diff --git a/plugins/outputs/application_insights/README.md b/plugins/outputs/application_insights/README.md
index c64e844885565..34017a89f0bab 100644
--- a/plugins/outputs/application_insights/README.md
+++ b/plugins/outputs/application_insights/README.md
@@ -7,6 +7,9 @@ This plugin writes telegraf metrics to [Azure Application Insights](https://azur
 [[outputs.application_insights]]
   ## Instrumentation key of the Application Insights resource.
   instrumentation_key = "xxxxxxxx-xxxx-xxxx-xxxx-xxxxxxxx"
+  
+  ## Regions that require endpoint modification https://docs.microsoft.com/en-us/azure/azure-monitor/app/custom-endpoints
+  # endpoint_url = "https://dc.services.visualstudio.com/v2/track"
 
   ## Timeout for closing (default: 5s).
   # timeout = "5s"
diff --git a/plugins/outputs/application_insights/application_insights.go b/plugins/outputs/application_insights/application_insights.go
index 3da4202187126..3ab16af6fc313 100644
--- a/plugins/outputs/application_insights/application_insights.go
+++ b/plugins/outputs/application_insights/application_insights.go
@@ -24,6 +24,7 @@ type DiagnosticsMessageSubscriber interface {
 
 type ApplicationInsights struct {
 	InstrumentationKey      string
+	EndpointURL             string
 	Timeout                 internal.Duration
 	EnableDiagnosticLogging bool
 	ContextTagSources       map[string]string
@@ -43,6 +44,9 @@ var (
 	sampleConfig = `
   ## Instrumentation key of the Application Insights resource.
   instrumentation_key = "xxxxxxxx-xxxx-xxxx-xxxx-xxxxxxxx"
+  
+  ## Regions that require endpoint modification https://docs.microsoft.com/en-us/azure/azure-monitor/app/custom-endpoints
+  # endpoint_url = "https://dc.services.visualstudio.com/v2/track"
 
   ## Timeout for closing (default: 5s).
   # timeout = "5s"
@@ -76,7 +80,7 @@ func (a *ApplicationInsights) Connect() error {
 	}
 
 	if a.transmitter == nil {
-		a.transmitter = NewTransmitter(a.InstrumentationKey)
+		a.transmitter = NewTransmitter(a.InstrumentationKey, a.EndpointURL)
 	}
 
 	if a.EnableDiagnosticLogging && a.diagMsgSubscriber != nil {
diff --git a/plugins/outputs/application_insights/transmitter.go b/plugins/outputs/application_insights/transmitter.go
index 44bc1b80626b5..024ea32809fb0 100644
--- a/plugins/outputs/application_insights/transmitter.go
+++ b/plugins/outputs/application_insights/transmitter.go
@@ -1,13 +1,21 @@
 package application_insights
 
-import "github.com/Microsoft/ApplicationInsights-Go/appinsights"
+import (
+	"github.com/Microsoft/ApplicationInsights-Go/appinsights"
+)
 
 type Transmitter struct {
 	client appinsights.TelemetryClient
 }
 
-func NewTransmitter(ikey string) *Transmitter {
-	return &Transmitter{client: appinsights.NewTelemetryClient(ikey)}
+func NewTransmitter(ikey string, endpointURL string) *Transmitter {
+	if len(endpointURL) == 0 {
+		return &Transmitter{client: appinsights.NewTelemetryClient(ikey)}
+	} else {
+		telemetryConfig := appinsights.NewTelemetryConfiguration(ikey)
+		telemetryConfig.EndpointUrl = endpointURL
+		return &Transmitter{client: appinsights.NewTelemetryClientFromConfig(telemetryConfig)}
+	}
 }
 
 func (t *Transmitter) Track(telemetry appinsights.Telemetry) {