Inefficient Plotly usage

[PaulJonasJost]

We currently observe all values below the "Do something" button and run the plotting routine. This leads to two things:

1. We always need to check whether we want to recompute or otherwise recompute all data
2. We need to rerender the complete plot.

This leads to cluttered up observe{} with various degrees of workaround to prevent recomputation and absolutely unusable interactive plots for large ones (e.g. Volcanos, probably heatmaps as well).

Suggested Solution:
Jst as in #440 we can observe singular changes and use a plotlyproxy to just change layout/design