diff --git a/x-pack/plugins/security_solution/cypress/integration/exceptions/exceptions_flyout.spec.ts b/x-pack/plugins/security_solution/cypress/integration/exceptions/exceptions_flyout.spec.ts
index d68def1284468..60202a4f6a52a 100644
--- a/x-pack/plugins/security_solution/cypress/integration/exceptions/exceptions_flyout.spec.ts
+++ b/x-pack/plugins/security_solution/cypress/integration/exceptions/exceptions_flyout.spec.ts
@@ -29,10 +29,21 @@ import {
   EXCEPTION_ITEM_CONTAINER,
   ADD_EXCEPTIONS_BTN,
   EXCEPTION_FIELD_LIST,
+  EDIT_EXCEPTIONS_BTN,
+  EXCEPTION_EDIT_FLYOUT_SAVE_BTN,
+  EXCEPTION_FLYOUT_VERSION_CONFLICT,
+  EXCEPTION_FLYOUT_LIST_DELETED_ERROR,
 } from '../../screens/exceptions';
 
 import { DETECTIONS_RULE_MANAGEMENT_URL } from '../../urls/navigation';
 import { cleanKibana, reload } from '../../tasks/common';
+import {
+  createExceptionList,
+  createExceptionListItem,
+  updateExceptionListItem,
+  deleteExceptionList,
+} from '../../tasks/api_calls/exceptions';
+import { getExceptionList } from '../../objects/exception';
 
 // NOTE: You might look at these tests and feel they're overkill,
 // but the exceptions flyout has a lot of logic making it difficult
@@ -42,18 +53,28 @@ import { cleanKibana, reload } from '../../tasks/common';
 describe('Exceptions flyout', () => {
   before(() => {
     cleanKibana();
-    loginAndWaitForPageWithoutDateRange(DETECTIONS_RULE_MANAGEMENT_URL);
-    createCustomRule({ ...getNewRule(), index: ['exceptions-*'] });
-    reload();
-    goToRuleDetails();
-
-    cy.get(RULE_STATUS).should('have.text', '—');
-
     // this is a made-up index that has just the necessary
     // mappings to conduct tests, avoiding loading large
     // amounts of data like in auditbeat_exceptions
     esArchiverLoad('exceptions');
-
+    loginAndWaitForPageWithoutDateRange(DETECTIONS_RULE_MANAGEMENT_URL);
+    createExceptionList(getExceptionList(), getExceptionList().list_id).then((response) =>
+      createCustomRule({
+        ...getNewRule(),
+        index: ['exceptions-*'],
+        exceptionLists: [
+          {
+            id: response.body.id,
+            list_id: getExceptionList().list_id,
+            type: getExceptionList().type,
+            namespace_type: getExceptionList().namespace_type,
+          },
+        ],
+      })
+    );
+    reload();
+    goToRuleDetails();
+    cy.get(RULE_STATUS).should('have.text', '—');
     goToExceptionsTab();
   });
 
@@ -62,7 +83,12 @@ describe('Exceptions flyout', () => {
   });
 
   it('Does not overwrite values and-ed together', () => {
-    cy.get(ADD_EXCEPTIONS_BTN).click({ force: true });
+    cy.root()
+      .pipe(($el) => {
+        $el.find(ADD_EXCEPTIONS_BTN).trigger('click');
+        return $el.find(ADD_AND_BTN);
+      })
+      .should('be.visible');
 
     // add multiple entries with invalid field values
     addExceptionEntryFieldValue('agent.name', 0);
@@ -80,8 +106,12 @@ describe('Exceptions flyout', () => {
   });
 
   it('Does not overwrite values or-ed together', () => {
-    cy.get(ADD_EXCEPTIONS_BTN).click({ force: true });
-
+    cy.root()
+      .pipe(($el) => {
+        $el.find(ADD_EXCEPTIONS_BTN).trigger('click');
+        return $el.find(ADD_AND_BTN);
+      })
+      .should('be.visible');
     // exception item 1
     addExceptionEntryFieldValueOfItemX('agent.name', 0, 0);
     cy.get(ADD_AND_BTN).click();
@@ -197,11 +227,89 @@ describe('Exceptions flyout', () => {
   });
 
   it('Contains custom index fields', () => {
-    cy.get(ADD_EXCEPTIONS_BTN).click({ force: true });
-
+    cy.root()
+      .pipe(($el) => {
+        $el.find(ADD_EXCEPTIONS_BTN).trigger('click');
+        return $el.find(ADD_AND_BTN);
+      })
+      .should('be.visible');
     cy.get(FIELD_INPUT).eq(0).click({ force: true });
     cy.get(EXCEPTION_FIELD_LIST).contains('unique_value.test');
 
     closeExceptionBuilderFlyout();
   });
+
+  describe('flyout errors', () => {
+    before(() => {
+      // create exception item via api
+      createExceptionListItem(getExceptionList().list_id, {
+        list_id: getExceptionList().list_id,
+        item_id: 'simple_list_item',
+        tags: [],
+        type: 'simple',
+        description: 'Test exception item',
+        name: 'Sample Exception List Item',
+        namespace_type: 'single',
+        entries: [
+          {
+            field: 'host.name',
+            operator: 'included',
+            type: 'match_any',
+            value: ['some host', 'another host'],
+          },
+        ],
+      });
+
+      reload();
+      cy.get(RULE_STATUS).should('have.text', '—');
+      goToExceptionsTab();
+    });
+
+    context('When updating an item with version conflict', () => {
+      it('Displays version conflict error', () => {
+        cy.get(EDIT_EXCEPTIONS_BTN).should('be.visible');
+        cy.get(EDIT_EXCEPTIONS_BTN).click({ force: true });
+
+        // update exception item via api
+        updateExceptionListItem('simple_list_item', {
+          name: 'Updated item name',
+          item_id: 'simple_list_item',
+          tags: [],
+          type: 'simple',
+          description: 'Test exception item',
+          namespace_type: 'single',
+          entries: [
+            {
+              field: 'host.name',
+              operator: 'included',
+              type: 'match_any',
+              value: ['some host', 'another host'],
+            },
+          ],
+        });
+
+        // try to save and see version conflict error
+        cy.get(EXCEPTION_EDIT_FLYOUT_SAVE_BTN).click({ force: true });
+
+        cy.get(EXCEPTION_FLYOUT_VERSION_CONFLICT).should('be.visible');
+
+        closeExceptionBuilderFlyout();
+      });
+    });
+
+    context('When updating an item for a list that has since been deleted', () => {
+      it('Displays missing exception list error', () => {
+        cy.get(EDIT_EXCEPTIONS_BTN).should('be.visible');
+        cy.get(EDIT_EXCEPTIONS_BTN).click({ force: true });
+
+        // delete exception list via api
+        deleteExceptionList(getExceptionList().list_id, getExceptionList().namespace_type);
+
+        // try to save and see error
+        cy.get(EXCEPTION_EDIT_FLYOUT_SAVE_BTN).click({ force: true });
+
+        cy.get(EXCEPTION_FLYOUT_LIST_DELETED_ERROR).should('be.visible');
+      });
+    });
+  });
 });
diff --git a/x-pack/plugins/security_solution/cypress/objects/exception.ts b/x-pack/plugins/security_solution/cypress/objects/exception.ts
index fbb000f43fdd2..637adc9fc0134 100644
--- a/x-pack/plugins/security_solution/cypress/objects/exception.ts
+++ b/x-pack/plugins/security_solution/cypress/objects/exception.ts
@@ -22,6 +22,17 @@ export interface ExceptionList {
   type: 'detection' | 'endpoint';
 }
 
+export interface ExceptionListItem {
+  description: string;
+  list_id: string;
+  item_id: string;
+  name: string;
+  namespace_type: 'single' | 'agnostic';
+  tags: string[];
+  type: 'simple';
+  entries: Array<{ field: string; operator: string; type: string; value: string[] }>;
+}
+
 export const getExceptionList = (): ExceptionList => ({
   description: 'Test exception list description',
   list_id: 'test_exception_list',
diff --git a/x-pack/plugins/security_solution/cypress/screens/exceptions.ts b/x-pack/plugins/security_solution/cypress/screens/exceptions.ts
index e1b9e0639dfaa..c94c2be8b976f 100644
--- a/x-pack/plugins/security_solution/cypress/screens/exceptions.ts
+++ b/x-pack/plugins/security_solution/cypress/screens/exceptions.ts
@@ -5,6 +5,8 @@
  * 2.0.
  */
 
+export const EDIT_EXCEPTIONS_BTN = '[data-test-subj="exceptionsViewerEditBtn"]';
+
 export const ADD_EXCEPTIONS_BTN = '[data-test-subj="exceptionsHeaderAddExceptionBtn"]';
 
 export const CLOSE_ALERTS_CHECKBOX =
@@ -61,3 +63,10 @@ export const EXCEPTION_FIELD_LIST =
   '[data-test-subj="comboBoxOptionsList fieldAutocompleteComboBox-optionsList"]';
 
 export const EXCEPTION_FLYOUT_TITLE = '[data-test-subj="exception-flyout-title"]';
+
+export const EXCEPTION_EDIT_FLYOUT_SAVE_BTN = '[data-test-subj="edit-exception-confirm-button"]';
+
+export const EXCEPTION_FLYOUT_VERSION_CONFLICT =
+  '[data-test-subj="exceptionsFlyoutVersionConflict"]';
+
+export const EXCEPTION_FLYOUT_LIST_DELETED_ERROR = '[data-test-subj="errorCalloutContainer"]';
diff --git a/x-pack/plugins/security_solution/cypress/screens/rule_details.ts b/x-pack/plugins/security_solution/cypress/screens/rule_details.ts
index a057f27df4280..a9134e5b124eb 100644
--- a/x-pack/plugins/security_solution/cypress/screens/rule_details.ts
+++ b/x-pack/plugins/security_solution/cypress/screens/rule_details.ts
@@ -33,6 +33,8 @@ export const DETAILS_TITLE = '.euiDescriptionList__title';
 
 export const EXCEPTIONS_TAB = '[data-test-subj="exceptionsTab"]';
 
+export const EXCEPTIONS_TAB_SEARCH = '[data-test-subj="exceptionsHeaderSearch"]';
+
 export const FALSE_POSITIVES_DETAILS = 'False positive examples';
 
 export const INDEX_PATTERNS_DETAILS = 'Index patterns';
diff --git a/x-pack/plugins/security_solution/cypress/tasks/api_calls/exceptions.ts b/x-pack/plugins/security_solution/cypress/tasks/api_calls/exceptions.ts
index 7363bd5991b1c..ab6c649c7c61f 100644
--- a/x-pack/plugins/security_solution/cypress/tasks/api_calls/exceptions.ts
+++ b/x-pack/plugins/security_solution/cypress/tasks/api_calls/exceptions.ts
@@ -5,7 +5,7 @@
  * 2.0.
  */
 
-import { ExceptionList } from '../../objects/exception';
+import { ExceptionList, ExceptionListItem } from '../../objects/exception';
 
 export const createExceptionList = (
   exceptionList: ExceptionList,
@@ -23,3 +23,58 @@ export const createExceptionList = (
     headers: { 'kbn-xsrf': 'cypress-creds' },
     failOnStatusCode: false,
   });
+
+export const createExceptionListItem = (
+  exceptionListId: string,
+  exceptionListItem?: ExceptionListItem
+) =>
+  cy.request({
+    method: 'POST',
+    url: '/api/exception_lists/items',
+    body: {
+      list_id: exceptionListItem?.list_id ?? exceptionListId,
+      item_id: exceptionListItem?.item_id ?? 'simple_list_item',
+      tags: exceptionListItem?.tags ?? ['user added string for a tag', 'malware'],
+      type: exceptionListItem?.type ?? 'simple',
+      description: exceptionListItem?.description ?? 'This is a sample endpoint type exception',
+      name: exceptionListItem?.name ?? 'Sample Exception List Item',
+      entries: exceptionListItem?.entries ?? [
+        {
+          field: 'actingProcess.file.signer',
+          operator: 'excluded',
+          type: 'exists',
+        },
+        {
+          field: 'host.name',
+          operator: 'included',
+          type: 'match_any',
+          value: ['some host', 'another host'],
+        },
+      ],
+    },
+    headers: { 'kbn-xsrf': 'cypress-creds' },
+    failOnStatusCode: false,
+  });
+
+export const updateExceptionListItem = (
+  exceptionListItemId: string,
+  exceptionListItemUpdate?: Partial<ExceptionListItem>
+) =>
+  cy.request({
+    method: 'PUT',
+    url: '/api/exception_lists/items',
+    body: {
+      item_id: exceptionListItemId,
+      ...exceptionListItemUpdate,
+    },
+    headers: { 'kbn-xsrf': 'cypress-creds' },
+    failOnStatusCode: false,
+  });
+
+export const deleteExceptionList = (listId: string, namespaceType: string) =>
+  cy.request({
+    method: 'DELETE',
+    url: `/api/exception_lists?list_id=${listId}&namespace_type=${namespaceType}`,
+    headers: { 'kbn-xsrf': 'cypress-creds' },
+    failOnStatusCode: false,
+  });
diff --git a/x-pack/plugins/security_solution/cypress/tasks/rule_details.ts b/x-pack/plugins/security_solution/cypress/tasks/rule_details.ts
index e69c217c4a764..d42ebcf9da68e 100644
--- a/x-pack/plugins/security_solution/cypress/tasks/rule_details.ts
+++ b/x-pack/plugins/security_solution/cypress/tasks/rule_details.ts
@@ -91,7 +91,12 @@ export const goToAlertsTab = () => {
 };
 
 export const goToExceptionsTab = () => {
-  cy.get(EXCEPTIONS_TAB).click();
+  cy.root()
+    .pipe(($el) => {
+      $el.find(EXCEPTIONS_TAB).trigger('click');
+      return $el.find(ADD_EXCEPTIONS_BTN);
+    })
+    .should('be.visible');
 };
 
 export const removeException = () => {
diff --git a/x-pack/plugins/security_solution/public/common/components/exceptions/edit_exception_flyout/index.tsx b/x-pack/plugins/security_solution/public/common/components/exceptions/edit_exception_flyout/index.tsx
index 6d01908732ec1..0ed810b4ad263 100644
--- a/x-pack/plugins/security_solution/public/common/components/exceptions/edit_exception_flyout/index.tsx
+++ b/x-pack/plugins/security_solution/public/common/components/exceptions/edit_exception_flyout/index.tsx
@@ -410,27 +410,35 @@ export const EditExceptionFlyout = memo(function EditExceptionFlyout({
             </FlyoutCheckboxesSection>
           </>
         )}
-      {updateError != null && (
-        <EuiFlyoutFooter>
-          <ErrorCallout
-            http={http}
-            errorInfo={updateError}
-            rule={maybeRule}
-            onCancel={onCancel}
-            onSuccess={handleDissasociationSuccess}
-            onError={handleDissasociationError}
-          />
-        </EuiFlyoutFooter>
-      )}
-      {hasVersionConflict && (
-        <EuiFlyoutFooter>
-          <EuiCallOut title={i18n.VERSION_CONFLICT_ERROR_TITLE} color="danger" iconType="alert">
-            <p>{i18n.VERSION_CONFLICT_ERROR_DESCRIPTION}</p>
-          </EuiCallOut>
-        </EuiFlyoutFooter>
-      )}
-      {updateError == null && (
-        <EuiFlyoutFooter>
+
+      <EuiFlyoutFooter>
+        {hasVersionConflict && (
+          <>
+            <EuiCallOut
+              title={i18n.VERSION_CONFLICT_ERROR_TITLE}
+              color="danger"
+              iconType="alert"
+              data-test-subj="exceptionsFlyoutVersionConflict"
+            >
+              <p>{i18n.VERSION_CONFLICT_ERROR_DESCRIPTION}</p>
+            </EuiCallOut>
+            <EuiSpacer size="m" />
+          </>
+        )}
+        {updateError != null && (
+          <>
+            <ErrorCallout
+              http={http}
+              errorInfo={updateError}
+              rule={maybeRule}
+              onCancel={onCancel}
+              onSuccess={handleDissasociationSuccess}
+              onError={handleDissasociationError}
+            />
+            <EuiSpacer size="m" />
+          </>
+        )}
+        {updateError === null && (
           <FlyoutFooterGroup justifyContent="spaceBetween">
             <EuiButtonEmpty data-test-subj="cancelExceptionAddButton" onClick={onCancel}>
               {i18n.CANCEL}
@@ -446,8 +454,8 @@ export const EditExceptionFlyout = memo(function EditExceptionFlyout({
               {i18n.EDIT_EXCEPTION_SAVE_BUTTON}
             </EuiButton>
           </FlyoutFooterGroup>
-        </EuiFlyoutFooter>
-      )}
+        )}
+      </EuiFlyoutFooter>
     </EuiFlyout>
   );
 });