diff --git a/.github/CHANGELOG.md b/.github/CHANGELOG.md
index 72a58dbe67..e26332c540 100644
--- a/.github/CHANGELOG.md
+++ b/.github/CHANGELOG.md
@@ -56,6 +56,9 @@ array([-0.87758256, -0.47942554])
 
 ### Improvements
 
+* Lightning wheels are now checked with `twine check` post-creation for PyPI compatibility.
+  [(#430)](https://github.com/PennyLaneAI/pennylane-lightning/pull/430)
+
 * Lightning has been made compatible with the change in return types specification.
   [(#427)](https://github.com/PennyLaneAI/pennylane-lightning/pull/427)
 
diff --git a/.github/workflows/wheel_linux_aarch64.yml b/.github/workflows/wheel_linux_aarch64.yml
index 8b20f2d506..6dc6b0dd6c 100644
--- a/.github/workflows/wheel_linux_aarch64.yml
+++ b/.github/workflows/wheel_linux_aarch64.yml
@@ -167,6 +167,11 @@ jobs:
 
         run: python3 -m cibuildwheel --output-dir wheelhouse
 
+      - name: Validate wheels
+        run: |
+         python3 -m pip install twine
+         python3 -m twine check ./wheelhouse/*.whl
+
       - uses: actions-ecosystem/action-regex-match@v2
         id: rc_build
         with:
diff --git a/.github/workflows/wheel_linux_ppc64le.yml b/.github/workflows/wheel_linux_ppc64le.yml
index f2d4623a8d..5a596f8536 100644
--- a/.github/workflows/wheel_linux_ppc64le.yml
+++ b/.github/workflows/wheel_linux_ppc64le.yml
@@ -167,6 +167,11 @@ jobs:
 
         run: python3 -m cibuildwheel --output-dir wheelhouse
 
+      - name: Validate wheels
+        run: |
+          python3 -m pip install twine
+          python3 -m twine check ./wheelhouse/*.whl
+
       - uses: actions-ecosystem/action-regex-match@v2
         id: rc_build
         with:
diff --git a/.github/workflows/wheel_linux_x86_64.yml b/.github/workflows/wheel_linux_x86_64.yml
index b954e868ab..5d6c996a02 100644
--- a/.github/workflows/wheel_linux_x86_64.yml
+++ b/.github/workflows/wheel_linux_x86_64.yml
@@ -186,6 +186,11 @@ jobs:
 
         run: python3.8 -m cibuildwheel --output-dir wheelhouse
 
+      - name: Validate wheels
+        run: |
+          python3.8 -m pip install twine
+          python3.8 -m twine check ./wheelhouse/*.whl
+
       - uses: actions-ecosystem/action-regex-match@v2
         id: rc_build
         with:
diff --git a/.github/workflows/wheel_macos_arm64.yml b/.github/workflows/wheel_macos_arm64.yml
index 7b7afedfe0..f356e9a6a5 100644
--- a/.github/workflows/wheel_macos_arm64.yml
+++ b/.github/workflows/wheel_macos_arm64.yml
@@ -105,6 +105,11 @@ jobs:
         run: |
           python -m cibuildwheel --output-dir wheelhouse
 
+      - name: Validate wheels
+        run: |
+          python -m pip install twine
+          python -m twine check ./wheelhouse/*.whl
+
       - uses: actions/upload-artifact@v2
         if: ${{ github.event_name == 'release' || github.ref == 'refs/heads/master' }}
         with:
diff --git a/.github/workflows/wheel_macos_x86_64.yml b/.github/workflows/wheel_macos_x86_64.yml
index 4811f81222..3313e09397 100644
--- a/.github/workflows/wheel_macos_x86_64.yml
+++ b/.github/workflows/wheel_macos_x86_64.yml
@@ -179,6 +179,11 @@ jobs:
         run: |
           python -m cibuildwheel --output-dir wheelhouse
 
+      - name: Validate wheels
+        run: |
+          python -m pip install twine
+          python -m twine check ./wheelhouse/*.whl
+
       - uses: actions-ecosystem/action-regex-match@v2
         id: rc_build
         with:
diff --git a/.github/workflows/wheel_noarch.yml b/.github/workflows/wheel_noarch.yml
index 9acc46d509..4eb70e9c0b 100644
--- a/.github/workflows/wheel_noarch.yml
+++ b/.github/workflows/wheel_noarch.yml
@@ -42,6 +42,11 @@ jobs:
         env:
           SKIP_COMPILATION: True
 
+      - name: Validate wheels
+        run: |
+          python -m pip install twine
+          python -m twine check main/dist/*.whl
+
       - uses: actions/upload-artifact@v2
         if: ${{ github.event_name == 'release' || github.ref == 'refs/heads/master' }}
         with:
diff --git a/.github/workflows/wheel_win_x86_64.yml b/.github/workflows/wheel_win_x86_64.yml
index 3fffecf379..926dbb0151 100644
--- a/.github/workflows/wheel_win_x86_64.yml
+++ b/.github/workflows/wheel_win_x86_64.yml
@@ -182,6 +182,11 @@ jobs:
           }
           cd ..
 
+      - name: Validate wheels
+        run: |
+          python -m pip install twine
+          python -m twine check ./wheelhouse/*.whl
+
       - uses: actions-ecosystem/action-regex-match@v2
         id: rc_build
         with:
diff --git a/pennylane_lightning/_version.py b/pennylane_lightning/_version.py
index 96347d2310..8dab0a1c06 100644
--- a/pennylane_lightning/_version.py
+++ b/pennylane_lightning/_version.py
@@ -16,4 +16,4 @@
    Version number (major.minor.patch[-label])
 """
 
-__version__ = "0.30.0-dev2"
+__version__ = "0.30.0-dev3"