diff --git a/x-pack/plugins/apm/public/components/app/service_inventory/service_list/ServiceListMetric.tsx b/x-pack/plugins/apm/public/components/app/service_inventory/service_list/ServiceListMetric.tsx
index af2cde7f861cc..7a4721407e69b 100644
--- a/x-pack/plugins/apm/public/components/app/service_inventory/service_list/ServiceListMetric.tsx
+++ b/x-pack/plugins/apm/public/components/app/service_inventory/service_list/ServiceListMetric.tsx
@@ -5,6 +5,7 @@
  * 2.0.
  */
 
+import { EuiFlexGroup, EuiFlexItem, EuiText } from '@elastic/eui';
 import React from 'react';
 import { Coordinate } from '../../../../../typings/timeseries';
 import { SparkPlot } from '../../../shared/charts/spark_plot';
@@ -14,18 +15,32 @@ export function ServiceListMetric({
   series,
   valueLabel,
   comparisonSeries,
+  hideSeries = false,
 }: {
   color: 'euiColorVis1' | 'euiColorVis0' | 'euiColorVis7';
   series?: Coordinate[];
   comparisonSeries?: Coordinate[];
   valueLabel: React.ReactNode;
+  hideSeries?: boolean;
 }) {
+  if (!hideSeries) {
+    return (
+      <SparkPlot
+        valueLabel={valueLabel}
+        series={series}
+        color={color}
+        comparisonSeries={comparisonSeries}
+      />
+    );
+  }
+
   return (
-    <SparkPlot
-      valueLabel={valueLabel}
-      series={series}
-      color={color}
-      comparisonSeries={comparisonSeries}
-    />
+    <EuiFlexGroup gutterSize="none" alignItems="flexEnd">
+      <EuiFlexItem>
+        <EuiText size="s" textAlign="right">
+          {valueLabel}
+        </EuiText>
+      </EuiFlexItem>
+    </EuiFlexGroup>
   );
 }
diff --git a/x-pack/plugins/apm/public/components/app/service_inventory/service_list/index.tsx b/x-pack/plugins/apm/public/components/app/service_inventory/service_list/index.tsx
index 39e65f7eb15d1..f50816809df07 100644
--- a/x-pack/plugins/apm/public/components/app/service_inventory/service_list/index.tsx
+++ b/x-pack/plugins/apm/public/components/app/service_inventory/service_list/index.tsx
@@ -17,7 +17,10 @@ import { TypeOf } from '@kbn/typed-react-router-config';
 import { orderBy } from 'lodash';
 import React, { useMemo } from 'react';
 import { ValuesType } from 'utility-types';
-import { euiStyled } from '../../../../../../../../src/plugins/kibana_react/common';
+import {
+  BreakPoints,
+  useBreakPoints,
+} from '../../../../hooks/use_break_points';
 import { NOT_AVAILABLE_LABEL } from '../../../../../common/i18n';
 import { ServiceHealthStatus } from '../../../../../common/service_health_status';
 import {
@@ -38,6 +41,7 @@ import { ITableColumn, ManagedTable } from '../../../shared/managed_table';
 import { ServiceLink } from '../../../shared/service_link';
 import { HealthBadge } from './HealthBadge';
 import { ServiceListMetric } from './ServiceListMetric';
+import { TruncateWithTooltip } from '../../../shared/truncate_with_tooltip';
 
 type ServiceListAPIResponse = APIReturnType<'GET /api/apm/services'>;
 type Items = ServiceListAPIResponse['items'];
@@ -49,13 +53,6 @@ function formatString(value?: string | null) {
   return value || NOT_AVAILABLE_LABEL;
 }
 
-const ToolTipWrapper = euiStyled.span`
-  width: 100%;
-  .apmServiceList__serviceNameTooltip {
-    width: 100%;
-  }
-`;
-
 const SERVICE_HEALTH_STATUS_ORDER = [
   ServiceHealthStatus.unknown,
   ServiceHealthStatus.healthy,
@@ -67,11 +64,16 @@ export function getServiceColumns({
   query,
   showTransactionTypeColumn,
   comparisonData,
+  breakPoints,
 }: {
   query: TypeOf<ApmRoutes, '/services'>['query'];
   showTransactionTypeColumn: boolean;
+  breakPoints: BreakPoints;
   comparisonData?: ServicesDetailedStatisticsAPIResponse;
 }): Array<ITableColumn<ServiceListItem>> {
+  const { isSmall, isLarge, isXl } = breakPoints;
+  const showWhenSmallOrGreaterThanLarge = isSmall || !isLarge;
+  const showWhenSmallOrGreaterThanXL = isSmall || !isXl;
   return [
     {
       field: 'healthStatus',
@@ -96,34 +98,38 @@ export function getServiceColumns({
       width: '40%',
       sortable: true,
       render: (_, { serviceName, agentName }) => (
-        <ToolTipWrapper data-test-subj="apmServiceListAppLink">
-          <EuiToolTip
-            delay="long"
-            content={formatString(serviceName)}
-            id="service-name-tooltip"
-            anchorClassName="apmServiceList__serviceNameTooltip"
-          >
+        <TruncateWithTooltip
+          data-test-subj="apmServiceListAppLink"
+          text={formatString(serviceName)}
+          content={
             <ServiceLink
               agentName={agentName}
               query={query}
               serviceName={serviceName}
             />
-          </EuiToolTip>
-        </ToolTipWrapper>
-      ),
-    },
-    {
-      field: 'environments',
-      name: i18n.translate('xpack.apm.servicesTable.environmentColumnLabel', {
-        defaultMessage: 'Environment',
-      }),
-      width: `${unit * 10}px`,
-      sortable: true,
-      render: (_, { environments }) => (
-        <EnvironmentBadge environments={environments ?? []} />
+          }
+        />
       ),
     },
-    ...(showTransactionTypeColumn
+    ...(showWhenSmallOrGreaterThanLarge
+      ? [
+          {
+            field: 'environments',
+            name: i18n.translate(
+              'xpack.apm.servicesTable.environmentColumnLabel',
+              {
+                defaultMessage: 'Environment',
+              }
+            ),
+            width: `${unit * 10}px`,
+            sortable: true,
+            render: (_, { environments }) => (
+              <EnvironmentBadge environments={environments ?? []} />
+            ),
+          } as ITableColumn<ServiceListItem>,
+        ]
+      : []),
+    ...(showTransactionTypeColumn && showWhenSmallOrGreaterThanXL
       ? [
           {
             field: 'transactionType',
@@ -149,12 +155,13 @@ export function getServiceColumns({
           comparisonSeries={
             comparisonData?.previousPeriod[serviceName]?.latency
           }
+          hideSeries={!showWhenSmallOrGreaterThanLarge}
           color="euiColorVis1"
           valueLabel={asMillisecondDuration(latency || 0)}
         />
       ),
       align: 'left',
-      width: `${unit * 10}px`,
+      width: showWhenSmallOrGreaterThanLarge ? `${unit * 10}px` : 'auto',
     },
     {
       field: 'throughput',
@@ -169,12 +176,13 @@ export function getServiceColumns({
           comparisonSeries={
             comparisonData?.previousPeriod[serviceName]?.throughput
           }
+          hideSeries={!showWhenSmallOrGreaterThanLarge}
           color="euiColorVis0"
           valueLabel={asTransactionRate(throughput)}
         />
       ),
       align: 'left',
-      width: `${unit * 10}px`,
+      width: showWhenSmallOrGreaterThanLarge ? `${unit * 10}px` : 'auto',
     },
     {
       field: 'transactionErrorRate',
@@ -193,13 +201,14 @@ export function getServiceColumns({
             comparisonSeries={
               comparisonData?.previousPeriod[serviceName]?.transactionErrorRate
             }
+            hideSeries={!showWhenSmallOrGreaterThanLarge}
             color="euiColorVis7"
             valueLabel={valueLabel}
           />
         );
       },
       align: 'left',
-      width: `${unit * 10}px`,
+      width: showWhenSmallOrGreaterThanLarge ? `${unit * 10}px` : 'auto',
     },
   ];
 }
@@ -217,6 +226,7 @@ export function ServiceList({
   comparisonData,
   isLoading,
 }: Props) {
+  const breakPoints = useBreakPoints();
   const displayHealthStatus = items.some((item) => 'healthStatus' in item);
 
   const showTransactionTypeColumn = items.some(
@@ -229,8 +239,13 @@ export function ServiceList({
 
   const serviceColumns = useMemo(
     () =>
-      getServiceColumns({ query, showTransactionTypeColumn, comparisonData }),
-    [query, showTransactionTypeColumn, comparisonData]
+      getServiceColumns({
+        query,
+        showTransactionTypeColumn,
+        comparisonData,
+        breakPoints,
+      }),
+    [query, showTransactionTypeColumn, comparisonData, breakPoints]
   );
 
   const columns = displayHealthStatus
diff --git a/x-pack/plugins/apm/public/components/app/service_inventory/service_list/service_list.test.tsx b/x-pack/plugins/apm/public/components/app/service_inventory/service_list/service_list.test.tsx
index d6cf7bf018d0f..51636e938f8cb 100644
--- a/x-pack/plugins/apm/public/components/app/service_inventory/service_list/service_list.test.tsx
+++ b/x-pack/plugins/apm/public/components/app/service_inventory/service_list/service_list.test.tsx
@@ -7,6 +7,7 @@
 
 import React, { ReactNode } from 'react';
 import { MemoryRouter } from 'react-router-dom';
+import { BreakPoints } from '../../../../hooks/use_break_points';
 import { ServiceHealthStatus } from '../../../../../common/service_health_status';
 import { MockApmPluginContextWrapper } from '../../../../context/apm_plugin/mock_apm_plugin_context';
 import { mockMoment, renderWithTheme } from '../../../../utils/testHelpers';
@@ -42,7 +43,12 @@ describe('ServiceList', () => {
     ).not.toThrowError();
   });
 
-  it('renders columns correctly', () => {
+  describe('responsive columns', () => {
+    const query = {
+      rangeFrom: 'now-15m',
+      rangeTo: 'now',
+    };
+
     const service: any = {
       serviceName: 'opbeans-python',
       agentName: 'python',
@@ -59,20 +65,132 @@ describe('ServiceList', () => {
         timeseries: [],
       },
       environments: ['test'],
+      transactionType: 'request',
     };
-    const renderedColumns = getServiceColumns({
-      query: {
-        rangeFrom: 'now-15m',
-        rangeTo: 'now',
-      },
-      showTransactionTypeColumn: false,
-    }).map((c) => c.render!(service[c.field!], service));
-
-    expect(renderedColumns[0]).toMatchInlineSnapshot(`
-      <HealthBadge
-        healthStatus="unknown"
-      />
-    `);
+    describe('when small', () => {
+      it('shows environment, transaction type and sparklines', () => {
+        const renderedColumns = getServiceColumns({
+          query,
+          showTransactionTypeColumn: true,
+          breakPoints: {
+            isSmall: true,
+            isLarge: true,
+            isXl: true,
+          } as BreakPoints,
+        }).map((c) =>
+          c.render ? c.render!(service[c.field!], service) : service[c.field!]
+        );
+        expect(renderedColumns.length).toEqual(7);
+        expect(renderedColumns[2]).toMatchInlineSnapshot(`
+          <EnvironmentBadge
+            environments={
+              Array [
+                "test",
+              ]
+            }
+          />
+        `);
+        expect(renderedColumns[3]).toMatchInlineSnapshot(`"request"`);
+        expect(renderedColumns[4]).toMatchInlineSnapshot(`
+          <ServiceListMetric
+            color="euiColorVis1"
+            hideSeries={false}
+            valueLabel="0 ms"
+          />
+        `);
+      });
+    });
+
+    describe('when Large', () => {
+      it('hides environment, transaction type and sparklines', () => {
+        const renderedColumns = getServiceColumns({
+          query,
+          showTransactionTypeColumn: true,
+          breakPoints: {
+            isSmall: false,
+            isLarge: true,
+            isXl: true,
+          } as BreakPoints,
+        }).map((c) =>
+          c.render ? c.render!(service[c.field!], service) : service[c.field!]
+        );
+        expect(renderedColumns.length).toEqual(5);
+        expect(renderedColumns[2]).toMatchInlineSnapshot(`
+          <ServiceListMetric
+            color="euiColorVis1"
+            hideSeries={true}
+            valueLabel="0 ms"
+          />
+        `);
+      });
+
+      describe('when XL', () => {
+        it('hides transaction type', () => {
+          const renderedColumns = getServiceColumns({
+            query,
+            showTransactionTypeColumn: true,
+            breakPoints: {
+              isSmall: false,
+              isLarge: false,
+              isXl: true,
+            } as BreakPoints,
+          }).map((c) =>
+            c.render ? c.render!(service[c.field!], service) : service[c.field!]
+          );
+          expect(renderedColumns.length).toEqual(6);
+          expect(renderedColumns[2]).toMatchInlineSnapshot(`
+            <EnvironmentBadge
+              environments={
+                Array [
+                  "test",
+                ]
+              }
+            />
+          `);
+          expect(renderedColumns[3]).toMatchInlineSnapshot(`
+            <ServiceListMetric
+              color="euiColorVis1"
+              hideSeries={false}
+              valueLabel="0 ms"
+            />
+          `);
+        });
+      });
+
+      describe('when XXL', () => {
+        it('hides transaction type', () => {
+          const renderedColumns = getServiceColumns({
+            query,
+            showTransactionTypeColumn: true,
+            breakPoints: {
+              isSmall: false,
+              isLarge: false,
+              isXl: false,
+            } as BreakPoints,
+          }).map((c) =>
+            c.render ? c.render!(service[c.field!], service) : service[c.field!]
+          );
+          expect(renderedColumns.length).toEqual(7);
+          expect(renderedColumns[2]).toMatchInlineSnapshot(`
+          <EnvironmentBadge
+            environments={
+              Array [
+                "test",
+              ]
+            }
+          />
+        `);
+          expect(renderedColumns[3]).toMatchInlineSnapshot(`"request"`);
+          expect(renderedColumns[4]).toMatchInlineSnapshot(`
+          <ServiceListMetric
+            color="euiColorVis1"
+            hideSeries={false}
+            valueLabel="0 ms"
+          />
+        `);
+        });
+      });
+    });
   });
 
   describe('without ML data', () => {
diff --git a/x-pack/plugins/apm/public/components/shared/truncate_with_tooltip/index.tsx b/x-pack/plugins/apm/public/components/shared/truncate_with_tooltip/index.tsx
index d9268c14aa2ea..3b649d77172ee 100644
--- a/x-pack/plugins/apm/public/components/shared/truncate_with_tooltip/index.tsx
+++ b/x-pack/plugins/apm/public/components/shared/truncate_with_tooltip/index.tsx
@@ -27,13 +27,14 @@ const ContentWrapper = euiStyled.div`
 interface Props {
   text: string;
   content?: React.ReactNode;
+  'data-test-subj'?: string;
 }
 
 export function TruncateWithTooltip(props: Props) {
-  const { text, content } = props;
+  const { text, content, ...rest } = props;
 
   return (
-    <TooltipWrapper>
+    <TooltipWrapper {...rest}>
       <EuiToolTip
         delay="long"
         content={text}
diff --git a/x-pack/plugins/apm/public/hooks/use_break_points.ts b/x-pack/plugins/apm/public/hooks/use_break_points.ts
index e6e7dc2dff899..3b428a02dc97b 100644
--- a/x-pack/plugins/apm/public/hooks/use_break_points.ts
+++ b/x-pack/plugins/apm/public/hooks/use_break_points.ts
@@ -10,6 +10,8 @@ import useWindowSize from 'react-use/lib/useWindowSize';
 import useDebounce from 'react-use/lib/useDebounce';
 import { isWithinMaxBreakpoint, isWithinMinBreakpoint } from '@elastic/eui';
 
+export type BreakPoints = ReturnType<typeof getScreenSizes>;
+
 export function getScreenSizes(windowWidth: number) {
   return {
     isXSmall: isWithinMaxBreakpoint(windowWidth, 'xs'),