diff --git a/packages/core/src/__tests__/field.spec.ts b/packages/core/src/__tests__/field.spec.ts
index 5b0688963da..54997c2fb37 100644
--- a/packages/core/src/__tests__/field.spec.ts
+++ b/packages/core/src/__tests__/field.spec.ts
@@ -1,4 +1,4 @@
-import { autorun, batch } from '@formily/reactive'
+import { autorun, batch, observable } from '@formily/reactive'
 import { createForm, onFieldReact, isField } from '../'
 import { DataField } from '../types'
 import { attach, sleep } from './shared'
@@ -2109,18 +2109,17 @@ test('destroy field need auto remove initialValues', () => {
 })
 
 test('validateFirst', async () => {
-  const form = attach(createForm<any>({
-    validateFirst: false
-  }))
+  const form = attach(
+    createForm<any>({
+      validateFirst: false,
+    })
+  )
   const aaValidate = jest.fn(() => 'aaError')
   const aa = attach(
     form.createField({
       name: 'aa',
       validateFirst: true,
-      validator: [
-        aaValidate,
-        aaValidate,
-      ]
+      validator: [aaValidate, aaValidate],
     })
   )
   await aa.onInput('aa')
@@ -2128,10 +2127,7 @@ test('validateFirst', async () => {
   const bb = attach(
     form.createField({
       name: 'bb',
-      validator: [
-        bbValidate,
-        bbValidate,
-      ],
+      validator: [bbValidate, bbValidate],
       validateFirst: false,
     })
   )
@@ -2140,10 +2136,7 @@ test('validateFirst', async () => {
   const cc = attach(
     form.createField({
       name: 'cc',
-      validator: [
-        ccValidate,
-        ccValidate,
-      ],
+      validator: [ccValidate, ccValidate],
     })
   )
   await cc.onInput('cc')
@@ -2152,3 +2145,22 @@ test('validateFirst', async () => {
   expect(bbValidate).toBeCalledTimes(2)
   expect(ccValidate).toBeCalledTimes(2)
 })
+
+test('reactions should not be triggered when field destroyed', () => {
+  const form = attach(createForm<any>())
+  const handler = jest.fn()
+  const obs = observable({ bb: 123 })
+  const aa = attach(
+    form.createField({
+      name: 'aa',
+      initialValue: 'test',
+      reactions() {
+        handler(obs.bb)
+      },
+    })
+  )
+  obs.bb = 321
+  aa.destroy()
+  obs.bb = 111
+  expect(handler).toBeCalledTimes(2)
+})
diff --git a/packages/core/src/models/BaseField.ts b/packages/core/src/models/BaseField.ts
index a2f0799a504..b3727b4e1eb 100644
--- a/packages/core/src/models/BaseField.ts
+++ b/packages/core/src/models/BaseField.ts
@@ -124,6 +124,10 @@ export class BaseField<Decorator = any, Component = any, TextType = any> {
     return this.display === 'visible'
   }
 
+  get destroyed() {
+    return !this.form.fields[this.address.toString()]
+  }
+
   set hidden(hidden: boolean) {
     if (!isValid(hidden)) return
     if (hidden) {
diff --git a/packages/core/src/shared/internals.ts b/packages/core/src/shared/internals.ts
index d5321b121ad..3c464d947ed 100644
--- a/packages/core/src/shared/internals.ts
+++ b/packages/core/src/shared/internals.ts
@@ -1063,7 +1063,14 @@ export const createReactions = (field: GeneralField) => {
   field.form.addEffects(field, () => {
     reactions.forEach((reaction) => {
       if (isFn(reaction)) {
-        field.disposers.push(autorun(batch.scope.bound(() => reaction(field))))
+        field.disposers.push(
+          autorun(
+            batch.scope.bound(() => {
+              if (field.destroyed) return
+              reaction(field)
+            })
+          )
+        )
       }
     })
   })