diff --git a/pandas/_libs/algos.pyx b/pandas/_libs/algos.pyx
index 124792638e3df..908bf59987527 100644
--- a/pandas/_libs/algos.pyx
+++ b/pandas/_libs/algos.pyx
@@ -1,4 +1,4 @@
-# cython: profile=False
+# -*- coding: utf-8 -*-
 
 cimport cython
 from cython cimport Py_ssize_t
diff --git a/pandas/_libs/groupby.pyx b/pandas/_libs/groupby.pyx
index 5681d01c6bb25..077ef925a8321 100644
--- a/pandas/_libs/groupby.pyx
+++ b/pandas/_libs/groupby.pyx
@@ -1,5 +1,4 @@
 # -*- coding: utf-8 -*-
-# cython: profile=False
 
 cimport cython
 from cython cimport Py_ssize_t
diff --git a/pandas/_libs/hashing.pyx b/pandas/_libs/hashing.pyx
index a9775d3950187..65fdeb8e33efd 100644
--- a/pandas/_libs/hashing.pyx
+++ b/pandas/_libs/hashing.pyx
@@ -1,4 +1,4 @@
-# cython: profile=False
+# -*- coding: utf-8 -*-
 # Translated from the reference implementation
 # at https://github.com/veorq/SipHash
 
diff --git a/pandas/_libs/hashtable.pyx b/pandas/_libs/hashtable.pyx
index b9a72a0c8285f..2ced98198afc6 100644
--- a/pandas/_libs/hashtable.pyx
+++ b/pandas/_libs/hashtable.pyx
@@ -1,4 +1,4 @@
-# cython: profile=False
+# -*- coding: utf-8 -*-
 
 cimport cython
 
diff --git a/pandas/_libs/index.pyx b/pandas/_libs/index.pyx
index 5918560cf1436..4965469d05276 100644
--- a/pandas/_libs/index.pyx
+++ b/pandas/_libs/index.pyx
@@ -1,4 +1,4 @@
-# cython: profile=False
+# -*- coding: utf-8 -*-
 from datetime import datetime, timedelta, date
 
 cimport cython
diff --git a/pandas/_libs/indexing.pyx b/pandas/_libs/indexing.pyx
index c680706b7b2d2..af6e00bad7f6b 100644
--- a/pandas/_libs/indexing.pyx
+++ b/pandas/_libs/indexing.pyx
@@ -1,4 +1,5 @@
-# cython: profile=False
+# -*- coding: utf-8 -*-
+
 
 cdef class _NDFrameIndexerBase:
     """
diff --git a/pandas/_libs/join.pyx b/pandas/_libs/join.pyx
index 27d2a639d13e6..ebb7bd40694ec 100644
--- a/pandas/_libs/join.pyx
+++ b/pandas/_libs/join.pyx
@@ -1,4 +1,4 @@
-# cython: profile=False
+# -*- coding: utf-8 -*-
 
 cimport cython
 from cython cimport Py_ssize_t
diff --git a/pandas/_libs/khash.pxd b/pandas/_libs/khash.pxd
index 4c00e273b33b7..971a45e365586 100644
--- a/pandas/_libs/khash.pxd
+++ b/pandas/_libs/khash.pxd
@@ -1,5 +1,4 @@
 # -*- coding: utf-8 -*-
-# cython: profile=False
 from cpython cimport PyObject
 from numpy cimport int64_t, uint64_t, int32_t, uint32_t, float64_t
 
diff --git a/pandas/_libs/missing.pxd b/pandas/_libs/missing.pxd
index b90975df8e247..2c1f13eeb5dff 100644
--- a/pandas/_libs/missing.pxd
+++ b/pandas/_libs/missing.pxd
@@ -1,5 +1,4 @@
 # -*- coding: utf-8 -*-
-# cython: profile=False
 
 from tslibs.nattype cimport is_null_datetimelike
 
diff --git a/pandas/_libs/missing.pyx b/pandas/_libs/missing.pyx
index e9c3cf12eb328..c787cc61e8773 100644
--- a/pandas/_libs/missing.pyx
+++ b/pandas/_libs/missing.pyx
@@ -1,5 +1,4 @@
 # -*- coding: utf-8 -*-
-# cython: profile=False
 
 from cpython cimport PyFloat_Check, PyComplex_Check
 
diff --git a/pandas/_libs/reduction.pyx b/pandas/_libs/reduction.pyx
index 3588ac14c87d1..2ccb58dd67014 100644
--- a/pandas/_libs/reduction.pyx
+++ b/pandas/_libs/reduction.pyx
@@ -1,5 +1,4 @@
 # -*- coding: utf-8 -*-
-# cython: profile=False
 from distutils.version import LooseVersion
 
 from cython cimport Py_ssize_t
diff --git a/pandas/_libs/reshape.pyx b/pandas/_libs/reshape.pyx
index 4fd1fd0f37b1d..8d7e314517ed8 100644
--- a/pandas/_libs/reshape.pyx
+++ b/pandas/_libs/reshape.pyx
@@ -1,4 +1,4 @@
-# cython: profile=False
+# -*- coding: utf-8 -*-
 
 cimport cython
 from cython cimport Py_ssize_t
diff --git a/pandas/_libs/skiplist.pxd b/pandas/_libs/skiplist.pxd
index 78f206962bcfc..a273d2c445d18 100644
--- a/pandas/_libs/skiplist.pxd
+++ b/pandas/_libs/skiplist.pxd
@@ -1,5 +1,4 @@
 # -*- coding: utf-8 -*-
-# cython: profile=False
 
 from cython cimport Py_ssize_t
 
diff --git a/pandas/_libs/tslib.pyx b/pandas/_libs/tslib.pyx
index 04e039a9fc2c9..7b938d0279a7c 100644
--- a/pandas/_libs/tslib.pyx
+++ b/pandas/_libs/tslib.pyx
@@ -1,5 +1,4 @@
 # -*- coding: utf-8 -*-
-# cython: profile=False
 from cython cimport Py_ssize_t
 
 from cpython cimport PyFloat_Check, PyUnicode_Check
diff --git a/pandas/_libs/tslibs/ccalendar.pxd b/pandas/_libs/tslibs/ccalendar.pxd
index 04fb6eaf49c84..08f539a70a7ed 100644
--- a/pandas/_libs/tslibs/ccalendar.pxd
+++ b/pandas/_libs/tslibs/ccalendar.pxd
@@ -1,5 +1,4 @@
 # -*- coding: utf-8 -*-
-# cython: profile=False
 
 from cython cimport Py_ssize_t
 
diff --git a/pandas/_libs/tslibs/ccalendar.pyx b/pandas/_libs/tslibs/ccalendar.pyx
index 12d35f7ce2f58..ec54c023290b3 100644
--- a/pandas/_libs/tslibs/ccalendar.pyx
+++ b/pandas/_libs/tslibs/ccalendar.pyx
@@ -1,5 +1,4 @@
 # -*- coding: utf-8 -*-
-# cython: profile=False
 # cython: boundscheck=False
 """
 Cython implementations of functions resembling the stdlib calendar module
diff --git a/pandas/_libs/tslibs/conversion.pxd b/pandas/_libs/tslibs/conversion.pxd
index 96e4676fe91c0..4eb93c35b4afc 100644
--- a/pandas/_libs/tslibs/conversion.pxd
+++ b/pandas/_libs/tslibs/conversion.pxd
@@ -1,5 +1,4 @@
 # -*- coding: utf-8 -*-
-# cython: profile=False
 
 from cpython.datetime cimport datetime, tzinfo
 
diff --git a/pandas/_libs/tslibs/conversion.pyx b/pandas/_libs/tslibs/conversion.pyx
index 74a9823a85016..fe664cf03b0b9 100644
--- a/pandas/_libs/tslibs/conversion.pyx
+++ b/pandas/_libs/tslibs/conversion.pyx
@@ -1,5 +1,4 @@
 # -*- coding: utf-8 -*-
-# cython: profile=False
 
 cimport cython
 from cython cimport Py_ssize_t
diff --git a/pandas/_libs/tslibs/fields.pyx b/pandas/_libs/tslibs/fields.pyx
index 96f023f7fdafe..9cbad8acabff1 100644
--- a/pandas/_libs/tslibs/fields.pyx
+++ b/pandas/_libs/tslibs/fields.pyx
@@ -1,5 +1,4 @@
 # -*- coding: utf-8 -*-
-# cython: profile=False
 """
 Functions for accessing attributes of Timestamp/datetime64/datetime-like
 objects and arrays
diff --git a/pandas/_libs/tslibs/frequencies.pxd b/pandas/_libs/tslibs/frequencies.pxd
index 98d600c540ace..4e7949e55c836 100644
--- a/pandas/_libs/tslibs/frequencies.pxd
+++ b/pandas/_libs/tslibs/frequencies.pxd
@@ -1,5 +1,4 @@
 # -*- coding: utf-8 -*-
-# cython: profile=False
 
 cpdef object get_rule_month(object source, object default=*)
 
diff --git a/pandas/_libs/tslibs/nattype.pxd b/pandas/_libs/tslibs/nattype.pxd
index 24ce797575b2a..382ac9d323918 100644
--- a/pandas/_libs/tslibs/nattype.pxd
+++ b/pandas/_libs/tslibs/nattype.pxd
@@ -1,5 +1,4 @@
 # -*- coding: utf-8 -*-
-# cython: profile=False
 
 from numpy cimport int64_t
 cdef int64_t NPY_NAT
diff --git a/pandas/_libs/tslibs/nattype.pyx b/pandas/_libs/tslibs/nattype.pyx
index 25b1572cfe52f..08d9128ff660c 100644
--- a/pandas/_libs/tslibs/nattype.pyx
+++ b/pandas/_libs/tslibs/nattype.pyx
@@ -1,5 +1,4 @@
 # -*- coding: utf-8 -*-
-# cython: profile=False
 
 from cpython cimport (
     PyFloat_Check, PyComplex_Check,
diff --git a/pandas/_libs/tslibs/np_datetime.pxd b/pandas/_libs/tslibs/np_datetime.pxd
index c3d229d4e5006..803c8cb18e3d5 100644
--- a/pandas/_libs/tslibs/np_datetime.pxd
+++ b/pandas/_libs/tslibs/np_datetime.pxd
@@ -1,5 +1,4 @@
 # -*- coding: utf-8 -*-
-# cython: profile=False
 
 from cpython.datetime cimport date, datetime
 
diff --git a/pandas/_libs/tslibs/np_datetime.pyx b/pandas/_libs/tslibs/np_datetime.pyx
index a0099837e876a..f0aa6389fba56 100644
--- a/pandas/_libs/tslibs/np_datetime.pyx
+++ b/pandas/_libs/tslibs/np_datetime.pyx
@@ -1,5 +1,4 @@
 # -*- coding: utf-8 -*-
-# cython: profile=False
 
 from cpython cimport (Py_EQ, Py_NE, Py_GE, Py_GT, Py_LT, Py_LE,
                       PyUnicode_Check, PyUnicode_AsASCIIString)
diff --git a/pandas/_libs/tslibs/timedeltas.pxd b/pandas/_libs/tslibs/timedeltas.pxd
index e139cb38cb241..dbdead1dba551 100644
--- a/pandas/_libs/tslibs/timedeltas.pxd
+++ b/pandas/_libs/tslibs/timedeltas.pxd
@@ -1,5 +1,4 @@
 # -*- coding: utf-8 -*-
-# cython: profile=False
 
 from numpy cimport int64_t
 
diff --git a/pandas/_libs/tslibs/timedeltas.pyx b/pandas/_libs/tslibs/timedeltas.pyx
index c32ad2f4d599c..b84c1a753215a 100644
--- a/pandas/_libs/tslibs/timedeltas.pyx
+++ b/pandas/_libs/tslibs/timedeltas.pyx
@@ -1,5 +1,4 @@
 # -*- coding: utf-8 -*-
-# cython: profile=False
 import collections
 import textwrap
 import warnings
diff --git a/pandas/_libs/tslibs/timestamps.pxd b/pandas/_libs/tslibs/timestamps.pxd
index e9e484c715f9a..d6b649becc479 100644
--- a/pandas/_libs/tslibs/timestamps.pxd
+++ b/pandas/_libs/tslibs/timestamps.pxd
@@ -1,5 +1,4 @@
 # -*- coding: utf-8 -*-
-# cython: profile=False
 
 from numpy cimport int64_t
 from np_datetime cimport npy_datetimestruct
diff --git a/pandas/_libs/tslibs/timestamps.pyx b/pandas/_libs/tslibs/timestamps.pyx
index 67420fda8aa51..3ab1396c0fe38 100644
--- a/pandas/_libs/tslibs/timestamps.pyx
+++ b/pandas/_libs/tslibs/timestamps.pyx
@@ -1,5 +1,4 @@
 # -*- coding: utf-8 -*-
-# cython: profile=False
 import warnings
 
 from cpython cimport (PyObject_RichCompareBool, PyObject_RichCompare,
diff --git a/pandas/_libs/tslibs/timezones.pxd b/pandas/_libs/tslibs/timezones.pxd
index 67353f3eec614..e8a10a0728212 100644
--- a/pandas/_libs/tslibs/timezones.pxd
+++ b/pandas/_libs/tslibs/timezones.pxd
@@ -1,5 +1,4 @@
 # -*- coding: utf-8 -*-
-# cython: profile=False
 
 cdef bint is_utc(object tz)
 cdef bint is_tzlocal(object tz)
diff --git a/pandas/_libs/tslibs/timezones.pyx b/pandas/_libs/tslibs/timezones.pyx
index a787452d90c07..4d87a37866c49 100644
--- a/pandas/_libs/tslibs/timezones.pyx
+++ b/pandas/_libs/tslibs/timezones.pyx
@@ -1,5 +1,4 @@
 # -*- coding: utf-8 -*-
-# cython: profile=False
 
 from cython cimport Py_ssize_t
 
diff --git a/pandas/_libs/window.pyx b/pandas/_libs/window.pyx
index efc8a02014bc0..c43750c754209 100644
--- a/pandas/_libs/window.pyx
+++ b/pandas/_libs/window.pyx
@@ -1,4 +1,4 @@
-# cython: profile=False
+# -*- coding: utf-8 -*-
 # cython: boundscheck=False, wraparound=False, cdivision=True
 
 cimport cython