diff --git a/packages/react-dom-bindings/src/server/ReactDOMLegacyServerStreamConfig.js b/packages/react-dom-bindings/src/server/ReactDOMLegacyServerStreamConfig.js
index d1b68be1b350e..ed7e32f65d5c6 100644
--- a/packages/react-dom-bindings/src/server/ReactDOMLegacyServerStreamConfig.js
+++ b/packages/react-dom-bindings/src/server/ReactDOMLegacyServerStreamConfig.js
@@ -54,6 +54,12 @@ export function stringToPrecomputedChunk(content: string): PrecomputedChunk {
   return content;
 }
 
+export function clonePrecomputedChunk(
+  chunk: PrecomputedChunk,
+): PrecomputedChunk {
+  return chunk;
+}
+
 export function closeWithError(destination: Destination, error: mixed): void {
   // $FlowFixMe: This is an Error object or the destination accepts other types.
   destination.destroy(error);
diff --git a/packages/react-dom-bindings/src/server/ReactDOMServerFormatConfig.js b/packages/react-dom-bindings/src/server/ReactDOMServerFormatConfig.js
index b6a5727314cbe..91d241e4e7929 100644
--- a/packages/react-dom-bindings/src/server/ReactDOMServerFormatConfig.js
+++ b/packages/react-dom-bindings/src/server/ReactDOMServerFormatConfig.js
@@ -37,6 +37,7 @@ import {
   writeChunkAndReturn,
   stringToChunk,
   stringToPrecomputedChunk,
+  clonePrecomputedChunk,
 } from 'react-server/src/ReactServerStreamConfig';
 
 import {
@@ -2443,7 +2444,10 @@ export function writeCompletedBoundaryInstruction(
     if (!responseState.sentCompleteBoundaryFunction) {
       responseState.sentCompleteBoundaryFunction = true;
       responseState.sentStyleInsertionFunction = true;
-      writeChunk(destination, completeBoundaryWithStylesScript1FullBoth);
+      writeChunk(
+        destination,
+        clonePrecomputedChunk(completeBoundaryWithStylesScript1FullBoth),
+      );
     } else if (!responseState.sentStyleInsertionFunction) {
       responseState.sentStyleInsertionFunction = true;
       writeChunk(destination, completeBoundaryWithStylesScript1FullPartial);
diff --git a/packages/react-noop-renderer/src/ReactNoopFlightServer.js b/packages/react-noop-renderer/src/ReactNoopFlightServer.js
index 522620c6f5a50..586512bc963f4 100644
--- a/packages/react-noop-renderer/src/ReactNoopFlightServer.js
+++ b/packages/react-noop-renderer/src/ReactNoopFlightServer.js
@@ -45,6 +45,9 @@ const ReactNoopFlightServer = ReactFlightServer({
   stringToPrecomputedChunk(content: string): string {
     return content;
   },
+  clonePrecomputedChunk(chunk: string): string {
+    return chunk;
+  },
   isModuleReference(reference: Object): boolean {
     return reference.$$typeof === Symbol.for('react.module.reference');
   },
diff --git a/packages/react-server-dom-relay/src/ReactServerStreamConfigFB.js b/packages/react-server-dom-relay/src/ReactServerStreamConfigFB.js
index a1874ce362386..bc5e97680018a 100644
--- a/packages/react-server-dom-relay/src/ReactServerStreamConfigFB.js
+++ b/packages/react-server-dom-relay/src/ReactServerStreamConfigFB.js
@@ -59,6 +59,12 @@ export function stringToPrecomputedChunk(content: string): PrecomputedChunk {
   return content;
 }
 
+export function clonePrecomputedChunk(
+  chunk: PrecomputedChunk,
+): PrecomputedChunk {
+  return chunk;
+}
+
 export function closeWithError(destination: Destination, error: mixed): void {
   destination.done = true;
   destination.fatal = true;
diff --git a/packages/react-server/src/ReactServerStreamConfigBrowser.js b/packages/react-server/src/ReactServerStreamConfigBrowser.js
index 082e0edbaf46c..2d9346efe54db 100644
--- a/packages/react-server/src/ReactServerStreamConfigBrowser.js
+++ b/packages/react-server/src/ReactServerStreamConfigBrowser.js
@@ -46,6 +46,15 @@ export function writeChunk(
   }
 
   if (chunk.length > VIEW_SIZE) {
+    if (__DEV__) {
+      if (precomputedChunkSet.has(chunk)) {
+        console.error(
+          'A large precomputed chunk was passed to writeChunk without being copied.' +
+            ' Large chunks get enqueued directly and are not copied. This is incompatible with precomputed chunks because you cannot enqueue the same precomputed chunk twice.' +
+            ' Use "cloneChunk" to make a copy of this large precomputed chunk before writing it. This is a bug in React.',
+        );
+      }
+    }
     // this chunk may overflow a single view which implies it was not
     // one that is cached by the streaming renderer. We will enqueu
     // it directly and expect it is not re-used
@@ -117,8 +126,24 @@ export function stringToChunk(content: string): Chunk {
   return textEncoder.encode(content);
 }
 
+const precomputedChunkSet: Set<Chunk> = __DEV__ ? new Set() : (null: any);
+
 export function stringToPrecomputedChunk(content: string): PrecomputedChunk {
-  return textEncoder.encode(content);
+  const precomputedChunk = textEncoder.encode(content);
+
+  if (__DEV__) {
+    precomputedChunkSet.add(precomputedChunk);
+  }
+
+  return precomputedChunk;
+}
+
+export function clonePrecomputedChunk(
+  precomputedChunk: PrecomputedChunk,
+): PrecomputedChunk {
+  return precomputedChunk.length > VIEW_SIZE
+    ? precomputedChunk.slice()
+    : precomputedChunk;
 }
 
 export function closeWithError(destination: Destination, error: mixed): void {
diff --git a/packages/react-server/src/ReactServerStreamConfigBun.js b/packages/react-server/src/ReactServerStreamConfigBun.js
index c50ce77fa9a7b..fd90c17a3d1e0 100644
--- a/packages/react-server/src/ReactServerStreamConfigBun.js
+++ b/packages/react-server/src/ReactServerStreamConfigBun.js
@@ -64,6 +64,12 @@ export function stringToPrecomputedChunk(content: string): PrecomputedChunk {
   return content;
 }
 
+export function clonePrecomputedChunk(
+  chunk: PrecomputedChunk,
+): PrecomputedChunk {
+  return chunk;
+}
+
 export function closeWithError(destination: Destination, error: mixed): void {
   // $FlowFixMe[method-unbinding]
   if (typeof destination.error === 'function') {
diff --git a/packages/react-server/src/ReactServerStreamConfigNode.js b/packages/react-server/src/ReactServerStreamConfigNode.js
index 5790682d301c9..458c84e076d87 100644
--- a/packages/react-server/src/ReactServerStreamConfigNode.js
+++ b/packages/react-server/src/ReactServerStreamConfigNode.js
@@ -95,6 +95,15 @@ function writeViewChunk(destination: Destination, chunk: PrecomputedChunk) {
     return;
   }
   if (chunk.byteLength > VIEW_SIZE) {
+    if (__DEV__) {
+      if (precomputedChunkSet && precomputedChunkSet.has(chunk)) {
+        console.error(
+          'A large precomputed chunk was passed to writeChunk without being copied.' +
+            ' Large chunks get enqueued directly and are not copied. This is incompatible with precomputed chunks because you cannot enqueue the same precomputed chunk twice.' +
+            ' Use "cloneChunk" to make a copy of this large precomputed chunk before writing it. This is a bug in React.',
+        );
+      }
+    }
     // this chunk may overflow a single view which implies it was not
     // one that is cached by the streaming renderer. We will enqueu
     // it directly and expect it is not re-used
@@ -185,8 +194,26 @@ export function stringToChunk(content: string): Chunk {
   return content;
 }
 
+const precomputedChunkSet = __DEV__ ? new Set() : null;
+
 export function stringToPrecomputedChunk(content: string): PrecomputedChunk {
-  return textEncoder.encode(content);
+  const precomputedChunk = textEncoder.encode(content);
+
+  if (__DEV__) {
+    if (precomputedChunkSet) {
+      precomputedChunkSet.add(precomputedChunk);
+    }
+  }
+
+  return precomputedChunk;
+}
+
+export function clonePrecomputedChunk(
+  precomputedChunk: PrecomputedChunk,
+): PrecomputedChunk {
+  return precomputedChunk.length > VIEW_SIZE
+    ? precomputedChunk.slice()
+    : precomputedChunk;
 }
 
 export function closeWithError(destination: Destination, error: mixed): void {
diff --git a/packages/react-server/src/forks/ReactServerStreamConfig.custom.js b/packages/react-server/src/forks/ReactServerStreamConfig.custom.js
index 8a5fd3173c96b..0e7bafab961aa 100644
--- a/packages/react-server/src/forks/ReactServerStreamConfig.custom.js
+++ b/packages/react-server/src/forks/ReactServerStreamConfig.custom.js
@@ -41,3 +41,4 @@ export const close = $$$hostConfig.close;
 export const closeWithError = $$$hostConfig.closeWithError;
 export const stringToChunk = $$$hostConfig.stringToChunk;
 export const stringToPrecomputedChunk = $$$hostConfig.stringToPrecomputedChunk;
+export const clonePrecomputedChunk = $$$hostConfig.clonePrecomputedChunk;