diff --git a/scripts/fuzz_opt.py b/scripts/fuzz_opt.py
index 8bef4e98c8c..683c2bed718 100755
--- a/scripts/fuzz_opt.py
+++ b/scripts/fuzz_opt.py
@@ -332,8 +332,9 @@ def is_git_repo():
     'exception-handling.wast',
     'translate-eh-old-to-new.wast',
     'rse-eh.wast',
-    # Non-UTF8 strings trap in V8
+    # Non-UTF8 strings trap in V8, and have limitations in our interpreter
     'string-lowering.wast',
+    'precompute-strings.wast',
 ]
 
 
diff --git a/src/wasm-interpreter.h b/src/wasm-interpreter.h
index 5179d6ad03f..ccb56aba81c 100644
--- a/src/wasm-interpreter.h
+++ b/src/wasm-interpreter.h
@@ -1903,7 +1903,12 @@ class ExpressionRunner : public OverriddenVisitor<SubType, Flow> {
     return Literal(curr->string.toString());
   }
 
-  bool hasNonAsciiUpTo(const Literals& values, Index end) {
+  // Returns if there is a non-ascii character in a list of values, looking only
+  // up to an index that is provided (not inclusive). If the index is not
+  // provided we look in the entire list.
+  bool hasNonAsciiUpTo(const Literals& values,
+                       std::optional<Index> maybeEnd = std::nullopt) {
+    Index end = maybeEnd ? *maybeEnd : values.size();
     for (Index i = 0; i < end; ++i) {
       if (uint32_t(values[i].geti32()) > 127) {
         return true;
@@ -1930,7 +1935,7 @@ class ExpressionRunner : public OverriddenVisitor<SubType, Flow> {
 
     // This is only correct if all the bytes stored in `values` correspond to
     // single unicode code points. See `visitStringWTF16Get` for details.
-    if (hasNonAsciiUpTo(data->values, data->values.size())) {
+    if (hasNonAsciiUpTo(data->values)) {
       return Flow(NONCONSTANT_FLOW);
     }
 
@@ -1998,7 +2003,7 @@ class ExpressionRunner : public OverriddenVisitor<SubType, Flow> {
     }
 
     // We don't handle non-ascii code points correctly yet.
-    if (hasNonAsciiUpTo(refValues, refValues.size())) {
+    if (hasNonAsciiUpTo(refValues)) {
       return Flow(NONCONSTANT_FLOW);
     }
 
@@ -2138,7 +2143,47 @@ class ExpressionRunner : public OverriddenVisitor<SubType, Flow> {
     return Flow(NONCONSTANT_FLOW);
   }
   Flow visitStringSliceWTF(StringSliceWTF* curr) {
-    return Flow(NONCONSTANT_FLOW);
+    // For now we only support JS-style strings.
+    if (curr->op != StringSliceWTF16) {
+      return Flow(NONCONSTANT_FLOW);
+    }
+
+    Flow ref = visit(curr->ref);
+    if (ref.breaking()) {
+      return ref;
+    }
+    Flow start = visit(curr->start);
+    if (start.breaking()) {
+      return start;
+    }
+    Flow end = visit(curr->end);
+    if (end.breaking()) {
+      return end;
+    }
+
+    auto refData = ref.getSingleValue().getGCData();
+    if (!refData) {
+      trap("null ref");
+    }
+    auto& refValues = refData->values;
+    auto startVal = start.getSingleValue().getUnsigned();
+    auto endVal = end.getSingleValue().getUnsigned();
+    if (endVal > refValues.size()) {
+      trap("array oob");
+    }
+    if (hasNonAsciiUpTo(refValues, endVal)) {
+      return Flow(NONCONSTANT_FLOW);
+    }
+    Literals contents;
+    if (endVal > startVal) {
+      contents.reserve(endVal - startVal);
+      for (size_t i = startVal; i < endVal; i++) {
+        if (i < refValues.size()) {
+          contents.push_back(refValues[i]);
+        }
+      }
+    }
+    return makeGCData(contents, curr->type);
   }
   Flow visitStringSliceIter(StringSliceIter* curr) {
     return Flow(NONCONSTANT_FLOW);
diff --git a/test/lit/exec/strings.wast b/test/lit/exec/strings.wast
index 706602b1ce5..5ff8ce47a87 100644
--- a/test/lit/exec/strings.wast
+++ b/test/lit/exec/strings.wast
@@ -244,6 +244,17 @@
       )
     )
   )
+
+  ;; CHECK:      [fuzz-exec] calling slice
+  ;; CHECK-NEXT: [fuzz-exec] note result: slice => string("def")
+  (func $slice (export "slice") (result (ref string))
+    ;; Slicing [3:6] here should definitely output "def".
+    (stringview_wtf16.slice
+      (string.const "abcdefgh")
+      (i32.const 3)
+      (i32.const 6)
+    )
+  )
 )
 ;; CHECK:      [fuzz-exec] calling new_wtf16_array
 ;; CHECK-NEXT: [fuzz-exec] note result: new_wtf16_array => string("ello")
@@ -309,6 +320,9 @@
 ;; CHECK-NEXT: [LoggingExternalInterface logging 98]
 ;; CHECK-NEXT: [LoggingExternalInterface logging 99]
 ;; CHECK-NEXT: [LoggingExternalInterface logging 0]
+
+;; CHECK:      [fuzz-exec] calling slice
+;; CHECK-NEXT: [fuzz-exec] note result: slice => string("def")
 ;; CHECK-NEXT: [fuzz-exec] comparing compare.1
 ;; CHECK-NEXT: [fuzz-exec] comparing compare.10
 ;; CHECK-NEXT: [fuzz-exec] comparing compare.2
@@ -329,3 +343,4 @@
 ;; CHECK-NEXT: [fuzz-exec] comparing get_codeunit
 ;; CHECK-NEXT: [fuzz-exec] comparing get_length
 ;; CHECK-NEXT: [fuzz-exec] comparing new_wtf16_array
+;; CHECK-NEXT: [fuzz-exec] comparing slice
diff --git a/test/lit/passes/precompute-strings.wast b/test/lit/passes/precompute-strings.wast
index aa138b289c0..f704306481a 100644
--- a/test/lit/passes/precompute-strings.wast
+++ b/test/lit/passes/precompute-strings.wast
@@ -129,4 +129,33 @@
    (i32.const 0)
   )
  )
+
+ ;; CHECK:      (func $slice (type $1) (result (ref string))
+ ;; CHECK-NEXT:  (string.const "def")
+ ;; CHECK-NEXT: )
+ (func $slice (export "slice") (result (ref string))
+  ;; Slicing [3:6] here should definitely output "def".
+  (stringview_wtf16.slice
+   (string.const "abcdefgh")
+   (i32.const 3)
+   (i32.const 6)
+  )
+ )
+
+ ;; CHECK:      (func $slice-bad (type $1) (result (ref string))
+ ;; CHECK-NEXT:  (stringview_wtf16.slice
+ ;; CHECK-NEXT:   (string.const "abcd\c2\a3fgh")
+ ;; CHECK-NEXT:   (i32.const 3)
+ ;; CHECK-NEXT:   (i32.const 6)
+ ;; CHECK-NEXT:  )
+ ;; CHECK-NEXT: )
+ (func $slice-bad (export "slice-bad") (result (ref string))
+  ;; This slice contains non-ascii, so we do not optimize.
+  (stringview_wtf16.slice
+   ;; abcd£fgh
+   (string.const "abcd\C2\A3fgh")
+   (i32.const 3)
+   (i32.const 6)
+  )
+ )
 )