diff --git a/packages/ketcher-macromolecules/src/components/monomerLibrary/RnaBuilder/RnaAccordion/RnaAccordion.tsx b/packages/ketcher-macromolecules/src/components/monomerLibrary/RnaBuilder/RnaAccordion/RnaAccordion.tsx
index c2b7c93779..19213e46ab 100644
--- a/packages/ketcher-macromolecules/src/components/monomerLibrary/RnaBuilder/RnaAccordion/RnaAccordion.tsx
+++ b/packages/ketcher-macromolecules/src/components/monomerLibrary/RnaBuilder/RnaAccordion/RnaAccordion.tsx
@@ -109,7 +109,7 @@ export const RnaAccordion = ({ libraryName, duplicatePreset, editPreset }) => {
     } else {
       setExpandedAccordion(rnaBuilderItem);
       const { sugarValidations, phosphateValidations, baseValidations } =
-        getValidations(newPreset);
+        getValidations(newPreset, isEditMode);
 
       dispatch(setSugarValidations(sugarValidations));
       dispatch(setPhosphateValidations(phosphateValidations));
diff --git a/packages/ketcher-macromolecules/src/components/monomerLibrary/RnaBuilder/RnaEditor/RnaEditor.tsx b/packages/ketcher-macromolecules/src/components/monomerLibrary/RnaBuilder/RnaEditor/RnaEditor.tsx
index 708dda27c0..6743eb9068 100644
--- a/packages/ketcher-macromolecules/src/components/monomerLibrary/RnaBuilder/RnaEditor/RnaEditor.tsx
+++ b/packages/ketcher-macromolecules/src/components/monomerLibrary/RnaBuilder/RnaEditor/RnaEditor.tsx
@@ -31,10 +31,14 @@ import {
   selectIsEditMode,
   selectPresetFullName,
   setActiveRnaBuilderItem,
+  setBaseValidations,
   setIsEditMode,
+  setPhosphateValidations,
+  setSugarValidations,
 } from 'state/rna-builder';
 import { scrollToElement } from 'helpers/dom';
 import { selectIsSequenceEditInRNABuilderMode } from 'state/common';
+import { getValidations } from 'helpers/rnaValidations';
 
 export const scrollToSelectedPreset = (presetName) => {
   scrollToElement(`[data-rna-preset-item-name="${presetName}"]`);
@@ -66,6 +70,15 @@ export const RnaEditor = ({ duplicatePreset }) => {
     dispatch(setActiveRnaBuilderItem(RnaBuilderPresetsItem.Presets));
   }, [activePreset]);
 
+  useEffect(() => {
+    const { sugarValidations, phosphateValidations, baseValidations } =
+      getValidations(activePreset, isEditMode);
+
+    dispatch(setSugarValidations(sugarValidations));
+    dispatch(setPhosphateValidations(phosphateValidations));
+    dispatch(setBaseValidations(baseValidations));
+  }, [isEditMode]);
+
   const expandEditor = () => {
     setExpanded(!expanded);
     if (!activePreset?.nameInList) {
diff --git a/packages/ketcher-macromolecules/src/components/monomerLibrary/RnaBuilder/RnaEditor/RnaEditorExpanded/RnaEditorExpanded.tsx b/packages/ketcher-macromolecules/src/components/monomerLibrary/RnaBuilder/RnaEditor/RnaEditorExpanded/RnaEditorExpanded.tsx
index f3652284c3..1cf759f147 100644
--- a/packages/ketcher-macromolecules/src/components/monomerLibrary/RnaBuilder/RnaEditor/RnaEditorExpanded/RnaEditorExpanded.tsx
+++ b/packages/ketcher-macromolecules/src/components/monomerLibrary/RnaBuilder/RnaEditor/RnaEditorExpanded/RnaEditorExpanded.tsx
@@ -225,7 +225,7 @@ export const RnaEditorExpanded = ({
     dispatch(setActiveRnaBuilderItem(selectedGroup));
 
     const { sugarValidations, phosphateValidations, baseValidations } =
-      getValidations(newPreset);
+      getValidations(newPreset, isEditMode);
 
     dispatch(setSugarValidations(sugarValidations));
     dispatch(setPhosphateValidations(phosphateValidations));
diff --git a/packages/ketcher-macromolecules/src/helpers/rnaValidations.ts b/packages/ketcher-macromolecules/src/helpers/rnaValidations.ts
index 1c5b39bba1..c369ad7e15 100644
--- a/packages/ketcher-macromolecules/src/helpers/rnaValidations.ts
+++ b/packages/ketcher-macromolecules/src/helpers/rnaValidations.ts
@@ -2,6 +2,7 @@ import { IRnaPreset } from 'components/monomerLibrary/RnaBuilder/types';
 
 export const getValidations = (
   newPreset: IRnaPreset,
+  isEditMode: boolean,
 ): {
   sugarValidations: string[];
   phosphateValidations: string[];
@@ -11,6 +12,14 @@ export const getValidations = (
   const phosphateValidations: string[] = [];
   const baseValidations: string[] = [];
 
+  if (!isEditMode) {
+    return {
+      sugarValidations,
+      phosphateValidations,
+      baseValidations,
+    };
+  }
+
   if (newPreset?.phosphate) {
     sugarValidations.push('R2');
   }