Subject: [PATCH 06/10] [skip actions] Restyle files --- package/tests/testthat/test-graph-snaps.R | 14 ++++++++------ 1 file changed, 8 insertions(+), 6 deletions(-) diff --git a/package/tests/testthat/test-graph-snaps.R b/package/tests/testthat/test-graph-snaps.R index 694f474167..087dcba8e2 100644 --- a/package/tests/testthat/test-graph-snaps.R +++ b/package/tests/testthat/test-graph-snaps.R @@ -50,12 +50,14 @@ for (snapshot_variant in intersect(snapshot_variants, rds_variants)) { variant = snapshot_variant ) } else { - plot_dims <- sapply(c("width", "height"), function(x) if (paste0(i, ".", x) %in% names(data_snap)) { - data_snap[[paste0(i, ".", x)]] - } else if (x %in% names(data_snap)) { - data_snap[[x]] - } else { - if (x == "width") 7 else 5 + plot_dims <- sapply(c("width", "height"), function(x) { + if (paste0(i, ".", x) %in% names(data_snap)) { + data_snap[[paste0(i, ".", x)]] + } else if (x %in% names(data_snap)) { + data_snap[[x]] + } else { + if (x == "width") 7 else 5 + } }) # Some plot objects have multiple plots in them and stored as unnamed list of plots if (inherits(data_snap[[i]], "list")) { From da6d1e8cb29d4587032dd5f914d33f7928155945 Mon Sep 17 00:00:00 2001 From: Emily de la Rua Date: Thu, 14 Dec 2023 17:50:30 -0500 Subject: [PATCH 07/10] Empty commit From f3dc73c15b81b0dfb32d41fb7c0d78f90c0f97c8 Mon Sep 17 00:00:00 2001 From: Emily de la Rua Date: Fri, 15 Dec 2023 10:31:03 -0500 Subject: [PATCH 08/10] Add svglite to Suggests --- package/DESCRIPTION | 1 + 1 file changed, 1 insertion(+) diff --git a/package/DESCRIPTION b/package/DESCRIPTION index 58b9c6ff89..2710d3cecc 100644 --- a/package/DESCRIPTION +++ b/package/DESCRIPTION @@ -32,6 +32,7 @@ Suggests: scda.2022 (>= 0.1.5), stats, stringr, + svglite (>= 2.1.2), teal (>= 0.14.0.9027), teal.modules.clinical (>= 0.8.16.9019), teal.modules.general (>= 0.2.16.9014), From b4e33ecd29caf67eb030cc86b1c123fea9856426 Mon Sep 17 00:00:00 2001 From: Emily de la Rua Date: Fri, 15 Dec 2023 14:25:24 -0500 Subject: [PATCH 09/10] Update tern version - refresh checks once tern#1158 is merged --- package/DESCRIPTION | 2 +- 1 file changed, 1 insertion(+), 1 deletion(-) diff --git a/package/DESCRIPTION b/package/DESCRIPTION index 2710d3cecc..5963d03466 100644 --- a/package/DESCRIPTION +++ b/package/DESCRIPTION @@ -36,7 +36,7 @@ Suggests: teal (>= 0.14.0.9027), teal.modules.clinical (>= 0.8.16.9019), teal.modules.general (>= 0.2.16.9014), - tern (>= 0.9.3), + tern (>= 0.9.3.9002), tern.mmrm (>= 0.2.2), tern.rbmi, tibble, From a65ee1211cda1d9a4f11116fc5910040514875f5 Mon Sep 17 00:00:00 2001 From: Emily de la Rua Date: Fri, 15 Dec 2023 14:31:48 -0500 Subject: [PATCH 10/10] Add comments --- package/tests/testthat/test-graph-snaps.R | 10 +++++----- 1 file changed, 5 insertions(+), 5 deletions(-) diff --git a/package/tests/testthat/test-graph-snaps.R b/package/tests/testthat/test-graph-snaps.R index 087dcba8e2..068443f590 100644 --- a/package/tests/testthat/test-graph-snaps.R +++ b/package/tests/testthat/test-graph-snaps.R @@ -44,19 +44,19 @@ for (snapshot_variant in intersect(snapshot_variants, rds_variants)) { data_snap <- readRDS(path) plot_nms <- grep("width|height", names(data_snap), value = TRUE, invert = TRUE) for (i in plot_nms) { - if (grepl("table", i)) { + if (grepl("table", i)) { # process tables within graph templates testthat::expect_snapshot( print(data_snap[[i]]), variant = snapshot_variant ) } else { - plot_dims <- sapply(c("width", "height"), function(x) { + plot_dims <- sapply(c("width", "height"), function(x) { # check for plotting area dimensions if (paste0(i, ".", x) %in% names(data_snap)) { - data_snap[[paste0(i, ".", x)]] + data_snap[[paste0(i, ".", x)]] # variant-specific dimensions } else if (x %in% names(data_snap)) { - data_snap[[x]] + data_snap[[x]] # template-specific default dimensions } else { - if (x == "width") 7 else 5 + if (x == "width") 7 else 5 # ggplot2 default dimensions } }) # Some plot objects have multiple plots in them and stored as unnamed list of plots