diff --git a/config/config_test.go b/config/config_test.go
index 4479f1f96f..ae0af557ba 100644
--- a/config/config_test.go
+++ b/config/config_test.go
@@ -14,7 +14,6 @@ import (
 	"github.com/0xPolygonHermez/zkevm-node/config/types"
 	"github.com/0xPolygonHermez/zkevm-node/log"
 	"github.com/0xPolygonHermez/zkevm-node/pricegetter"
-	"github.com/0xPolygonHermez/zkevm-node/sequencer"
 	"github.com/ethereum/go-ethereum/common"
 	"github.com/stretchr/testify/assert"
 	"github.com/stretchr/testify/require"
@@ -106,10 +105,6 @@ func Test_Defaults(t *testing.T) {
 			path:          "Sequencer.MaxSteps",
 			expectedValue: uint32(8388608),
 		},
-		{
-			path:          "Sequencer.MaxSequenceSize",
-			expectedValue: sequencer.MaxSequenceSize{Int: new(big.Int).SetInt64(2000000)},
-		},
 		{
 			path:          "Sequencer.MaxAllowedFailedCounter",
 			expectedValue: uint64(50),
diff --git a/config/default.go b/config/default.go
index 873a821d10..94fcbc5f54 100644
--- a/config/default.go
+++ b/config/default.go
@@ -64,7 +64,6 @@ SyncChunkSize = 100
 GenBlockNumber = 66
 
 [Sequencer]
-MaxSequenceSize = "2000000"
 WaitPeriodPoolIsEmpty = "1s"
 WaitPeriodSendSequence = "5s"
 LastBatchVirtualizationTimeMaxWaitPeriod = "5s"
diff --git a/config/environments/local/local.node.config.toml b/config/environments/local/local.node.config.toml
index 89d714b36e..9618237a32 100644
--- a/config/environments/local/local.node.config.toml
+++ b/config/environments/local/local.node.config.toml
@@ -55,7 +55,6 @@ SyncChunkSize = 100
 GenBlockNumber = 66
 
 [Sequencer]
-MaxSequenceSize = "2000000"
 WaitPeriodPoolIsEmpty = "1s"
 WaitPeriodSendSequence = "5s"
 LastBatchVirtualizationTimeMaxWaitPeriod = "5s"
diff --git a/sequencer/config.go b/sequencer/config.go
index d20ff0559c..dee7f85238 100644
--- a/sequencer/config.go
+++ b/sequencer/config.go
@@ -1,11 +1,7 @@
 package sequencer
 
 import (
-	"fmt"
-	"math/big"
-
 	"github.com/0xPolygonHermez/zkevm-node/config/types"
-	base "github.com/0xPolygonHermez/zkevm-node/encoding"
 )
 
 // Config represents the configuration of a sequencer
@@ -57,9 +53,6 @@ type Config struct {
 	// MaxSteps is max steps batch can handle
 	MaxSteps uint32 `mapstructure:"MaxSteps"`
 
-	// Maximum size, in gas size, a sequence can reach
-	MaxSequenceSize MaxSequenceSize `mapstructure:"MaxSequenceSize"`
-
 	// Maximum allowed failed counter for the tx before it becomes invalid
 	MaxAllowedFailedCounter uint64 `mapstructure:"MaxAllowedFailedCounter"`
 
@@ -134,19 +127,3 @@ type FinalizerCfg struct {
 	// to be read in order to provide the private keys to sign the L1 txs
 	PrivateKeys []types.KeystoreFileConfig `mapstructure:"PrivateKeys"`
 }
-
-// MaxSequenceSize is a wrapper type that parses token amount to big int
-type MaxSequenceSize struct {
-	*big.Int `validate:"required"`
-}
-
-// UnmarshalText unmarshal token amount from float string to big int
-func (m *MaxSequenceSize) UnmarshalText(data []byte) error {
-	amount, ok := new(big.Int).SetString(string(data), base.Base10)
-	if !ok {
-		return fmt.Errorf("failed to unmarshal string to float")
-	}
-	m.Int = amount
-
-	return nil
-}
diff --git a/sequencer/sequencesender.go b/sequencer/sequencesender.go
index 9915ef2ad6..18655bd77d 100644
--- a/sequencer/sequencesender.go
+++ b/sequencer/sequencesender.go
@@ -4,7 +4,6 @@ import (
 	"context"
 	"errors"
 	"fmt"
-	"math/big"
 	"time"
 
 	ethman "github.com/0xPolygonHermez/zkevm-node/etherman"
@@ -22,6 +21,16 @@ import (
 const (
 	ethTxManagerOwner = "sequencer"
 	monitoredIDFormat = "sequence-from-%v-to-%v"
+	// txSlotSize is used to calculate how many data slots a single transaction
+	// takes up based on its size. The slots are used as DoS protection, ensuring
+	// that validating a new transaction remains a constant operation (in reality
+	// O(maxslots), where max slots are 4 currently).
+	txSlotSize = 32 * 1024
+	// txMaxSize is the maximum size a single transaction can have. This field has
+	// non-trivial consequences: larger transactions are significantly harder and
+	// more expensive to propagate; larger transactions also take more resources
+	// to validate whether they fit into the pool or not.
+	txMaxSize = 4 * txSlotSize // 128KB
 )
 
 func (s *Sequencer) tryToSendSequence(ctx context.Context, ticker *time.Ticker) {
@@ -135,12 +144,13 @@ func (s *Sequencer) getSequencesToSend(ctx context.Context) ([]types.Sequence, e
 		// Check if can be send
 		sender := common.HexToAddress(s.cfg.Finalizer.SenderAddress)
 		tx, err = s.etherman.EstimateGasSequenceBatches(sender, sequences)
-		if err == nil && new(big.Int).SetUint64(tx.Gas()).Cmp(s.cfg.MaxSequenceSize.Int) >= 1 {
+		if err == nil && tx.Size() > txMaxSize {
 			metrics.SequencesOvesizedDataError()
-			log.Infof("oversized Data on TX oldHash %s (%d > %d)", tx.Hash(), tx.Gas(), s.cfg.MaxSequenceSize)
+			log.Infof("oversized Data on TX oldHash %s (txSize %d > 128KB)", tx.Hash(), tx.Size())
 			err = txpool.ErrOversizedData
 		}
 		if err != nil {
+			log.Infof("Handling estimage gas send sequence error: %v", err)
 			sequences, err = s.handleEstimateGasSendSequenceErr(ctx, sequences, currentBatchNumToSequence, err)
 			if sequences != nil {
 				// Handling the error gracefully, re-processing the sequence as a sanity check
diff --git a/test/config/debug.node.config.toml b/test/config/debug.node.config.toml
index bd408d01ea..413c8a1e06 100644
--- a/test/config/debug.node.config.toml
+++ b/test/config/debug.node.config.toml
@@ -55,7 +55,6 @@ SyncChunkSize = 100
 GenBlockNumber = 66
 
 [Sequencer]
-MaxSequenceSize = "2000000"
 WaitPeriodPoolIsEmpty = "1s"
 WaitPeriodSendSequence = "5s"
 LastBatchVirtualizationTimeMaxWaitPeriod = "5s"
diff --git a/test/config/test.node.config.toml b/test/config/test.node.config.toml
index 286cc783cd..f39260edb7 100644
--- a/test/config/test.node.config.toml
+++ b/test/config/test.node.config.toml
@@ -55,7 +55,6 @@ SyncChunkSize = 100
 GenBlockNumber = 66
 
 [Sequencer]
-MaxSequenceSize = "2000000"
 WaitPeriodPoolIsEmpty = "1s"
 WaitPeriodSendSequence = "15s"
 LastBatchVirtualizationTimeMaxWaitPeriod = "10s"