diff --git a/native/native.tests/tests/org/jetbrains/kotlin/konan/test/blackbox/NativeSimpleTestUtils.kt b/native/native.tests/tests/org/jetbrains/kotlin/konan/test/blackbox/NativeSimpleTestUtils.kt
index 22895e2b35d5a..4a646a906e319 100644
--- a/native/native.tests/tests/org/jetbrains/kotlin/konan/test/blackbox/NativeSimpleTestUtils.kt
+++ b/native/native.tests/tests/org/jetbrains/kotlin/konan/test/blackbox/NativeSimpleTestUtils.kt
@@ -141,17 +141,31 @@ internal fun AbstractNativeSimpleTest.cinteropToLibrary(
     outputDir: File,
     freeCompilerArgs: TestCompilerArgs
 ): TestCompilationResult<out TestCompilationArtifact.KLIB> {
-    val testCase: TestCase = generateCInteropTestCaseFromSingleDefFile(defFile, freeCompilerArgs)
+    val args = freeCompilerArgs + cinteropModulesCachePathArguments(freeCompilerArgs.cinteropArgs, outputDir)
+    val testCase: TestCase = generateCInteropTestCaseFromSingleDefFile(defFile, args)
     return CInteropCompilation(
         classLoader = testRunSettings.get(),
         targets = targets,
-        freeCompilerArgs = freeCompilerArgs,
+        freeCompilerArgs = args,
         defFile = testCase.modules.single().files.single().location,
         dependencies = emptyList(),
         expectedArtifact = getLibraryArtifact(testCase, outputDir)
     ).result
 }
 
+private fun cinteropModulesCachePathArguments(
+    cinteropArgs: List<String>,
+    outputDir: File,
+) = if (cinteropArgs.contains("-fmodules") && cinteropArgs.none { it.startsWith(FMODULES_CACHE_PATH_EQ) }) {
+    // Don't reuse the system-wide module cache to make the test run more predictably.
+    // See e.g. https://youtrack.jetbrains.com/issue/KT-68254.
+    TestCInteropArgs("-compiler-option", "$FMODULES_CACHE_PATH_EQ$outputDir/modulesCachePath")
+} else {
+    TestCompilerArgs.EMPTY
+}
+
+private const val FMODULES_CACHE_PATH_EQ = "-fmodules-cache-path="
+
 internal class CompiledExecutable(
     val testCase: TestCase,
     val compilationResult: TestCompilationResult.Success<out TestCompilationArtifact.Executable>