diff --git a/slither/__main__.py b/slither/__main__.py
index caaef5730..4fc83a11e 100644
--- a/slither/__main__.py
+++ b/slither/__main__.py
@@ -14,7 +14,7 @@
 from typing import Tuple, Optional, List, Dict, Type, Union, Any, Sequence
 
 
-from crytic_compile import cryticparser, CryticCompile
+from crytic_compile import cryticparser, CryticCompile, InvalidCompilation
 from crytic_compile.platform.standard import generate_standard_export
 from crytic_compile.platform.etherscan import SUPPORTED_NETWORK
 from crytic_compile import compile_all, is_supported
@@ -93,7 +93,13 @@ def process_all(
     detector_classes: List[Type[AbstractDetector]],
     printer_classes: List[Type[AbstractPrinter]],
 ) -> Tuple[List[Slither], List[Dict], List[Output], int]:
-    compilations = compile_all(target, **vars(args))
+
+    try:
+        compilations = compile_all(target, **vars(args))
+    except InvalidCompilation:
+        logger.error("Unable to compile all targets.")
+        sys.exit(2)
+
     slither_instances = []
     results_detectors = []
     results_printers = []
diff --git a/tests/e2e/test_cli.py b/tests/e2e/test_cli.py
new file mode 100644
index 000000000..72e0441d6
--- /dev/null
+++ b/tests/e2e/test_cli.py
@@ -0,0 +1,20 @@
+import sys
+import tempfile
+import pytest
+
+from slither.__main__ import main_impl
+
+
+def test_cli_exit_on_invalid_compilation_file(caplog):
+
+    with tempfile.NamedTemporaryFile("w") as f:
+        f.write("pragma solidity ^0.10000.0;")
+
+        sys.argv = ["slither", f.name]
+        with pytest.raises(SystemExit) as pytest_wrapped_e:
+            main_impl([], [])
+
+    assert pytest_wrapped_e.type == SystemExit
+    assert pytest_wrapped_e.value.code == 2
+
+    assert caplog.record_tuples[0] == ("Slither", 40, "Unable to compile all targets.")