diff --git a/.gitignore b/.gitignore
index 990f6517fe9..9f244805f60 100644
--- a/.gitignore
+++ b/.gitignore
@@ -314,4 +314,7 @@ examples/**/sam/.aws-sam
 
 cdk.out
 # NOTE: different accounts will be used for E2E thus creating unnecessary git clutter
-cdk.context.json
\ No newline at end of file
+cdk.context.json
+
+# vim
+*.swp
diff --git a/aws_lambda_powertools/event_handler/openapi/params.py b/aws_lambda_powertools/event_handler/openapi/params.py
index ffcef8b5096..747f48686c4 100644
--- a/aws_lambda_powertools/event_handler/openapi/params.py
+++ b/aws_lambda_powertools/event_handler/openapi/params.py
@@ -932,7 +932,8 @@ def analyze_param(
     ModelField | None
         The type annotation and the Pydantic field representing the parameter
     """
-    field_info, type_annotation = get_field_info_and_type_annotation(annotation, value, is_path_param)
+    field_info, type_annotation = \
+        get_field_info_and_type_annotation(annotation, value, is_path_param, is_response_param)
 
     # If the value is a FieldInfo, we use it as the FieldInfo for the parameter
     if isinstance(value, FieldInfo):
@@ -962,7 +963,9 @@ def analyze_param(
     return field
 
 
-def get_field_info_and_type_annotation(annotation, value, is_path_param: bool) -> tuple[FieldInfo | None, Any]:
+def get_field_info_and_type_annotation(
+    annotation, value, is_path_param: bool, is_response_param: bool
+) -> tuple[FieldInfo | None, Any]:
     """
     Get the FieldInfo and type annotation from an annotation and value.
     """
@@ -976,6 +979,10 @@ def get_field_info_and_type_annotation(annotation, value, is_path_param: bool) -
         # If the annotation is a Response type, we recursively call this function with the inner type
         elif get_origin(annotation) is Response:
             field_info, type_annotation = get_field_info_response_type(annotation, value)
+        # If the annotation is a tuple with two elements, we use the first element as the type annotation,
+        # just like we did in the APIGateway._to_response
+        elif is_response_param and get_origin(annotation) is tuple and len(get_args(annotation)) == 2:
+            field_info, type_annotation = get_field_info_tuple_type(annotation, value)
         # If the annotation is not an Annotated type, we use it as the type annotation
         else:
             type_annotation = annotation
@@ -983,12 +990,22 @@ def get_field_info_and_type_annotation(annotation, value, is_path_param: bool) -
     return field_info, type_annotation
 
 
+def get_field_info_tuple_type(annotation, value) -> tuple[FieldInfo | None, Any]:
+    (inner_type, _) = get_args(annotation)
+
+    # If the inner type is an Annotated type, we need to extract the type annotation and the FieldInfo
+    if get_origin(inner_type) is Annotated:
+        return get_field_info_annotated_type(inner_type, value, False)
+
+    return None, inner_type
+
+
 def get_field_info_response_type(annotation, value) -> tuple[FieldInfo | None, Any]:
     # Example: get_args(Response[inner_type]) == (inner_type,)  # noqa: ERA001
     (inner_type,) = get_args(annotation)
 
     # Recursively resolve the inner type
-    return get_field_info_and_type_annotation(inner_type, value, False)
+    return get_field_info_and_type_annotation(inner_type, value, False, True)
 
 
 def get_field_info_annotated_type(annotation, value, is_path_param: bool) -> tuple[FieldInfo | None, Any]:
diff --git a/tests/functional/event_handler/_pydantic/test_openapi_params.py b/tests/functional/event_handler/_pydantic/test_openapi_params.py
index a57156db130..3c83d3eda72 100644
--- a/tests/functional/event_handler/_pydantic/test_openapi_params.py
+++ b/tests/functional/event_handler/_pydantic/test_openapi_params.py
@@ -172,6 +172,42 @@ def handler() -> Response[Annotated[str, Body(title="Response title")]]:
     assert response.schema_.type == "string"
 
 
+def test_openapi_with_tuple_returns():
+    app = APIGatewayRestResolver()
+
+    @app.get("/")
+    def handler() -> tuple[str, int]:
+        return "Hello, world", 200
+
+    schema = app.get_openapi_schema()
+    assert len(schema.paths.keys()) == 1
+
+    get = schema.paths["/"].get
+    assert get.parameters is None
+
+    response = get.responses[200].content[JSON_CONTENT_TYPE]
+    assert response.schema_.title == "Return"
+    assert response.schema_.type == "string"
+
+
+def test_openapi_with_tuple_annotated_returns():
+    app = APIGatewayRestResolver()
+
+    @app.get("/")
+    def handler() -> tuple[Annotated[str, Body(title="Response title")], int]:
+        return "Hello, world", 200
+
+    schema = app.get_openapi_schema()
+    assert len(schema.paths.keys()) == 1
+
+    get = schema.paths["/"].get
+    assert get.parameters is None
+
+    response = get.responses[200].content[JSON_CONTENT_TYPE]
+    assert response.schema_.title == "Response title"
+    assert response.schema_.type == "string"
+
+
 def test_openapi_with_omitted_param():
     app = APIGatewayRestResolver()