diff --git a/content/browser/browser_main_loop.cc b/content/browser/browser_main_loop.cc
index b5159df02a3e9..8f21c09bad209 100644
--- a/content/browser/browser_main_loop.cc
+++ b/content/browser/browser_main_loop.cc
@@ -465,10 +465,10 @@ void BrowserMainLoop::EarlyInitialization() {
   net::EnsureWinsockInit();
 #endif
 
-#if !defined(USE_OPENSSL)
+#if defined(USE_NSS_CERTS) || !defined(USE_OPENSSL)
   // We want to be sure to init NSPR on the main thread.
   crypto::EnsureNSPRInit();
-#endif  // !defined(USE_OPENSSL)
+#endif
 
 #if !defined(OS_IOS)
   if (parsed_command_line_.HasSwitch(switches::kRendererProcessLimit)) {