diff --git a/build-aux/m4/bitcoin_runtime_lib.m4 b/build-aux/m4/bitcoin_runtime_lib.m4
deleted file mode 100644
index 1a6922deca485..0000000000000
--- a/build-aux/m4/bitcoin_runtime_lib.m4
+++ /dev/null
@@ -1,42 +0,0 @@
-# On some platforms clang builtin implementations
-# require compiler-rt as a runtime library to use.
-#
-# See:
-# - https://bugs.llvm.org/show_bug.cgi?id=28629
-
-m4_define([_CHECK_RUNTIME_testbody], [[
-  bool f(long long x, long long y, long long* p)
-  {
-    return __builtin_mul_overflow(x, y, p);
-  }
-  int main() { return 0; }
-]])
-
-AC_DEFUN([CHECK_RUNTIME_LIB], [
-
-  AC_LANG_PUSH([C++])
-
-  AC_MSG_CHECKING([for __builtin_mul_overflow])
-  AC_LINK_IFELSE(
-    [AC_LANG_SOURCE([_CHECK_RUNTIME_testbody])],
-    [
-      AC_MSG_RESULT([yes])
-      AC_DEFINE([HAVE_BUILTIN_MUL_OVERFLOW], [1], [Define if you have a working __builtin_mul_overflow])
-    ],
-    [
-      ax_check_save_flags="$LDFLAGS"
-      LDFLAGS="$LDFLAGS --rtlib=compiler-rt -lgcc_s"
-      AC_LINK_IFELSE(
-        [AC_LANG_SOURCE([_CHECK_RUNTIME_testbody])],
-        [
-          AC_MSG_RESULT([yes, with additional linker flags])
-          RUNTIME_LDFLAGS="--rtlib=compiler-rt -lgcc_s"
-          AC_DEFINE([HAVE_BUILTIN_MUL_OVERFLOW], [1], [Define if you have a working __builtin_mul_overflow])
-        ],
-        [AC_MSG_RESULT([no])])
-      LDFLAGS="$ax_check_save_flags"
-    ])
-
-  AC_LANG_POP
-  AC_SUBST([RUNTIME_LDFLAGS])
-])
diff --git a/configure.ac b/configure.ac
index d6efa491df2d3..2b84eb19235d9 100644
--- a/configure.ac
+++ b/configure.ac
@@ -1387,8 +1387,6 @@ if test x$enable_fuzz_binary = xyes; then
      ]],[[
       */ int not_main() {
      ]])])
-
-  CHECK_RUNTIME_LIB
 fi
 
 if test x$enable_wallet != xno; then
diff --git a/doc/dependencies.md b/doc/dependencies.md
index 43aeede6b89a7..19d81449b299a 100644
--- a/doc/dependencies.md
+++ b/doc/dependencies.md
@@ -8,7 +8,7 @@ You can find installation instructions in the `build-*.md` file for your platfor
 | --- | --- |
 | [Autoconf](https://www.gnu.org/software/autoconf/) | [2.69](https://github.com/bitcoin/bitcoin/pull/17769) |
 | [Automake](https://www.gnu.org/software/automake/) | [1.13](https://github.com/bitcoin/bitcoin/pull/18290) |
-| [Clang](https://clang.llvm.org) | [13.0](https://github.com/bitcoin/bitcoin/pull/28210) |
+| [Clang](https://clang.llvm.org) | [14.0](https://github.com/bitcoin/bitcoin/pull/29208) |
 | [GCC](https://gcc.gnu.org) | [10.1](https://github.com/bitcoin/bitcoin/pull/28348) |
 | [Python](https://www.python.org) (scripts, tests) | [3.9](https://github.com/bitcoin/bitcoin/pull/28211) |
 | [systemtap](https://sourceware.org/systemtap/) ([tracing](tracing.md))| N/A |
diff --git a/src/Makefile.test.include b/src/Makefile.test.include
index 00e0429688fd7..705db24bd7890 100644
--- a/src/Makefile.test.include
+++ b/src/Makefile.test.include
@@ -243,7 +243,7 @@ if ENABLE_FUZZ_BINARY
 test_fuzz_fuzz_CPPFLAGS = $(AM_CPPFLAGS) $(BITCOIN_INCLUDES)
 test_fuzz_fuzz_CXXFLAGS = $(AM_CXXFLAGS) $(PIE_FLAGS)
 test_fuzz_fuzz_LDADD = $(FUZZ_SUITE_LD_COMMON)
-test_fuzz_fuzz_LDFLAGS = $(FUZZ_SUITE_LDFLAGS_COMMON) $(RUNTIME_LDFLAGS)
+test_fuzz_fuzz_LDFLAGS = $(FUZZ_SUITE_LDFLAGS_COMMON)
 test_fuzz_fuzz_SOURCES = \
  test/fuzz/addition_overflow.cpp \
  test/fuzz/addrman.cpp \
diff --git a/src/test/fuzz/addition_overflow.cpp b/src/test/fuzz/addition_overflow.cpp
index 372c1a370e852..edc89a0e18462 100644
--- a/src/test/fuzz/addition_overflow.cpp
+++ b/src/test/fuzz/addition_overflow.cpp
@@ -11,14 +11,6 @@
 #include <string>
 #include <vector>
 
-#if defined(__has_builtin)
-#if __has_builtin(__builtin_add_overflow)
-#define HAVE_BUILTIN_ADD_OVERFLOW
-#endif
-#elif defined(__GNUC__)
-#define HAVE_BUILTIN_ADD_OVERFLOW
-#endif
-
 namespace {
 template <typename T>
 void TestAdditionOverflow(FuzzedDataProvider& fuzzed_data_provider)
@@ -32,14 +24,12 @@ void TestAdditionOverflow(FuzzedDataProvider& fuzzed_data_provider)
     assert(is_addition_overflow_custom == AdditionOverflow(j, i));
     assert(maybe_add == CheckedAdd(j, i));
     assert(sat_add == SaturatingAdd(j, i));
-#if defined(HAVE_BUILTIN_ADD_OVERFLOW)
     T result_builtin;
     const bool is_addition_overflow_builtin = __builtin_add_overflow(i, j, &result_builtin);
     assert(is_addition_overflow_custom == is_addition_overflow_builtin);
     if (!is_addition_overflow_custom) {
         assert(i + j == result_builtin);
     }
-#endif
     if (is_addition_overflow_custom) {
         assert(sat_add == std::numeric_limits<T>::min() || sat_add == std::numeric_limits<T>::max());
     } else {
diff --git a/src/test/fuzz/multiplication_overflow.cpp b/src/test/fuzz/multiplication_overflow.cpp
index c7251650c2580..3a6127f31f8e7 100644
--- a/src/test/fuzz/multiplication_overflow.cpp
+++ b/src/test/fuzz/multiplication_overflow.cpp
@@ -2,10 +2,6 @@
 // Distributed under the MIT software license, see the accompanying
 // file COPYING or http://www.opensource.org/licenses/mit-license.php.
 
-#if defined(HAVE_CONFIG_H)
-#include <config/bitcoin-config.h>
-#endif
-
 #include <test/fuzz/FuzzedDataProvider.h>
 #include <test/fuzz/fuzz.h>
 #include <test/fuzz/util.h>
@@ -21,18 +17,12 @@ void TestMultiplicationOverflow(FuzzedDataProvider& fuzzed_data_provider)
     const T i = fuzzed_data_provider.ConsumeIntegral<T>();
     const T j = fuzzed_data_provider.ConsumeIntegral<T>();
     const bool is_multiplication_overflow_custom = MultiplicationOverflow(i, j);
-#if defined(HAVE_BUILTIN_MUL_OVERFLOW)
     T result_builtin;
     const bool is_multiplication_overflow_builtin = __builtin_mul_overflow(i, j, &result_builtin);
     assert(is_multiplication_overflow_custom == is_multiplication_overflow_builtin);
     if (!is_multiplication_overflow_custom) {
         assert(i * j == result_builtin);
     }
-#else
-    if (!is_multiplication_overflow_custom) {
-        (void)(i * j);
-    }
-#endif
 }
 } // namespace