diff --git a/tools/run_tests/artifacts/build_artifact_python.sh b/tools/run_tests/artifacts/build_artifact_python.sh
index 4c00710cd9894..866fe15295cff 100755
--- a/tools/run_tests/artifacts/build_artifact_python.sh
+++ b/tools/run_tests/artifacts/build_artifact_python.sh
@@ -165,7 +165,10 @@ then
   "${PYTHON}" -m virtualenv venv || { "${PYTHON}" -m pip install virtualenv==20.0.23 && "${PYTHON}" -m virtualenv venv; }
   # Ensure the generated artifacts are valid using "twine check"
   venv/bin/python -m pip install "twine<=2.0" "readme_renderer<40.0"
-  venv/bin/python -m twine check dist/* tools/distrib/python/grpcio_tools/dist/* src/python/grpcio_observability/dist/*
+  venv/bin/python -m twine check dist/* tools/distrib/python/grpcio_tools/dist/*
+  if [ "$GRPC_BUILD_MAC" == "" ]; then
+    venv/bin/python -m twine check src/python/grpcio_observability/dist/*
+  fi
   rm -rf venv/
 fi
 
@@ -212,22 +215,30 @@ then
     "${AUDITWHEEL}" repair "$wheel" --strip --wheel-dir "$ARTIFACT_DIR"
     rm "$wheel"
   done
-  for wheel in src/python/grpcio_observability/dist/*.whl; do
-    "${AUDITWHEEL}" show "$wheel" | tee /dev/stderr |  grep -E -w "$AUDITWHEEL_PLAT"
-    "${AUDITWHEEL}" repair "$wheel" --strip --wheel-dir "$ARTIFACT_DIR"
-    rm "$wheel"
-  done
 else
   cp -r dist/*.whl "$ARTIFACT_DIR"
   cp -r tools/distrib/python/grpcio_tools/dist/*.whl "$ARTIFACT_DIR"
-  cp -r src/python/grpcio_observability/dist/*.whl "$ARTIFACT_DIR"
 fi
 
-# grpcio, grpcio-tools and grpcio-observability have already been copied to artifact_dir
+# grpcio and grpcio-tools have already been copied to artifact_dir
 # by "auditwheel repair", now copy the .tar.gz source archives as well.
 cp -r dist/*.tar.gz "$ARTIFACT_DIR"
 cp -r tools/distrib/python/grpcio_tools/dist/*.tar.gz "$ARTIFACT_DIR"
-cp -r src/python/grpcio_observability/dist/*.tar.gz "$ARTIFACT_DIR"
+
+
+if [ "$GRPC_BUILD_MAC" == "" ]; then
+  if [ "$GRPC_RUN_AUDITWHEEL_REPAIR" != "" ]
+  then
+    for wheel in src/python/grpcio_observability/dist/*.whl; do
+      "${AUDITWHEEL}" show "$wheel" | tee /dev/stderr |  grep -E -w "$AUDITWHEEL_PLAT"
+      "${AUDITWHEEL}" repair "$wheel" --strip --wheel-dir "$ARTIFACT_DIR"
+      rm "$wheel"
+    done
+  else
+    cp -r src/python/grpcio_observability/dist/*.whl "$ARTIFACT_DIR"
+  fi
+  cp -r src/python/grpcio_observability/dist/*.tar.gz "$ARTIFACT_DIR"
+fi
 
 # We need to use the built grpcio-tools/grpcio to compile the health proto
 # Wheels are not supported by setup_requires/dependency_links, so we