diff --git a/contrib/guix/manifest.scm b/contrib/guix/manifest.scm
index b21b1bc43a318d..1c8fdf755993ff 100644
--- a/contrib/guix/manifest.scm
+++ b/contrib/guix/manifest.scm
@@ -20,7 +20,6 @@
              (gnu packages llvm)
              (gnu packages mingw)
              (gnu packages moreutils)
-             (gnu packages perl)
              (gnu packages pkg-config)
              (gnu packages python)
              (gnu packages python-crypto)
@@ -598,7 +597,6 @@ parse, modify and abstract ELF, PE and MachO formats.")
         gcc-toolchain-10
         (list gcc-toolchain-10 "static")
         ;; Scripting
-        perl
         python-minimal ;; (3.9)
         ;; Git
         git
diff --git a/depends/packages/qt.mk b/depends/packages/qt.mk
index e865dbdaf25bef..4ea8a0513a2128 100644
--- a/depends/packages/qt.mk
+++ b/depends/packages/qt.mk
@@ -57,6 +57,7 @@ $(package)_config_opts += -no-linuxfb
 $(package)_config_opts += -no-libjpeg
 $(package)_config_opts += -no-libproxy
 $(package)_config_opts += -no-libudev
+$(package)_config_opts += -no-mimetype-database
 $(package)_config_opts += -no-mtdev
 $(package)_config_opts += -no-openssl
 $(package)_config_opts += -no-openvg