diff --git a/pkg/ccl/backupccl/testdata/backup-restore/multiregion b/pkg/ccl/backupccl/testdata/backup-restore/multiregion
index 94435ec36be2..934e3b93cd58 100644
--- a/pkg/ccl/backupccl/testdata/backup-restore/multiregion
+++ b/pkg/ccl/backupccl/testdata/backup-restore/multiregion
@@ -69,10 +69,24 @@ exec-sql
 RESTORE FROM LATEST IN 'nodelocal://1/full_cluster_backup/' WITH skip_localities_check;
 ----
 
+exec-sql
+ALTER DATABASE d SET PRIMARY REGION 'eu-central-1';
+ALTER DATABASE d DROP REGION 'us-east-1';
+ALTER DATABASE d DROP REGION 'us-west-1';
+ALTER DATABASE d ADD REGION 'eu-north-1';
+----
+
 exec-sql
 RESTORE DATABASE d FROM LATEST IN 'nodelocal://1/database_backup/' WITH skip_localities_check, new_db_name='d_new';
 ----
 
+exec-sql
+ALTER DATABASE d_new SET PRIMARY REGION 'eu-central-1';
+ALTER DATABASE d_new DROP REGION 'us-east-1';
+ALTER DATABASE d_new DROP REGION 'us-west-1';
+ALTER DATABASE d_new ADD REGION 'eu-north-1';
+----
+
 exec-sql
 DROP DATABASE d_new;
 ----
diff --git a/pkg/sql/alter_database.go b/pkg/sql/alter_database.go
index 99772b5d12d2..bcaf0e29ac22 100644
--- a/pkg/sql/alter_database.go
+++ b/pkg/sql/alter_database.go
@@ -897,6 +897,10 @@ func (n *alterDatabasePrimaryRegionNode) switchPrimaryRegion(params runParams) e
 		return err
 	}
 
+	// Validate the final zone config at the end of the transaction, since
+	// we will not be validating localities right now.
+	*params.extendedEvalCtx.validateDbZoneConfig = true
+
 	// Update the database's zone configuration.
 	if err := ApplyZoneConfigFromDatabaseRegionConfig(
 		params.ctx,
@@ -904,7 +908,7 @@ func (n *alterDatabasePrimaryRegionNode) switchPrimaryRegion(params runParams) e
 		updatedRegionConfig,
 		params.p.InternalSQLTxn(),
 		params.p.execCfg,
-		true, /* validateLocalities */
+		false, /*validateLocalities*/
 		params.extendedEvalCtx.Tracing.KVTracingEnabled(),
 	); err != nil {
 		return err
@@ -2021,6 +2025,8 @@ func (n *alterDatabaseSecondaryRegion) startExec(params runParams) error {
 		return err
 	}
 
+	*params.extendedEvalCtx.validateDbZoneConfig = true
+
 	// Update the database's zone configuration.
 	if err := ApplyZoneConfigFromDatabaseRegionConfig(
 		params.ctx,
diff --git a/pkg/sql/catalog/descs/collection.go b/pkg/sql/catalog/descs/collection.go
index 3f4af2020898..c9177928653c 100644
--- a/pkg/sql/catalog/descs/collection.go
+++ b/pkg/sql/catalog/descs/collection.go
@@ -702,6 +702,18 @@ func (tc *Collection) GetUncommittedTables() (tables []catalog.TableDescriptor)
 	return tables
 }
 
+// GetUncommittedDatabases returns all the databases updated or created in the
+// transaction.
+func (tc *Collection) GetUncommittedDatabases() (databases []catalog.DatabaseDescriptor) {
+	_ = tc.uncommitted.iterateUncommittedByID(func(desc catalog.Descriptor) error {
+		if database, ok := desc.(catalog.DatabaseDescriptor); ok {
+			databases = append(databases, database)
+		}
+		return nil
+	})
+	return databases
+}
+
 func newMutableSyntheticDescriptorAssertionError(id descpb.ID) error {
 	return errors.AssertionFailedf("attempted mutable access of synthetic descriptor %d", id)
 }
diff --git a/pkg/sql/conn_executor.go b/pkg/sql/conn_executor.go
index b54ed4fde584..568c9a7475e1 100644
--- a/pkg/sql/conn_executor.go
+++ b/pkg/sql/conn_executor.go
@@ -1357,6 +1357,9 @@ type connExecutor struct {
 		// comprising statements.
 		numRows int
 
+		// validateDbZoneConfig should the DB zone config on commit.
+		validateDbZoneConfig bool
+
 		// txnCounter keeps track of how many SQL txns have been open since
 		// the start of the session. This is used for logging, to
 		// distinguish statements that belong to separate SQL transactions.
@@ -1914,6 +1917,7 @@ func (ex *connExecutor) resetExtraTxnState(ctx context.Context, ev txnEvent) {
 	} else {
 		ex.extraTxnState.descCollection.ReleaseAll(ctx)
 		ex.extraTxnState.jobs.reset()
+		ex.extraTxnState.validateDbZoneConfig = false
 		ex.extraTxnState.schemaChangerState.memAcc.Clear(ctx)
 		ex.extraTxnState.schemaChangerState = &SchemaChangerState{
 			mode:   ex.sessionData().NewSchemaChangerMode,
@@ -3403,14 +3407,15 @@ func (ex *connExecutor) initEvalCtx(ctx context.Context, evalCtx *extendedEvalCo
 			RangeStatsFetcher:              p.execCfg.RangeStatsFetcher,
 			JobsProfiler:                   p,
 		},
-		Tracing:           &ex.sessionTracing,
-		MemMetrics:        &ex.memMetrics,
-		Descs:             ex.extraTxnState.descCollection,
-		TxnModesSetter:    ex,
-		jobs:              ex.extraTxnState.jobs,
-		statsProvider:     ex.server.sqlStats,
-		indexUsageStats:   ex.indexUsageStats,
-		statementPreparer: ex,
+		Tracing:              &ex.sessionTracing,
+		MemMetrics:           &ex.memMetrics,
+		Descs:                ex.extraTxnState.descCollection,
+		TxnModesSetter:       ex,
+		jobs:                 ex.extraTxnState.jobs,
+		validateDbZoneConfig: &ex.extraTxnState.validateDbZoneConfig,
+		statsProvider:        ex.server.sqlStats,
+		indexUsageStats:      ex.indexUsageStats,
+		statementPreparer:    ex,
 	}
 	evalCtx.copyFromExecCfg(ex.server.cfg)
 }
diff --git a/pkg/sql/conn_executor_exec.go b/pkg/sql/conn_executor_exec.go
index 32968afd3105..4f94edf900dc 100644
--- a/pkg/sql/conn_executor_exec.go
+++ b/pkg/sql/conn_executor_exec.go
@@ -1311,6 +1311,10 @@ func (ex *connExecutor) commitSQLTransactionInternal(ctx context.Context) error
 		ex.state.mu.txn.ConfigureStepping(ctx, prevSteppingMode)
 	}
 
+	if err := ex.validateDbZoneConfigs(ctx); err != nil {
+		return err
+	}
+
 	if err := ex.createJobs(ctx); err != nil {
 		return err
 	}
@@ -1356,6 +1360,33 @@ func (ex *connExecutor) commitSQLTransactionInternal(ctx context.Context) error
 	return nil
 }
 
+// validateDbZoneConfigs validates zone configs for any modified databases.
+func (ex *connExecutor) validateDbZoneConfigs(ctx context.Context) error {
+	// If no DDL was executed requiring pre-commit validation,
+	// then nothing to do.
+	if !ex.extraTxnState.validateDbZoneConfig {
+		return nil
+	}
+	for _, db := range ex.extraTxnState.descCollection.GetUncommittedDatabases() {
+		regionConfig, err := SynthesizeRegionConfig(
+			ctx, ex.planner.txn, db.GetID(), ex.planner.Descriptors(),
+		)
+		if err != nil {
+			return err
+		}
+		_, err = generateAndValidateZoneConfigForMultiRegionDatabase(ctx,
+			ex.planner.regionsProvider(),
+			ex.planner.execCfg,
+			regionConfig,
+			true, /*validateLocalities*/
+		)
+		if err != nil {
+			return err
+		}
+	}
+	return nil
+}
+
 // createJobs creates jobs for the records cached in schemaChangeJobRecords
 // during this transaction.
 func (ex *connExecutor) createJobs(ctx context.Context) error {
diff --git a/pkg/sql/planner.go b/pkg/sql/planner.go
index b19dec4c4511..1f771cd7c498 100644
--- a/pkg/sql/planner.go
+++ b/pkg/sql/planner.go
@@ -109,6 +109,9 @@ type extendedEvalContext struct {
 	SchemaChangerState *SchemaChangerState
 
 	statementPreparer statementPreparer
+
+	// validateDbZoneConfig should the DB zone config on commit.
+	validateDbZoneConfig *bool
 }
 
 // copyFromExecCfg copies relevant fields from an ExecutorConfig.