diff --git a/.github/workflows/CI-win.yml b/.github/workflows/CI-win.yml
index 9b9aa7721eb..ca6741df280 100644
--- a/.github/workflows/CI-win.yml
+++ b/.github/workflows/CI-win.yml
@@ -16,7 +16,7 @@ on:
 jobs:
   build-windows:
     runs-on: windows-${{ matrix.config.server }}
-    name: build-${{ matrix.config.toolchain}}-${{ matrix.config.arch}}
+    name: build-${{ join(matrix.config.*, '-') }}
     strategy:
       fail-fast: false
       matrix:
@@ -25,27 +25,40 @@ jobs:
           - {toolchain: Visual Studio 16 2019, arch: x64, server: 2019}
           - {toolchain: Visual Studio 17 2022, arch: Win32, server: 2022}
           - {toolchain: Visual Studio 17 2022, arch: x64, server: 2022}
+          - {toolchain: Visual Studio 17 2022, arch: x64, server: 2022, config: ASAN}
     steps:
       - uses: actions/checkout@v2
       - name: Envinfo
         run: npx envinfo
       - name: Build
         shell: cmd
-        run: |
-          mkdir -p build
-          cd build
-          cmake .. -DBUILD_TESTING=ON -G "${{ matrix.config.toolchain }}" -A ${{ matrix.config.arch }}
-          cmake --build .
+        run:
+          cmake -S . -B build -DBUILD_TESTING=ON
+            -G "${{ matrix.config.toolchain }}" -A ${{ matrix.config.arch }}
+            ${{ matrix.config.config == 'ASAN' && '-DASAN=on -DCMAKE_MSVC_RUNTIME_LIBRARY=MultiThreaded' || '' }}
+
+          cmake --build build --config RelWithDebInfo
+
+          ls -l build
       - name: platform_output
         shell: cmd
-        run: |
-          build\\Debug\\uv_run_tests.exe platform_output
+        run:
+          build\\RelWithDebInfo\\uv_run_tests.exe platform_output
       - name: platform_output_a
         shell: cmd
-        run: |
-          build\\Debug\\uv_run_tests_a.exe platform_output
+        run:
+          build\\RelWithDebInfo\\uv_run_tests_a.exe platform_output
       - name: Test
+        # only valid with libuv-master with the fix for
+        # https://github.com/libuv/leps/blob/master/005-windows-handles-not-fd.md
+        if: ${{ matrix.config.config != 'ASAN' }}
         shell: cmd
-        run: |
+        run:
           cd build
-          ctest -C Debug -V
+
+          ctest -C RelWithDebInfo -V
+      - name: Test only static
+        if: ${{ matrix.config.config == 'ASAN' }}
+        shell: cmd
+        run:
+          build\\RelWithDebInfo\\uv_run_tests_a.exe
diff --git a/CMakeLists.txt b/CMakeLists.txt
index 358bcd6d3dc..74ee79362c3 100644
--- a/CMakeLists.txt
+++ b/CMakeLists.txt
@@ -5,6 +5,9 @@ cmake_policy(SET CMP0064 NEW) # Support if (TEST) operator
 if(POLICY CMP0091)
   cmake_policy(SET CMP0091 NEW) # Enable MSVC_RUNTIME_LIBRARY setting
 endif()
+if(POLICY CMP0092)
+  cmake_policy(SET CMP0092 NEW) # disable /W3 warning, if possible
+endif()
 
 project(libuv LANGUAGES C)
 
@@ -33,7 +36,7 @@ cmake_dependent_option(LIBUV_BUILD_BENCH
 # Qemu Build
 option(QEMU "build for qemu" OFF)
 if(QEMU)
-  add_definitions(-D__QEMU__=1)
+  list(APPEND uv_defines __QEMU__=1)
 endif()
 
 # Note: these are mutually exclusive.
@@ -41,33 +44,39 @@ option(ASAN "Enable AddressSanitizer (ASan)" OFF)
 option(MSAN "Enable MemorySanitizer (MSan)" OFF)
 option(TSAN "Enable ThreadSanitizer (TSan)" OFF)
 
-if((ASAN OR TSAN) AND NOT (CMAKE_C_COMPILER_ID MATCHES "AppleClang|GNU|Clang"))
-  message(SEND_ERROR "Sanitizer support requires clang or gcc. Try again with -DCMAKE_C_COMPILER.")
-endif()
-
 if(MSAN AND NOT CMAKE_C_COMPILER_ID MATCHES "AppleClang|Clang")
   message(SEND_ERROR "MemorySanitizer requires clang. Try again with -DCMAKE_C_COMPILER=clang")
 endif()
 
 if(ASAN)
-  add_definitions(-D__ASAN__=1)
-  set (CMAKE_C_FLAGS "${CMAKE_C_FLAGS} -fno-omit-frame-pointer -fsanitize=address")
-  set (CMAKE_SHARED_LINKER_FLAGS "${CMAKE_SHARED_LINKER_FLAGS} -fno-omit-frame-pointer -fsanitize=address")
-  set (CMAKE_EXE_LINKER_FLAGS "${CMAKE_EXE_LINKER_FLAGS} -fno-omit-frame-pointer -fsanitize=address")
+  list(APPEND uv_defines __ASAN__=1)
+  if(CMAKE_C_COMPILER_ID MATCHES "AppleClang|GNU|Clang")
+    set (CMAKE_C_FLAGS "${CMAKE_C_FLAGS} -fno-omit-frame-pointer -fsanitize=address")
+    set (CMAKE_SHARED_LINKER_FLAGS "${CMAKE_SHARED_LINKER_FLAGS} -fno-omit-frame-pointer -fsanitize=address")
+    set (CMAKE_EXE_LINKER_FLAGS "${CMAKE_EXE_LINKER_FLAGS} -fno-omit-frame-pointer -fsanitize=address")
+  elseif(MSVC)
+    set (CMAKE_C_FLAGS "${CMAKE_C_FLAGS} /fsanitize=address")
+  else()
+    message(SEND_ERROR "AddressSanitizer support requires clang, gcc, or msvc. Try again with -DCMAKE_C_COMPILER.")
+  endif()
 endif()
 
 if(MSAN)
-  add_definitions(-D__MSAN__=1)
+  list(APPEND uv_defines __MSAN__=1)
   set (CMAKE_C_FLAGS "${CMAKE_C_FLAGS} -fno-omit-frame-pointer -fsanitize=memory")
   set (CMAKE_SHARED_LINKER_FLAGS "${CMAKE_SHARED_LINKER_FLAGS} -fno-omit-frame-pointer -fsanitize=memory")
   set (CMAKE_EXE_LINKER_FLAGS "${CMAKE_EXE_LINKER_FLAGS} -fno-omit-frame-pointer -fsanitize=memory")
 endif()
 
 if(TSAN)
-  add_definitions(-D__TSAN__=1)
-  set (CMAKE_C_FLAGS "${CMAKE_C_FLAGS} -fno-omit-frame-pointer -fsanitize=thread")
-  set (CMAKE_SHARED_LINKER_FLAGS "${CMAKE_SHARED_LINKER_FLAGS} -fno-omit-frame-pointer -fsanitize=thread")
-  set (CMAKE_EXE_LINKER_FLAGS "${CMAKE_EXE_LINKER_FLAGS} -fno-omit-frame-pointer -fsanitize=thread")
+  list(APPEND uv_defines __TSAN__=1)
+  if(CMAKE_C_COMPILER_ID MATCHES "AppleClang|GNU|Clang")
+    set (CMAKE_C_FLAGS "${CMAKE_C_FLAGS} -fno-omit-frame-pointer -fsanitize=thread")
+    set (CMAKE_SHARED_LINKER_FLAGS "${CMAKE_SHARED_LINKER_FLAGS} -fno-omit-frame-pointer -fsanitize=thread")
+    set (CMAKE_EXE_LINKER_FLAGS "${CMAKE_EXE_LINKER_FLAGS} -fno-omit-frame-pointer -fsanitize=thread")
+  else()
+    message(SEND_ERROR "ThreadSanitizer support requires clang or gcc. Try again with -DCMAKE_C_COMPILER.")
+  endif()
 endif()
 
 # Compiler check