diff --git a/.changeset/witty-dolls-raise.md b/.changeset/witty-dolls-raise.md
new file mode 100644
index 00000000..ea0ae78d
--- /dev/null
+++ b/.changeset/witty-dolls-raise.md
@@ -0,0 +1,5 @@
+---
+'@hono/zod-openapi': minor
+---
+
+Add defaultHook as an option for OpenAPIHono
diff --git a/packages/zod-openapi/README.md b/packages/zod-openapi/README.md
index 1968240e..b0223b12 100644
--- a/packages/zod-openapi/README.md
+++ b/packages/zod-openapi/README.md
@@ -174,6 +174,57 @@ app.openapi(
 )
 ```
 
+### A DRY approach to handling validation errors
+
+In the case that you have a common error formatter, you can initialize the `OpenAPIHono` instance with a `defaultHook`.
+
+```ts
+const app = new OpenAPIHono({
+  defaultHook: (result, c) => {
+    if (!result.success) {
+      return c.jsonT(
+        {
+          ok: false,
+          errors: formatZodErrors(result),
+          source: 'custom_error_handler',
+        },
+        422
+      )
+    }
+  },
+})
+```
+
+You can still override the `defaultHook` by providing the hook at the call site when appropriate.
+
+```ts
+// uses the defaultHook
+app.openapi(createPostRoute, (c) => {
+  const { title } = c.req.valid('json')
+  return c.jsonT({ title })
+})
+
+// override the defaultHook by passing in a hook
+app.openapi(
+  createBookRoute,
+  (c) => {
+    const { title } = c.req.valid('json')
+    return c.jsonT({ title })
+  },
+  (result, c) => {
+    if (!result.success) {
+      return c.jsonT(
+        {
+          ok: false,
+          source: 'routeHook' as const,
+        },
+        400
+      )
+    }
+  }
+)
+```
+
 ### OpenAPI v3.1
 
 You can generate OpenAPI v3.1 spec using the following methods:
@@ -211,7 +262,7 @@ You can configure middleware for each endpoint from a route created by `createRo
 import { prettyJSON } from 'hono/pretty-json'
 import { cache } from 'honoc/cache'
 
-app.use(route.getRoutingPath(), prettyJSON(), cache({ cacheName: "my-cache" }))
+app.use(route.getRoutingPath(), prettyJSON(), cache({ cacheName: 'my-cache' }))
 app.openapi(route, handler)
 ```
 
diff --git a/packages/zod-openapi/src/index.ts b/packages/zod-openapi/src/index.ts
index 063ab46f..4c7f1a12 100644
--- a/packages/zod-openapi/src/index.ts
+++ b/packages/zod-openapi/src/index.ts
@@ -151,7 +151,10 @@ type ConvertPathType<T extends string> = T extends `${infer _}/{${infer Param}}$
 
 type HandlerResponse<O> = TypedResponse<O> | Promise<TypedResponse<O>>
 
-type HonoInit = ConstructorParameters<typeof Hono>[0]
+export type OpenAPIHonoOptions<E extends Env> = {
+  defaultHook?: Hook<any, E, any, any>
+}
+type HonoInit<E extends Env> = ConstructorParameters<typeof Hono>[0] & OpenAPIHonoOptions<E>
 
 export type RouteHandler<
   R extends RouteConfig,
@@ -183,10 +186,12 @@ export class OpenAPIHono<
   BasePath extends string = '/'
 > extends Hono<E, S, BasePath> {
   openAPIRegistry: OpenAPIRegistry
+  defaultHook?: OpenAPIHonoOptions<E>['defaultHook']
 
-  constructor(init?: HonoInit) {
+  constructor(init?: HonoInit<E>) {
     super(init)
     this.openAPIRegistry = new OpenAPIRegistry()
+    this.defaultHook = init?.defaultHook
   }
 
   openapi = <
@@ -201,7 +206,7 @@ export class OpenAPIHono<
   >(
     route: R,
     handler: Handler<E, P, I, HandlerResponse<OutputType<R>>>,
-    hook?: Hook<I, E, P, OutputType<R>>
+    hook: Hook<I, E, P, OutputType<R>> | undefined = this.defaultHook
   ): OpenAPIHono<E, S & ToSchema<R['method'], P, I['in'], OutputType<R>>, BasePath> => {
     this.openAPIRegistry.registerPath(route)
 
diff --git a/packages/zod-openapi/test/index.test.ts b/packages/zod-openapi/test/index.test.ts
index b9ec374b..65c0fa78 100644
--- a/packages/zod-openapi/test/index.test.ts
+++ b/packages/zod-openapi/test/index.test.ts
@@ -1,6 +1,7 @@
 /* eslint-disable node/no-extraneous-import */
 /* eslint-disable @typescript-eslint/no-explicit-any */
-import type { Hono, Env, ToSchema } from 'hono'
+import type { RouteConfig } from '@asteasolutions/zod-to-openapi'
+import type { Hono, Env, ToSchema, Context } from 'hono'
 import { hc } from 'hono/client'
 import { describe, it, expect, expectTypeOf } from 'vitest'
 import { OpenAPIHono, createRoute, z } from '../src'
@@ -15,6 +16,17 @@ describe('Constructor', () => {
     const app = new OpenAPIHono({ getPath })
     expect(app.getPath).toBe(getPath)
   })
+
+  it('Should accept a defaultHook', () => {
+    type FakeEnv = { Variables: { fake: string }; Bindings: { other: number } }
+    const app = new OpenAPIHono<FakeEnv>({
+      defaultHook: (result, c) => {
+        // Make sure we're passing context types through
+        expectTypeOf(c).toMatchTypeOf<Context<FakeEnv, any, any>>()
+      },
+    })
+    expect(app.defaultHook).toBeDefined()
+  })
 })
 
 describe('Basic - params', () => {
@@ -757,4 +769,143 @@ describe('With hc', () => {
       expect(client.books.$url().pathname).toBe('/books')
     })
   })
+
+  describe('defaultHook', () => {
+    const app = new OpenAPIHono({
+      defaultHook: (result, c) => {
+        if (!result.success) {
+          const res = c.jsonT(
+            {
+              ok: false,
+              source: 'defaultHook',
+            },
+            400
+          )
+          return res
+        }
+      },
+    })
+
+    const TitleSchema = z.object({
+      title: z.string().openapi({}),
+    })
+
+    function errorResponse() {
+      return {
+        400: {
+          content: {
+            'application/json': {
+              schema: z.object({
+                ok: z.boolean().openapi({}),
+                source: z.enum(['routeHook', 'defaultHook']).openapi({}),
+              }),
+            },
+          },
+          description: 'A validation error',
+        },
+      } satisfies RouteConfig['responses']
+    }
+
+    const createPostRoute = createRoute({
+      method: 'post',
+      path: '/posts',
+      operationId: 'createPost',
+      request: {
+        body: {
+          content: {
+            'application/json': {
+              schema: TitleSchema,
+            },
+          },
+        },
+      },
+      responses: {
+        200: {
+          content: {
+            'application/json': {
+              schema: TitleSchema,
+            },
+          },
+          description: 'A post',
+        },
+        ...errorResponse(),
+      },
+    })
+    const createBookRoute = createRoute({
+      method: 'post',
+      path: '/books',
+      operationId: 'createBook',
+      request: {
+        body: {
+          content: {
+            'application/json': {
+              schema: TitleSchema,
+            },
+          },
+        },
+      },
+      responses: {
+        200: {
+          content: {
+            'application/json': {
+              schema: TitleSchema,
+            },
+          },
+          description: 'A book',
+        },
+        ...errorResponse(),
+      },
+    })
+
+    // use the defaultHook
+    app.openapi(createPostRoute, (c) => {
+      const { title } = c.req.valid('json')
+      return c.jsonT({ title })
+    })
+
+    // use a routeHook
+    app.openapi(
+      createBookRoute,
+      (c) => {
+        const { title } = c.req.valid('json')
+        return c.jsonT({ title })
+      },
+      (result, c) => {
+        if (!result.success) {
+          const res = c.jsonT(
+            {
+              ok: false,
+              source: 'routeHook' as const,
+            },
+            400
+          )
+          return res
+        }
+      }
+    )
+
+    it('uses the defaultHook', async () => {
+      const res = await app.request('/posts', {
+        method: 'POST',
+        body: JSON.stringify({ bad: 'property' }),
+      })
+      expect(res.status).toBe(400)
+      expect(await res.json()).toEqual({
+        ok: false,
+        source: 'defaultHook',
+      })
+    })
+
+    it('it uses the route hook instead of the defaultHook', async () => {
+      const res = await app.request('/books', {
+        method: 'POST',
+        body: JSON.stringify({ bad: 'property' }),
+      })
+      expect(res.status).toBe(400)
+      expect(await res.json()).toEqual({
+        ok: false,
+        source: 'routeHook',
+      })
+    })
+  })
 })